CN104147388A - 一种治疗偏头疼的中药组合物及其制备方法 - Google Patents
一种治疗偏头疼的中药组合物及其制备方法 Download PDFInfo
- Publication number
- CN104147388A CN104147388A CN201410422937.8A CN201410422937A CN104147388A CN 104147388 A CN104147388 A CN 104147388A CN 201410422937 A CN201410422937 A CN 201410422937A CN 104147388 A CN104147388 A CN 104147388A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- medicine composition
- traditional chinese
- radix
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 34
- 239000000203 mixture Substances 0.000 title claims abstract description 26
- 208000019695 Migraine disease Diseases 0.000 title claims abstract description 18
- 206010027599 migraine Diseases 0.000 title claims abstract description 18
- 238000002360 preparation method Methods 0.000 title claims abstract description 18
- 241001643642 Viticis Species 0.000 claims abstract description 14
- 229940079593 drug Drugs 0.000 claims abstract description 8
- 239000002775 capsule Substances 0.000 claims description 22
- 241000628997 Flos Species 0.000 claims description 13
- 239000009636 Huang Qi Substances 0.000 claims description 13
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 13
- 239000000463 material Substances 0.000 claims description 7
- 239000000843 powder Substances 0.000 claims description 7
- 239000008187 granular material Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 239000003826 tablet Substances 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 8
- 230000007812 deficiency Effects 0.000 abstract description 4
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 241000305491 Gastrodia elata Species 0.000 abstract 1
- 235000019083 Osmanthus fragrans Nutrition 0.000 abstract 1
- 244000242564 Osmanthus fragrans Species 0.000 abstract 1
- 244000170916 Paeonia officinalis Species 0.000 abstract 1
- 235000006484 Paeonia officinalis Nutrition 0.000 abstract 1
- 235000008599 Poria cocos Nutrition 0.000 abstract 1
- 244000197580 Poria cocos Species 0.000 abstract 1
- 230000003213 activating effect Effects 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 230000003014 reinforcing effect Effects 0.000 abstract 1
- 229940126680 traditional chinese medicines Drugs 0.000 abstract 1
- 206010019233 Headaches Diseases 0.000 description 18
- 231100000869 headache Toxicity 0.000 description 18
- 208000002193 Pain Diseases 0.000 description 14
- 239000000796 flavoring agent Substances 0.000 description 7
- 235000019634 flavors Nutrition 0.000 description 7
- 239000003795 chemical substances by application Substances 0.000 description 6
- 229920002472 Starch Polymers 0.000 description 5
- 239000008107 starch Substances 0.000 description 5
- 235000019698 starch Nutrition 0.000 description 5
- 206010012735 Diarrhoea Diseases 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 230000001717 pathogenic effect Effects 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 210000000952 spleen Anatomy 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 206010010904 Convulsion Diseases 0.000 description 3
