CN104083659A - Traditional Chinese medicine preparation for treating calculus - Google Patents

Traditional Chinese medicine preparation for treating calculus Download PDF

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CN104083659A
CN104083659A CN201410317927.8A CN201410317927A CN104083659A CN 104083659 A CN104083659 A CN 104083659A CN 201410317927 A CN201410317927 A CN 201410317927A CN 104083659 A CN104083659 A CN 104083659A
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calculus
chinese medicine
traditional chinese
medicine preparation
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刘静明
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GUANGXI ZHENGTANG PHARMACEUTICAL PRODUCT CO Ltd
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GUANGXI ZHENGTANG PHARMACEUTICAL PRODUCT CO Ltd
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Abstract

The invention discloses a pure traditional Chinese medicine composition, and in particular relates to a traditional Chinese medicine preparation for treating calculus. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 40-200 parts of lysimachia christinae hance, 30-150 parts of peach kernel, 40-200 parts of rhizoma phragmitis, 20-50 parts of lygodium japonicum, 10-60 parts of endothelium corneum gigeriae galli, 10-60 parts of bighead atractylodes rhizome, 10-30 parts of akebiaquinata, 25-180 parts of monkshood, 10-50 parts of white peony root and 10-30 parts of oyster. The traditional Chinese medicine preparation has unique curative effect and relatively high curative rate on kidney calculus, gall-calculus, ureteral calculus and bladder calculus; ordinary patients can be cured only in 10-15 days and do not need to take the medicine for a long time, and the medicine has no obvious side effect. Tested by more than 200 patients, the total effective rate is 98%, and no relapse phenomenon occurs at present after the patients are cured.

Description

A kind of Chinese medicine preparation for the treatment of calculus
Technical field
The present invention relates to a kind of pure Traditional Chinese medicine composition, particularly a kind of Chinese medicine preparation that is used for the treatment of the diseases such as kidney stone, cholelithiasis, ureteral calculus, vesical calculus.
Background technology
Calculus refers in the catheter lumen in human body or animal body or chamber sexual organ's (as kidney, ureter, gallbladder or bladder etc.) chamber in the solid mass that forms.Be mainly seen in gallbladder and bladder, renal pelvis, be also found in the chamber of pancreas conduit, glandula conduit etc., can cause tube chamber to block, the get involved discharge of organ liquid of impact, produces the symptoms such as pain, hemorrhage or infection.
Calculi therapy way substantially be divided into two large classes, i.e. non-operative treatment and operative treatment.Non-operative treatment is medicine lithodialysis.The sick common medicine for the treatment of kidney calculi symptom, mainly contains following a few class: the medicines such as SHILINTONG PIAN, PAISHI KELI, compound recipe money grass particle at present.Take these Sal Nitri medicines and cure the symptoms, not the disease, after drug withdrawal, relapse rate is almost 100%.Operative treatment mainly contains extracorporeal shock-wave lithotripsy (ESWL) and two kinds of means of Minimally Invasive Surgery.The patient who adopts extracorporeal shock wave lithotripsy, follows the tracks of by successive treatment, finds that relapse rate is very high.And the shortcoming of minimal invasive operation is also that relapse rate is high, because the residual Microlithiasis of meeting in body, the time has been grown the regeneration that can cause calculus.
Theory of Chinese medical science thinks that it is exactly diet that renal calculus forms main cause.It is by can the lithogenous relevant composition absorption of shape too much causing in diet.
oxalic acid accumulates too much:accumulating in a large number of the interior oxalic acid of body is one of factor causing renal calculus.As these people such as Herba Spinaciae, beans, Fructus Vitis viniferae, cocoa, Folium Camelliae sinensis, Fructus Citri tangerinae, Fructus Lycopersici esculenti, Rhizoma Solani tuber osi, Fructus Pruni salicinae, bamboo sprout generally like the thing of eating, just containing the higher food of oxalic acid.Doctor finds by research: in 200 grams of Herba Spinaciaes, containing 725.6 milligrams of oxalic acid, if a people once all eats up 200 grams of Herba Spinaciaes, eat latter 8 hours, check that urine mesoxalic acid excretion is 20~25 milligrams, be equivalent to the average total amount of oxalic acid that normal person discharges for 24 hours.
