CN104127542B - A kind of pharmaceutical composition for the treatment of children's's repetitive upper respiratory tract infection - Google Patents
A kind of pharmaceutical composition for the treatment of children's's repetitive upper respiratory tract infection Download PDFInfo
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- CN104127542B CN104127542B CN201410377501.1A CN201410377501A CN104127542B CN 104127542 B CN104127542 B CN 104127542B CN 201410377501 A CN201410377501 A CN 201410377501A CN 104127542 B CN104127542 B CN 104127542B
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Abstract
The present invention relates to a kind of pharmaceutical composition for the treatment of children's's repetitive upper respiratory tract infection, it comprises the medical materials such as Semen Armeniacae Amarum, Cortex Magnoliae Officinalis, Radix seu Herba Gei aleppici, Radix Scutellariae, Flos Lonicerae, lobus cardiacus Folium seu radix sidae mysorensis, Radix Puerariae, Radix Saposhnikoviae.The pharmaceutical composition for the treatment of children's repetitive upper respiratory tract infection of the present invention has the effects such as heat-clearing and toxic substances removing, dampness removing antiinflammatory, antiinflammatory removing heat from blood, lung qi dispersing antitussive, dispelling phlegm and relieving sore-throat; For the good effect of the symptom such as watery nasal discharge, nasal obstruction, cough, laryngopharynx swelling and pain that upper respiratory tract infection and anemopyretic cold cause, there is significant curative effects such as recovering soon, relapse rate is low, safety is high, have no side effect.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of pharmaceutical composition for the treatment of children's's repetitive upper respiratory tract infection.
Background technology
Respiratory tract infection is clinical common disease.Respiratory tract infection repeatedly refers to that respiratory tract infection number of times that infant occurs every year is more than 6 times, and twice interval time is more than 1 week.That treats the little repetitive upper respiratory tract infection of children's in the market mostly is compound Western medicine preparation, Western medicine is many containing chemical compositions such as antipyretic-antalgic class or central stimulant such as acetaminophen, chlorphenamine maleate and caffeine, to children's's gastrointestinal, hepatic and renal function to such an extent as to brain development all exists certain side effect, and it is many just for the various symptoms of flu, as remissions such as nasal obstruction, watery nasal discharge, coughs, to causing the virus of flu itself to there is no any therapeutical effect, cure the symptoms, not the disease.Mostly Chinese medicine is to disperse is main compound recipe or antipyretic and antidotal type medicine, often to cough-relieving, reduce phlegm, antiviral has effect, antipyretic response is not good enough again.Therefore, the medicine of new treatment children's repetitive upper respiratory tract infection is needed clinically.
Summary of the invention
The object of this invention is to provide a kind of pharmaceutical composition for the treatment of children's's repetitive upper respiratory tract infection.
In order to realize object of the present invention, the invention provides a kind of pharmaceutical composition for the treatment of children's's repetitive upper respiratory tract infection, it comprises the crude drug of following weight portion: Semen Armeniacae Amarum 1-10 part, Cortex Magnoliae Officinalis 1-5 part, Radix seu Herba Gei aleppici 5-20 part, Radix Scutellariae 1-10 part, Flos Lonicerae 5-15 part, lobus cardiacus Folium seu radix sidae mysorensis 5-20 part, Radix Puerariae 1-5 part, Radix Saposhnikoviae 1-10 part and Fructus Gardeniae 1-5 part.
Preferably, the pharmaceutical composition for the treatment of children's repetitive upper respiratory tract infection of the present invention comprises the crude drug of following weight portion: 5 parts, Semen Armeniacae Amarum, Cortex Magnoliae Officinalis 3 parts, Radix seu Herba Gei aleppici 10 parts, Radix Scutellariae 5 parts, Flos Lonicerae 8 parts, lobus cardiacus Folium seu radix sidae mysorensis 10 parts, Radix Puerariae 3 parts, Radix Saposhnikoviae 5 parts and Fructus Gardeniae 3 parts.
More preferably, the pharmaceutical composition for the treatment of children's repetitive upper respiratory tract infection of the present invention also comprises the crude drug of following weight portion: Semen Sojae Preparatum seven 1-10 part, Herba Apii graveolentis 10-20 part, Herba Solidaginis 5-25 part, Fructus Evodiae 5-25 part, Herba Kalanchoes Laciniatae 10-30 part, Cortex Rhamni Globosae Radicis 5-25 part, Radix et Rhizoma Smilacis Ripariae 10-30 part, Rhizoma Saururi (Herba Saururi) 10-30 part, Lignum Acronychiae 10-30 part and Ipomoea hungaiensis Lingelsh. Et Borza. 10-25 part.
Most preferably, the pharmaceutical composition for the treatment of children's repetitive upper respiratory tract infection of the present invention, it is characterized in that, it also comprises the crude drug of following weight portion: Semen Sojae Preparatum 78 parts, Herba Apii graveolentis 12 parts, Herba Solidaginis 10 parts, Fructus Evodiae 10 parts, Herba Kalanchoes Laciniatae 12 parts, Cortex Rhamni Globosae Radicis 10 parts, Radix et Rhizoma Smilacis Ripariae 12 parts, Rhizoma Saururi (Herba Saururi) 20 parts, Lignum Acronychiae 20 parts and Ipomoea hungaiensis Lingelsh. Et Borza. 20 parts.
