CN104144716A - 用于角膜的可缝合的混合型超多孔水凝胶角膜假体 - Google Patents

用于角膜的可缝合的混合型超多孔水凝胶角膜假体 Download PDF

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Publication number
CN104144716A
CN104144716A CN201280060886.8A CN201280060886A CN104144716A CN 104144716 A CN104144716 A CN 104144716A CN 201280060886 A CN201280060886 A CN 201280060886A CN 104144716 A CN104144716 A CN 104144716A
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CN
China
Prior art keywords
collagen
phema
pmma
cells
hydrogel
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280060886.8A
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English (en)
Chinese (zh)
Inventor
迈克尔·卓
阿枚利亚·扎兰德尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Illinois at Urbana Champaign
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University of Illinois at Urbana Champaign
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by University of Illinois at Urbana Champaign filed Critical University of Illinois at Urbana Champaign
Publication of CN104144716A publication Critical patent/CN104144716A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/14—Eye parts, e.g. lenses or corneal implants; Artificial eyes
    • A61F2/142—Cornea, e.g. artificial corneae, keratoprostheses or corneal implants for repair of defective corneal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/48—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with macromolecular fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/02—Enzymes or microbial cells immobilised on or in an organic carrier
    • C12N11/04—Enzymes or microbial cells immobilised on or in an organic carrier entrapped within the carrier, e.g. gel or hollow fibres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Transplantation (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • Composite Materials (AREA)
  • Vascular Medicine (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
CN201280060886.8A 2011-10-28 2012-10-26 用于角膜的可缝合的混合型超多孔水凝胶角膜假体 Pending CN104144716A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/284,301 US20120071580A1 (en) 2008-07-31 2011-10-28 Suturable Hybrid Superporous Hydrogel Keratoprosthesis for Cornea
US13/284,301 2011-10-28
PCT/US2012/062116 WO2013063390A1 (en) 2011-10-28 2012-10-26 A suturable hybrid superporous hydrogel keratoprosthesis for cornea

Publications (1)

Publication Number Publication Date
CN104144716A true CN104144716A (zh) 2014-11-12

Family

ID=48168545

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280060886.8A Pending CN104144716A (zh) 2011-10-28 2012-10-26 用于角膜的可缝合的混合型超多孔水凝胶角膜假体

Country Status (9)

Country Link
US (1) US20120071580A1 (enExample)
EP (1) EP2771042A4 (enExample)
JP (1) JP2014533153A (enExample)
KR (1) KR20140093966A (enExample)
CN (1) CN104144716A (enExample)
AU (1) AU2012328583A1 (enExample)
CA (1) CA2853714A1 (enExample)
IN (1) IN2014CN03269A (enExample)
WO (1) WO2013063390A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110025402A (zh) * 2019-05-21 2019-07-19 王丽强 含生物材料的人工角膜
CN115052554A (zh) * 2019-07-31 2022-09-13 修订光学公司 2.0 角膜嵌体设计和矫正视力的方法

