CN104107272B - A kind of pharmaceutical composition for treating fracture - Google Patents
A kind of pharmaceutical composition for treating fracture Download PDFInfo
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- CN104107272B CN104107272B CN201410337241.5A CN201410337241A CN104107272B CN 104107272 B CN104107272 B CN 104107272B CN 201410337241 A CN201410337241 A CN 201410337241A CN 104107272 B CN104107272 B CN 104107272B
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- treating fracture
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Abstract
The present invention relates to a kind of pharmaceutical composition and its preparation method for being used to treat fracture, it is made up of the rhizome of davallia, lopseed, Radix Angelicae Sinensis, cortex acanthopanacis, the bark of eucommia, Morinda officinalis, donkey-hide gelatin, the fruit of Chinese wolfberry, formulation includes hard capsule, tablet, granule, and present invention aims at provide a kind of medicine for the treatment fracture for having definite curative effect.
Description
Technical field
The invention belongs to field of medicaments, and in particular to a kind of to treat pharmaceutical composition of fracture and preparation method thereof.
Background technology
Fracture refers to body bone because direct or indirect external force causes fragmentation or deformation.It is former when skeleton is newly formed
Originally it is soft flexible and plasticity, with the growth at age, the composition of cartilage is gradually few, and the composition of os osseum becomes many, bone gradually
Unlock beginning easily generation.Bone is no neural in itself, but the periosteum outside bone then has intensive nerve, therefore is had during fracture
Serious pain.And can concurrently internal haemorrhage, swelling and surrounding big neural, arteriovenous compressing and damage.
The content of the invention
The present invention goal of the invention be to provide it is a kind of treat Traditional Chinese medicine composition of fracture and preparation method thereof, treat
Effect significantly, reduces the pain of patient in terms of effect, detumescence, analgesic, reduces treatment time, creates good social and economy
Benefit.
The present invention drug regimen raw material be by weight ratio：130-170 parts of the rhizome of davallia, 130-170 parts of lopseed, when
Return a part 160-200,130-170 parts of cortex acanthopanacis, 180-220 parts of the bark of eucommia, 160-200 parts of Morinda officinalis, 100-140 parts of donkey-hide gelatin, matrimony vine
It is sub- 100-140 parts.
Preferably：150 parts of the rhizome of davallia, 150 parts of lopseed, 180 parts of Radix Angelicae Sinensis, 150 parts of cortex acanthopanacis, 200 parts of the bark of eucommia, Morinda officinalis
180 parts, 120 parts of donkey-hide gelatin, 120 parts of the fruit of Chinese wolfberry.Above-mentioned raw materials by the method received in pharmacy be made hard capsule, tablet,
Granula etc., wherein preferably granule.
The preparation method of above pharmaceutical composition is：Take above pharmaceutical composition bulk drug to mix, be ground into 10~20 mesh
Coarse granule, is added water 6 times, and with microwave assisted extraction methods, continuous 60 DEG C are extracted three times, and extract is centrifuged, and net immersion liquid is concentrated into
Relative density is 1.30~1.35 thick paste, and vacuum drying, dry cream is crushed, plus proper auxiliary materials, and corresponding formulation is made.
Auxiliary material in the present invention can be acceptable any excipient or carrier in pharmacy.
The present invention screens gained on the basis of traditional Chinese medical theory by a large amount of clinical practices.It is fast that it is formulated simple, action
It is fast, evident in efficacy, short treating period, uneasy to recur.
The rhizome of davallia：The strong bone of kidney tonifying, continues and hinders pain relieving.Modern pharmacy research has shown that rhizome of davallia water decoction gavage is to experimental big
The healing of mouse bone injury has facilitation, and having to Rat Experimental arthritis stimulates bone articular cartilage compensatory cellular hyperplasia to make
With, and can partly improve because the change of mechanical stress line causes the retrogression of articular cartilage, so as to reduce osteoarthropathy variability.
Lopseed：Dispelling wind and eliminating dampness, stimulate the circulation of the blood and cause the muscles and joints to relax.Modern pharmacy research has shown that, lopseed analgesia anti rheumatism action and bigcatkin willow
Acids medicine is similar.
