CN104115478B - 发光成像扫描仪 - Google Patents

发光成像扫描仪 Download PDF

Info

Publication number
CN104115478B
CN104115478B CN201280069894.9A CN201280069894A CN104115478B CN 104115478 B CN104115478 B CN 104115478B CN 201280069894 A CN201280069894 A CN 201280069894A CN 104115478 B CN104115478 B CN 104115478B
Authority
CN
China
Prior art keywords
ccd
sample
image sensor
pixel
detector
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201280069894.9A
Other languages
English (en)
Chinese (zh)
Other versions
CN104115478A (zh
Inventor
A.博齐德
C.莱西亚克
D.W.康兹
D.L.弗兰岑
W.比格斯
J.P.安德森
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laikuo Biotechnology Co ltd
Original Assignee
Li Cor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Li Cor Inc filed Critical Li Cor Inc
Publication of CN104115478A publication Critical patent/CN104115478A/zh
Application granted granted Critical
Publication of CN104115478B publication Critical patent/CN104115478B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means
    • C12Q1/6825—Nucleic acid detection involving sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01J—MEASUREMENT OF INTENSITY, VELOCITY, SPECTRAL CONTENT, POLARISATION, PHASE OR PULSE CHARACTERISTICS OF INFRARED, VISIBLE OR ULTRAVIOLET LIGHT; COLORIMETRY; RADIATION PYROMETRY
    • G01J1/00—Photometry, e.g. photographic exposure meter
    • G01J1/02—Details
    • G01J1/04—Optical or mechanical part supplementary adjustable parts
    • G01J1/0403—Mechanical elements; Supports for optical elements; Scanning arrangements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5302—Apparatus specially adapted for immunological test procedures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N1/00—Scanning, transmission or reproduction of documents or the like, e.g. facsimile transmission; Details thereof
    • H04N1/04—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa
    • H04N1/10—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa using flat picture-bearing surfaces
    • H04N1/1013—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa using flat picture-bearing surfaces with sub-scanning by translatory movement of at least a part of the main-scanning components
    • H04N1/1017—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa using flat picture-bearing surfaces with sub-scanning by translatory movement of at least a part of the main-scanning components the main-scanning components remaining positionally invariant with respect to one another in the sub-scanning direction
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N1/00—Scanning, transmission or reproduction of documents or the like, e.g. facsimile transmission; Details thereof
    • H04N1/04—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa
    • H04N1/19—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa using multi-element arrays
    • H04N1/191—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa using multi-element arrays the array comprising a one-dimensional array, or a combination of one-dimensional arrays, or a substantially one-dimensional array, e.g. an array of staggered elements
    • H—ELECTRICITY
    • H04—ELECTRIC COMMUNICATION TECHNIQUE
    • H04N—PICTORIAL COMMUNICATION, e.g. TELEVISION
    • H04N1/00—Scanning, transmission or reproduction of documents or the like, e.g. facsimile transmission; Details thereof
    • H04N1/04—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa
    • H04N1/19—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa using multi-element arrays
    • H04N1/191—Scanning arrangements, i.e. arrangements for the displacement of active reading or reproducing elements relative to the original or reproducing medium, or vice versa using multi-element arrays the array comprising a one-dimensional array, or a combination of one-dimensional arrays, or a substantially one-dimensional array, e.g. an array of staggered elements
    • H04N1/192—Simultaneously or substantially simultaneously scanning picture elements on one main scanning line
    • H04N1/193—Simultaneously or substantially simultaneously scanning picture elements on one main scanning line using electrically scanned linear arrays, e.g. linear CCD arrays
    • H04N1/1932—Simultaneously or substantially simultaneously scanning picture elements on one main scanning line using electrically scanned linear arrays, e.g. linear CCD arrays using an array of elements displaced from one another in the sub scan direction, e.g. a diagonally arranged array
    • H04N1/1933—Staggered element arrays, e.g. arrays with elements arranged in a zigzag