Preferably, described pharmaceutical composition can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, ointment or decoction.
Generally acknowledged that " organic conception ", " determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs ", " compound recipe use ", " compound compatibility medication is as used military forces " are the traditional Chinese medical science the most effective most scientific several large advantages at present, wherein " compound compatibility medication is as used military forces " is the original theory of Chinese medicine of very science.The tight compatibility that in traditional Chinese medical science prescription, each medicine is all linked with one another as arrayed troops for battle is that it is better than the effective means of Western medicine formula.Tcm prescription theory is thought, each prescription, not only need to select the appropriate compatibility of suitable medicament according to etiology and pathogenesis, also should meet the basic structure of prescription simultaneously, the i.e. prescription compatibility theory of " monarch, minister, help, make ", the prescription compatibility of so-called " monarch, minister, help, make " is exactly that it is based upon the scientific matching on the comprehensive judgement basis of disease pathogenesis.In medical side by too many levels, Mutiple Targets Integrate adjustment biological mechanism, can to obtain than Western medicine more lastingly, the more therapeutic effect that has no side effect of green natural, and this curative effect be based upon the above-mentioned traditional Chinese medical science tradition original theory accurate instruction on, the present invention just have followed this principle.
For compositions of the present invention, according to the prescription compatibility theory of " monarch, minister, help, make ", lobus cardiacus Folium seu radix sidae mysorensis and Radix seu Herba Gei aleppici are monarch drug; Radix et Rhizoma Smilacis Ripariae, Flos Lonicerae, Herba Solidaginis, Semen Sojae Preparatum seven, Cortex Magnoliae Officinalis are ministerial drug; Rhizoma Saururi (Herba Saururi), Herba Kalanchoes Laciniatae, Semen Armeniacae Amarum, Radix Scutellariae, Cortex Rhamni Globosae Radicis, Radix Puerariae, Radix Saposhnikoviae, Fructus Gardeniae, Ipomoea hungaiensis Lingelsh. Et Borza. are adjuvant drug; Herba Apii graveolentis, Fructus Evodiae and Lignum Acronychiae are for making medicine.The efficient combination of said medicine, supports mutually, has the effects such as heat-clearing and toxic substances removing, dampness removing antiinflammatory, antiinflammatory removing heat from blood, lung qi dispersing antitussive, dispelling phlegm and relieving sore-throat, and achieves through clinical trial and useful be satisfied with technique effect.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment decoction of the present invention
Take 5 grams, Semen Armeniacae Amarum, Cortex Magnoliae Officinalis 3 grams, Radix seu Herba Gei aleppici 10 grams, Radix Scutellariae 5 grams, Flos Lonicerae 8 grams, lobus cardiacus Folium seu radix sidae mysorensis 10 grams, Radix Puerariae 3 grams, Radix Saposhnikoviae 5 grams, Fructus Gardeniae 3 grams, Semen Sojae Preparatum 78 grams, Herba Apii graveolentis 12 grams, Herba Solidaginis 10 grams, Fructus Evodiae 10 grams, Herba Kalanchoes Laciniatae 12 grams, Cortex Rhamni Globosae Radicis 10 grams, Radix et Rhizoma Smilacis Ripariae 12 grams, Rhizoma Saururi (Herba Saururi) 20 grams, Lignum Acronychiae 20 grams and Ipomoea hungaiensis Lingelsh. Et Borza. 20 grams, add 3000 ml waters, heat 3 hours at 100 DEG C, filter, filtrate is cooled to room temperature, obtains decoction of the present invention.
Experimental example
Physical data
Be collected in the 50 children of going to a doctor to my institute year May in March, 2013 to 2014.All infants all meet Gynecology & Pediatrics Dept. medical diagnosis on disease criterion of therapeutical effect (1994) inside and outside the traditional Chinese medical science.Wherein man 25 example, female 25 example, children age 1-6 year between, average (4.3 ± 2.2) year.The infant that infant is all got rid of cardiomyopathy, draw kidney diaseases, disease in the blood system, immunodeficiency diseases and this treatment use immunosuppressant in first 1 month.
The decoction prepared in embodiment is used to treat, every day twice, oral 300 milliliters at every turn.Continuous treatment 15 days.And follow up a case by regular visits to 3 months.
Criterion of therapeutical effect
Recovery from illness: clinical symptoms disappears completely, occurs between follow-up period without upper respiratory tract infection.Effective: this upper respiratory tract infection symptoms disappears completely, between follow-up period, upper respiratory tract infection 1-2 time occurs, but each symptom is all slighter.Effective: this upper respiratory tract infection symptoms is alleviated to some extent, between follow-up period, upper respiratory tract infection 1-3 time occurs, comparatively compare symptom before treatment slight, the course of disease shortens.Invalid: this upper respiratory tract infection still has clinical symptoms through the treatment of 1 month, as cough and expectoration etc., and between follow-up period, still have upper respiratory tract infection to take place frequently.