purine metabolism is not normal:pluck, seafood, Semen arachidis hypogaeae, fresh kidney beans, Herba Spinaciae etc., all contain more purine composition.Purine will carry out metabolism after entering in body, and the end product of its metabolism is uric acid.Uric acid can impel urine Oxalate precipitation.If, once eating too much the abundant food of purine-containing, the metabolism of purine is not normal again, forms urinary stone just oxalates deposits in urine.
fat picked-up is too many:the meat of various animals, especially lard are all lardy food.Having eaten body fat must increase more, and fat can reduce combinative calcium in intestinal, thereby causes the absorption of oxalates is increased, if once there is excretory function fault, as perspire many, drink water less, urine amount is few, renal calculus is just formation in this case probably.So doctors often say, in order to prevent to obtain calculus, will drink water hot day more, while having eaten the many food of profit, also will drink water more, and unimpeded to promote to urinate, diluted urine composition, just reduces the danger of terrible calculus.
sugar increases:sugar is the important nutrients of human body, often appropriate supplement, but increase is too many quickly, and especially lactose, also can make calculus create conditions.Brainstrust is found: no matter normal person or calculus patient, after edible 100 grams of sucrose, cross the urine that goes to check them for 2 hours, find that calcium and concentration of oxalic acid in urine all rise, if take lactose, it more can promote the absorption of calcium, more may cause calcium oxalate accumulating and forming urinary stone in vivo.
protein is excessive:renal calculus composition is carried out to assay, find that the calcium oxalate in calculus accounts for 87.5%.The source of the calcium oxalate of so large proportion be exactly because protein in except the raw material that contains oxalic acid---glycine, hydroxyproline, protein can also promote the absorption of function of intestinal canal to calcium.If the often food of excessive edible high protein, just the composition of calcium in kidney and urine, oxalic acid, uric acid is generally increased.If can not unnecessary calcium, oxalic acid, uric acid be excreted by renal function timely and effectively, like this, the condition that obtains kidney stone, lithureteria has just formed.The main cause that current world economy developed country renal calculus sickness rate increases is exactly like this.
Summary of the invention
The technical problem to be solved in the present invention is: the Chinese medicine preparation of the treatment calculus of a kind of calculus fast, evident in efficacy, non-relapse after healing is provided, and this Chinese medicine preparation can be used in the diseases such as treatment kidney stone, cholelithiasis, ureteral calculus, vesical calculus.
The technical scheme solving the problems of the technologies described above is: a kind of Chinese medicine preparation for the treatment of calculus, and its various raw material medicines in portions by weight are counted proportioning and are:
40~200 parts of Herba Lysimachiaes, 30~150 parts, Semen Persicae, 20~100 parts of Rhizoma Phragmitiss,
15~60 parts of Spora Lygodii, 10~60 parts of Endothelium Corneum Gigeriae Galli, 10~60 parts of the Rhizoma Atractylodis Macrocephalaes,
20~60 parts of Caulis Akebiaes, 25~180 parts of Radix Aconiti Lateralis Preparatas, 10~60 parts of the Radix Paeoniae Albas,
10~60 parts of Concha Ostreaes.
Treat a Chinese medicine preparation for calculus, its various raw material medicines in portions by weight are counted proportion optimization and are:
60~130 parts of Herba Lysimachiaes, 50~110 parts, Semen Persicae, 20~50 parts of Rhizoma Phragmitiss,
20~50 parts of Spora Lygodii, 15~40 parts of Endothelium Corneum Gigeriae Galli, 15~50 parts of the Rhizoma Atractylodis Macrocephalaes,
20~60 parts of Caulis Akebiaes, 80~150 parts of Radix Aconiti Lateralis Preparatas, 10~60 parts of the Radix Paeoniae Albas,
10~60 parts of Concha Ostreaes.
