CN104096185A - Medicine for preventing and curing mixed infection among poultry, as well as preparation method and application of medicine - Google Patents
Medicine for preventing and curing mixed infection among poultry, as well as preparation method and application of medicine Download PDFInfo
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- CN104096185A CN104096185A CN201410374393.2A CN201410374393A CN104096185A CN 104096185 A CN104096185 A CN 104096185A CN 201410374393 A CN201410374393 A CN 201410374393A CN 104096185 A CN104096185 A CN 104096185A
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Abstract
The invention belongs to the field of veterinary medicines, and particularly discloses a medicine for preventing and curing mixed infection among poultry, as well as a preparation method and application of the medicine. The medicine comprises the following raw materials by weight percentage: 20 to 40 percent of zedoary extractive, 10 to 20 percent of Chinese angelica extractive, 15 to 25 percent of herba schizonepetae extractive, 15 to 25 percent of tilmicosin and the balance of auxiliary materials. The medicine is simple to prepare, and scientific in compatibility, adopts simple and highly available raw materials, is low in cost and affordable, can increase artery blood flow in the poultry and white blood cell quantity, is anti-inflammatory and febrifugal, can ease pain and adjust the organism immunologic function of the poultry, can prevent and cure mixed infection of bacteria, viruses and mycoplasmas of the poultry such as chickens, ducks and gooses, is a poultry mixed infection preventing and curing medicine which meets the requirements of safe veterinary medicines and guarantees animal-derived food safety, and can effectively reduce the use of antibiotics during poultry cultivation to further reduce medicine residue in the poultry.
Description
(1) technical field
The invention belongs to field of veterinary, particularly a kind of medicine of preventing and treating an avian mixed infection and its preparation method and application.
(2) background technology
The large-scale cultivation of poultry has become the main flow of contemporary aviculture; under large-scale cultivation pattern; group of birds body density is large, stressors increases; be easy to cause that poultry morbidity is even dead, wherein the mixed infection of the antibacterial of poultry, virus, mycoplasma has become one of general and serious disease of poultry farms.Along with being on the increase with complicated of poultry disease especially infectious disease, it is serious that chicken group mixes morbidity, and mortality rate is higher, to raiser, has caused huge economic loss.Wherein, the antibacterial of poultry, virus, mycoplasma mixed infection all have generation in China each province, particularly occurred frequently at poultry farming close quarters, and family's avian mixed infection is without obvious seasonality, all can occur throughout the year, are easy to cause that poultry morbidity is even dead.Common family's avian mixed infection disease has low pathogenicity bird flu and colibacillosis mixed infection, atypical newcastle and colibacillosis mixed infection, escherichia coli and mycoplasma mixed infection, low pathogenicity bird flu and necrotic enteritis mixed infection, mycoplasma and the mixed infection of low pathogenicity bird flu, infectious bronchitis and salmonella paratyphi mixed infection etc.The constitutional factor that causes an avian mixed infection is some birds viruses, poultry infects after virus, and its immunity degradation, is then easy to be encroached on by mycoplasma and antibacterial, cause secondary infection, the reason of poultry death is the bacteremia causing due to antibacterial secondary infection mostly.Family avian mixed infection treatment difficulty large, mortality rate is high, provisions fowl dealer has brought great economic loss.At present, the primary treatment scheme of reply man avian mixed infection is for promoting the astragalus polysaccharides of poultry immunity power and the cephalosporins compatibility for the treatment of bacterial disease, this scheme therapeutic effect feeds back throughout the country and differs and cure rear easily recurrence, and poultry tends to cause uncertain therapeutic efficacy to be cut due to the generation of drug resistance, and China Ministry of Agriculture has forbidden that antiviral Western medicine applies in poultry farming field.In addition, the treatment field of current family avian mixed infection is the exploratory stage in the initial stage also, the object of research is mainly bacterial disease and mycoplasma disease how to control poultry, also seldom have the treatment research that relates to poultry virus disease, this has caused very large technology barrier to the rehabilitation after family's avian mixed infection.
(3) summary of the invention
The present invention is in order to make up the deficiencies in the prior art, provide a kind of prepare simple, compatibility science, cost low, can directly be added in poultry feed, easy to use, instant effect, can reduce antibacterials in poultry farming process use, reduce medicine of the control man avian mixed infection of drug residue in poultry body and its preparation method and application.