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Signal Processing (AREA)
  • Multimedia (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Plasma & Fusion (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CN201280069894.9A 2011-12-16 2012-03-28 发光成像扫描仪 Expired - Fee Related CN104115478B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161576941P 2011-12-16 2011-12-16
US61/576,941 2011-12-16
US13/432,410 2012-03-28
US13/432,410 US8486644B2 (en) 2011-12-16 2012-03-28 Chemiluminescence compact imaging scanner
PCT/US2012/030979 WO2013089817A1 (en) 2011-12-16 2012-03-28 Luminescence imaging scanner

Publications (2)

Publication Number Publication Date
CN104115478A CN104115478A (zh) 2014-10-22
CN104115478B true CN104115478B (zh) 2016-04-20

Family

ID=48610490

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280069894.9A Expired - Fee Related CN104115478B (zh) 2011-12-16 2012-03-28 发光成像扫描仪

Country Status (7)

Country Link
US (3) US8486644B2 (enExample)
EP (1) EP2792137B1 (enExample)
JP (1) JP5789724B2 (enExample)
CN (1) CN104115478B (enExample)
AU (1) AU2012352965B2 (enExample)
CA (1) CA2859475C (enExample)
WO (1) WO2013089817A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2859475C (en) 2011-12-16 2015-07-07 Li-Cor, Inc. Luminescence imaging scanner
US9912847B1 (en) 2012-09-25 2018-03-06 Amazon Technologies, Inc. Image capture guidance to reduce specular reflection effects
USD721704S1 (en) * 2013-06-06 2015-01-27 Li-Cor, Inc. Chemiluminescence compact imaging scanner lid
US10180400B2 (en) 2013-08-20 2019-01-15 Optricon Entwicklungsgesellschaft Fur Optische Technologien Mbh Device for digital reading of quick tests
JP6161072B2 (ja) * 2013-12-26 2017-07-12 国立研究開発法人産業技術総合研究所 多チャンネル式化学発光計測システム
US9383336B2 (en) 2014-04-04 2016-07-05 General Electric Company System and method for flat panel detector gel and blot imaging
JP6407811B2 (ja) * 2015-07-08 2018-10-17 富士フイルム株式会社 撮像装置および方法
CN105067817B (zh) * 2015-07-08 2017-05-10 上海清流生物医药科技有限公司 感光芯片采集信号的方法和装置及追踪细胞的方法和装置
EP3350577B1 (en) * 2015-09-16 2022-02-16 Global Life Sciences Solutions Germany Gmbh System and method for flat panel detector gel and blot imaging
WO2017100935A1 (en) 2015-12-18 2017-06-22 Immersive Ventures Inc. Systems and methods for multi-sensor image capture
CN106124778B (zh) * 2016-07-27 2018-06-12 深圳市博卡生物技术有限公司 免疫印迹分析仪
US10652414B2 (en) * 2016-09-12 2020-05-12 Hewlett-Packard Development Company, L.P. Scanner apparatus having an optical sensor
JP6972638B2 (ja) * 2017-04-27 2021-11-24 コニカミノルタ株式会社 画像形成装置
CN109085157A (zh) * 2017-06-14 2018-12-25 淳洁 用于化学发光检测的探测单元、电子暗盒压片装置及其用途
USD876662S1 (en) * 2017-10-27 2020-02-25 Royal Biotech Inc Vial lab multi-reader
CN111386694B (zh) * 2017-12-01 2022-06-17 惠普发展公司，有限责任合伙企业 图像传感器连线取向
CN119534433A (zh) 2017-12-15 2025-02-28 生物辐射实验室股份有限公司 测定的组合成像
GB2571743A (en) * 2018-03-07 2019-09-11 Pop Bio Ltd A method of capturing image data of a luminescent sample and apparatus for the same
EP4038196A4 (en) * 2019-10-01 2024-01-24 Beth Israel Deaconess Medical Center, Inc. Rapid antimicrobial susceptibility testing by image analysis
CN114076762A (zh) * 2020-08-13 2022-02-22 南京金斯瑞生物科技有限公司 成像装置、图像处理方法及装置和成像系统
CN112162091B (zh) * 2020-10-28 2024-08-02 普迈德（北京）科技有限公司 一种免疫定量光学分析扫描装置
CN113011549A (zh) * 2021-02-20 2021-06-22 重庆博奥新景医学科技有限公司 一种应用于化学发光分析仪发光值的自适应测量计算方法
JP2023098404A (ja) * 2021-12-28 2023-07-10 キヤノン株式会社 画像読取装置とその制御方法、及びプログラム

