CN104758437A - Traditional Chinese medicine composition for treating kidney stone, preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating kidney stone, preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating kidney stone, a preparation method and an application thereof, wherein the traditional Chinese medicine composition includes following raw materials, by mass: 68-76 parts of jasminum nudiflorum leaves, 18-22 parts of radix dipsaci asperoidis, 18-22 parts of loranthus parasiticus, 14-16 parts of frankincense, 14-16 parts of myrrh, 12-18 parts of raw rehmannia roots and 5-7 parts of Chinese prickly ash. The preparation method comprises steps of washing the raw materials, crushing the raw materials, performing water-extraction, performing a drying process and forming the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared with the jasminum nudiflorum leaves having effects of clearing heat, draining dampness and removing toxin as a main medicine and the radix dipsaci asperoidis and the loranthus parasiticus having effects of tonifying liver and kidney and fortifying muscles and bones as auxiliary medicines, with addition of the frankincense, the myrrh and the raw rehmannia roots belonging to the meridians in heart, liver and spleen and with addition of the Chinese prickly ash having effects of warming the middle to relieve pain, by means of the cooperation of the medicines, the traditional Chinese medicine composition has effects of freeing meridian and relieving pain, draining water and treating stranguria, dispersing stasis and dissipating bind, and removing the stones. The traditional Chinese medicine composition is suitable for kidney stone patients suffered from sore pain in waist, lacking in strength in whole body, obstruction in urination and hematuresis and the like symptoms, is significant in curative effects, is free of toxic and side effects and is low in cost.
Description
Technical field
The present invention relates to medical art, specifically a kind of Chinese medicine composition for the treatment of renal calculus and preparation method thereof and application.
Background technology
Calculus is the solid mass formed in the catheter lumen in human body or animal body or in the chamber of chamber sexual organ (as kidney, ureter, gallbladder or bladder etc.).Be mainly seen in gallbladder and bladder, renal pelvis, also show in the chamber of pancreas conduit, salivary ducts etc.Calculus is made up of inorganic salt or Organic substance.Generally have a core in calculus, be made up of the epithelial cell come off, bacterial aggregate, parasitic ovum or polypide, excrement block or foreign body, inorganic salt or Organic substance deposit on core more layer by layer.Due to the difference of afflicted organ, the composition contained by lithogenous mechanism, shape, quality, all not identical on impact of body etc.Generally speaking, calculus can cause tube chamber to block, and affects the discharge of afflicted organ's liquid, produces the symptoms such as pain, hemorrhage or secondary infection.
Renal calculus is a kind of frequently-occurring disease, commonly encountered diseases, clinical with renal colic and hematuria for cardinal symptom, often urinary tract obstruction can be caused, and secondary infection, according to the difference of stone composition, renal calculus can divide calcium oxalate stone, calcium phosphate stone, urate calculus, struvite calculus, cystine stone and purine calculus six class, clinically often be divided into the case of a physically strong patient running a high fever and simulataneous insufficiency and excessive disease two type: the case of a physically strong patient running a high fever, burning into sand stone time in urine, urine is involved and abstruse, or interrupt suddenly when urinating, the poverty-stricken pain of urethra, cramp and pain in the lower abdomen, or waist angina abdominis unbearably, blood is with in urine, red tongue, yellow and thin fur, stringy pulse or band number, simulataneous insufficiency and excessive disease, sick sandstone for a long time does not go, and can accompany and see spiritlessness and weakness, down in spirits, the few China of pallor, and light red tongue has indentation, thready and weak pulse without strength, or companion's waist abdomen has a dull ache, soreness of the waist and knees, feverish sensation in the palms and soles, hectic fever, night sweat, spiritlessness and weakness, and the few tongue of red tongue, pulse condition is counted accurately.
At present, the medicine of clinical treatment renal calculus is more, but due to the structure of kidney special, the effect of Drug therapy and the fossil lithodialysis function of medicine not satisfactory, most patient must not proceed to operative treatment then; And operative treatment is often with side effect such as drug allergy, operation wound is large, and treatment time is long, postoperative easy recurrence, and financial expenditure is large, brings serious economy and body burden to sufferer.