Radix Angelicae Sinensis：Replenishing and activating blood, menstruction regulating and pain relieving.Modern pharmacy research has shown that Radix Angelicae Sinensis can remarkably promote hemoglobin and red
The generation of cell.
Cortex acanthopanacis：Dispelling wind and eliminating dampness, strong muscles and bones, tonify the liver and kidney, it is promoting blood circulation and removing obstruction in channels.Modern pharmacy research has shown that, the slender acanthopanax severe edema due to hypofunction of the spleen
Pan-fried alcohol extract can substantially suppress the allergic inflammation reaction of rat adjuvant arthroncus and immune complex mediation, separately
With sedation and analgesia effect.
The bark of eucommia：Tonify the liver and kidney, strengthen muscles and bones.Modern pharmacy research has shown that eucommia ulmoides extracts can significantly improve castrated rats
Bone biomechanical level, effectively prevents the generation of fracture caused by osteoporosis.
Morinda officinalis：Tonify the kidney and support yang, strengthen muscles and bones, dispelling wind and eliminating dampness.Modern pharmacy research has shown that Morinda officinalis can improve skeletonization
Cytoactive.
Donkey-hide gelatin：Tonify the blood and arrest bleeding, nourishing Yin and moistening dryness.
The fruit of Chinese wolfberry：Liver-kidney tonifying, benefiting shrewd head.The adjustable body's immunity of the modern pharmacology research confirmation fruit of Chinese wolfberry,
Tumour growth and cell mutation can effectively be suppressed, with the work in terms of anti-aging, anti-fatty liver, regulation blood fat and blood glucose
With.
In order to show that medicine of the present invention has therapeutic effect to fracture, the present invention has carried out following clinical trial.
1. object and method
1.1 Object Selections are through clarifying a diagnosis as the patient 80 of fracture totally, and all patients are grouped at random, are divided into 40
Example control group patient, 40 treatment group patients.22 patients are women in control group, and 18 patients are male, the age from 25~
62 years old, the median age was 42.3 years old.23 patients are women in treatment group, and 17 patients are male, the age from 23~63 years old, in
The position age is 40.1 years old.The every situation contrast no significant difference of control group and treatment group, can carry out comparative study.Control group chi
Scratch bone shaft fracture 6, fracture of scaphoid 3, fracture of metacarpal bone and phalanges of fingers 2, humerus shaft fracture 7, fracture of shaft of tibia and fibula 8,
Calcaneum, refer to (toe) bone fracture 3, femur backbone fracture 5, pelvic fracture 6；Treatment group's chi scratches bone shaft fracture 5, nut bone
Fracture 4, fracture of metacarpal bone and phalanges of fingers 3, humerus shaft fracture 6, fracture of shaft of tibia and fibula 6, calcaneum, refer to (toe) bone fracture 5,
Femur backbone fracture 5, pelvic fracture 6.Control group and treatment group's disease event contrast no significant difference.
After 1.2 methods are clarified a diagnosis, give after gimmick and the operation reduction of the fracture, fixing process, this oral hair for the treatment of group
The bright granule of embodiment 1, once two bags, one day three bags；The oral bone setting tablet of control group, one time four, three times per day.It is all
The time of patient's drug application treatment is 4-8 weeks or so.
1.3 evaluation indexes are estimated according to following standard to all patients.Pain：1. painless (0 point)；2. it is endurable
Pain, it is not necessary to take anodyne intervention, rests (2 points)；3. pain substantially, be impatient at by dynamic then exacerbation, need to take a small amount of
Anodyne, sleeps impacted (4 points)；4. sharp ache, it is difficult to stand, need to take antalgesic, sleep adversely effected (6 points).
Swelling：1. fracture is without swelling (0 point)；2. surrounding soft tissue's mild swelling, dermatoglyph is slightly shallow, and surrounding blood circulation is slight by shadow
Ring (2 points)；3. substantially, surrounding blood circulation is impacted substantially, and dermatoglyph substantially shoals (4 points) for swelling；4. serious swelling, epidermis
Shinny, texture disappears, and Tension Vesicle has (6 points).
