CN104127508A - Medicine composition for treating protrusion of lumbar intervertebral disc and preparation method thereof - Google Patents
Medicine composition for treating protrusion of lumbar intervertebral disc and preparation method thereof Download PDFInfo
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Abstract
The invention provides a medicine composition for treating protrusion of a lumbar intervertebral disc and a preparation method of the medicine composition. The medicine composition is prepared from teasel root, kadsura pepper stem, caulis sinomenii, garden balsam stem, lycopodium clavatum, hematoxylon and rock salt, has a remarkable function in treating protrusion of the lumbar intervertebral disc, is free of obvious adverse reaction after being used, and is high in security.
Description
Technical field
The invention belongs to field of traditional Chinese, be specifically related to a kind of pharmaceutical composition that is used for the treatment of prolapse of lumbar intervertebral disc and preparation method thereof.
Background technology
Prolapse of lumbar intervertebral disc, has another name called Annulus Fibrosus of Lumbar Intervertebral Discs break disease or lumbar nucleus pulposus herniation.It is a kind of common disease that after Anular disruption, the outstanding compressing of vertebral pulp spinal nerve root causes lumbago and skelalgia, the multiple person between twenty and fifty that are born in 20-45 year, and wherein male is more than women.Most of patients has trauma history in various degree, waist bends and stretches spinning movement because posture is unbalanced with the pulling force being subject to, make patient's lower limb when stretching, bend over to remove and carry weight and hold thing rotation along y direction, the anterior increased pressure of intervertebral disc, push backward intervertebral disc, under rotation is milled, cause Anular disruption and vertebral pulp backward or rear outside outstanding.The regression of intervertebral disc is also a major reason of prolapse of lumbar intervertebral disc, the generation of prolapse of lumbar intervertebral disc is many in intervertebral disc self degeneration, on the basis becoming fragile in fibrous ring, can be because of due to acute waist wound or long-term chronic strain, cause annulus fibrosus disci intervertebralis to break, vertebral pulp is outstanding, and compressing spinal nerve root causes lumbago and skelalgia.
The traditional Chinese medical science is recognized very early to prolapse of lumbar intervertebral disc, according to its pathogeneticing characteristic, classical symptom, carry out dialectical analysis, prolapse of lumbar intervertebral disc belongs to the sick categories such as Chinese medicine " lumbago ", " arthromyodynia ", as far back as < < Plain Questions thorn lumbago piece of writing > > just have " belt vessel makes us lumbago; can not pitching; face upward and probably fall forward, weight lifting hinder waist " description.This disease is relevant with factors such as congestion, wind and cold, rheumatism, deficiency of the liver and kindey.The < < General Treatise on the Cause and Symptoms of Diseases is finally waited the etiology and pathogenesis that > > proposes " people of husband's wound, kidney qi is deficient, and the main waist foot of kidney; it is through passing through kidney network ridge; ailment said due to cold or exposure is taken advantage of a weak point in opponent's defence, and soldier enters kidney channel, therefore yet lumbago finally ", point out " deficiency of kidney-QI; be subject to doing also of ailment said due to cold or exposure, impairment caused by overstrain is suffered from a deficiency of the kidney, void is subject in air-cooled; air-cooled and vital qi is handed over and striven, therefore waist foot pain " simultaneously.
Modern Chinese medicine thinks and causes that the cause of disease main manifestations of prolapse of lumbar intervertebral disc is syndrome of static blood blocking collaterals specifically have the following aspects: or natural endowment is not enough, and fatigue is too in addition; Or weakness due to chronic disease or worn with age or intemperate sexual intercourse so that caused by liver and kidney deficiency, be difficult Ru Yangjinmai and a lumbago and skelalgia; Or because of traumatic injury wound, because of prolonged illness, QI-blood circulation is not smooth, or position is not just, and waist undue force, gets rid of gas sprain and contusion, causes meridian qi and blood retardance obstructed, all can make blood stasis stay in waist pain occurs; Or because of the damp that is affected by the cold, with the passing of time, QI and blood is not smooth, due to the blood stasis of blood is stagnant for evil resistance passages through which vital energy circulates.The main clinical manifestation of prolapse of lumbar intervertebral disc obstruction of collaterals by blood stasis disease is: lumbago is as thorn, localized pain, and gently pitching inconvenience, heavy because bitterly not changing one's position, sore spot tenderness, with skelalgia, numb limbs and tense tendons, aversion to wind and cold, meets cold increasing the weight of, happiness Wen Xinuan etc., purplish tongue, or have ecchymosis, hesitant pulse.