The present invention is achieved through the following technical solutions:
Prevent and treat a medicine for an avian mixed infection, by the raw material of following percentage by weight, formed: Rhizoma Curcumae extract 20-40%, Radix Angelicae Sinensis extract 10-20%, Herba Schizonepetae extract 15-25%, tilmicosin 15-25%, surplus is adjuvant.
The medicine of this control man avian mixed infection, the percentage by weight of its preferred each raw material is: Rhizoma Curcumae extract 30%, Radix Angelicae Sinensis extract 15%, Herba Schizonepetae extract 20%, tilmicosin 20% and adjuvant 15%.
Described adjuvant is any one and precipitated calcium carbonate, ground calcium carbonate, powdered rice hulls in oral glucose, anhydrous glucose, sucrose or lactose, add any one the combination in beneficial powder or maize cob meal.
The preparation method of the medicine of this control man avian mixed infection, comprises the steps:
By above-mentioned percentage by weight, take Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, tilmicosin and adjuvant and pulverize respectively the rear 80-100 of mistake mesh sieve, then by Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, tilmicosin and adjuvant mix homogeneously, obtain the medicine of this control man avian mixed infection.
The application of the medicine that the present invention prevents and treats an avian mixed infection in control man avian mixed infection.
Usage and dosage: the ratio in every 1000 kilogram of feed with 1000 grams of medicines of the present invention, medicine of the present invention is mixed in poultry feed, after fully mixing, for poultry free choice feeding, be used in conjunction 6-7 days.
The pharmaceutical characteristic of each raw material of the present invention is as follows:
Rhizoma Curcumae extract: Rhizoma Curcumae bitter in the mouth, pungent, temperature, returns liver, spleen channel, circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving, cures mainly QI and blood pained, eating accumulation, abdominal distention ， mass in the abdomen mass in the abdomen, traumatic injury.Modern study shows, the main pharmacological component of Rhizoma Curcumae extract is curcumenol, methoxyl group ethyl cinnamate, epicurzerenone, curzerene, pyrocurcuzerenone, isocurcumenol, procurcumenol, deoxidation curzerenone etc., after oral, there is antiviral, antibacterial, antineoplastic action, can also make blood flow volume increase, quantity of leucocyte in animal body raise, there is the effect that regulates animal body immunologic function;
Radix Angelicae Sinensis extract: Radix Angelicae Sinensis sweet in the mouth, temperature, return liver, the heart, spleen channel, enrich blood and invigorate blood circulation, moisturize laxation.Cure mainly all Zheng ， of blood deficiency mass in the abdomen knot poly-, asthenia cold abdominalgia, flaccidity syndrome and arthralgia syndrome, numbness of the skin, dryness of the intestine dyschezia, heavy after bloody dysentery, ulcer sores, injury from falling down.Modern study shows: Radix Angelicae Sinensis extract has the function that promotes body hemopoietic function, anticoagulant and antithrombotic, blood fat reducing, and blood and hemopoietic function are had to the effect regulating for the treatment of; Also having enriches blood invigorates blood circulation, regulates the effect of body's immunity and anti-hypoxia;
Herba Schizonepetae extract: Herba Schizonepetae acrid in the mouth, tepor, return lung, Liver Channel, dispel the wind, induce sweat, rash, hemostasis.Cure mainly cold, fever, headache, eye itching, cough, laryngopharynx swelling and pain, measles, rubella, carbuncle, skin ulcer scabies, epistaxis, spits blood, and has blood in stool.Modern study shows: the main pharmacological component of Herba Schizonepetae extract is D-menthone, racemization menthone, nepetol, schizonodiol etc., there is antiinflammatory, antipyretic, analgesic activity, and have stronger antibacterial action, respiratory system, central nervous system are had to adjusting immunity function;
Tilmicosin: tilmicosin has powerful killing action to mycoplasma, gram positive bacteria and part gram negative bacteria, effective especially to Mycoplasma, tilmicosin main metabolites in animal body has antibacterial activity equally, and effect rapidly, metabolite drug level peak occurs after following the concentration peak of medicine of the present invention closely, and circulation time in vivo will be longer than tilmicosin, not only additionally increased antimicrobial effect, also extend the time of pathogen and medicament contact, be conducive to the treatment of disease; Tilmicosin is oral can extensively be gathered rapidly after entering in animal body in leukocyte, and infiltrates to subcellular organelle, carries the leukocyte of tilmicosin and can initiatively find and near infected animal infection site, more be conducive to the treatment of systemic infection.