Summary of the invention
The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of renal calculus and preparation method thereof and application, to solve the problem.
For achieving the above object, the invention provides following technical scheme:
Treat a Chinese medicine composition for renal calculus, comprise Folium Jasmini Nudiflori 68-76 part, Radix Dipsaci 18-22 part, Herba Taxilli 18-22 part, Olibanum 14-16 part, Myrrha 14-16 part, Radix Rehmanniae 12-18 part and Pericarpium Zanthoxyli 5-7 part according to the raw material of mass fraction.
As the further scheme of the present invention: comprise Folium Jasmini Nudiflori 68 parts, Radix Dipsaci 18 parts, Herba Taxilli 22 parts, Olibanum 14 parts, Myrrha 16 parts, Radix Rehmanniae 18 parts and 5 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
As the further scheme of the present invention: comprise Folium Jasmini Nudiflori 76 parts, Radix Dipsaci 19 parts, Herba Taxilli 21 parts, Olibanum 16 parts, Myrrha 15 parts, Radix Rehmanniae 12 parts and 6 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
As the further scheme of the present invention: comprise Folium Jasmini Nudiflori 71 parts, Radix Dipsaci 20 parts, Herba Taxilli 20 parts, Olibanum 15 parts, Myrrha 15 parts, Radix Rehmanniae 15 parts and 6 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
As the further scheme of the present invention: comprise Folium Jasmini Nudiflori 72 parts, Radix Dipsaci 21 parts, Herba Taxilli 19 parts, Olibanum 16 parts, Myrrha 14 parts, Radix Rehmanniae 17 parts and 7 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
As the further scheme of the present invention: comprise Folium Jasmini Nudiflori 74 parts, Radix Dipsaci 22 parts, Herba Taxilli 18 parts, Olibanum 15 parts, Myrrha 16 parts, Radix Rehmanniae 13 parts and 5 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
The preparation method of the Chinese medicine composition of described treatment renal calculus, comprises the following steps:
(1) clean, pulverize: respectively by Folium Jasmini Nudiflori, Radix Dipsaci, Herba Taxilli, Olibanum, Myrrha, Radix Rehmanniae and Pericarpium Zanthoxyli, clean roguing, dry, pulverize;
(2) water extraction: take the various medical materials after pulverizing in proportion, mix homogeneously, added the water soaking of its quality 5-6 times amount after 1 hour, and heating decoction 2 hours, filters, and obtains first time Aqueous extracts; In the medicinal residues that filtration obtains, add the water of its quality 3-5 times amount, heating decocts 1-1.5 hour, filters, and obtains second time Aqueous extracts; Merge Aqueous extracts and second time Aqueous extracts for the first time, filter, be concentrated into the half of original volume, obtain concentrated solution;
(3) dry: to dry 1 hour under concentrated solution being placed on 80 DEG C of temperature, after stirring, dry under being then placed in 80 DEG C of temperature;
(4) molding: by dried mixture according to the metering of 1-2g/ grain, make capsule formulation according to the preparation for processing of capsule.
Described Chinese medicine composition is applied in treatment renal calculus.
Compared with prior art, the invention has the beneficial effects as follows:
The present invention with the Folium Jasmini Nudiflori of heat clearing away, dampness removing, removing toxic substances for principal agent, with the Radix Dipsaci of invigorating the liver and kidney, bone and muscle strengthening and Herba Taxilli for accessory drugs, in addition the Olibanum of GUIXIN, liver, spleen channel, Myrrha and Radix Rehmanniae, there is the Pericarpium Zanthoxyli of warming middle-JIAO to relieve pain, all medicines share, and play inducing menstruation to relieve menalgia, relieving stranguria by diuresis, blood stasis-eliminating and stagnation-dissipating, calculus effect altogether.