At present, the method for the treatment of prolapse of lumbar intervertebral disc mainly contains the methods such as physical therapy, operative treatment and Drug therapy.But also there is following many deficiencies in existing physical therapy, operative treatment and Drug therapy, as: therapeutic method of surgery expense is high, and increases patient's misery; Although physical therapy method can alleviate patient's misery, can not effect a radical cure prolapse of lumbar intervertebral disc; Western medicine prolapse of lumbar intervertebral disc is with easing pain and diminishing inflammation, can relief of symptoms, but side effect is larger.Owing to confirming by a large amount of clinical practice experiences, only have only a few patients with lumbar disc herniation must carry out outside operative treatment again, most patients adopt Chinese traditional treatment method to obtain good curative effect, and obtain clinical approval.Therefore the invention provides a kind of pharmaceutical composition that is used for the treatment of prolapse of lumbar intervertebral disc obstruction of collaterals by blood stasis disease and preparation method thereof.
Summary of the invention
For this reason, technical problem to be solved by this invention is to provide a kind of especially pharmaceutical composition of prolapse of lumbar intervertebral disc syndrome of static blood blocking collaterals of prolapse of lumbar intervertebral disc that is used for the treatment of, and reaches the object for the treatment of both the principal and secondary aspects of a disease.
The present invention further discloses the preparation method of described pharmaceutical composition.
For solving the problems of the technologies described above, a kind of pharmaceutical composition that is used for the treatment of prolapse of lumbar intervertebral disc of the present invention, the crude drug of described pharmaceutical composition consists of: Radix Dipsaci 120-180 weight portion, Caulis Piperis Kadsurae 100-150 weight portion, Caulis Sinomenii 100-150 weight portion, Herba speranskiae tuberculatae 120-180 weight portion, Herba Lycopodii 100-150 weight portion, Flos Carthami 80-120 weight portion, Lignum Sappan 80-120 weight portion and Halitum 10-50 weight portion.
Described pharmaceutical composition, the crude drug of described pharmaceutical composition consists of: Radix Dipsaci 150 weight portions, Caulis Piperis Kadsurae 120 weight portions, Caulis Sinomenii 120 weight portions, Herba speranskiae tuberculatae 150 weight portions, Herba Lycopodii 120 weight portions, Flos Carthami 100 weight portions, Lignum Sappan 100 weight portions and Halitum 30 weight portions.
The invention provides a kind of method of preparing above-mentioned pharmaceutical composition, comprise the steps:
According to selected parts by weight, getting described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extracts, merge and filtration gained extracting solution, gained filtrate decompression is concentrated into and obtains clear paste, standing and filter after, get filtrate and add conventional adjuvant, according to common process, make acceptable exterior-applied formulation clinically.
Preferably, described preparation method, comprises the steps:
According to selected parts by weight, getting described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extracts 1-3 time, the water that at every turn adds 10-20 times of drug weight, each 1-3 hour that decocts, merge and filter gained extracting solution, gained filtrate decompression is concentrated into the clear paste that 60 ℃ of relative densities are 1.05-1.10, standing and filter after, get filtrate and add conventional adjuvant, according to common process, make acceptable spray, liniment, unguentum, paste, lotion, patch or fumigation and washing agent clinically.
Be more preferably, described preparation method, comprises the steps:
According to selected parts by weight, get described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extract 2 times, the water that adds for the first time 15 times of drug weight, decoct 1.5 hours, the water that adds for the second time 10 times of drug weight, decoct 1.5 hours, merge and filter gained extracting solution, gained filtrate decompression is concentrated into the clear paste that 60 ℃ of relative densities are 1.08, standing and filter after, get filtrate and add conventional adjuvant, according to common process, make acceptable spray clinically, liniment, unguentum, paste, lotion, patch or fumigation and washing agent.
Preferably, described dosage form is fumigation and washing agent.
The invention provides a kind of clinical acceptable external preparation that adds conventional adjuvant, makes according to common process by above-mentioned pharmaceutical composition.
Preferably, described external preparation is acceptable spray, liniment, unguentum, paste, lotion, patch or fumigation and washing agent clinically.
Preferred, described external preparation is fumigation and washing agent.
The invention provides a kind of fumigation and washing agent that is used for the treatment of prolapse of lumbar intervertebral disc, by aforementioned pharmaceutical compositions, adding 2-5 weight portion sodium benzoate is adjuvant, according to common process, is prepared from.