Treat a Chinese medicine preparation for calculus, its various raw material medicines in portions by weight are counted proportion optimization and are:
60 parts of Herba Lysimachiaes, 70 parts, Semen Persicae, 50 parts of Rhizoma Phragmitiss,
20 parts of Spora Lygodii, 30 parts of Endothelium Corneum Gigeriae Galli, 20 parts of the Rhizoma Atractylodis Macrocephalaes,
25 parts of Caulis Akebiaes, 25 parts of Radix Aconiti Lateralis Preparatas, 30 parts of the Radix Paeoniae Albas,
20 parts of Concha Ostreaes.
In the present invention, the characteristic of various crude drug is as follows:
Herba Lysimachiae: function cures mainly: relieving stranguria by diuresis; Heat-clearing and toxic substances removing; Dissipating blood stasis for subsidence of swelling.Cure mainly liver and gall and urinary system calculus; Pyretic stranguria; Oedema due to nephritis; Jaundice due to damp-heat; Sore carbuncle; Venom; Traumatic injury.
Semen Persicae: function cures mainly: blood stasis removing and clots absorbing, moisturize laxation.Control amenorrhea , mass in the abdomen, calentura blood-retention, migratory arthralgia, malaria, traumatic injury, swelling and pain due to blood stasis, the dry constipation of blood.
Rhizoma Phragmitis: function cures mainly: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
Spora Lygodii: function cures mainly: inducing diuresis for treating stranguria syndrome, pain relieving.
Endothelium Corneum Gigeriae Galli: function cures mainly: promoting digestion and invigorating the stomach, arresting seminal emission.Removing food stagnancy is stagnant, strengthening the spleen and stomach.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
The Rhizoma Atractylodis Macrocephalae: function cures mainly: invigorating the spleen and replenishing QI, dampness diuretic, strengthening superficial resistance to stop perspiration, QI invigorating is antiabortive.
Caulis Akebiae: function cures mainly: pathogenic fire purging row water, promoting blood circulation.Control hot urination, stranguria with turbid discharge, edema, irritable feverish sensation in the chest, sore throat pharyngalgia, inflexible pain all over, women's amenorrhea, galactostasis.
Radix Aconiti Lateralis Preparata: function cures mainly: recuperating depleted YANG and rescuing the patient from collapse, warming and recuperating the spleen and kidney, dispersing cold for relieving pain.The large heat of great Xin, warming YANG is by cold.
The Radix Paeoniae Alba: function cures mainly: suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, astringing YIN to stop sweating.Be used for having a headache dizzy, hypochondriac pain, stomachache, limb pain twin, blood deficiency and yellow complexion, menoxenia, spontaneous perspiration, night sweat.
Concha Ostreae: function cures mainly: yin fluid astringing, YANG hyperactivity suppressing, hidroschesis, arresting seminal emission, reduces phlegm, softening the hard mass.Control infantile convulsion, dizzy, spontaneous perspiration, night sweat, seminal emission, stranguria with turbid discharge, metrorrhagia, leukorrhagia, scrofula, goiter.The insomnia that is used for palpitating with fear, vertigo and tinnitus, tuberculous lymphadenitis, abdominal mass mass in the abdomen, spontaneous sweating, seminal emission metrorrhagia and leukorrhagia, stomachache pantothenic acid.
The Chinese medicine preparation clearing away heat and promoting diuresis of the present invention's treatment calculus, Tonglin Paishi.There is unique curative effect for disease being located in lower-JIAO damp-heat syndrome persons such as kidney stone, cholelithiasis, ureteral calculus, vesical calculuses.The present invention takes through 200 multidigit patients, and effective percentage has reached 98%, after curing, has not seen the phenomenon that has recurrence at present.This product is to treatment kidney stone, cholelithiasis, and ureteral calculus vesical calculus disease has unique curative effect and higher cure rate, and general patient only needs just can cure for 10-15 days, without Long-term taking medicine, without significantly side effect.
The technical characterictic of a kind of Chinese medicine preparation for the treatment of calculus below in conjunction with embodiment to the present invention is further described.
