CN104145026A - 分析物的检测 - Google Patents

分析物的检测 Download PDF

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Publication number
CN104145026A
CN104145026A CN201280066877.XA CN201280066877A CN104145026A CN 104145026 A CN104145026 A CN 104145026A CN 201280066877 A CN201280066877 A CN 201280066877A CN 104145026 A CN104145026 A CN 104145026A
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CN
China
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eis
methods
analyte
sample
nucleic acid
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CN201280066877.XA
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English (en)
Chinese (zh)
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H·舒尔茨
D·科里根
蒂尔·巴赫曼
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ITI Scotland Ltd
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ITI Scotland Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3275—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction
    • G01N27/3277—Sensing specific biomolecules, e.g. nucleic acid strands, based on an electrode surface reaction being a redox reaction, e.g. detection by cyclic voltammetry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308—Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • G01N33/5438—Electrodes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
    • C12Q2565/60—Detection means characterised by use of a special device
    • C12Q2565/607—Detection means characterised by use of a special device being a sensor, e.g. electrode
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Electrochemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CN201280066877.XA 2011-11-22 2012-11-21 分析物的检测 Pending CN104145026A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB1120118.3 2011-11-22
GBGB1120118.3A GB201120118D0 (en) 2011-11-22 2011-11-22 Detecting analytes
GB1212662.9 2012-07-17
GB1212662.9A GB2496932A (en) 2011-11-22 2012-07-17 Nucleic acid detection using electrochemical impedance spectroscopy
PCT/EP2012/073240 WO2013076143A1 (en) 2011-11-22 2012-11-21 Detecting analytes

Publications (1)

Publication Number Publication Date
CN104145026A true CN104145026A (zh) 2014-11-12

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Application Number Title Priority Date Filing Date
CN201280066877.XA Pending CN104145026A (zh) 2011-11-22 2012-11-21 分析物的检测

Country Status (13)

Country Link
US (1) US9777337B2 (enExample)
EP (1) EP2776583A1 (enExample)
JP (1) JP2015503095A (enExample)
KR (1) KR20140096104A (enExample)
CN (1) CN104145026A (enExample)
AU (1) AU2012342522A1 (enExample)
BR (1) BR112014012045A2 (enExample)
GB (2) GB201120118D0 (enExample)
IN (1) IN2014CN03508A (enExample)
MX (1) MX2014006118A (enExample)
RU (1) RU2014125212A (enExample)
WO (1) WO2013076143A1 (enExample)
ZA (1) ZA201404463B (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104914151A (zh) * 2015-05-08 2015-09-16 首都师范大学 一种用于氨苄西林和磺胺地索辛电化学传感器自组装钝化层的形成方法及其电化学传感器
CN105784675A (zh) * 2015-01-13 2016-07-20 爱科来株式会社 等离子体分光分析方法和等离子体分光分析装置
CN107430016A (zh) * 2015-02-06 2017-12-01 吉纳普赛斯股份有限公司 用于检测和分析生物物质的系统和方法
CN108152250A (zh) * 2017-10-27 2018-06-12 南京邮电大学 生物识别探针的构建方法及其逻辑运算方法
CN109564185A (zh) * 2016-10-24 2019-04-02 双孔人公司 样品中多核苷酸序列的分数丰度
US11486873B2 (en) 2016-03-31 2022-11-01 Ontera Inc. Multipore determination of fractional abundance of polynucleotide sequences in a sample

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GB201415864D0 (en) 2014-09-08 2014-10-22 Univ Edinburgh Methods of detecting of multidrug resistant bacteria
CN107209134B (zh) * 2015-02-20 2020-05-26 索尼公司 电特性测量设备、电特性测量系统、电特性测量方法以及用于使计算机实现所述方法的电特性测量程序
US10012645B2 (en) * 2016-08-24 2018-07-03 The Florida International University Board Of Trustees Rapid zika virus detection using nano-enabled electrochemical sensing system
WO2019026517A1 (ja) * 2017-07-31 2019-02-07 国立大学法人大阪大学 溶液中に存在する対象物質の検出方法および検出するためのシステム
KR102294374B1 (ko) * 2019-09-09 2021-08-26 한국교통대학교산학협력단 전기화학적 무선 진단이 가능한 탄소 양자점의 제조방법, 및 이를 활용한 전기화학적 무선진단방법
CN111562254A (zh) * 2020-05-27 2020-08-21 济南大学 一种基于功能化磁性二氧化硅的化学发光传感器的制备方法
WO2024235904A1 (en) * 2023-05-16 2024-11-21 Roche Molecular Systems, Inc. Detection of target analytes using multimodal signal probes