The invention provides a kind of method of preparing described fumigation and washing agent, comprise according to selected parts by weight and get the step that described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extract, merge gained extracting solution and filter, gained filtrate decompression is concentrated into clear paste, standing and filter after, add the sodium benzoate of selected parts by weight to make it to dissolve, add purified water and adjust volume, obtain.
The invention provides the purposes of a kind of described pharmaceutical composition in the medicine of preparation treatment prolapse of lumbar intervertebral disc.
The purposes of described pharmaceutical composition, described prolapse of lumbar intervertebral disc is prolapse of lumbar intervertebral disc syndrome of static blood blocking collaterals.
The pharmaceutical composition that is used for the treatment of prolapse of lumbar intervertebral disc of the present invention, by pharmaceutical composition prepared by Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum compatibility, aspect treatment prolapse of lumbar intervertebral disc, there is significant effect, especially aspect prolapse of lumbar intervertebral disc syndrome of static blood blocking collaterals, and after using, do not find obvious adverse reaction, safe.
Experimental example
The clinical observation of traditional Chinese medicine composition for treating prolapse of lumbar intervertebral disc of the present invention
1, data and method
Clinical data: the patient that the present invention suffers from prolapse of lumbar intervertebral disc to 254 examples carries out clinical observation.
The evaluation criterion of clinical therapeutic efficacy is:
(1) clinical cure: original transference cure;
(2) effective: original symptom partly disappears;
(3) invalid: symptom and sign is unchanged.
Medication: the fumigation and washing agent of embodiment 1 preparation is placed in fumigation treatment couch container, adds water to 1500-2000ml.Patient lies on the back in smoked, and to control bed upper, and the stifling affected part of medicine steam that utilizes medicine to add to produce after water boil is with treatment disease, and additional manual adjustable electric-controlled on-off control temperature.Once a day, each 30 minutes 3 weeks is a course for the treatment of.
2, therapeutic outcome
Use the medicine composite for curing example patient of the embodiment of the present invention 1 preparation after 2-3 the course for the treatment of, observe the therapeutic outcome of patients with lumbar disc herniation, found that, wherein cure 217 examples, effective 254 examples, invalid 0 example, cure rate is 85.4%, obvious effective rate is 100%, and does not find obvious adverse reaction after using.
The specific embodiment
Embodiment 1
[prescription] Radix Dipsaci 120g, Caulis Piperis Kadsurae 150g, Caulis Sinomenii 100g, Herba speranskiae tuberculatae 180g, Herba Lycopodii 100g, Flos Carthami 120g, Lignum Sappan 80g and Halitum 50g.
[preparation method] got described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding according to selected parts by weight and extracted 1 time, the water that adds 20 times of drug weight, decoct 3 hours, merge and filtration gained extracting solution, gained filtrate decompression is concentrated into the clear paste that 60 ℃ of relative densities are 1.05, then standing over night filtration, to gained filtrate, add sodium benzoate 2g and make its dissolving, then add purified water and adjust total amount to 1000ml, stir evenly, embedding, obtains fumigation and washing agent.
Embodiment 2
[prescription] Radix Dipsaci 180g, Caulis Piperis Kadsurae 100g, Caulis Sinomenii 150g, Herba speranskiae tuberculatae 120g, Herba Lycopodii 150g, Flos Carthami 80g, Lignum Sappan 120g and Halitum 10g.
[preparation method] got described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding according to selected parts by weight and extracted 3 times, the water that at every turn adds 10 times of drug weight, each decoction 1 hour, merge and filtration gained extracting solution, gained filtrate decompression is concentrated into the clear paste that 60 ℃ of relative densities are 1.10, then standing over night filtration, to gained filtrate, add sodium benzoate 4g and make its dissolving, then add purified water and adjust total amount to 1000ml, stir evenly, embedding, obtains fumigation and washing agent.
Embodiment 3
[prescription] Radix Dipsaci 150g, Caulis Piperis Kadsurae 120g, Caulis Sinomenii 120g, Herba speranskiae tuberculatae 150g, Herba Lycopodii 120g, Flos Carthami 100g, Lignum Sappan 100g and Halitum 30g.
[preparation method] gets described Radix Dipsaci according to selected parts by weight, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extract 2 times, the water that adds for the first time 15 times of drug weight, decoct 1.5 hours, the water that adds for the second time 10 times of drug weight, decoct 1.5 hours, merge and filtration gained extracting solution, gained filtrate decompression is concentrated into the clear paste that 60 ℃ of relative densities are 1.08, then standing over night filtration, to gained filtrate, add sodium benzoate 3g and make its dissolving, then add purified water and adjust total amount to 1000ml, stir evenly, embedding, obtain fumigation and washing agent.
