CN104095790A - Composition for relieving dermal irritation of cosmetic and preparation method of composition - Google Patents
Composition for relieving dermal irritation of cosmetic and preparation method of composition Download PDFInfo
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- CN104095790A CN104095790A CN201410321118.4A CN201410321118A CN104095790A CN 104095790 A CN104095790 A CN 104095790A CN 201410321118 A CN201410321118 A CN 201410321118A CN 104095790 A CN104095790 A CN 104095790A
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Abstract
The invention provides a composition for relieving dermal irritation of a cosmetic and a preparation method of the composition, and aims to provide the composition which can effectively relieve the dermal irritation of the cosmetic. The composition is characterized by comprising the following ingredients by total weight percentage: 0.1 to 10.0 percent of a brank seed extractive, and 0.5 to 10.0 percent of saccharide isomerate. Taking the brank seed extractive and saccharide isomerate as active ingredients, the composition can relieve dermal irritation caused by other ingredients in the cosmetic, and improve the dermal safety of the cosmetic. The composition can be any cosmetic with a dermal irritation relieving function.
Description
[technical field]
The present invention relates to a kind of composition and method of making the same that can be used for cosmetics.More specifically, the present invention relates to a kind of containing isomery oligosaccharide and Semen Fagopyri Esculenti seed extract as effective ingredient, can alleviate cosmetics to skin irritant composition and method of making the same.
[background technology]
Contact dermatitis is contact skin environmental stimuli material and the local inflammatory response that causes skin to occur, and clinical symptoms has the inflammatory stimulus reactions such as the excitements such as pruritus, causalgia, heating and erythema, edema.From histology's angle, on corium, can find edema phenomenon, on epidermis and corium, can observe monocytic inflow.According to clinical symptoms or expression mechanism, contact dermatitis can be divided into irritant contact dermatitis, allergic contact dermatitis, stimulus to the sense organ dermatitis, photoxic dermatitis etc.Specifically, irritant contact dermatitis is that the Keratinocyte that the source that is upset stimulates can secrete the various cytokines with physiologically active, and cell is around under the effect of this class factor, be beneficial to the growth of inflammation medium cytokine etc., finally cause the hyperfunction and induction leukocyte of vasodilation and blood vessel permeability to move, make position that stimulus stimulates occur the nonimmune reaction of the inflammation such as erythema and edema.Allergic contact dermatitis, as immunoreation, owing to being the special role of chemical substance, is difficult to perceive, and there will be relatively serious clinical response, also can cause once in a while systemic reaction.Stimulus to the sense organ dermatitis there will not be the clinical symptoms such as erythema or edema, and cardinal symptom shows as the subjectivity symptoms such as pruritus, causalgia, heating.Photoxic dermatitis refers to that photostimulation source molecule is after reacting with light, causes a series of physiochemistry reactions, and its symptom comprises heating, pruritus, erythema and edema.But these type dermatitis are difficult to clearly distinguish, conflicting part is a lot.The common process of certain material incentive skin is exactly that material infiltrates skin, interacts with epidermis cell or hypodermal cell, and activating immune system, its result causes inflammatory reaction.The general cosmetics relevant to skin all contain can releasing stimulus or the material of inflammation, uses in personal care product's crowd, and more than 10% expression has side effect to skin.Therefore,, in order to alleviate cosmetics skin irritation, a lot of methods have been attempted.But functional raw material itself will play the effect of stimulus in a lot of situations.Because used the chemical substances such as more than 5,500 kinds spice, antiseptic, BASE, each constituent may cause various side effect, and the situation that the raw material using itself can play stimulus effect is also very many.
At present, very limited about removing the research of the method that causes skin irritation material.In the medicine of non-cosmetics, to alleviate stimulation and the amelioration of inflammation material as object, at on-steroidal, there are flufenamic acid, ibuprofen, indomethacin etc. in system; Steroid system has prednisolone, dexamethasone etc., these major parts for skin, to have safety aspect problem, or in cosmetics, belongs to banned substance.Therefore, urgently research and develop a kind of to human body few side effects and there is antiinflammatory and alleviate the material of effect of stimulation.
[summary of the invention]
In order to overcome above-mentioned defect, the invention is intended to provide one can be used for effectively alleviating cosmetics to skin irritant composition and method of making the same.The present invention realizes by the following method:
One is used for alleviating cosmetics to skin irritant compositions, it is characterized in that, comprises following component by total weight percent said composition:
Semen Fagopyri Esculenti seed extract: 0.1-10.0%
Isomery oligosaccharide: 0.5-10.0%
Describedly it is characterized in that for alleviating cosmetics to skin irritant compositions, is 0.5-5.0% by the content of Semen Fagopyri Esculenti seed extract in total weight percent said composition.