Detailed description of the invention
Embodiment mono-: a kind of Chinese medicine preparation for the treatment of calculus, its various raw material medicines in portions by weight are counted proportioning and are:
400 kilograms of 500 kilograms of monarch drug Rhizoma Phragmitiss of 500 kilograms of monarch drug Semen Persicaes of monarch drug Herba Lysimachiae
200 kilograms of 200 kilograms of ministerial drug Rhizoma Atractylodis Macrocephalaes of 300 kilograms of ministerial drug Endothelium Corneum Gigeriae Galli of ministerial drug Spora Lygodii
150 kilograms of 250 kilograms of ministerial drug Radix Paeoniae Albas of 200 kilograms of ministerial drug Radix Aconiti Lateralis Preparatas of ministerial drug Caulis Akebiae
150 kilograms of ministerial drug Concha Ostreaes.
The preparation method of above-mentioned Chinese medicine composition is: get above whole medical material, add for the first time alcohol heating reflux 1.5 hours, extracting solution filters, filtrate recycling ethanol is also concentrated in right amount, mat woven of fine bamboo strips secondary, and adding water 3.5 times to measure decocts 1.5 hours, filter, merging filtrate, it is 1.24~1.26 that filtrate is concentrated into 90 DEG C of relative densities, let cool, concentrated solution is constantly stirred, and slowly add 95% ethanol, adjust solution and become pH=8-9, ethanol content reaches 50-80%, staticly settles 48-72 hour, gets supernatant liquid filtering; Filtrate and appropriate adjuvant mix, dry, granulation agent or tablet.
Function of the present invention cures mainly: clearing away heat-damp and promoting diuresis, treating stranguria and eliminating stone.For stranguria caused by urinary stone, stranguria with blood, for urinary stone diseases such as renal calculus, ureteral calculus, vesical calculuses, also can be used for urinary system calculus and belong to Accumulation of Dampness Heat and Blood Stasis card person.
Embodiment bis-~embodiment seven:
Treat a Chinese medicine preparation for calculus, the crude drug of said composition and parts by weight refer to subordinate list one, and the preparation method of this Chinese medicine composition is identical with embodiment mono-.
Subordinate list one
Below by clinical trial case case, curative effect of the present invention is described further.
Case 1: patient Chen, man, 50 years old, LiuZhou people from city, because of lumbago stomachache; there is band blood when urine twinge; on March 2nd, 2013, because of the aggravation of stomachache lumbago, with hematuria, is 12 × 11 millimeters, right kidney stage casing calculus through hospital diagnosis; after taking a course for the treatment of of medicine of the present invention on March 10th, 2013, all discharge kidney stone from urethra through urine.Calculus is as large in Semen arachidis hypogaeae, and abnormal symptom disappears, and follows up a case by regular visits to and within 1 year, has no recurrence.
Case 2: Mr. Zhong, man, 48 years old, people from Liujiang County, because of lumbago stomachache, urine twinge, in Mays 6 in 2012 Nikkei hospital diagnosis be 10 × 11 millimeters, large section of calculus of left kidney, on May 7th, 2012 start to take after the course for the treatment of of medicine of the present invention, through hospital, check calculus disappears, and follows up a case by regular visits to and within 2 years, has no recurrence.
Case 3: Mr. Zeng, man 50 years old, people from Liuzhou City, on May 7th, 2012 is because of lumbago, stomachache, urine twinge, yellow urine, in June 9 in 2012 Nikkei hospital diagnosis be 12 × 9 millimeters of right side renal calculuss, take 1 course for the treatment of of medicine of the present invention on June 11st, 2012, when calculus drains into urethral orifice with urine, hold under the arm out with pliers, transference cure, repeatedly pays a return visit and has no recurrence.
Case 4: Zhu Guangping, man, 60 years old, Jiang Ping people from town, Dongxing City, on March 7th, 2002 is because of lumbago, stomachache, urine twinge, yellow urine, in March 9 in 2004 Nikkei hospital diagnosis be 11 × 8 millimeters of right side renal calculuss, take 1 course for the treatment of of medicine of the present invention on March 11st, 2004, take this medicine, after 12 days, kidney stone is all discharged from urethra.Drug withdrawal is not recurred so far.
Case 5: Mr. Ye, man, 40 years old, people from Liubei District, Liuzhou City, because of left side waist angor, with frequent micturition, urgent micturition, sometimes urinated and interrupts suddenly, and activity can continue to urinate a little, and the violent angor of left abdomen paroxysmal simultaneously, with feeling sick, vomit, being in a cold sweat.Be left ureter upper end calculus through hospital diagnosis.Start to take medicine of the present invention on May 9th, 2013, take after 12 days, all discharge from urethra.Patient's transference cure, repeatedly pays a return visit and has no recurrence.