- 230000000202 analgesic effect Effects 0.000 description 3
- 235000009508 confectionery Nutrition 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 244000052769 pathogen Species 0.000 description 3
- 230000007958 sleep Effects 0.000 description 3
- 208000011580 syndromic disease Diseases 0.000 description 3
- 230000008673 vomiting Effects 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 2
- 201000000736 Amenorrhea Diseases 0.000 description 2
- 206010001928 Amenorrhoea Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- 206010062717 Increased upper airway secretion Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- 206010033557 Palpitations Diseases 0.000 description 2
- 206010034960 Photophobia Diseases 0.000 description 2
- 208000004880 Polyuria Diseases 0.000 description 2
- -1 absorption carrier Substances 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 231100000540 amenorrhea Toxicity 0.000 description 2
- 239000011230 binding agent Substances 0.000 description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 description 2
- 230000036461 convulsion Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000035619 diuresis Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 238000002651 drug therapy Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000945 filler Substances 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 235000008216 herbs Nutrition 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
- 206010025482 malaise Diseases 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000026435 phlegm Diseases 0.000 description 2
- 208000037920 primary disease Diseases 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 230000000541 pulsatile effect Effects 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 210000002435 tendon Anatomy 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 208000004371 toothache Diseases 0.000 description 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
- 206010001497 Agitation Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010009346 Clonus Diseases 0.000 description 1
- 206010010726 Conjunctival oedema Diseases 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 208000005171 Dysmenorrhea Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- 206010070840 Gastrointestinal tract irritation Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 206010022998 Irritability Diseases 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
- 206010028748 Nasal obstruction Diseases 0.000 description 1
- 206010029216 Nervousness Diseases 0.000 description 1
- 206010030302 Oliguria Diseases 0.000 description 1
- 229920003081 Povidone K 30 Polymers 0.000 description 1
- 206010036790 Productive cough Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
