CN104095895A - Panax quinquefolium and pearl oral solution and preparation method thereof - Google Patents

Panax quinquefolium and pearl oral solution and preparation method thereof Download PDF

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Publication number
CN104095895A
CN104095895A CN201410334705.7A CN201410334705A CN104095895A CN 104095895 A CN104095895 A CN 104095895A CN 201410334705 A CN201410334705 A CN 201410334705A CN 104095895 A CN104095895 A CN 104095895A
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citric acid
margarita
weight portion
filter
panacis quinquefolii
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CN201410334705.7A
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王云山
张振建
张晓春
郑晓芹
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  • Coloring Foods And Improving Nutritive Qualities (AREA)
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Abstract

The invention aims to provide a panax quinquefolium and pearl oral solution which is high in utilization rate of panax quinquefolium and pearls and capable of tonifying qi, nourishing yin, removing toxins, promoting tissue regeneration, moisturizing the skin and removing patches.

Description

A kind of western pearl oral liquid and preparation method thereof
Technical field
Patent of the present invention relates to drug research field, specifically refers to the prescription composition of the western pearl oral liquid of a kind of boosting qi and nourishing yin, removing toxic substances and promoting granulation, moistening skin and eliminating spot.The invention still further relates to the preparation method of this western pearl oral liquid.
Background technology
Margarita is the product that the bivalve irriates such as Pteriidae animal Pteria martensii Dunker Pteria martensii (Dunker), Unionidae animal hydriopsis cumingii Hyriopsis cumingii (Lea) or cristaria plicata Cristaria plicata (Leach) form.In Margarita, more than 90% be calcium carbonate (CaCO 3), Organic substance accounts for 5% left and right, in its chromoprotein, contain 16 seed amino acids, content with alanine (alanine) and glycine (glycine) is higher, and inferior is aspartic acid (aspartic cid), leucine (leucine) and arginine (arginine).In Margarita, also contain in addition porphyrins (PFC).Margarita property is sweet, cold, salty in the mouth,, GUIXIN, Liver Channel.There is the arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, effect of moistening skin and eliminating spot.Modern study shows that Margarita all has unique effect at aspects such as improving body immunity, slow down aging, freckle removing and whitening, supplement calcium.There is researcher to the oral pearl suspension 200mg/ of mice (kgd) × 25d, can make the brown pigment content in cardiac muscle and cerebral tissue obviously reduce.Porphyrins (PFC) can suppress interior free yl reaction, thereby plays delaying senility function.The instructions of taking that Margarita is conventional is to beat powder to swallow, and bioavailability is low.
Radix Panacis Quinquefolii is the dry root of Araliaceae Radix Panacis Quinquefolii .PanaxquinquefoliumL., nature and flavor: sweet, micro-hardship, and cool.There is boosting qi and nourishing yin, effect of clearing away heat and promoting production of body fluid.The traditional Chinese medical science is thought, the capable blood of gas, and blood is stagnation resolvation, and compatibility Radix Panacis Quinquefolii has increased effect of boosting qi and nourishing yin of the present invention, speckle dispelling, treats from root.The using method that " Chinese Pharmacopoeia " recorded is separately to decoct and take.More conventional using method is shave, buccal.These usings method or not too convenient, or be exactly that utilization ratio is not high.
Chinese patent application publication No. CN101828661A, Shen Qing Publication day is that the patent of invention of on 09 15th, 2010 discloses one for improving moisture of skin, the health food of reduce wrinkle, raw material by following weight parts is made, collagen protein powder 10-15, soybean isoflavone 6-8, Margarita powder 3-5, Aloe extract 3-5, Radix Panacis Quinquefolii extract 3-5, Fructus Jujubae 2-3, vitamin c powder 1-2, oligofructose 3-5, Carboxymethyl cellulose sodium 3-8, citric acid 1-5, malic acid 1-5, sucralose 5-20, this invention is by collagen protein powder, soybean isoflavone, Margarita powder, Aloe extract, Poria extract, Radix Panacis Quinquefolii extract, Cortex Phellodendri extract, Fructus Jujubae and vitamin c powder carry out reasonable assembly, carry out toxin expelling from inside, QI invigorating, YIN nourishing, and the collagen protein of supplementary human body shortage, reach moisturizing from the inside to surface, the effect of wrinkle removing, and add the raw materials such as oligofructose to play flavor adjustment, promote the effect of intestinal absorption.Although used citric acid and malic acid in this invention, just as spice and acidulant, Margarita rubs in this health food with the form of powdery, and the utilization rate of Margarita is still very low.
Summary of the invention
The object of the present invention is to provide the western pearl oral liquid of a kind of, boosting qi and nourishing yin high to Radix Panacis Quinquefolii and Margarita utilization rate, removing toxic substances and promoting granulation, moistening skin and eliminating spot.
The technical solution used in the present invention is:
A kind of western pearl oral liquid, this western pearl oral liquid is to be made up of the raw material of following weight parts:
This western pearl oral liquid is to be made up of the Margarita of the Radix Panacis Quinquefolii of 40 weight portions, 12 weight portions, the citric acid of 24 weight portions and the water of 1600 weight portions.
A preparation method for western pearl oral liquid, comprises the following steps:
1) citric acid of 15-60 weight portion is added in the water of 240-1000 weight portion, stir citric acid is dissolved completely, obtain aqueous citric acid solution;
2) by after the crushing pearl of 7.5-30 weight portion, join in aqueous citric acid solution, stir, place 24-48 hour;
3) by step 2) in the solution that obtains filter, obtain Margarita extracting solution for subsequent use;
4) Radix Panacis Quinquefolii of 25-100 weight portion is put into and decocted vessel, add the water of 400-1600 weight portion, decoct 1-3 hour, filter, obtain decoction liquor and medicinal residues;
5) in step 4) continue to add the water of 600-1200 weight portion in Chinese medicine slag, again decoct 1-3 hour, filter, obtain decoction liquor and medicinal residues;
6) to step 4), 5) decoction liquor that forms merges standing sedimentation 24 hours;
7) by step 6) in decoction liquor again filter, to filter after solution concentrate, obtain the Radix Panacis Quinquefolii extracting solution that weight portion is 200-1000;
8) by step 3) in the Margarita extracting solution and the step 7 that obtain) in the Radix Panacis Quinquefolii extracting solution that obtains mix according to weight proportion 1:1, stir.