Embodiment 4
[prescription] Radix Dipsaci 135g, Caulis Piperis Kadsurae 110g, Caulis Sinomenii 135g, Herba speranskiae tuberculatae 135g, Herba Lycopodii 135g, Flos Carthami 90g, Lignum Sappan 110g and Halitum 20g.
[preparation method] got described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding according to selected parts by weight and extracted 2 times, the water that adds for the first time 10 times of drug weight, decoct 1 hour, the water that adds for the second time 15 times of drug weight, decoct 2 hours, merge and filtration gained extracting solution, the clear paste that when gained filtrate decompression is concentrated into 60 ℃, relative density is 1.05, then standing over night filtration, get filtrate and add conventional adjuvant, according to common process, make acceptable spray clinically.
Embodiment 5
[prescription] Radix Dipsaci 165g, Caulis Piperis Kadsurae 135g, Caulis Sinomenii 110g, Herba speranskiae tuberculatae 165g, Herba Lycopodii 110g, Flos Carthami 110g, Lignum Sappan 110g and Halitum 40g.
[preparation method] gets described Radix Dipsaci according to selected parts by weight, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extract 3 times, the water that adds for the first time 15 times of drug weight, decoct 1.5 hours, the water that adds for the second time 10 times of drug weight, decoct 1.5 hours, , the water that adds for the third time 20 times of drug weight, decoct 1 hour, merge and filtration gained extracting solution, gained filtrate decompression is concentrated into the clear paste that 60 ℃ of relative densities are 1.10, then standing over night filtration, get filtrate and add conventional adjuvant, according to common process, make acceptable liniment clinically.
Embodiment 6
[prescription] Radix Dipsaci 120g, Caulis Piperis Kadsurae 100g, Caulis Sinomenii 100g, Herba speranskiae tuberculatae 120g, Herba Lycopodii 100g, Flos Carthami 80g, Lignum Sappan 80g and Halitum 10g.
[preparation method] got described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding according to selected parts by weight and extracted 1 time, the water that adds 20 times of drug weight, decoct 3 hours, merge and filtration gained extracting solution, the clear paste that when gained filtrate decompression is concentrated into 60 ℃, relative density is 1.06, then standing over night filtration, then standing over night filtration, get filtrate and add conventional adjuvant, according to common process, make acceptable unguentum clinically.
Embodiment 7
[prescription] Radix Dipsaci 180g, Caulis Piperis Kadsurae 150g, Caulis Sinomenii 150g, Herba speranskiae tuberculatae 180g, Herba Lycopodii 150g, Flos Carthami 120g, Lignum Sappan 120g and Halitum 50g.
[preparation method] gets described Radix Dipsaci according to selected parts by weight, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extract 2 times, the water that adds for the first time 20 times of drug weight, decoct 3 hours, the water that adds for the second time 15 times of drug weight, decoct 1 hour, merge and filtration gained extracting solution, the clear paste that when gained filtrate decompression is concentrated into 60 ℃, relative density is 1.10, then standing over night filtration, to gained filtrate, add sodium benzoate 3g and make its dissolving, then standing over night filtration, get filtrate and add conventional adjuvant, according to common process, make acceptable paste clinically.
Embodiment 8
[prescription] Radix Dipsaci 170g, Caulis Piperis Kadsurae 140g, Caulis Sinomenii 105g, Herba speranskiae tuberculatae 140g, Herba Lycopodii 115g, Flos Carthami 95g, Lignum Sappan 85g and Halitum 25g.
[preparation method] got described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding according to selected parts by weight and extracted 3 times, the water that at every turn adds 15 times of drug weight, each decoction 2 hours, merge and filtration gained extracting solution, the clear paste that when gained filtrate decompression is concentrated into 60 ℃, relative density is 1.10, then standing over night filtration, to gained filtrate, add sodium benzoate 3g and make its dissolving, then standing over night filtration, get filtrate and add conventional adjuvant, according to common process, make acceptable patch clinically.
Obviously, above-described embodiment is only for example is clearly described, and the not restriction to embodiment.For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description.Here exhaustive without also giving all embodiments.And the apparent variation of being extended out thus or change are still among the protection domain in the invention.