Result
Through treatment, find in 50 routine infants, recovery from illness 42 example, effective 5 examples, effective 3 examples, total effective rate is 100%.
Model case
Health, female, 5 years old, National Day on October 2nd, 2013 gos for a ride with mother and plays, and opens wide automobile window, sleep soundly and catch cold in way, that night, with sending out hot body temperature 39.5 DEG C high, selects antibiotics, Western medicine of bringing down a fever, and moves back (all the time not lower than 38 DEG C) but soon bounces during high heat.Diagnosis: carve and examine: body temperature 39 DEG C, lethargy, whole body is lossless, and neck, body are scorching hot, Shou Zuleng, throat hypodynia, xerostomia thinks drink, and poor appetite, constipation with dry stool, yellow urine is few, and tongue is partially red, yellow and thin fur, floating and rapid pulse.The decoction prepared in embodiment is used to treat, every day twice, oral 300 milliliters at every turn.Continuous treatment 15 days.And follow up a case by regular visits to 3 months.Through treatment, clinical symptoms disappears completely, occurs between follow-up period without upper respiratory tract infection.
Xue so-and-so, man, 4 years old, infant generated heat, and cough, examines over three days, symptoms including cough, watery nasal discharge, gurgling with sputum, and two is just normal, indagation body temperature 38 DEG C, the micro-Huang of the red tongue of words and greasy, and swallow red, fingerprint purple, two pulmonary respiration sounds are thick.Accompany a little rale.The decoction prepared in embodiment is used to treat, every day twice, oral 300 milliliters at every turn.Continuous treatment 15 days.And follow up a case by regular visits to 3 months.Through treatment, clinical symptoms disappears completely, occurs between follow-up period without upper respiratory tract infection.
Liu, female, 2 years old, infant cough, rale, time have heating, once in treatments such as outer court's bronchopneumonia erythromycin, do not imitate.Its mother states diet difference, sleep disorder, and nocturnal cough is heavy, abundant expectoration tachypnea, and hope that its complexion owes China, spirit is also poor, the micro-fan of the wing of nose, and wheezing sound in the throat is sound, dry lip red tongue with yellowish and greasy fur, and fingerprint is livid purple, and two lungs have rale sound, and there is a little wet ring in the north.The decoction prepared in embodiment is used to treat, every day twice, oral 300 milliliters at every turn.Continuous treatment 15 days.And follow up a case by regular visits to 3 months.Through treatment, clinical symptoms disappears completely, occurs between follow-up period without upper respiratory tract infection.
Claims (1)
1. treat the pharmaceutical composition of children's's repetitive upper respiratory tract infection for one kind, it is characterized in that, it is made up of the crude drug of following weight portion: 5 parts, Semen Armeniacae Amarum, Cortex Magnoliae Officinalis 3 parts, Radix seu Herba Gei aleppici 10 parts, Radix Scutellariae 5 parts, Flos Lonicerae 8 parts, lobus cardiacus Folium seu radix sidae mysorensis 10 parts, Radix Puerariae 3 parts, Radix Saposhnikoviae 5 parts, Fructus Gardeniae 3 parts, Semen Sojae Preparatum 78 parts, Herba Apii graveolentis 12 parts, Herba Solidaginis 10 parts, Fructus Evodiae 10 parts, Herba Kalanchoes Laciniatae 12 parts, Cortex Rhamni Globosae Radicis 10 parts, Radix et Rhizoma Smilacis Ripariae 12 parts, Rhizoma Saururi (Herba Saururi) 20 parts, Lignum Acronychiae 20 parts and Ipomoea hungaiensis Lingelsh. Et Borza. 20 parts.
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| CN106474376A (en) * | 2016-12-14 | 2017-03-08 | 陈俊玲 | A kind of Chinese medicine composition of pediatric treatment repetitive upper respiratory tract infection |
| CN107929502A (en) * | 2017-12-08 | 2018-04-20 | 刘凡涛 | A kind of Chinese medicine composition for treating children's upper respiratory tract infection and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1438038A (en) * | 2003-02-19 | 2003-08-27 | 章炳炜 | Chinese medicine formula for preventing common cold by fumigating air to act respiratory tract and using method |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1438038A (en) * | 2003-02-19 | 2003-08-27 | 章炳炜 | Chinese medicine formula for preventing common cold by fumigating air to act respiratory tract and using method |
Non-Patent Citations (1)
| Title |
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| 葛根芩连汤加味在儿科急症中的作用;王玉明等;《黑龙江中医药》;19951231(第2期);第24-25页,尤其是第24页右栏最后1段，第25页左栏第1-2段 * |
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Inventor after: Di Dedong Inventor before: Ji Dedong |
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Address after: 273100 Qufu Maternal and Child Health-Care Hospital, Jining Road, Qufu, Shandong 24, China Patentee after: Di Dedong Address before: 273100 Qufu Maternal and Child Health-Care Hospital, Jining Road, Qufu, Shandong 24, China Patentee before: Ji Dedong |
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