- 239000004141 Sodium laurylsulphate Substances 0.000 description 1
- 208000007107 Stomach Ulcer Diseases 0.000 description 1
- 241000270708 Testudinidae Species 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 206010047531 Visual acuity reduced Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 102000011759 adducin Human genes 0.000 description 1
- 108010076723 adducin Proteins 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 208000022531 anorexia Diseases 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 239000001506 calcium phosphate Substances 0.000 description 1
- 229910000389 calcium phosphate Inorganic materials 0.000 description 1
- 235000011010 calcium phosphates Nutrition 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 208000019902 chronic diarrheal disease Diseases 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 238000004132 cross linking Methods 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 206010061428 decreased appetite Diseases 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 description 1
- 239000007919 dispersible tablet Substances 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 206010015037 epilepsy Diseases 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- SMANXXCATUTDDT-QPJJXVBHSA-N flunarizine Chemical compound C1=CC(F)=CC=C1C(C=1C=CC(F)=CC=1)N1CCN(C\C=C\C=2C=CC=CC=2)CC1 SMANXXCATUTDDT-QPJJXVBHSA-N 0.000 description 1
- 229960000326 flunarizine Drugs 0.000 description 1
- 201000005917 gastric ulcer Diseases 0.000 description 1
- 208000007565 gingivitis Diseases 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229960001680 ibuprofen Drugs 0.000 description 1
- 230000001709 ictal effect Effects 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000009191 jumping Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 229940031703 low substituted hydroxypropyl cellulose Drugs 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 239000012567 medical material Substances 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 201000009240 nasopharyngitis Diseases 0.000 description 1
- 201000008383 nephritis Diseases 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000001253 polyvinylpolypyrrolidone Substances 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 201000009890 sinusitis Diseases 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
本发明公开了一种治疗偏头痛的中药组合物，其特征是，由天麻、白芷、茯苓、黄芪、赤芍、蔓荆子、桂花等七味中药材制成。本发明以祛邪活络为主，祛风、散寒、化湿、清热，虚实夹杂，扶正祛邪并举，具有用药精简、见效快，有效率高，治愈后不复发等优点。
Description
技术领域
本发明涉及一种治疗偏头疼的中药组合物及其制备方法，属中药技术领域。
背景技术
偏头痛是一种发生在头部或左或右、是以头痛暴作、疼痛剧烈、反复发作为特征的搏动性头痛。发作前常有先兆，如眼前闪光、视物模糊、肢体麻木等，可伴恶心、呕吐，安静、黑暗环境内或睡眠后头痛缓解，反复发作特征相似。本病属中医学“头痛”、“头风”、“偏头痛”、“偏头风”等范畴。
欧美国家患病率为1500～2000/10万人口(1.5％～2％)。中国患病率为732.1/10万人口(0.73％)，发病率65.8/10万人口(0.06％)。国外患病年龄以25～45岁多见，45％病人在儿童和青春期起病，但1～12岁儿童不少见，首次发病<10岁占25％。男孩发病年龄小于女孩。中国患病年龄以20～45岁多见，10岁以下仅42.6/10万人口，14岁以下仅182/10万人口。国外女性较男性多2～3倍。中国患病率男性392.8/10万人口，女性1579.2/10万人口。