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101617435B1 (ko) 2013-10-29 2016-05-02 주식회사 티이바이오스 Phema 및 pmma로 이루어지는 멤브레인 및 그의 제조방법
CN103989553B (zh) * 2014-03-25 2017-01-11 周辉 一种角膜损伤无瘢痕修复装置的制造方法和储存方法
US20150308952A1 (en) * 2014-04-23 2015-10-29 Littelfuse, Inc. Urea concentration sensor
SG11201811252PA (en) 2016-07-26 2019-01-30 Singapore Health Serv Pte Ltd Optical cylinder and method of surface treatment of the same
RU2646804C1 (ru) * 2016-12-28 2018-03-07 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Офтальмологическое средство для регенерации роговицы глаза
CN108727610B (zh) * 2018-06-11 2020-09-15 浙江大学 一种具有高强韧、形状记忆和自修复特性的双网络水凝胶及其制备方法
CA3106459A1 (en) * 2018-07-24 2020-01-30 Newsouth Innovations Pty Limited Bio-ink for 3d printing
US11950997B2 (en) * 2019-05-20 2024-04-09 The Trustees Of The Stevens Institute Of Technology Artificial cornea with double-side microtextured pHEMA hydrogel
KR102304034B1 (ko) 2019-11-27 2021-09-17 울산과학기술원 인공각막 제조 방법
WO2021195587A1 (en) * 2020-03-26 2021-09-30 The Trustees Of The Stevens Institute Of Technology Artificial cornea with double-side microtextured phema hydrogel
WO2022124542A1 (ko) * 2020-12-11 2022-06-16 (주)티이바이오스 아크릴계 합성 고분자를 이용한 인공 장기용 스캐폴드 및 이의 제조방법
KR102646243B1 (ko) 2022-03-07 2024-03-11 울산과학기술원 영상 처리를 통한 인공 각막 제조 방법 및 장치
US20240108454A1 (en) * 2022-10-03 2024-04-04 EyeYon Medical Ltd. Patch to treat corneal perforation
KR102759485B1 (ko) * 2023-09-01 2025-01-23 주식회사 티이바이오스 성질이 다른 광학부 및 지지부의 계면 접착을 이용한 인공각막의 제조 방법
WO2025048014A1 (ko) * 2023-09-01 2025-03-06 주식회사 티이바이오스 성질이 다른 광학부 및 지지부의 계면 접착을 이용한 인공각막의 제조 방법
CN117482289B (zh) * 2023-11-29 2024-05-28 山东第一医科大学附属眼科研究所(山东省眼科研究所、山东第一医科大学附属青岛眼科医院) 一种具有抗菌和药物序贯释放能力的双网络多功能水凝胶的制备方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
US5300116A (en) * 1992-08-05 1994-04-05 Lions Eye Institute Of Western Australia Keratoprosthesis
US20070233240A1 (en) * 2004-10-05 2007-10-04 Frank Curtis W Intraocular lens implant

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MXPA04012703A (es) * 2002-06-18 2005-03-23 Univ Leland Stanford Junior Cornea artificial.
US20060287721A1 (en) * 2004-10-05 2006-12-21 David Myung Artificial cornea
US9999497B2 (en) * 2005-01-31 2018-06-19 Yichieh Shiuey Corneal implants and methods and systems for placement
US8029515B2 (en) * 2005-01-31 2011-10-04 Yichieh Shiuey Corneal implants and methods and systems for placement
US7988992B2 (en) * 2006-07-06 2011-08-02 KOS Life Sciences Abbott Laboratories Superporous hydrogels for heavy-duty applications
US20100080840A1 (en) * 2008-07-31 2010-04-01 Michael Cho Hybrid superporous hydrogel scaffold for cornea regeneration

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5300116A (en) * 1992-08-05 1994-04-05 Lions Eye Institute Of Western Australia Keratoprosthesis
US20070233240A1 (en) * 2004-10-05 2007-10-04 Frank Curtis W Intraocular lens implant

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110025402A (zh) * 2019-05-21 2019-07-19 王丽强 含生物材料的人工角膜
CN110025402B (zh) * 2019-05-21 2021-09-24 王丽强 含生物材料的人工角膜
CN115052554A (zh) * 2019-07-31 2022-09-13 修订光学公司 2.0 角膜嵌体设计和矫正视力的方法

Also Published As

Publication number Publication date
IN2014CN03269A (enExample) 2015-07-03
EP2771042A1 (en) 2014-09-03
KR20140093966A (ko) 2014-07-29
US20120071580A1 (en) 2012-03-22
EP2771042A4 (en) 2015-08-05
AU2012328583A1 (en) 2014-05-22
CA2853714A1 (en) 2013-05-02
WO2013063390A1 (en) 2013-05-02
JP2014533153A (ja) 2014-12-11

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Application publication date: 20141112