Describedly it is characterized in that for alleviating cosmetics to skin irritant compositions, is 1.0-5.0% by the content of isomery oligosaccharide in total weight percent said composition.
Describedly it is characterized in that for alleviating cosmetics to skin irritant compositions, the percentage ratio that described Semen Fagopyri Esculenti seed extract and isomery oligosaccharide account for gross weight is 0.6-10.0%.
Describedly it is characterized in that for alleviating cosmetics to skin irritant compositions, Semen Fagopyri Esculenti seed extract and isomery oligosaccharide weight ratio are 1:1.
Describedly it is characterized in that for alleviating cosmetics to skin irritant compositions, the percentage ratio that Semen Fagopyri Esculenti seed extract and isomery oligosaccharide account for gross weight is 6%.
7. preparation is claimed in claim 1 is characterized in that for alleviating the method for cosmetics to skin irritant compositions, hundred parts of tables composed as follows of its raw material weight:
Its preparation method comprises the steps:
1. A is organized to raw material, B group raw material and be heated to respectively 85 DEG C;
2. C is organized to raw material and add B group raw material, stir, form BC mixed phase;
3. A is added in BC mixed phase, stir, form ABC mixed phase;
4. ABC mixed phase is cooled to after 45 DEG C, adds D group raw material, then stir and be cooled to 36 DEG C, stop stirring discharging.
In compositions of the present invention, contained Semen Fagopyri Esculenti seed extract and isomery oligosaccharide are effective ingredient, can alleviate the skin irritation that in cosmetics, other compositions cause, can improve used for cosmetic in the safety of skin.Wherein, Semen Fagopyri Esculenti seed extract elite can suppress the biosynthesis of this inflammation medium relevant to causing the scytitiss such as pain, erythema, pruritus of PEG2.
Cosmetics in the present invention do not have specific limited.Can be for example the cosmetics that soft skin astringent, nutrition astringent, massage cream, nourishing cream, facial film, gel class or bath gel shampoo etc. wash away type, can be also for neck skin-type product with similar cream, ointment, gel, frost, pad pasting or spray etc.Use as sensitive skin, in baby and child's cosmetics, also can add to reduce stimulation.
[detailed description of the invention]
Describe the present invention in detail below with reference to detailed description of the invention.But detailed description of the invention is only to having invented explanation effect, the protection domain being not intended to limit the present invention.
Embodiment 1, a kind of anti-anaphylaxis frost
Hundred parts of tables composed as follows of its raw material weight:
Wherein, D group raw material forms the active component of the skin irritant compositions of alleviation of the present invention, and all the other are carrier.
Its preparation method comprises the steps:
1. A is organized to raw material, B group raw material and be heated to respectively 85 DEG C;
2. C is organized to raw material and add B group raw material, stir, form BC mixed phase;
3. A is added in BC mixed phase, stir, form ABC mixed phase;
4. ABC mixed phase is cooled to after 45 DEG C, adds D group raw material, then stir and be cooled to 36 DEG C, stop stirring, discharging and get final product.
Embodiment 2-4, moisture retention liquid
Mix according to the formula of embodiment 2-4 in following table, obtain respectively three kinds of moisture retention liquids of embodiment 2-4.
(in this table, numerical value is all weight percentage)
Three kinds of moisture retention liquid antiphlogistic effects tests of embodiment 2-4:
Taking 15 women and male as object, substances 20 μ l rub 50 times in the circle that is 1.3cm at diameter with tune spatula, first 2 times is to have smeared material, after not having the Xi Ertuobo skin test box (hill top chamber) of filter paper to put up the inside, be fixed with adhesive, create a sealing condition.Because can there is box reaction (chamber reaction) in hill top chamber, so paste when skin at the 3rd time to the 8th time, smear material, utilize adhesive to fix after putting filter paper.Pasted skin once every 23 hours, open after paster 1 hour, check according to the terminology standard (terminology) of makeup association of the U.S. (CTFA) guide (1981).Do not paste skin weekend.Paste after finishing the 4th day of skin, in order to observe late response, carried out appending inspection.Data are utilized last check result, confirm, after the equal variance of row literary compositions inspection (Levene ' s test), to carry out variance analysis by agreeing formula analytic process (Duncan's Test).After getting over, verify after (p<0.05), then compare.Substances is respectively the moisture retention liquid of embodiment 2-4.