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999053288A2 (en) * 1998-04-14 1999-10-21 Immunetics, Inc. Systems and methods for interpreting immunoblot test results
EP1985995A2 (en) * 1996-08-16 2008-10-29 GE Healthcare Niagara Inc. A digital imaging system for assays in well plates, gels and blots

Family Cites Families (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873564A (en) * 1971-03-03 1975-03-25 Synvar Ass 2-Imidazolinyl-3-oxide-1-oxypropionic acid
US4200892A (en) * 1978-03-27 1980-04-29 Rca Corporation Solid state image sensor
US4208094A (en) * 1978-10-02 1980-06-17 Bell Telephone Laboratories, Incorporated Optical switch
US4382672A (en) * 1980-09-29 1983-05-10 Xerox Corporation Illumination arrangement for elimination of gray borders in copying device
JPS59105762A (ja) * 1982-12-09 1984-06-19 Toshiba Corp 原稿読取装置
JP2556486B2 (ja) * 1986-11-14 1996-11-20 キヤノン株式会社 フィルム読取装置
US4819070A (en) * 1987-04-10 1989-04-04 Texas Instruments Incorporated Image sensor array
US4845552A (en) * 1987-08-20 1989-07-04 Bruno Jaggi Quantitative light microscope using a solid state detector in the primary image plane
US4775799A (en) * 1987-10-23 1988-10-04 Eastman Kodak Company Input scanner having digital and analog mode selection
JPH083481B2 (ja) 1989-06-07 1996-01-17 日立ソフトウェアエンジニアリング株式会社 蛍光式電気泳動パターン読み取り装置
JPH0312794A (ja) 1989-06-09 1991-01-21 Tokyo Electric Co Ltd 商品販売データ処理装置
US5053887A (en) * 1989-06-27 1991-10-01 Ibm Corporation Technique for producing a fine grained dithered halftone image having an increased number of gray levels
US5299272A (en) * 1993-01-27 1994-03-29 Origin Medststems, Inc. Method for attaching a gradient index lens to an optical fibre in the course of making an optical instrument
JP3254865B2 (ja) * 1993-12-17 2002-02-12 ソニー株式会社 カメラ装置
US5471515A (en) * 1994-01-28 1995-11-28 California Institute Of Technology Active pixel sensor with intra-pixel charge transfer
US6741344B1 (en) * 1994-02-10 2004-05-25 Affymetrix, Inc. Method and apparatus for detection of fluorescently labeled materials
US5504527A (en) 1994-06-28 1996-04-02 Eastman Kodak Company Image sensor with improved charge transfer inefficiency characteristics
US5459325A (en) 1994-07-19 1995-10-17 Molecular Dynamics, Inc. High-speed fluorescence scanner
US5528050A (en) 1995-07-24 1996-06-18 Molecular Dynamics, Inc. Compact scan head with multiple scanning modalities
JP3012794B2 (ja) * 1995-10-02 2000-02-28 日立ソフトウエアエンジニアリング株式会社 スキャナ装置
DE19707225A1 (de) 1997-02-24 1998-08-27 Bodenseewerk Perkin Elmer Co Lichtabtastvorrichtung
US6072570A (en) * 1997-07-24 2000-06-06 Innotech Image quality mapper for progressive eyeglasses
EP0902280A3 (en) 1997-09-11 2000-04-12 Hitachi Software Engineering Co., Ltd. Apparatus for reading a luminescence pattern of a sample
DE19752925C2 (de) 1997-11-28 2003-11-27 Agfa Gevaert Ag Vorrichtung zum Auslesen von einer in einem Phosphorträger abgespeicherten Information und Röntgenkassette
US6529239B1 (en) * 1998-06-01 2003-03-04 Fairchild Imaging, Inc. Image sensor with stripes of cyan filter material perpendicular to stripes of yellow filter material
US6320196B1 (en) 1999-01-28 2001-11-20 Agilent Technologies, Inc. Multichannel high dynamic range scanner
US6696686B1 (en) * 1999-06-06 2004-02-24 Elgems Ltd. SPECT for breast cancer detection
EP1221038A4 (en) 1999-07-21 2004-09-08 Applera Corp Luminescence detection workstation
US6867851B2 (en) 1999-11-04 2005-03-15 Regents Of The University Of Minnesota Scanning of biological samples
JP3952117B2 (ja) 2000-01-21 2007-08-01 富士フイルム株式会社 放射線画像読取装置
US6492655B2 (en) 2000-04-05 2002-12-10 Fuji Photo Film Co., Ltd. Method and apparatus for reading image information
