CN1041091A - 含有单月桂酸甘油酯的口香糖 - Google Patents
含有单月桂酸甘油酯的口香糖 Download PDFInfo
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- ARIWANIATODDMH-UHFFFAOYSA-N rac-1-monolauroylglycerol Chemical compound CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 title claims abstract description 47
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- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 22
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 11
- 235000019739 Dicalciumphosphate Nutrition 0.000 claims description 4
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims description 4
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- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 claims description 4
- 229940038472 dicalcium phosphate Drugs 0.000 claims description 4
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- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 4
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- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- 229930006000 Sucrose Natural products 0.000 claims 1
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- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 1
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- QQVIHTHCMHWDBS-UHFFFAOYSA-N perisophthalic acid Natural products OC(=O)C1=CC=CC(C(O)=O)=C1 QQVIHTHCMHWDBS-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/066—Chewing gum characterised by the composition containing organic or inorganic compounds characterised by the fat used
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/06—Chewing gum characterised by the composition containing organic or inorganic compounds
- A23G4/12—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins
- A23G4/126—Chewing gum characterised by the composition containing organic or inorganic compounds containing microorganisms or enzymes; containing paramedical or dietetical agents, e.g. vitamins containing vitamins, antibiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A61K9/0058—Chewing gums
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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Abstract
公开了一种用于除去牙斑并阻止牙斑形成的口香糖组合物和使用该组合物的方法。该组合物含有15％至90％树胶基料、5％至80％甜味剂和疏松剂、1％至10％甘油、有选择地含有色素和香味剂，并含有0.25％至0.75％单月桂酸甘油酯。较好的是，该组合物也包括高含量的填充剂。该方法包括咀嚼本发明的口香糖组合物至少20分钟，较好是连续4天每天至少5次。
Description
本发明涉及有助于防止牙斑形成和除去牙斑的口香糖组合物，更具体地说，本发明涉及含有单月桂酸甘油酯的口香糖组合物，以及应用这类组合物的方法。
在龋齿的形成中牙斑所起的作用是人所共知的。最近在导致老人牙齿脱落的牙周病中牙斑所起的作用也有了评论。
通过应用口香糖，和特别的组合物以及用于这类口香糖中的成份而试图减少牙斑也是人所共知的。例如美国专利第4，400，372号叙述了一种设计用来清洁和擦洗牙齿，含有无毒酸和锻烧的高岭土颗粒的口香糖。美国专利第4，568，537号叙述了一种口香糖配方，在咀嚼时这种配方可改变口腔环境以减少牙齿脱矿质作用，并指出了口香糖达到了同样的机械清洁牙齿作用。