This test for identification criteria and rank criteria for classifying is as following table:
Three kinds of moisture retention liquids are alleviated skin irritation result of the test as following table:
(all above table Plays classifications of numerical value in this table)
Can recognize by this result of the test, the dosage form that contains Semen Fagopyri Esculenti seed extract or isomery oligosaccharide is low to the stimulation of skin.Simultaneously visible, contain the embodiment 4 of two kinds of compositions to skin irritation remission effect the best simultaneously.
Claims (7)
1. for alleviating cosmetics to a skin irritant compositions, it is characterized in that, comprise following component by total weight percent said composition:
Semen Fagopyri Esculenti seed extract: 0.1-10.0%
Isomery oligosaccharide: 0.5-10.0%.
2. according to claim 1ly it is characterized in that for alleviating cosmetics to skin irritant compositions, is 0.5-5.0% by the content of Semen Fagopyri Esculenti seed extract in total weight percent said composition.
3. according to claim 1ly it is characterized in that for alleviating cosmetics to skin irritant compositions, is 1.0-5.0% by the content of isomery oligosaccharide in total weight percent said composition.
According to described in arbitrary claim in claims 1 to 3 for alleviating cosmetics to skin irritant compositions, it is characterized in that, the percentage ratio that described Semen Fagopyri Esculenti seed extract and isomery oligosaccharide account for gross weight is 0.6-10.0%.
5. according to claim 4ly it is characterized in that for alleviating cosmetics to skin irritant compositions, Semen Fagopyri Esculenti seed extract and isomery oligosaccharide weight ratio are 1:1.
6. according to claim 4ly it is characterized in that for alleviating cosmetics to skin irritant compositions, the percentage ratio that Semen Fagopyri Esculenti seed extract and isomery oligosaccharide account for gross weight is 6%.
7. prepare described in claim 1 for alleviating the method for cosmetics to skin irritant compositions, it is characterized in that hundred parts of tables composed as follows of its raw material weight:
Its preparation method comprises the steps:
1. A is organized to raw material, B group raw material and be heated to respectively 85 DEG C;
2. C is organized to raw material and add B group raw material, stir, form BC mixed phase;
3. A is added in BC mixed phase, stir, form ABC mixed phase;
4. ABC mixed phase is cooled to after 45 DEG C, adds D group raw material, then stir and be cooled to 36 DEG C, stop stirring discharging.
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| CN201410321118.4A CN104095790B (en) | 2014-07-04 | 2014-07-04 | For alleviating cosmetics to skin irritant composition and method of making the same |
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| CN104095790B CN104095790B (en) | 2016-04-06 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490715A (en) * | 2015-01-08 | 2015-04-08 | 上海圣婕化妆品有限公司 | Anti-allergy stress relief face mask essence containing saccharide isomerate and preparation method thereof |
| CN105919887A (en) * | 2016-06-07 | 2016-09-07 | 陈萍 | Whitening moisturizing cosmetic and preparation process thereof |
| WO2019032555A1 (en) * | 2017-08-07 | 2019-02-14 | Mary Kay Inc. | Topical skin compositions for treating erythema or skin inflammation |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103417466A (en) * | 2013-08-15 | 2013-12-04 | 江南大学 | Natural moisture-preserving and skin-protecting composition and application thereof in cosmetics |
| CN104125821A (en) * | 2011-12-28 | 2014-10-29 | 赢创工业集团股份有限公司 | Aqueous hair and skin cleaning compositions comprising biotensides |
-
2014
- 2014-07-04 CN CN201410321118.4A patent/CN104095790B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104125821A (en) * | 2011-12-28 | 2014-10-29 | 赢创工业集团股份有限公司 | Aqueous hair and skin cleaning compositions comprising biotensides |
| CN103417466A (en) * | 2013-08-15 | 2013-12-04 | 江南大学 | Natural moisture-preserving and skin-protecting composition and application thereof in cosmetics |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104490715A (en) * | 2015-01-08 | 2015-04-08 | 上海圣婕化妆品有限公司 | Anti-allergy stress relief face mask essence containing saccharide isomerate and preparation method thereof |
| CN105919887A (en) * | 2016-06-07 | 2016-09-07 | 陈萍 | Whitening moisturizing cosmetic and preparation process thereof |
| CN105919887B (en) * | 2016-06-07 | 2018-12-28 | 广州梵之容化妆品有限公司 | A kind of cosmetics and its preparation process with skin whitening, moisturizing function |
| WO2019032555A1 (en) * | 2017-08-07 | 2019-02-14 | Mary Kay Inc. | Topical skin compositions for treating erythema or skin inflammation |
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| Publication number | Publication date |
|---|---|
| CN104095790B (en) | 2016-04-06 |
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