1.4 curative effect index clinical cures：Clinical practice administration time shortens more than 1/4 than similar healing time,
Reach clinical healing standard person.It is clinical effective：Clinical practice administration time than similar healing time shift to an earlier date 1/4-1/6 with
On, reach clinical healing standard person.It is clinical effective：Clinical practice administration time shifts to an earlier date 1/5-1/6 than similar healing time,
Reach clinical healing standard person.It is clinical invalid：Clinical practice administration time is equal to or more than similar healing time, reaches and faces
Bed healing standard person.Healing time is standard by clinical healing temporal reference value, is compared.
All data of 1.5 statistical procedures are handled using ssps16.0 softwares, and application t is examined, x2Examine
Data are handled.
2. result
All patients control group and observation group's therapeutic effect contrast after treatment, detailed results are shown in Table 1.All patient's warps
Detumescence integration contrast situation after treatment, detailed results are shown in Table 2.Treatment group and control group analgesic integration contrast, detailed results are shown in
Table 3.
The control group of table 1 and observation group's therapeutic effect contrast
Note：* P ＜ 0.05 are compared with control group
2 two groups of detumescence integration situations of table compare
Note：* P ＜ 0.05 are compared with control group
3 two groups of analgesic integration situations of table compare
Note：* P ＜ 0.05 are compared with control group
As can be seen from the above results, treatment group and control group compare, in terms of curative effect, detumescence, analgesic, medicine of the present invention
It is superior to control drug bone setting tablet.It follows that the pharmaceutical composition of the treatment fracture in the present invention, clinically to bone
The treatment of folding has treatment time short, and detumescence is fast, the advantages of analgesic effect onset time is fast.
Specific embodiment
The rhizome of davallia 150g of embodiment 1, lopseed 150g, Radix Angelicae Sinensis 180g, cortex acanthopanacis 150g, bark of eucommia 200g, Morinda officinalis
180g, donkey-hide gelatin 120g, fruit of Chinese wolfberry 120g.
The preparation method of granule of the present invention：Take above pharmaceutical composition bulk drug to mix, be ground into thick of 10~20 mesh
Grain, is added water 6 times, and with microwave assisted extraction methods, continuous 60 DEG C are extracted three times, and extract is centrifuged, and net immersion liquid is concentrated into relatively
Density is 1.30~1.35 thick paste, and vacuum drying, dry cream is crushed, and adds amylum pregelatinisatum, sodium carboxymethylcellulose, mixing
80 mesh sieves, plus suitable quantity of water granulation are crossed, 60 DEG C are dried under reduced pressure, and whole grain is distributed into 100 bags, produced.
The rhizome of davallia 145g of embodiment 2, lopseed 160g, Radix Angelicae Sinensis 160g, cortex acanthopanacis 175g, bark of eucommia 205g, Morinda officinalis
190g, donkey-hide gelatin 110g, fruit of Chinese wolfberry 135g.
The preparation method of capsule of the present invention：Take above pharmaceutical composition bulk drug to mix, be ground into thick of 10~20 mesh
Grain, is added water 6 times, and with microwave assisted extraction methods, continuous 60 DEG C are extracted three times, and extract is centrifuged, and net immersion liquid is concentrated into relatively
Density is 1.30~1.35 thick paste, and vacuum drying, dry cream is crushed, and is loaded capsule, is produced.
The rhizome of davallia 160g of embodiment 3, lopseed 145g, Radix Angelicae Sinensis 190g, cortex acanthopanacis 145g, bark of eucommia 185g, Morinda officinalis
175g, donkey-hide gelatin 125g, fruit of Chinese wolfberry 113g.
The preparation method of Tablets：Take above pharmaceutical composition bulk drug to mix, be ground into 10~20 mesh coarse granules,
Add water 6 times, with microwave assisted extraction methods, continuous 60 DEG C extract three times, and extract is centrifuged, and net immersion liquid is concentrated into relatively close
The thick paste for 1.30~1.35 is spent, is dried in vacuo, dry cream is crushed, plus starch, talcum powder and Magnesium Stearate proper quantity, is pelletized, compacting
In flakes, it is coated, produces.