WO2002025571A2 (en) * 2000-09-19 2002-03-28 Visioneer, Inc. Fast, auto-cropping, bi-directional multi-resolution scanner apparatus, system and software therefor
JP4091248B2 (ja) * 2000-12-25 2008-05-28 富士フイルム株式会社 スキャナ装置
US20020131958A1 (en) * 2001-01-22 2002-09-19 John Chapman Method for purifying a biological composition
JP2002314762A (ja) * 2001-04-09 2002-10-25 Sony Corp 画像読取装置
US20040051808A1 (en) 2001-05-18 2004-03-18 Hashem Akhavan-Tafti Compact optical imaging device
US7557929B2 (en) * 2001-12-18 2009-07-07 Massachusetts Institute Of Technology Systems and methods for phase measurements
JP3641619B2 (ja) 2002-05-14 2005-04-27 株式会社日立製作所 生体試料検査装置
US20040021911A1 (en) * 2002-07-31 2004-02-05 Corson John F. Array scanner noise reduction system
US20040041939A1 (en) * 2002-08-28 2004-03-04 Hofer Gregory V. Method of compensating for the integration of light by the vertical shift registers in an interline transfer charge coupled device
US7345796B2 (en) 2002-10-11 2008-03-18 Kabushiki Kaisha Toshiba Image scanner for use in image forming apparatus
US20040224332A1 (en) * 2003-01-29 2004-11-11 Affymetrix, Inc. System and method for calibration and focusing a scanner instrument using elements associated with a biological probe array
JP2004294957A (ja) * 2003-03-28 2004-10-21 Konica Minolta Holdings Inc 放射線画像読取方法及び装置
WO2005019469A2 (en) * 2003-08-11 2005-03-03 Research Foundation Of Cuny Rna detection and quantitation
AU2003258451A1 (en) * 2003-09-18 2005-04-06 Photonfocus Ag Optoelectronic detector with multiple readout nodes and its use thereof
US7169560B2 (en) * 2003-11-12 2007-01-30 Helicos Biosciences Corporation Short cycle methods for sequencing polynucleotides
US20090141132A1 (en) 2004-07-26 2009-06-04 Cellular Technology Ltd. Instrumentation for image acquisition from biological and non-biological assays
US7727471B2 (en) 2004-09-09 2010-06-01 Palo Alto Research Center Incorporated Rare cell detection using flat-panel imager and chemiluminescent or radioisotopic tags
US7843609B2 (en) * 2004-09-30 2010-11-30 Lexmark International, Inc. Motion control method and apparatus for a flat bed scanner
EP1700865A1 (en) * 2005-03-11 2006-09-13 AXXAM S.r.l. Photoproteins with enhanced bioluminescence and their use as intracellular calcium indicators
FR2891924B1 (fr) 2005-10-10 2007-12-28 Biospace Mesures Dispositif et procede d'imagerie en luminescence
US7537934B2 (en) 2005-12-30 2009-05-26 Intel Corporation Chemiluminescence sensor array
TW200733712A (en) 2006-02-23 2007-09-01 Microtek Int Inc Structures and methods thereof for a scanner with two CCD arrays
EP2005128A2 (en) 2006-03-24 2008-12-24 Chemimage Corporation System and method to perform raman imaging without luminescence
JP2008241447A (ja) 2007-03-27 2008-10-09 Fujifilm Corp 画像読取装置及び画像読取方法
ATE548654T1 (de) * 2007-04-13 2012-03-15 Amicus Therapeutics Inc Pas-färbung mit nachweis im infrarotbereich
CA2728363C (en) * 2008-06-26 2019-02-19 Orphazyme Aps Use of hsp70 as a regulator of enzymatic activity
FR2946157B1 (fr) 2009-06-02 2015-03-27 Commissariat Energie Atomique Systeme d'imagerie a microlentilles et dispositif associe pour la detection d'un echantillon.
WO2011087521A1 (en) * 2010-01-13 2011-07-21 University Of Notre Dame Du Lac Chemiluminescent dyes and dye-stained particles
DE202010002010U1 (de) 2010-02-05 2010-05-06 Berthold Technologies Gmbh & Co. Kg Messvorrichtung zur Messung von Biolumineszenz, Chemolumineszenz oder Fluoreszenz von Objekten, Bestrahlungsvorrichtung und Messsystem
CN102985808B (zh) 2010-05-12 2016-08-24 利-考股份有限公司 宽动态范围成像
CA2859475C (en) * 2011-12-16 2015-07-07 Li-Cor, Inc. Luminescence imaging scanner