口香糖组合物也可以单独或以与其他成份结合的方式含有由于能够与在口腔中通过使碳水化合物发酵而形成酸（这种酸导致龋齿）的主要微生物-链球菌属突变体之间的相互作用而有抗-生龋作用的成份。例如美国专利第4，374，122和4，457，911号公开了3，4-二氢-6-甲基-1，2，3-氧杂噻嗪-4-酮-2，2-二氧化物和氢化的淀粉水解物，抑制链球菌属突变体的生长。
已经证明单月桂酸甘油酯可作为具有抗-生龋作用活性的食物成份。例如在美国油化学学会的专题论文集（1978）中论题为“油脂类的药理学作用”的文章中叙述了由kabara等人所进行的实验，这个实验应用了十二烷酸二羟丙基酯品种的单月桂酸甘油酯在体外和作为大鼠的食物组分在一个在体内的试验中进行。kabara的美国专利第4，067，997号叙述了相似的试验和含有单月桂酸甘油酯的多种组合物，包括外科擦洗剂和口腔洗液。
申请人已发现含有单月桂酸甘油酯的口香糖组合物具有减少牙斑的影响，特别是当口香糖也具有高含量填充剂时。本发明的口香糖组合物包含15%至90%的树胶基料，5%至80%的疏松和甜味剂，1%至10%甘油和有选择地加入的色素和香味剂，以及含有0.1至1.0%单月桂酸甘油酯。单月桂酸甘油酯的含量水平较好是在约0.25%至0.75%之间。较好是树胶组合物也含有至少10%的填充剂并且还有高含量的基料。
本发明也涉及应用本发明的树胶组合物至少20分钟来防止在牙齿上的牙斑形成的方法。
本发明的树胶组合物可以是口香糖或者是泡泡糖，在此，两者都称为口香糖。较好是在此所用的树胶基料属于一种粘性品种，对除去机械性的斑有帮助。
本发明的口香糖树胶组合物含有在通常的口香糖树胶组合物中存在的多种成份，含量水平也是通常的水平。树胶基料中通常包含15%至35%的树胶。但是，已经发现，以较高树胶基料含量加到树胶的咀嚼胶料中可促进牙斑的除去。适用于本发明的树胶基料包括Paloja、Astro和Magna（泡泡糖树胶基料）可由新泽西州Plainfield，L.A.Dreyfus公司买到。
在树胶组合物中通常都有填充剂，并且在做好的树胶基料中常常包含聚合物物料。对于本发明来说，在树胶基料中的任何填充剂和做成成品树胶组合物所加的填充剂加在一起成为所述的树胶组合物的填充剂的含量。较好是该填充剂含量至少为10%最好是在15%至50%之间。较好的填充剂包括碳酸钙、滑石粉、碳酸氢钠、磷酸二钙和它们的混合物。最好的填充剂是碳酸钙，含量在约22-24%的水平。
填充剂颗粒的粒度应在0.1微米至25微米之间。对于碳酸钙填充剂来说其粒度较好是在约0.5-10微米之间，平均粒度为2.5微米。
将填充剂与基料混合可在基料配制过程中，或在后来的树胶配制过程中进行，或者在每一阶段加入一部分。较好是将整个填充剂含量混入基料组合物中以减轻在树胶混合的现场对额外成份的需要。
本发明的口香糖组合物可以包含通常存在于口香糖中的其他成份，包括甜味剂、香味剂、色素、增韧剂、加工的助剂等等。由于这种口香糖是用于促进牙齿健康的，所以较好是应用非生龋的甜味剂。较好的甜味剂是木糖醇。
单月桂酸甘油酯在该树胶中的含量水平应在约0.1%至约10%之间，较好的水平是约0.25%至约0.75%。最好是含有约0.5%单月桂酸甘油酯的组合物。
本发明的较好的树胶组合物有如下的成份：
37.4%基料
23.8%填充剂
15%木糖醇
12.4%山梨糖醇
0.5%单月桂酸甘油酯
2.5%香味剂
6%甘油
0.3%糖精（Aspartame）
0.1%色素
单月桂酸甘油酯在本发明的树脂组合物中被认为具有几种抗牙斑的益处，例如可作为表面活化剂、抗微生物剂和抗粘附的化合物。
防止牙斑形成或除去牙斑的方法要求咀嚼本发明的含有单月桂酸甘油酯的口香糖至少20分钟，较好是至少30分。虽然咀嚼一次已可发现产生可察觉到的牙斑减少，但是本发明的较好的方法包括重复地咀嚼口香糖较好是一天五趟，每趟20分钟，连续重复4天。
已经发现本发明的口香糖组合物可除去大量的牙斑，因此，当按照本发明的方法应用时则牙斑的形成受到抑制。
应该理解，在此详述的较好的实施是本发明的多方面的说明，对本发明的较好的实施可做成多种变更和改变。因此，本发明的权利要求书（包括所有相等同的内容）限定了本发明的范围。
Claims (20)
1、在一种口香糖组合物中包含15%至90%的树胶基料、5%至80%疏松和甜味剂、1%至10%甘油和有选择地加入的色素和香味剂，这种改进包括在口香糖组合物中含有一定量的单月桂酸甘油酯以便有效地减少牙斑。
2、权利要求1的改进了的口香糖组合物，其中该组合物进一步包括10%至50%的从由碳酸钙、滑石粉、碳酸氢钠、磷酸二钙和它们的混合物组成的一组无机填充剂中挑选出的无机填充剂。
3、权利要求1的改进了的口香糖组合物，其中该组合物进一步包含约15%碳酸钙。
4、权利要求1的改进了的口香糖组合物，其中单月桂酸甘油酯构成了该组合物的约0.25%至0.75%。
5、权利要求1的改进了的口香糖组合物，其中单月桂酸甘油酯构成了该组合物的约0.25%。
6、权利要求1的改进了的口香糖组合物，其中该组合物包含大约：
（a）38%树胶基料;
（b）15%木糖醇;
（c）6%甘油;
（d）24%碳酸钙;
（e）12%山梨糖醇;
（f）2.5%香味剂;
（g）0.1%色素;
（h）0.3%糖精（aspartame）;和
（i）0.5%单月桂酸甘油酯
7、一种阻止牙斑形成的方法包括以下的步骤：
（a）提供一种包含约15%至90%树胶基料、约5%至80%疏松和甜味剂、约1%至10%甘油、有选择地加入的香味剂和色素以及约0.25至0.75%单月桂酸甘油酯的口香糖组合物;和
（b）咀嚼口香糖组合物至少20分钟。
8、权利要求7的方法，其中将口香糖咀嚼至少30分钟。
9、权利要求7的方法，其中在该口香糖组合物中树胶基料包含一种填充物其含量超过10%。
10、权利要求9的方法，其中填充剂的含量为约22-24%。
11、权利要求7的方法，其中的巯松和甜味剂是从由山梨糖醇、木糖醇、蔗糖、玉米糖浆和它们的混合物组成的一组疏松和甜味剂中挑选出来的。
12、权利要求7的方法，其中口香糖组合物包含约10%至50%的无机填充剂该填充剂是从由碳酸钙、滑石粉、碳酸氢钠、磷酸二钙和它们的混合物组成的一组无机填充剂中挑选出的一种无机填充剂。
13、权利要求12的方法，其中该口香糖组合物含有约22-24%碳酸钙。