Claims (5)
1. a kind of pharmaceutical composition for treating fracture, it is characterised in that in parts by weight, is made effective group of the pharmaceutical composition
Point raw material be：130-170 parts of the rhizome of davallia, 130-170 parts of lopseed, Radix Angelicae Sinensis part 160-200,130-170 parts of cortex acanthopanacis, the bark of eucommia
180-220 parts, 160-200 parts of Morinda officinalis, 100-140 parts of donkey-hide gelatin, 100-140 parts of the fruit of Chinese wolfberry.
2. a kind of pharmaceutical composition for treating fracture as claimed in claim 1, it is characterised in that in parts by weight, this is made
The raw material of pharmaceutical composition active principle is：150 parts of the rhizome of davallia, 150 parts of lopseed, 180 parts of Radix Angelicae Sinensis, 150 parts of cortex acanthopanacis, the bark of eucommia
200 parts, 180 parts of Morinda officinalis, 120 parts of donkey-hide gelatin, 120 parts of the fruit of Chinese wolfberry.
3. a kind of pharmaceutical composition for treating fracture as claimed in claim 1 or 2, it is characterised in that described pharmaceutical composition agent
Type is hard capsule, tablet, granule.
4. a kind of preparation method for the pharmaceutical composition for treating fracture as claimed in claim 1 or 2, it is characterised in that this method
For：Take above pharmaceutical composition bulk drug to mix, be ground into 10~20 mesh coarse granules, add water 6 times, it is continuous with microwave assisted extraction methods
60 DEG C are extracted three times, and extract is centrifuged, and net immersion liquid is concentrated into the thick paste that relative density is 1.30~1.35, and vacuum is done
Dry, dry cream is crushed, plus proper auxiliary materials, and corresponding formulation is made.
5. a kind of preparation method for the pharmaceutical composition for treating fracture as claimed in claim 2, it is characterised in that this method is：
Take rhizome of davallia 150g, lopseed 150g, Radix Angelicae Sinensis 180g, cortex acanthopanacis 150g, bark of eucommia 200g, Morinda officinalis 180g, donkey-hide gelatin 120g, matrimony vine
Sub- 120g, above bulk drug is mixed, and is ground into 10~20 mesh coarse granules, is added water 6 times, with the continuous 60 DEG C of extractions of microwave assisted extraction methods
Take three times, extract is centrifuged, net immersion liquid is concentrated into the thick paste that relative density is 1.30~1.35, is dried in vacuo, and does
Cream is crushed, and is added amylum pregelatinisatum, sodium carboxymethylcellulose, was mixed 80 mesh sieves, plus suitable quantity of water granulation, and 60 DEG C of decompressions are dry
Dry, whole grain is distributed into 100 bags.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410337241.5A CN104107272B (en) | 2014-07-09 | 2014-07-09 | A kind of pharmaceutical composition for treating fracture |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410337241.5A CN104107272B (en) | 2014-07-09 | 2014-07-09 | A kind of pharmaceutical composition for treating fracture |
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| Publication Number | Publication Date |
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| CN104107272A CN104107272A (en) | 2014-10-22 |
| CN104107272B true CN104107272B (en) | 2017-09-22 |
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| CN201410337241.5A Expired - Fee Related CN104107272B (en) | 2014-07-09 | 2014-07-09 | A kind of pharmaceutical composition for treating fracture |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403101A (en) * | 2001-09-11 | 2003-03-19 | 淄博茂桐骨伤病研究所 | Fracture-setting silky fowl ointment and its prepn |
| CN101664480A (en) * | 2009-10-10 | 2010-03-10 | 吴理靖 | Chinese herbal medicine medicament for treating hyperosteogeny |
| CN102793816A (en) * | 2011-05-26 | 2012-11-28 | 孟庆船 | Plaster for treating bone fracture |
-
2014
- 2014-07-09 CN CN201410337241.5A patent/CN104107272B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1403101A (en) * | 2001-09-11 | 2003-03-19 | 淄博茂桐骨伤病研究所 | Fracture-setting silky fowl ointment and its prepn |
| CN101664480A (en) * | 2009-10-10 | 2010-03-10 | 吴理靖 | Chinese herbal medicine medicament for treating hyperosteogeny |
| CN102793816A (en) * | 2011-05-26 | 2012-11-28 | 孟庆船 | Plaster for treating bone fracture |
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| Publication number | Publication date |
|---|---|
| CN104107272A (en) | 2014-10-22 |
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