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WO2009122159A2 (en) * 2008-03-31 2009-10-08 Cambridge Enterprise Limited Biosensor for analyte detection
WO2010060060A1 (en) * 2008-11-24 2010-05-27 Adnavance Technologies, Inc. Electrochemical methods of detecting nucleic acid hybridization
WO2011069997A2 (en) * 2009-12-09 2011-06-16 Iti Scotland Limited Detecting analytes

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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2009122159A2 (en) * 2008-03-31 2009-10-08 Cambridge Enterprise Limited Biosensor for analyte detection
WO2010060060A1 (en) * 2008-11-24 2010-05-27 Adnavance Technologies, Inc. Electrochemical methods of detecting nucleic acid hybridization
WO2011069997A2 (en) * 2009-12-09 2011-06-16 Iti Scotland Limited Detecting analytes

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WEN-TSO LIU, ET AL.: "Effects of Target Length on the Hybridization Efficiency and Specificity of rRNA-Based Oligonucleotide Microarrays", 《APPLIED AND ENVIRONMENTAL MICROBIOLOGY》, vol. 73, no. 1, 27 October 2006 (2006-10-27) *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105784675A (zh) * 2015-01-13 2016-07-20 爱科来株式会社 等离子体分光分析方法和等离子体分光分析装置
CN107430016A (zh) * 2015-02-06 2017-12-01 吉纳普赛斯股份有限公司 用于检测和分析生物物质的系统和方法
US11015219B2 (en) 2015-02-06 2021-05-25 Genapsys, Inc. Systems and methods for detection and analysis of biological species
CN107430016B (zh) * 2015-02-06 2021-08-03 吉纳普赛斯股份有限公司 用于检测和分析生物物质的系统和方法
CN104914151A (zh) * 2015-05-08 2015-09-16 首都师范大学 一种用于氨苄西林和磺胺地索辛电化学传感器自组装钝化层的形成方法及其电化学传感器
CN104914151B (zh) * 2015-05-08 2017-10-13 首都师范大学 一种用于氨苄西林和磺胺地索辛电化学传感器自组装钝化层的形成方法及其电化学传感器
US11486873B2 (en) 2016-03-31 2022-11-01 Ontera Inc. Multipore determination of fractional abundance of polynucleotide sequences in a sample
CN109564185A (zh) * 2016-10-24 2019-04-02 双孔人公司 样品中多核苷酸序列的分数丰度
US11435338B2 (en) 2016-10-24 2022-09-06 Ontera Inc. Fractional abundance of polynucleotide sequences in a sample
CN108152250A (zh) * 2017-10-27 2018-06-12 南京邮电大学 生物识别探针的构建方法及其逻辑运算方法
CN108152250B (zh) * 2017-10-27 2020-02-18 南京邮电大学 生物识别探针的构建方法及其逻辑运算方法

Also Published As

Publication number Publication date
EP2776583A1 (en) 2014-09-17
GB201212662D0 (en) 2012-08-29
US9777337B2 (en) 2017-10-03
KR20140096104A (ko) 2014-08-04
GB201120118D0 (en) 2012-01-04
WO2013076143A1 (en) 2013-05-30
AU2012342522A1 (en) 2014-05-29
US20150148257A1 (en) 2015-05-28
JP2015503095A (ja) 2015-01-29
GB2496932A (en) 2013-05-29
IN2014CN03508A (enExample) 2015-10-09
RU2014125212A (ru) 2015-12-27
BR112014012045A2 (pt) 2017-05-30
ZA201404463B (en) 2015-10-28
MX2014006118A (es) 2015-04-16

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Application publication date: 20141112