Western pearl oral liquid provided by the invention has the following advantages:
1, Chinese medicine reasonable recipe of the present invention, easy to use, and without incompatibility, preparation technology is simple, has great practical value.
2, in the present invention, adopt citric acid and Margarita to carry out acidification reaction, obtained calcium citrate and filtered out, effectively extracted aminoacid, protein component in Margarita, greatly improved the service efficiency of Margarita.
3, in the present invention, used excessive citric acid, citric acid can be accelerated cutin and upgrade, thereby citric acid has skin whitening, defying age, anti-acne effect.Citric acid also has antiseptic effect simultaneously, and this product that is need to, adding in addition antiseptic, not used safer.
Detailed description of the invention
The present invention is a kind of oral liquid made from Radix Panacis Quinquefolii, Margarita, citric acid crude drug, by the consulting of " Chinese Pharmacopoeia " (version in 2010), " 21 of Chinese medicine ministry standards ", does not find the pharmaceutical preparation of identical prescription.At " middle National IP Network " enterprising line retrieval, retrieve as key word taking " Radix Panacis Quinquefolii " and containing " Margarita " in addition, do not find pertinent literature report.
Radix Panacis Quinquefolii, Margarita are " Chinese Pharmacopoeia " and record kind, and are integration of edible and medicinal herbs kind, have corresponding quality standard, detection method and using dosage, and the drug use dosage of patent of the present invention is within " Chinese Pharmacopoeia " regulation, and use is safer.Citric acid also has corresponding national standard (food grade GB1987-2007), and the mass ratio that citric acid and calcium carbonate react is 384:300; Citric acid in patent prescription of the present invention and the usage ratio of Margarita are 2:1, can make the calcium carbonate in Margarita dissolve completely.
Radix Panacis Quinquefolii, nature and flavor: cool in nature, sweet in the mouth, micro-hardship.
Boosting qi and nourishing yin, clearing away heat and promoting production of body fluid.Lose for the deficiency of vital energy is cloudy, deficiency-heat is tired tired, cough with asthma expectorant blood, and interior-heat is quenched one's thirst, and dry mouth larynx is dry.Consumption 3~6g.
Compatibility application: 1. consumption of YIN caused by febrile disease, to quench one's thirst, dry mouth larynx is dry: join Herba Dendrobii, Radix Ophiopogonis, Radix Adenophorae (Radix Glehniae).
2. the deficiency of YIN, blood deficiency, asthenia is unable: join Radix Angelicae Sinensis, Radix Rehmanniae Preparata, the Radix Paeoniae Alba, Radix Paeoniae Rubra.
3. should not be with Rhizoma et radix veratri (Radix Rhizoma Veratri) with using.
Margarita, main component is calcium carbonate, natural peral is containing calcium carbonate 91.72%, Organic substance 5.94%, water 2.23%.Application has following effect clinically: the arresting convulsion of calming the nerves, improving eyesight removing nebula, removing toxic substances and promoting granulation, moistening skin and eliminating spot.The insomnia that is used for palpitating with fear, infantile convulsion epilepsy, conjunctival congestion cataracta, skin infection is not held back, skin splash.
Citric acid quality standard is: food grade GB1987-2007; Belong to the one of fruit acid, there is gentle frank tart flavour, generally, for the manufacture of the food such as various beverages, soda pop, wine, confection, dessert, cookies, canned fruit juice, milk product, have no side effect.Citric acid can all dissolve the calcium carbonate in Margarita, and the effective ingredient such as protein, aminoacid that makes to be comprised in Margarita fully discharges, and has improved the bioavailability of Margarita.In addition citric acid can accelerate cutin upgrade, the renewal of cutin contribute to skin in melanic peeling off, the receipts of pore are thin, the dissolving of blackhead etc.Thereby citric acid has skin whitening, defying age, anti-acne effect.Citric acid also has antiseptic effect simultaneously.
In the present invention, adopt citric acid and Margarita to carry out acidification reaction, product comprises calcium citrate, because calcium citrate water solublity is poor, is filtered out, can effectively extract the composition such as aminoacid, protein in Margarita, greatly improve the service efficiency of Margarita.
Following examples are used for illustrating the present invention, but are not used for limiting the scope of the invention.
Embodiment 1:
Get Radix Panacis Quinquefolii 30g, Margarita 10g, citric acid 20g;
1) 20g citric acid is added in the water of 400ml, stir citric acid is dissolved completely, obtain aqueous citric acid solution;
2) by after the crushing pearl of 10g, join in aqueous citric acid solution, stir, place 48 hours;
3) by step 2) in the solution that obtains filter, the Margarita extracting solution that obtains about 400ml is for subsequent use;
4) Radix Panacis Quinquefolii of 30g is put into and decocted vessel, add the water of 500ml, decoct 2 hours, filter, obtain decoction liquor and medicinal residues;
5) in step 4) in continue to add the water of 400ml in the medicinal residues that form, again decoct 2 hours, filter, obtain decoction liquor and medicinal residues;
6) to step 4), 5) decoction liquor that forms merges standing sedimentation 24 hours;
7) by step 6) in decoction liquor again filter, to filter after solution concentrate, obtain being about the Radix Panacis Quinquefolii extracting solution of 400ml;
8) by step 3) in the 400ml Margarita extracting solution and the step 7 that obtain) in the 400ml Radix Panacis Quinquefolii extracting solution that obtains mix, stir.
Embodiment 2:
Get Radix Panacis Quinquefolii 40g, Margarita 12g, citric acid 25g;
1) 25g citric acid is added in the water of 500ml, stir citric acid is dissolved completely, obtain aqueous citric acid solution;
2) by after the crushing pearl of 12g, join in aqueous citric acid solution, stir, place 48 hours;
3) by step 2) in the solution that obtains filter, the Margarita extracting solution that obtains about 500ml is for subsequent use;
4) Radix Panacis Quinquefolii of 40g is put into and decocted vessel, add the water of 700ml, decoct 2 hours, filter, obtain decoction liquor and medicinal residues;
5) in step 4) in the medicinal residues that form continue to add the water of 500ml, again decoct 2 hours, filter, obtain decoction liquor and medicinal residues;
6) to step 4), 5) decoction liquor that forms merges standing sedimentation 24 hours;
7) by step 6) in decoction liquor again filter, to filter after solution concentrate, obtain being about the Radix Panacis Quinquefolii extracting solution of 500ml;
8) by step 3) in the 500ml Margarita extracting solution and the step 7 that obtain) in the 500ml Radix Panacis Quinquefolii extracting solution that obtains mix, stir.