14、权利要求13的方法，其中碳酸钙的粒度在0.1至25微米之间。
15、一种改进牙齿健康的方法包括以下步骤：
（a）提供一种口香糖组合物，该组合物含有约15%至90%树胶基料、约5%至80%巯松和甜味剂、约1%至10%甘油，有选择地含有香味剂和色素并含有约0.25%至0.75%单月桂酸甘油酯;和
（b）重复地咀嚼多份上述口香糖组合物，因此每天咀嚼至少5份上述口香糖组合物，每份至少咀嚼20分钟，至少连续咀嚼4天。
16、权利要求15的方法，其中口香糖组合物包含具有填充剂含量至少为10%的一种树胶基料。
17、权利要求15的方法，其中口香糖组合物进一步包含的15%至50%一种从由碳酸钙、滑石粉、碳酸氢钙、磷酸二钙和它们的混合物的一组填充剂中挑选出的无机填充剂。
18、权利要求17的方法，其中无机填充剂包括约22-24%碳酸钙。
19、权利要求15的方法，其中口香糖组合物包含约0.5%单月桂酸甘油酯。
20、权利要求1的改进的口香糖组合物，其中单月桂酸甘油酯构成了该组合物的0.1%至1.0%。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/243,404 US4952407A (en) | 1988-09-12 | 1988-09-12 | Chewing gum containing glycerol mono laurate |
| US243,404 | 1988-09-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1041091A true CN1041091A (zh) | 1990-04-11 |
Family
ID=22918649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN89107383A Pending CN1041091A (zh) | 1988-09-12 | 1989-09-09 | 含有单月桂酸甘油酯的口香糖 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US4952407A (zh) |
| EP (1) | EP0387330B1 (zh) |
| CN (1) | CN1041091A (zh) |
| AT (1) | ATE106676T1 (zh) |
| AU (1) | AU628386B2 (zh) |
| CA (1) | CA1332573C (zh) |
| DE (1) | DE68916004T2 (zh) |
| ES (1) | ES2016059A6 (zh) |
| FI (1) | FI96914C (zh) |
| NZ (1) | NZ230331A (zh) |
| PH (1) | PH25515A (zh) |
| WO (1) | WO1990002491A1 (zh) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100556301C (zh) * | 2002-01-28 | 2009-11-04 | 卡德伯里亚当斯美国有限责任公司 | 含有包封的除斑剂成分的口香糖和糖食组合物,其制备和应用方法 |
| CN104606064A (zh) * | 2014-12-30 | 2015-05-13 | 北京刷新活力健康科技有限公司 | 一种生物活性矿物粉体口香糖及其制备方法 |
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| US5702687A (en) * | 1995-10-03 | 1997-12-30 | Church & Dwight Co., Inc. | Chewing gum product with plaque-inhibiting benefits |
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| US5629035A (en) * | 1995-12-18 | 1997-05-13 | Church & Dwight Co., Inc. | Chewing gum product with encapsulated bicarbonate and flavorant ingredients |
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| US6846500B1 (en) * | 1999-03-25 | 2005-01-25 | Cadbury Adams Usa Llc | Oral care chewing gums and method of use |
| US6471945B2 (en) | 2000-03-10 | 2002-10-29 | Warner-Lambert Company | Stain removing chewing gum and confectionery compositions, and methods of making and using the same |
| US7041277B2 (en) * | 2000-03-10 | 2006-05-09 | Cadbury Adams Usa Llc | Chewing gum and confectionery compositions with encapsulated stain removing agent compositions, and methods of making and using the same |
| US6485739B2 (en) | 2000-03-10 | 2002-11-26 | Warner-Lambert Company | Stain removing chewing gum and confectionery compositions, and methods of making and using the same |
