CN104144922B - 作为ep2受体拮抗剂的2h-吲唑 - Google Patents

作为ep2受体拮抗剂的2h-吲唑 Download PDF

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Publication number
CN104144922B
CN104144922B CN201280067965.1A CN201280067965A CN104144922B CN 104144922 B CN104144922 B CN 104144922B CN 201280067965 A CN201280067965 A CN 201280067965A CN 104144922 B CN104144922 B CN 104144922B
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methyl
indazole
methanamide
base
piperidin
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Expired - Fee Related
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Chinese (zh)
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CN104144922A (zh
Inventor
N·布罗伊尔
A·门格尔
U·勒恩
A·罗特盖里
B·布赫曼
B·林登塔尔
A·特尔拉克
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Bayer Intellectual Property GmbH
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Bayer Intellectual Property GmbH
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Reproductive Health (AREA)
  • Rheumatology (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Psychology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
CN201280067965.1A 2011-11-28 2012-11-26 作为ep2受体拮抗剂的2h-吲唑 Expired - Fee Related CN104144922B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
DE102011087170 2011-11-28
DE10201087170.5 2011-11-28
DE102011087170.5 2011-11-28
DE102012206715.9 2012-04-24
DE102012206715 2012-04-24
PCT/EP2012/073556 WO2013079425A1 (en) 2011-11-28 2012-11-26 Novel 2h-indazoles as ep2 receptor antagonists

Publications (2)

Publication Number Publication Date
CN104144922A CN104144922A (zh) 2014-11-12
CN104144922B true CN104144922B (zh) 2016-08-31

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CN201280067965.1A Expired - Fee Related CN104144922B (zh) 2011-11-28 2012-11-26 作为ep2受体拮抗剂的2h-吲唑

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Country Link
US (1) US9062041B2 (https=)
EP (1) EP2785707B1 (https=)
JP (1) JP6192654B2 (https=)
KR (1) KR20140103984A (https=)
CN (1) CN104144922B (https=)
AR (1) AR089011A1 (https=)
AU (1) AU2012344015A1 (https=)
BR (1) BR112014012459A2 (https=)
CA (1) CA2856769A1 (https=)
CL (1) CL2014001392A1 (https=)
CO (1) CO6970595A2 (https=)
CR (1) CR20140257A (https=)
DO (1) DOP2014000114A (https=)
EA (1) EA201400623A1 (https=)
EC (1) ECSP14002542A (https=)
ES (1) ES2665510T3 (https=)
IL (1) IL232503A (https=)
IN (1) IN2014CN03854A (https=)
MX (1) MX2014006433A (https=)
PE (1) PE20141579A1 (https=)
PH (1) PH12014501195A1 (https=)
SG (1) SG11201402269RA (https=)
TW (1) TW201326154A (https=)
WO (1) WO2013079425A1 (https=)

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CA2848229C (en) 2011-09-16 2019-08-27 Fovea Pharmaceuticals Aniline derivatives, their preparation and their therapeutic application
TW201326154A (zh) 2011-11-28 2013-07-01 拜耳知識產權公司 作為ｅｐ２受體拮抗劑之新穎２ｈ－吲唑
EP2999469A1 (de) * 2013-05-23 2016-03-30 Bayer Pharma Aktiengesellschaft Pharmazeutische zusammensetzung und deren verwendung sowie anwendungsregime dieser pharmazeutischen zusammensetzung zur bedarfsweisen ( on-demand") kontrazeption
WO2014187793A1 (de) * 2013-05-23 2014-11-27 Bayer Pharma Aktiengesellschaft Verwendung einer pharmazeutischen zusammensetzung zur notfallkontrazeption
RU2016149812A (ru) 2014-06-06 2018-07-17 Флексус Байосайенсиз, Инк. Иммунорегулирующие средства
UY36391A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
BR112017008809A2 (pt) 2014-11-05 2017-12-19 Flexus Biosciences Inc agentes imunorreguladores
CN112969698A (zh) 2018-11-08 2021-06-15 葛兰素史密斯克莱知识产权发展有限公司 化学化合物
TW202241846A (zh) * 2020-12-24 2022-11-01 日商小野藥品工業股份有限公司 具有ｅｐ拮抗活性之化合物的鹽、溶劑合物及結晶

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DE102009049662A1 (de) * 2009-10-13 2011-04-14 Bayer Schering Pharma Aktiengesellschaft 2,5-Disubstituierte 2H-Indazole als EP2-Rezeptor-Antagonisten

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