Claims (3)

1. a western pearl oral liquid, this western pearl oral liquid is to be made up of the raw material of following weight parts:
2. the western pearl oral liquid of one according to claim 1, is characterized in that: this western pearl oral liquid is to be made up of the Margarita of the Radix Panacis Quinquefolii of 40 weight portions, 12 weight portions, the citric acid of 24 weight portions and the water of 1600 weight portions.
3. a preparation method for western pearl oral liquid as claimed in claim 1, comprises the following steps:
1) citric acid of 15-60 weight portion is added in the water of 240-1000 weight portion, stir citric acid is dissolved completely, obtain aqueous citric acid solution;
2) by after the crushing pearl of 7.5-30 weight portion, join in aqueous citric acid solution, stir, place 24-48 hour;
3) by step 2) in the solution that obtains filter, obtain Margarita extracting solution for subsequent use;
4) Radix Panacis Quinquefolii of 25-100 weight portion is put into and decocted vessel, add the water of 400-1600 weight portion, decoct 1-3 hour, filter, obtain decoction liquor and medicinal residues;
5) in step 4) continue to add the water of 600-1200 weight portion in Chinese medicine slag, again decoct 1-3 hour, filter, obtain decoction liquor and medicinal residues;
6) to step 4), 5) decoction liquor that forms merges standing sedimentation 24 hours;
7) by step 6) in decoction liquor again filter, to filter after solution concentrate, obtain the Radix Panacis Quinquefolii extracting solution that weight portion is 200-1000;
8) by step 3) in the Margarita extracting solution and the step 7 that obtain) in the Radix Panacis Quinquefolii extracting solution that obtains mix according to weight proportion 1:1, stir.
CN201410334705.7A 2014-07-15 2014-07-15 Panax quinquefolium and pearl oral solution and preparation method thereof Pending CN104095895A (en)

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Application Number Priority Date Filing Date Title
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108354990A (en) * 2018-03-26 2018-08-03 成都中医药大学 A kind of pharmaceutical composition of freckle removing and whitening and preparation method thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108354990A (en) * 2018-03-26 2018-08-03 成都中医药大学 A kind of pharmaceutical composition of freckle removing and whitening and preparation method thereof
CN108354990B (en) * 2018-03-26 2021-04-30 成都中医药大学 Freckle-removing and whitening pharmaceutical composition and preparation method thereof

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