目前西医只能靠止痛药来缓解疼痛，并无特效药物，而吃止痛药，往往初期有效，吃久了止不住疼痛，或者加大药量，药物的副作用也会随之出现，常见的有胃炎、胃出血、胃溃疡、解热镇痛性肾炎等，甚至会引起药物性头痛。可以说，对于偏头疼，现代西医没有办法治愈。
中药治疗偏头疼具有独到之处，我国对头痛病认识，在殷商甲骨文就有“疾首”的记载，《内经》称本病为“脑风”、“首风”，《素问·风论》认为其病因乃外在风邪寒气犯于头脑而致。现常用的方剂有丹参息痛方、天麻头痛散、疏肝止痛方、清热止痛方等等，效果较好。
发明内容
本发明人在祖传秘方的基础上，经过改良，提供了一种治疗偏头疼的中药组合物。
本发明技术方案是：一种治疗偏头疼的中药组合物，其特征是，由天麻、白芷、茯苓、黄芪、赤芍、蔓荆子、桂花等七味中药材制成。
作为优选，本发明一种治疗偏头痛的中药组合物，其特征是，其组成原料的重量份为：天麻6-12、白芷3-6、茯苓3-6、黄芪1-3、赤芍1-3、蔓荆子4-8、桂花3-6。
作为最优技术方案，本发明一种治疗偏头痛的中药组合物，其特征是，其组成原料的重量份为：天麻8、白芷4、茯苓4、黄芪2、赤芍1、蔓荆子4、桂花4。
方中：
天麻：[性味]甘，平。[归经]归肝经。[功能主治]平肝息风止痉。用于头痛眩晕，肢体麻木，小儿惊风，癫痫抽搐，破伤风。
白芷：[性味]辛，温。[归经]归胃、大肠、肺经。[功能主治]散风除湿，通窍止痛，消肿排脓。用于感冒头痛，眉棱骨痛，鼻塞，鼻渊，牙痛，白带，疮疡肿痛。
茯苓：[性味]甘、淡，平。[归经]归心、肺、脾、肾经。[功能主治]利水渗湿，健脾宁心。用于水肿尿少，痰饮眩悸，脾虚食少，便溏泄泻，心神不安，惊悸失眠。
黄芪：[性味]甘，温。[归经]归肺、脾经。[功能主治]补气固表，利尿托毒，排脓，敛疮生肌。用于气虚乏力，食少便溏，中气下陷，久泻脱肛，便血崩漏，表虚自汗，气虚水肿，内热消渴等。
赤芍：[性味]苦，微寒。[归经]归肝经。[功能主治]清热凉血，散瘀止痛。用于温毒发斑，吐血衄血，目赤肿痛，肝郁胁痛，经闭痛经，症瘕腹痛，跌扑损伤，痈肿疮疡。
蔓荆子：[性味]辛、苦，微寒。[归经]归膀胱、肝、胃经。[功能主治]疏散风热，清利头目。用于风热感冒头痛，齿龈肿痛，目赤多泪，目暗不明，头晕目眩。
桂花：[性味]花：辛，温。[功能主治]花：散寒破结，化痰止咳。用于牙痛，咳喘痰多，经闭腹痛。
优选地，本发明治疗偏头痛的中药组合物可以为片剂、分散片、颗粒剂、胶囊剂或汤剂。可以采用本领域技术人员熟知的方法来进行药剂的制备。根据需要，可以加入各种药学上可接受的载体。所述的载体包括药学领域常规的稀释剂、赋形剂、填充剂、粘合剂、湿润剂、崩解剂、吸收促进剂、表面活性剂、吸附载体、润滑剂等。本发明的药剂在制备时，可选择的填充剂有：淀粉、糖粉、磷酸钙、糊精、微晶纤维素、乳糖、预胶化淀粉、甘露醇等；可选择的粘合剂有：羧甲基纤维素钠、PVP-K30、羟丙基纤维素、淀粉浆、甲基纤维素、乙基纤维素、羟丙基甲基纤维素、胶化淀粉等；可选择的崩解剂有：干淀粉、交联聚维酮、交联羧甲基纤维素钠、羧甲基淀粉钠、低取代羟丙基纤维素等；可选择的润滑剂有：硬脂酸镁、滑石粉、十二烷基硫酸钠、微粉硅胶等。
本发明优选为片剂、胶囊剂、颗粒剂。
进一步优选为胶囊剂。
本发明还提供了一种治疗偏头痛中药组合物胶囊剂的制备方法，包含如下步骤：按照本发明重量份称取干燥后的天麻、白芷、茯苓、黄芪、赤芍、蔓荆子、桂花等七味中药材，混合均匀，粉碎成过80-100目的细粉，灭菌装入0号胶囊中即得本发明胶囊剂。当然本发明胶囊剂也可以根据现有的制剂工艺，加入其他辅料，如矫味剂。
本发明胶囊剂用法用量：每天2次，每次4-6粒，每粒含药量0.4g。7天一疗程。
本发明以祛邪活络为主，祛风、散寒、化湿、清热，虚实夹杂，扶正祛邪并举。本发明组方具有用药精简、原料药材来源易得、制剂制备工艺简单、价格低廉，见效快，有效率高，治愈后不复发等优点。并且本发明中药组合物全部药材都是药食同源材料，且服用剂量低，无胃肠刺激，安全性较好，适于在临床上大规模推广。
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。
实施例1
本治疗偏头痛的中药组合物颗粒剂，采用下述的重量配比制备：
天麻8重量份，白芷4重量份，茯苓4重量份，黄芪2重量份，赤芍1重量份，蔓荆子4重量份，桂花4重量份。
制备方法：对各原料进行严格筛选，净选、烘干、称取、粉碎成过80目的细粉，加入适量β环糊精，加95％乙醇制粒，60℃以下干燥，整粒，即得颗粒剂。
实施例2
本治疗偏头痛的中药组合物胶囊剂，采用下述的重量配比制备：
天麻8重量份，白芷4重量份，茯苓4重量份，黄芪2重量份，赤芍1重量份，蔓荆子4重量份，桂花4重量份。
制备方法：对各原料进行严格筛选，净选、烘干、称取然后粉碎成过80目的细粉，灭菌装入0号胶囊中即得本发明胶囊剂。
实施例3
本治疗偏头痛的中药组合物胶囊剂，采用下述的重量配比制备：
天麻10重量份，白芷4重量份，茯苓6重量份，黄芪3重量份，赤芍2重量份，蔓荆子8重量份，桂花6重量份。
制备方法：对各原料进行严格筛选，净选、烘干、称取然后粉碎成过80目的细粉，灭菌装入0号胶囊中即得本发明胶囊剂。
实施例4
本治疗偏头痛的中药组合物胶囊剂，采用下述的重量配比制备：
天麻6重量份，白芷6重量份，茯苓4重量份，黄芪5重量份，赤芍6重量份，蔓荆子6重量份，桂花4重量份。
制备方法：对各原料进行严格筛选，净选、烘干、称取然后粉碎成过100目的细粉，灭菌装入0号胶囊中即得本发明胶囊剂。
本发明药物的临床观察资料
1、一般资料
门诊患者200例。随机分为两组，各100例，两组性别、年龄、症状等均无显著性差异。
2、诊断标准
发作性中度到重度搏动性头痛，伴恶心、呕吐或畏光。体力活动使头痛加剧。发作开始时仅为轻到中度的钝痛或不适感，几分钟到几小时后达到严重的搏动性痛或跳痛。约2/3为一侧性头痛，也可为双侧头痛，有时疼痛放射至上颈部及肩部。
3、治疗方法
治疗组：口服本发明最优技术方案制得的胶囊剂，每天2次，每次4-6粒，7天一疗程，连续服用2个疗程。
对照组：口服盐酸氟桂嗪片10mg，每天3次，7天为一个疗程，连续服用2个疗程。
4、疗效标准
(1)治愈：症状消失无复发，相关实验室检查正常；
(2)显效：症状消失，颈颅多普勒超声检查正常，半年以内无复发；
(3)有效：症状减轻，实验室检查有所改善；
(4)无效：症状及实验室检查均无改善。
5、实验结果
治疗结果治疗两周后统计疗效，治疗组100例，其中治愈72例(72.0％)，显效18例(20.0％)，有效6例(6.0％)，无效2例(2.0％)；总有效率98.0％；对照组100例，其中治愈36例(36.0％)，显效24例(24.0％)，有效18例(18.0％)，无效22例(22.0％)，总有效率78.0％。