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1985995A2 (en) * 1996-08-16 2008-10-29 GE Healthcare Niagara Inc. A digital imaging system for assays in well plates, gels and blots
WO1999053288A2 (en) * 1998-04-14 1999-10-21 Immunetics, Inc. Systems and methods for interpreting immunoblot test results

Also Published As

Publication number Publication date
CA2859475C (en) 2015-07-07
CA2859475A1 (en) 2013-06-20
EP2792137B1 (en) 2015-09-30
JP2015505046A (ja) 2015-02-16
CN104115478A (zh) 2014-10-22
HK1198567A1 (en) 2015-05-15
US8486644B2 (en) 2013-07-16
US9809842B2 (en) 2017-11-07
WO2013089817A1 (en) 2013-06-20
JP5789724B2 (ja) 2015-10-07
US20130157282A1 (en) 2013-06-20
EP2792137A1 (en) 2014-10-22
US20140206568A1 (en) 2014-07-24
US20130280737A1 (en) 2013-10-24
AU2012352965B2 (en) 2014-08-21
US8722346B2 (en) 2014-05-13
AU2012352965A1 (en) 2014-07-17

Similar Documents

Publication Publication Date Title
CN104115478B (zh) 发光成像扫描仪
US11294160B2 (en) Microscopy imaging
US20230228682A1 (en) Microscopy imaging
US6596483B1 (en) System and method for detecting molecules using an active pixel sensor
US9891192B2 (en) System and method for flat panel detector gel and blot imaging
Golden et al. A comparison of imaging methods for use in an array biosensor
CN104937401B (zh) 用于大分析物阵列的图像捕获
Spibey et al. A unique charge‐coupled device/xenon arc lamp based imaging system for the accurate detection and quantitation of multicolour fluorescence
EP0746778A1 (en) Methods and apparatus for detecting and imaging particles
US11035794B2 (en) Scalable, large-area optical sensing platform with compact light delivery and imaging system
EP3350577B1 (en) System and method for flat panel detector gel and blot imaging
US6740890B1 (en) Time-resolved light decay measurements without using a gated detector
AU2014265018B2 (en) Luminescence imaging scanner
KR20140134285A (ko) 케미컬 센서, 케미컬 센서의 제조 방법, 화학물질 검출 장치
HK1198567B (en) Luminescence imaging scanner
LaBelle et al. Introduction to high performance CCD cameras

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C14 Grant of patent or utility model
GR01 Patent grant
TR01 Transfer of patent right

Effective date of registration: 20231213

Address after: Nebraska

Patentee after: Laikuo Biotechnology Co.,Ltd.

Address before: Nebraska

Patentee before: LI-COR, Inc.

TR01 Transfer of patent right
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20160420

CF01 Termination of patent right due to non-payment of annual fee