The present invention prevents and treats the medicine of an avian mixed infection and prepares simple, compatibility science, raw material is simple and easy to get, cost is low, economic and practical, multi-medicament is suitably coordinated, utilize its mutual collaborative or resistant function, improve curative effect, to adapt to the treatment requirement of the complicated state of an illness, reduce untoward reaction, evident in efficacy lasting, absorb fast, prove effective rapidly, can increase blood flow volume in poultry body, the quantity of leukocyte increasing, and there is antiinflammatory, antipyretic, analgesia, regulate the effect of poultry body's immunity, carrying the leukocyte of tilmicosin can initiatively find and close infected animal infection site, more be conducive to the treatment of systemic infection, and to mycoplasma, gram positive bacteria and part gram negative bacteria have powerful killing action, increased antimicrobial effect, also extended the time of pathogen and medicament contact, be applicable to a needs for avian mixed infection control, in adjuvant, be added with oral glucose, anhydrous glucose, sucrose or lactose, can improve mouthfeel and the palatability of medicine, can directly be added in poultry feed, easy to use, have no side effect and drug residue, there is the effect of the poultry bacterials such as prevention and treatment chicken, duck, goose, virus, mycoplasma mixed infection, be a kind of medicine that meets safe veterinary drug, ensures the control man avian mixed infection of animal-derived food safety, can effectively reduce in poultry farming process antibiotic use and then reduce the drug residue in poultry body.
(4) specific embodiment
Below in conjunction with embodiment, the invention will be further described, but the present invention is not limited thereto, and the preparation method in embodiment is conventional preparation method, no longer describes in detail.
Embodiment 1:(weight is in double centner, as follows)
The medicine of this control man's avian mixed infection, is comprised of the raw material of following weight: 7 kilograms of 30 kilograms of Rhizoma Curcumae extracts, 15 kilograms of Radix Angelicae Sinensis extracts, 20 kilograms of Herba Schizonepetae extracts, 20 kilograms of tilmicosins, 8 kilograms of oral glucoses and precipitated calcium carbonates;
The preparation method of the medicine of this control man avian mixed infection, adopts following steps:
By above-mentioned weight, take Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, tilmicosin, oral glucose and precipitated calcium carbonate and pulverize respectively the rear 80-100 of mistake mesh sieve, then by Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, tilmicosin, oral glucose and precipitated calcium carbonate mix homogeneously, obtain the medicine of this control man avian mixed infection.
Usage and dosage: the ratio in every 1000 kilogram of feed with 1000 grams of medicines of the present invention, medicine of the present invention is mixed in poultry feed, after fully mixing, for poultry free choice feeding, be used in conjunction 6-7 days.
Embodiment 2:
The medicine of this control man's avian mixed infection, is comprised of the raw material of following weight:
20 kilograms of 20 kilograms of Rhizoma Curcumae extracts, 10 kilograms of Radix Angelicae Sinensis extracts, 15 kilograms of Herba Schizonepetae extracts, 15 kilograms of tilmicosins, 20 kilograms of anhydrous glucose and powdered rice hulls.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 3:
The medicine of this control man's avian mixed infection, is comprised of the raw material of following weight:
40 kilograms of Rhizoma Curcumae extracts, 20 kilograms of Radix Angelicae Sinensis extracts, 17 kilograms of Herba Schizonepetae extracts, 18 kilograms of tilmicosins, 3 kilograms of sucrose and add 2 kilograms, beneficial powder.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 4:
The medicine of this control man's avian mixed infection, is comprised of the raw material of following weight:
5 kilograms of 25 kilograms of Rhizoma Curcumae extracts, 18 kilograms of Radix Angelicae Sinensis extracts, 23 kilograms of Herba Schizonepetae extracts, 22 kilograms of tilmicosins, 7 kilograms of lactose and ground calcium carbonate.
Preparation method and usage and dosage are with embodiment 1.
Embodiment 5:
The medicine of this control man's avian mixed infection, is comprised of the raw material of following weight:
1 kilogram of 35 kilograms of Rhizoma Curcumae extracts, 12 kilograms of Radix Angelicae Sinensis extracts, 25 kilograms of Herba Schizonepetae extracts, 25 kilograms of tilmicosins, 2 kilograms of oral glucoses and maize cob meal.
Preparation method and usage and dosage are with embodiment 1.
Rhizoma Curcumae extract used, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, tilmicosin, oral glucose, anhydrous glucose, sucrose, lactose, precipitated calcium carbonate, ground calcium carbonate, powdered rice hulls in embodiment 1-5, add beneficial powder, maize cob meal is commercially available prod.