典型病例：
某男，29岁。患者自诉6年前开始出现偏头痛，每次发作持续6-12小时不等，头痛时伴有畏光、烦躁、恶心呕吐等症状，睡眠稍有不足，偏头疼就发作。以前常吃止痛药止痛，但进来越发严重，发作更为频繁。来本院治疗后，给予本发明药物治疗2个疗程，头痛消失，随访1年，偏头痛没有复发。
某女，33岁。患者自诉4年前开始出现偏头痛，发作时疼痛剧烈，每次发作持4-24小时不等，同时伴有恶心，呕吐，情绪紧张或睡眠不足，则发作更频繁，曾服用去痛片、布洛芬等，服药后可暂时缓解，进来发作频率增高，来本院治疗后，给予本发明药物治疗2个疗程，头痛消失，随访1年，偏头痛没有复发。
Claims (6)
1.一种治疗偏头疼的中药组合物，其特征是，由天麻、白芷、茯苓、黄芪、赤芍、蔓荆子、桂花等七味中药材制成。
2.一种治疗偏头痛的中药组合物，其特征是，其组成原料的重量份为：天麻6-12、白芷3-6、茯苓3-6、黄芪1-3、赤芍1-3、蔓荆子4-8、桂花3-6。
3.一种治疗偏头痛的中药组合物，其特征是，其组成原料的重量份为：天麻8、白芷4、茯苓4、黄芪2、赤芍1、蔓荆子4、桂花4。
4.如权利要求1-3所述的一种治疗偏头痛的中药组合物，其特征是，其为片剂、颗粒剂、胶囊剂或汤剂。
5.如权利要求4所述的一种治疗偏头痛的中药组合物，其特征是，其为胶囊剂。
6.如权利要求4所述的一种治疗偏头痛的中药组合物的制备方法，包含如下步骤：按照本发明重量份称取干燥后的天麻、白芷、茯苓、黄芪、赤芍、蔓荆子、桂花等七味中药材，混合均匀，粉碎成过80-100目的细粉，灭菌装入0号胶囊中即得本发明胶囊剂。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410422937.8A CN104147388B (zh) | 2014-08-25 | 2014-08-25 | 一种治疗偏头疼的中药组合物及其制备方法 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410422937.8A CN104147388B (zh) | 2014-08-25 | 2014-08-25 | 一种治疗偏头疼的中药组合物及其制备方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104147388A true CN104147388A (zh) | 2014-11-19 |
| CN104147388B CN104147388B (zh) | 2015-04-29 |
Family
ID=51873151
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410422937.8A Expired - Fee Related CN104147388B (zh) | 2014-08-25 | 2014-08-25 | 一种治疗偏头疼的中药组合物及其制备方法 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104147388B (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168713A (zh) * | 2015-09-16 | 2015-12-23 | 崔皓 | 治疗偏头痛的中药 |
| CN106266637A (zh) * | 2016-11-07 | 2017-01-04 | 成都泠汐尚品科技有限公司 | 一种用于治疗偏头痛的中药组合物 |
| CN106344818A (zh) * | 2016-11-07 | 2017-01-25 | 成都泠汐尚品科技有限公司 | 一种用于治疗偏头痛的中药组合物的制备方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446455A (zh) * | 2012-05-27 | 2013-12-18 | 孙玉建 | 一种治疗头痛的中药 |
| CN103495042A (zh) * | 2013-09-09 | 2014-01-08 | 徐如阳 | 一种用于治偏头痛的中药组合物 |
-
2014
- 2014-08-25 CN CN201410422937.8A patent/CN104147388B/zh not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103446455A (zh) * | 2012-05-27 | 2013-12-18 | 孙玉建 | 一种治疗头痛的中药 |
| CN103495042A (zh) * | 2013-09-09 | 2014-01-08 | 徐如阳 | 一种用于治偏头痛的中药组合物 |
Non-Patent Citations (2)
| Title |
|---|
| 刘远琴等: "偏头痛的中医治疗研究", 《中国当代医药》 * |
| 田琳等: "《基于数据挖掘的现代中医药治疗头痛自拟处方用药规律分析》", 《中国中医药信息杂志》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105168713A (zh) * | 2015-09-16 | 2015-12-23 | 崔皓 | 治疗偏头痛的中药 |
| CN106266637A (zh) * | 2016-11-07 | 2017-01-04 | 成都泠汐尚品科技有限公司 | 一种用于治疗偏头痛的中药组合物 |
| CN106344818A (zh) * | 2016-11-07 | 2017-01-25 | 成都泠汐尚品科技有限公司 | 一种用于治疗偏头痛的中药组合物的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104147388B (zh) | 2015-04-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104208540B (zh) | 一种治疗胃癌的中药复方及其制备方法 | |
| CN104147388B (zh) | 一种治疗偏头疼的中药组合物及其制备方法 | |
| CN103432559A (zh) | 一种治疗血滞型月经减少及痛经的中药组合物及其制备方法和用途 | |
| CN103223101A (zh) | 一种治疗甲状腺囊肿的中药 | |
| CN104524247B (zh) | 一种治疗偏头痛的药物组合物及其用途 | |
| CN103599403A (zh) | 一种治疗偏头痛的中药组合物及其制备方法 | |