Case 6: CHENNU scholar, 30 years old, people from Nanning, painful urination, lumbago, dizziness headache, left renal calculus 0.6 × 0.8cm is found in ultrasound diagnosis, on March 10th, 2012 starts to take 2 courses for the treatment of of medicine of the present invention, calculus is discharged with urine one by one, continue to take 2 courses for the treatment of, calculus is all discharged, and repeatedly pays a return visit and has no recurrence.Zai Qu hospital rechecked and looked into that all are normal January 9 in 2014, no bounce-back so far.
Case 7: Wang Tao, man, 42 years old, on February 10th, 2010, waist burst in left side had an intense pain patient, be 0.4 × 0.7cm renal calculus on inspection, after treatment, alleviate to some extent, after half a year, left side waist is sent out and is had an intense pain again, again check and find recurrence of hepatolithiasis, start to take 2 courses for the treatment of of medicine of the present invention on March 1st, 2010, calculus is all discharged, and repeatedly pays a return visit and has no recurrence.On April 9th, 2014 rechecks and looks into that all are normal in hospital again, no bounce-back so far.
Case 8: Mr. Chen, man, 40 years old, be diagnosed as renal calculus in JIUYUE, 2008, take Chinese and western medicine medicine and fail to respond to any medical treatment, bilateral lumbago, be difficult to bend over and turn round the symptoms such as layback and do not feel any better, start to take two courses for the treatment of of medicine of the present invention in October, 2008, calculus disappears, and repeatedly check has no recurrence.
Case 9: Li Da, man, 41 years old, people from Liuzhou, lumbago for many years, time while sending out only, seek medical advice on January 19th, 2014, when medical, complexion HUANGBAI(sic), body of the tongue are dark violet, thick and greasy fur, bilateral percussion tenderness over kidney region, and two kidney B ultrasonic are found left kidney 1.1 × 0.7cm grains of sand calculus, right kidney 1.0 × 0.8cm calculus, give after anti-inflammatory analgesic in hospital, start to take the present invention real 12 medicine, pain relieving on the same day, calculus is all discharged, pain disappears substantially, for consolidating curative effect, continues to take 7 days, symptom thoroughly disappears, and repeatedly pays a return visit and has no recurrence.
Case 10: Chen Lin, man, 42 years old, people from Liuzhou, lumbago for many years, time while sending out only, seek medical advice on March 19th, 2013, when medical, complexion HUANGBAI(sic), body of the tongue are dark violet, thick and greasy fur, bilateral percussion tenderness over kidney region, two kidney B ultrasonic are found left kidney 1.1 × 0.7cm grains of sand calculus, right kidney 1.0 × 0.8cm calculus, give after anti-inflammatory analgesic in hospital, start to take medicine of the present invention, after 12 days, calculus is arranged transference cure with urine, repeatedly pays a return visit and has no recurrence.
Case 11: Zhou Jinsheng, man, 58 years old, it is medical that people from Liuzhou comes Liuzhou People's Hospital for the 1st time February in 2010, again comes Liuzhou People's Hospital in August, 2010 medical.Hospital admission, showed as at that time frequent urination, but urine amount is few, in urine, has a small amount of occult blood, B ultrasonic finds that vesical calculus is 10 × 0.8cm calculus, but appetite is normal, the mental status is good, injects symptom after numb Buddhist mycin on the 3rd and takes a turn for the better, start to take medicine of the present invention, after 12 days, calculus is arranged transference cure with urine, repeatedly pays a return visit and has no recurrence.