In order to verify the clinical treatment curative effect of medicine of the present invention to family's avian mixed infection, the inventor poultry that year December is fallen ill to mixed infection at different poultry farms in March, 2013 to 2013 adopts medicine of the present invention to carry out therapeutic test to ill poultry, specific as follows:
Treatment example 1:
Broiler breeding field, Accessories during Binzhou, Shandong Province, the sick chicken of dysentery, cough, sporadicly during broiler 15 age in days appears that spirit is depressed, in 19000 of cultivation Ai Wei mattress broiler, during 18 age in days jumpbogroup occur that spirit is depressed, dysentery, cough, and have fragmentary death, through clinical diagnosis, be mixed infection.
The medicine that adopts the made control of the embodiment of the present invention 1 man avian mixed infection, the ratio in every 1000 kilogram of feed with 1000 grams of medicines of the present invention, mixes medicine of the present invention in poultry feed, after fully mixing, for poultry free choice feeding, is used in conjunction 7 days.
After medication 3 days, jumpbogroup situation takes a turn for the better, and continues medication after 4 days, and chicken group each side recovering state is normal.
Treatment example 2:
Weifang City, Shandong Province meat-type duck plant, 8000 Cherry Village Ducks morbidities, occur that spirit is depressed, cough, has fragmentary death, through clinical diagnosis, is mixed infection.
The medicine that adopts the made control of the embodiment of the present invention 2 man avian mixed infection, the ratio in every 1000 kilogram of feed with 1000 grams of medicines of the present invention, mixes medicine of the present invention in poultry feed, after fully mixing, for poultry free choice feeding, is used in conjunction 6 days.
After medication 2 days, jumpbogroup situation takes a turn for the better, and continues medication after 4 days, and duck group each side recovering state is normal.
Treatment example 3:
(1) subjects:
More than 14000 the 20 age in days Ai Wei mattress broiler that raise broiler breeding field, Heze city of Shandong province, there is successively the symptoms such as sneeze, stream serosity or stickiness nose liquid, then most Broiler Chicken temperature rises, feed intake declines, there is the respiratory symptoms such as ataxia, cough, snore, indivedual sick chicken spirit is depressed, feather loose random, drop-head is closed one's eyes, mouth breathing, draw white loose stool.Cut open and examine the chicken that dies of illness, visible sick chicken nasal cavity has mucus, and larynx has the petechia of needle point size, tracheorrhagia is not serious, and bronchus is stopped up by yellow cheese thing, and torso bag has yellow cheese thing, the majority chicken lungs of dying of illness are downright bad, peritoneum has bubble, muddy individually, in the swelling of glandular stomach outward appearance, has gas, glandular stomach thelorrhagia, the swelling of duodenum lymph follicle, cecal tonsil swelling, rectum adularescent loose stool.According to epidemiology, clinical symptoms and pathological anatomical change, be diagnosed as low pathogenicity bird flu and mix mycoplasma infection.
(2) test method:
14000 of the Ai Wei mattress broiler of the remaining 20 age in days mixed infection morbidities of this plant, are divided into 4 groups at random, 3500 every group, are labeled as respectively matched group, test group 1, test group 2 and test group 3.Matched group adopts tilmicosin and astragalus polysaccharides by specification drinking-water drug treatment, and test group 1 adopts the embodiment of the present invention 1 Drug therapy, and test group 2 adopts the embodiment of the present invention 2 Drug therapys, and test group 3 adopts the embodiment of the present invention 3 Drug therapys.
The usage of test group 1-test group 3 and consumption are: the ratio in every 1000 kilogram of feed with 1000 grams of medicines of the present invention, medicine of the present invention is mixed in poultry feed, and after fully mixing, for poultry free choice feeding, be used in conjunction 6 days.
(3) result of the test:
Treat after 6 days, the mortality rate that calculates matched group and test group 1-3 chicken group is as following table 1:
Table 1 matched group and test group 1-3 therapeutic outcome
This type of disease is also multiple habitually in the past in this plant, adopts traditionally antibiotics and chemosynthesis class comprehensive drug treatment, though can control to a certain extent dead continuing to increase, chicken group easily produces drug resistance and drug residue, and later stage death rate is high.As can be seen from Table 1, the matched group mixed infection chicken faciation ratio with adopting tilmicosin and Effect of APS in Treating, adopts Drug therapy mixed infection chicken group's of the present invention mortality rate obviously to reduce.