Claims (10)
1. a pharmaceutical composition that is used for the treatment of prolapse of lumbar intervertebral disc, it is characterized in that, the crude drug of described pharmaceutical composition consists of: Radix Dipsaci 120-180 weight portion, Caulis Piperis Kadsurae 100-150 weight portion, Caulis Sinomenii 100-150 weight portion, Herba speranskiae tuberculatae 120-180 weight portion, Herba Lycopodii 100-150 weight portion, Flos Carthami 80-120 weight portion, Lignum Sappan 80-120 weight portion and Halitum 10-50 weight portion.
2. pharmaceutical composition according to claim 1, it is characterized in that, the crude drug of described pharmaceutical composition consists of: Radix Dipsaci 150 weight portions, Caulis Piperis Kadsurae 120 weight portions, Caulis Sinomenii 120 weight portions, Herba speranskiae tuberculatae 150 weight portions, Herba Lycopodii 120 weight portions, Flos Carthami 100 weight portions, Lignum Sappan 100 weight portions and Halitum 30 weight portions.
3. a method of preparing pharmaceutical composition as claimed in claim 1 or 2, is characterized in that, comprises the steps:
According to selected parts by weight, getting described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extracts, merge and filter gained extracting solution, gained filtrate decompression is concentrated into clear paste, standing and filter after, get filtrate and add conventional adjuvant, according to common process, make acceptable exterior-applied formulation clinically.
4. preparation method according to claim 3, is characterized in that, comprises the steps:
According to selected parts by weight, getting described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extracts 1-3 time, the water that at every turn adds 10-20 times of drug weight, each 1-3 hour that decocts, merge and filter gained extracting solution, the clear paste that when gained filtrate decompression is concentrated into 60 ℃, relative density is 1.05-1.10, standing and filter after, get filtrate and add conventional adjuvant, according to common process, make acceptable spray, liniment, unguentum, paste, lotion, patch or fumigation and washing agent clinically.
5. according to the preparation method described in claim 3 or 4, it is characterized in that, comprise the steps:
According to selected parts by weight, get described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extract 2 times, the water that adds for the first time 15 times of drug weight, decoct 1.5 hours, the water that adds for the second time 10 times of drug weight, decoct 1.5 hours, merge and filter gained extracting solution, the clear paste that when gained filtrate decompression is concentrated into 60 ℃, relative density is 1.08, standing and filter after, get filtrate and add conventional adjuvant, according to common process, make acceptable spray clinically, liniment, unguentum, paste, lotion, patch or fumigation and washing agent.
6. the clinical acceptable external preparation that adds conventional adjuvant, makes according to common process by the pharmaceutical composition described in claim 1 or 2.
7. a fumigation and washing agent that is used for the treatment of prolapse of lumbar intervertebral disc, is characterized in that, by pharmaceutical composition described in claim 1 or 2, adding 2-5 weight portion sodium benzoate is adjuvant, according to common process, is prepared from.
8. a method of preparing fumigation and washing agent described in claim 7, it is characterized in that, comprise according to selected parts by weight and get the step that described Radix Dipsaci, Caulis Piperis Kadsurae, Caulis Sinomenii, Herba speranskiae tuberculatae, Herba Lycopodii, Flos Carthami, Lignum Sappan and Halitum mixing and water adding extract, merge gained extracting solution and filter, gained filtrate decompression is concentrated into clear paste, standing and filter after, add the sodium benzoate of selected parts by weight to make it to dissolve, add purified water and adjust volume, obtain.
9. the purposes of the pharmaceutical composition described in claim 1 or 2 in the medicine of preparation treatment prolapse of lumbar intervertebral disc.
10. purposes according to claim 9, is characterized in that, described prolapse of lumbar intervertebral disc is prolapse of lumbar intervertebral disc syndrome of static blood blocking collaterals.
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| CN109078092A (en) * | 2018-09-27 | 2018-12-25 | 杨兴贵 | A kind of liquid medicine and preparation method thereof for treating protrusion of lumber intervertebral disc |
| CN111529667A (en) * | 2020-06-11 | 2020-08-14 | 浙江一真堂健康管理有限公司 | Traditional Chinese medicine composition for treating lumbar intervertebral disc protrusion and application |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109078092A (en) * | 2018-09-27 | 2018-12-25 | 杨兴贵 | A kind of liquid medicine and preparation method thereof for treating protrusion of lumber intervertebral disc |
| CN111529667A (en) * | 2020-06-11 | 2020-08-14 | 浙江一真堂健康管理有限公司 | Traditional Chinese medicine composition for treating lumbar intervertebral disc protrusion and application |
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| Publication number | Publication date |
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| CN104127508B (en) | 2016-06-29 |
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