| CN102488784A (zh) | 一种治疗腰疼的中药组合物 | |
| CN104547736A (zh) | 一种治疗甲状腺肿的药物 | |
| CN103446387B (zh) | 一种治疗甲亢的中药组合物及制备方法 | |
| CN105213758A (zh) | 一种治疗慢性肺炎的中药组合物及其制备方法 | |
| CN101983666A (zh) | 一种治疗风湿病的中药组合物及其制备方法 | |
| CN105434739A (zh) | 一种治疗霰粒肿的中药组合物及其制备方法 | |
| CN105194572A (zh) | 一种治疗胶质瘤的中药组合物 | |
| CN1939497A (zh) | 一种治疗输卵管阻塞性不孕症的中药制剂 | |
| CN104288421A (zh) | 一种治疗偏头痛的中药组合物 | |
| CN110841007B (zh) | 一种治疗脑中风后遗症的中药组合物及其应用 | |
| CN103520354A (zh) | 一种治疗血虚型乳腺增生的中药及制备方法 | |
| CN106266637A (zh) | 一种用于治疗偏头痛的中药组合物 | |
| CN103845690A (zh) | 一种治疗老年抑郁症的药物 | |
| CN103040990A (zh) | 一种治疗恶性肿瘤的药物组合物及其制备方法 | |
| CN102670885A (zh) | 一种治疗咳喘的药物及其制备方法 | |
| CN106344818A (zh) | 一种用于治疗偏头痛的中药组合物的制备方法 | |
| CN1256976C (zh) | 一种抗癌中药组合物及其制备方法 | |
| CN1733190A (zh) | 采取分期治疗乳腺病的中药制剂 | |
| CN103800724A (zh) | 一种治疗甲状腺炎的中药 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| ASS | Succession or assignment of patent right |
Owner name: WANG GUIXIA Free format text: FORMER OWNER: TANG GUOPING Effective date: 20150212 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| C53 | Correction of patent of invention or patent application | ||
| CB03 | Change of inventor or designer information |
Inventor after: Sun Zhongguo Inventor after: Fu Zhaowu Inventor after: Zhang Zhen Inventor before: Tang Guoping |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 276017 LINYI, SHANDONG PROVINCE TO: 276401 LINYI, SHANDONG PROVINCE Free format text: CORRECT: INVENTOR; FROM: TANG GUOPING TO: SUN ZHONGGUO FU ZHAOWU ZHANG ZHEN |
|
| TA01 | Transfer of patent application right |
Effective date of registration: 20150212 Address after: 276401 Yishui City, Linyi province Yishui County town of new lane, No. 18 Applicant after: Wang Guixia Address before: 276017 Shandong Province, Luozhuang District Fu Zhuang Office after the village of coke, No. 5 Applicant before: Tang Guoping |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20160105 Address after: 510630 Guangdong city of Guangzhou province Tianhe District Hua Jing Lu No. 37 room 703 (the home office use limit) Patentee after: Guangzhou universal wisdom pharmaceutical chain Co., Ltd. Address before: 276401 Yishui City, Linyi province Yishui County town of new lane, No. 18 Patentee before: Wang Guixia |
|
| CP01 | Change in the name or title of a patent holder | ||
| CP01 | Change in the name or title of a patent holder |
Address after: 510630 Guangdong city of Guangzhou province Tianhe District Hua Jing Lu No. 37 room 703 (the home office use limit) Patentee after: Guangzhou humanity wisdom Valley medicine Limited by Share Ltd Address before: 510630 Guangdong city of Guangzhou province Tianhe District Hua Jing Lu No. 37 room 703 (the home office use limit) Patentee before: Guangzhou universal wisdom pharmaceutical chain Co., Ltd. |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20150429 Termination date: 20200825 |