Treatment example 4:
(1) subjects:
26 Day-old Broiler Chickens that Shandong Jimo plant raises, chicken group has fragmentary death every day, there is cough, sneeze, rale, dehisce to stretch the symptoms such as neck breathing, sick chicken becomes thin, cuing open the visible internal organs of inspection has obvious fibrinous exudate, as fibrinous pericarditis, perihepatitis, airsacculitis, peritonitis etc.According to epidemiology, clinical symptoms and pathological anatomical change, be diagnosed as chicken low pathogenicity bird flu and colibacillosis mixed infection, the chicken group of morbidity remained to 6084 chickens and carry out contrast therapy test.
(2) test method:
6084 chickens are divided into 4 groups at random, 1521 every group, be labeled as respectively matched group, test group 1, test group 2 and test group 3, wherein, matched group continues to adopt florfenicol, norfloxacin antibacterial drug therapy, the administration of by specification drinking-water; Test group 1 adopts the embodiment of the present invention 1 medicine to treat, and test group 2 adopts the embodiment of the present invention 4 medicines to treat, and test group 3 adopts the embodiment of the present invention 5 medicines to treat; The usage of test group 1-test group 3 and consumption are: the ratio in every 1000 kilogram of feed with 1000 grams of medicines of the present invention, medicine of the present invention is mixed in poultry feed, and after fully mixing, for poultry free choice feeding, be used in conjunction 7 days.The mortality rate that matched group and test group 1-3 all added up in the course for the treatment of (7 days) is as shown in table 2.
(3) result of the test:
The mortality rate that matched group and test group 1-3 all added up in the course for the treatment of (7 days) is as shown in table 2 below:
Table 2 matched group and test group 1-3 therapeutic outcome
As can be seen from Table 2, while treating the 5th day, the test group 1-3 chicken group's of employing Drug therapy of the present invention mortality rate is starkly lower than the matched group chicken group's who adopts florfenicol, norfloxacin antibacterial drug therapy mortality rate, in treatment 6-7 days, matched group chicken group still has a large amount of sick chicken death phenomenons, and test group 1-3 chicken group's mortality rate obviously declines.Result of the test shows, medicine of the present invention can effectively be controlled advancing of disease, and Chinese medicine is after extracting, and onset is very fast.The requirement of Hou Ying plant, matched group also adopts Drug therapy of the present invention, is used in conjunction 6 days and has effectively controlled afterwards death, has further verified the effect of medicine of the present invention.
Claims (5)
1. a medicine of preventing and treating an avian mixed infection, is characterized in that: the raw material by following percentage by weight forms: Rhizoma Curcumae extract 20-40%, Radix Angelicae Sinensis extract 10-20%, Herba Schizonepetae extract 15-25%, tilmicosin 15-25%, surplus is adjuvant.
2. a kind of medicine of preventing and treating an avian mixed infection according to claim 1, is characterized in that: the raw material by following percentage by weight forms: Rhizoma Curcumae extract 30%, Radix Angelicae Sinensis extract 15%, Herba Schizonepetae extract 20%, tilmicosin 20% and adjuvant 15%.
3. a kind of medicine of preventing and treating an avian mixed infection according to claim 1 and 2, is characterized in that: described adjuvant is any one and precipitated calcium carbonate, ground calcium carbonate, powdered rice hulls in oral glucose, anhydrous glucose, sucrose or lactose, add any one the combination in beneficial powder or maize cob meal.
4. a preparation method for the medicine of a control avian mixed infection as claimed in claim 1, is characterized in that: comprise the steps:
By above-mentioned percentage by weight, take Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, tilmicosin and adjuvant and pulverize respectively the rear 80-100 of mistake mesh sieve, then by Rhizoma Curcumae extract, Radix Angelicae Sinensis extract, Herba Schizonepetae extract, tilmicosin and adjuvant mix homogeneously, obtain the medicine of this control man avian mixed infection.
5. the application of the medicine of a control avian mixed infection as claimed in claim 1 in control man avian mixed infection.
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| CN104523888A (en) * | 2014-12-25 | 2015-04-22 | 北京资源亚太饲料科技有限公司 | Pharmaceutical composition for preventing and treating respiratory tract diseases of poultry and preparation method and application of pharmaceutical composition |
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Effective date of registration: 20151109 Address after: 256618 No. nine, No. 480, Bohai Road, Shandong, Binzhou Applicant after: Binzhou, Shandong Province animal and veterinary research institute Address before: 256600 No. three, No. 510, the Yellow River Road, Shandong, Binzhou Applicant before: Liu Jishan |
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