Case 12: Wei Meihong, female, 41 years old, people from Liuzhou was in June, 2013 to Liuzhou City's mat woven of fine bamboo strips four hospital admissions, and hospital admission, from ultrasonic experiments, has been full of stiff bile, again concurrent Calculus in gallbladder.On July 10th, 2013: Patients on Recurrence alternate attack of chill and fever, epigastric discomfort is admitted to hospital.Ultrasound diagnosis: the 1. 2. 3. interior calculus (12mm) of common bile duct of the multiple calculus of right lobe of liver bile duct (calculus scope 38x24mm) of leftlobe of liver calculus of bile duct multiple (approximately calculus scope 47mm); Treatment: after nearly two months of antibiotic antiinflammatory for doctor trained in Western medicine, Chinese medicine function of gallbladder promoting, lithagogue treatment are invalid.Start to take medicine of the present invention, after 13 days, the multiple Check calculus of bile duct of hospital disappears, and pay a return visit patient and have no recurrence in February, 2014.

Claims (3)

1. a Chinese medicine preparation for the treatment of calculus, is characterized in that: its various raw material medicines in portions by weight are counted proportioning and are:
40~200 parts of Herba Lysimachiaes, 30~150 parts, Semen Persicae, 20~100 parts of Rhizoma Phragmitiss,
15~60 parts of Spora Lygodii, 10~60 parts of Endothelium Corneum Gigeriae Galli, 10~60 parts of the Rhizoma Atractylodis Macrocephalaes,
20~60 parts of Caulis Akebiaes, 25~180 parts of Radix Aconiti Lateralis Preparatas, 10~60 parts of the Radix Paeoniae Albas,
10~60 parts of Concha Ostreaes.
2. a kind of Chinese medicine preparation for the treatment of calculus according to claim 1, is characterized in that: its various raw material medicines in portions by weight are counted proportioning and are:
60~130 parts of Herba Lysimachiaes, 50~110 parts, Semen Persicae, 20~50 parts of Rhizoma Phragmitiss,
20~50 parts of Spora Lygodii, 15~40 parts of Endothelium Corneum Gigeriae Galli, 15~50 parts of the Rhizoma Atractylodis Macrocephalaes,
20~60 parts of Caulis Akebiaes, 80~150 parts of Radix Aconiti Lateralis Preparatas, 10~60 parts of the Radix Paeoniae Albas,
10~60 parts of Concha Ostreaes.
3. a kind of Chinese medicine preparation for the treatment of calculus according to claim 1, is characterized in that: its various raw material medicines in portions by weight are counted proportioning and are:
60 parts of Herba Lysimachiaes, 70 parts, Semen Persicae, 50 parts of Rhizoma Phragmitiss,
20 parts of Spora Lygodii, 30 parts of Endothelium Corneum Gigeriae Galli, 20 parts of the Rhizoma Atractylodis Macrocephalaes,
25 parts of Caulis Akebiaes, 25 parts of Radix Aconiti Lateralis Preparatas, 30 parts of the Radix Paeoniae Albas,
20 parts of Concha Ostreaes.
CN201410317927.8A 2014-07-07 2014-07-07 Traditional Chinese medicine preparation for treating calculus Pending CN104083659A (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104740463A (en) * 2015-04-09 2015-07-01 张�杰 Kidney-nourishing and qi-benefiting medicine for lithangiuria and preparation method of kidney-nourishing and qi-benefiting medicine
CN107812122A (en) * 2017-11-30 2018-03-20 郭氏博信中医科技(北京)股份有限公司 A kind of pharmaceutical composition for treating calculus and preparation method thereof
CN111481654A (en) * 2020-04-30 2020-08-04 汕头市龙湖区黄汉林中医内科诊所 Composition for rapidly relieving pain and treating or preventing rennet pain and preparation medicine and method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘胜贤: "消石排石汤加减治疗尿路结石47例", 《实用中医药杂志》 *
王亿平等: "祛石汤治疗尿路结石的临床观察", 《辽宁中医学院学报》 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104740463A (en) * 2015-04-09 2015-07-01 张�杰 Kidney-nourishing and qi-benefiting medicine for lithangiuria and preparation method of kidney-nourishing and qi-benefiting medicine
CN107812122A (en) * 2017-11-30 2018-03-20 郭氏博信中医科技(北京)股份有限公司 A kind of pharmaceutical composition for treating calculus and preparation method thereof
CN111481654A (en) * 2020-04-30 2020-08-04 汕头市龙湖区黄汉林中医内科诊所 Composition for rapidly relieving pain and treating or preventing rennet pain and preparation medicine and method thereof

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