| US7070818B1 (en) * | 2000-04-12 | 2006-07-04 | Dandy Sakiz Ve Sekerleme Sanayi A.S. | Aerated non-cariogenic low-calorie sugarless chewing gum |
| US7445769B2 (en) | 2002-10-31 | 2008-11-04 | Cadbury Adams Usa Llc | Compositions for removing stains from dental surfaces and methods of making and using the same |
| US7390518B2 (en) | 2003-07-11 | 2008-06-24 | Cadbury Adams Usa, Llc | Stain removing chewing gum composition |
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| US8591973B2 (en) | 2005-05-23 | 2013-11-26 | Kraft Foods Global Brands Llc | Delivery system for active components and a material having preselected hydrophobicity as part of an edible composition |
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| US9271904B2 (en) | 2003-11-21 | 2016-03-01 | Intercontinental Great Brands Llc | Controlled release oral delivery systems |
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-
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- 1988-09-12 US US07/243,404 patent/US4952407A/en not_active Expired - Lifetime
-
1989
- 1989-08-15 CA CA000608358A patent/CA1332573C/en not_active Expired - Fee Related
- 1989-08-16 NZ NZ230331A patent/NZ230331A/en unknown
- 1989-08-28 DE DE68916004T patent/DE68916004T2/de not_active Expired - Fee Related
- 1989-08-28 EP EP89910034A patent/EP0387330B1/en not_active Expired - Lifetime
- 1989-08-28 WO PCT/US1989/003725 patent/WO1990002491A1/en active IP Right Grant
- 1989-08-28 AU AU42015/89A patent/AU628386B2/en not_active Ceased
- 1989-08-28 AT AT89910034T patent/ATE106676T1/de active
- 1989-08-31 PH PH39182A patent/PH25515A/en unknown
- 1989-09-09 CN CN89107383A patent/CN1041091A/zh active Pending
- 1989-09-11 ES ES8903091A patent/ES2016059A6/es not_active Expired - Lifetime
-
1990
- 1990-04-30 FI FI902167A patent/FI96914C/fi not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100556301C (zh) * | 2002-01-28 | 2009-11-04 | 卡德伯里亚当斯美国有限责任公司 | 含有包封的除斑剂成分的口香糖和糖食组合物,其制备和应用方法 |
| CN104606064A (zh) * | 2014-12-30 | 2015-05-13 | 北京刷新活力健康科技有限公司 | 一种生物活性矿物粉体口香糖及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU628386B2 (en) | 1992-09-17 |
| NZ230331A (en) | 1991-07-26 |
| FI96914C (fi) | 1996-09-25 |
| WO1990002491A1 (en) | 1990-03-22 |
| US4952407A (en) | 1990-08-28 |
| ES2016059A6 (es) | 1990-10-01 |
| DE68916004D1 (de) | 1994-07-14 |
| ATE106676T1 (de) | 1994-06-15 |
| DE68916004T2 (de) | 1995-01-12 |
| EP0387330A4 (en) | 1991-01-16 |
| PH25515A (en) | 1991-07-24 |
| EP0387330B1 (en) | 1994-06-08 |
| EP0387330A1 (en) | 1990-09-19 |
| CA1332573C (en) | 1994-10-18 |
| FI96914B (fi) | 1996-06-14 |
| AU4201589A (en) | 1990-04-02 |
| FI902167A0 (fi) | 1990-04-30 |
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