The present invention has effect of anti-inflammatory analgetic, blood circulation promoting and blood stasis dispelling, promoting QI to circulate and dispersing the agglomeration of the pathogens, diuresis and expelling stone, is applicable to the renal calculus patient of the symptoms such as waist is ached, the whole body is weak, it is not smooth to urinate, hematuria, and evident in efficacy, has no side effect, with low cost; Compatibility science of the present invention, obviously can alleviate the pain of renal calculus patient, make ureter, the spasm of urethra alleviated, and impels urinary function normal, has calculus evident in efficacy, analgesic efficacy.
Detailed description of the invention
Below in conjunction with the embodiment of the present invention, be clearly and completely described the technical scheme in the embodiment of the present invention, obviously, described embodiment is only the present invention's part embodiment, instead of whole embodiments.Based on the embodiment in the present invention, those of ordinary skill in the art, not making the every other embodiment obtained under creative work prerequisite, belong to the scope of protection of the invention.
Embodiment 1
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of renal calculus, comprises Folium Jasmini Nudiflori 68 parts, Radix Dipsaci 18 parts, Herba Taxilli 22 parts, Olibanum 14 parts, Myrrha 16 parts, Radix Rehmanniae 18 parts and 5 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
The preparation method of the Chinese medicine composition of described treatment renal calculus, comprises the following steps:
(1) clean, pulverize: respectively by Folium Jasmini Nudiflori, Radix Dipsaci, Herba Taxilli, Olibanum, Myrrha, Radix Rehmanniae and Pericarpium Zanthoxyli, clean roguing, dry, pulverize;
(2) water extraction: take the various medical materials after pulverizing in proportion, mix homogeneously, added the water soaking of its quality 5-6 times amount after 1 hour, and heating decoction 2 hours, filters, and obtains first time Aqueous extracts; In the medicinal residues that filtration obtains, add the water of its quality 3-5 times amount, heating decocts 1-1.5 hour, filters, and obtains second time Aqueous extracts; Merge Aqueous extracts and second time Aqueous extracts for the first time, filter, be concentrated into the half of original volume, obtain concentrated solution;
(3) dry: to dry 1 hour under concentrated solution being placed on 80 DEG C of temperature, after stirring, dry under being then placed in 80 DEG C of temperature;
(4) molding: by dried mixture according to the metering of 1-2g/ grain, make capsule formulation according to the preparation for processing of capsule.
Embodiment 2
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of renal calculus, comprises Folium Jasmini Nudiflori 76 parts, Radix Dipsaci 19 parts, Herba Taxilli 21 parts, Olibanum 16 parts, Myrrha 15 parts, Radix Rehmanniae 12 parts and 6 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
The preparation method of the Chinese medicine composition of described treatment renal calculus, comprises the following steps:
(1) clean, pulverize: respectively by Folium Jasmini Nudiflori, Radix Dipsaci, Herba Taxilli, Olibanum, Myrrha, Radix Rehmanniae and Pericarpium Zanthoxyli, clean roguing, dry, pulverize;
(2) water extraction: take the various medical materials after pulverizing in proportion, mix homogeneously, added the water soaking of its quality 5-6 times amount after 1 hour, and heating decoction 2 hours, filters, and obtains first time Aqueous extracts; In the medicinal residues that filtration obtains, add the water of its quality 3-5 times amount, heating decocts 1-1.5 hour, filters, and obtains second time Aqueous extracts; Merge Aqueous extracts and second time Aqueous extracts for the first time, filter, be concentrated into the half of original volume, obtain concentrated solution;
(3) dry: to dry 1 hour under concentrated solution being placed on 80 DEG C of temperature, after stirring, dry under being then placed in 80 DEG C of temperature;
(4) molding: by dried mixture according to the metering of 1-2g/ grain, make capsule formulation according to the preparation for processing of capsule.
Embodiment 3
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of renal calculus, comprises Folium Jasmini Nudiflori 71 parts, Radix Dipsaci 20 parts, Herba Taxilli 20 parts, Olibanum 15 parts, Myrrha 15 parts, Radix Rehmanniae 15 parts and 6 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
The preparation method of the Chinese medicine composition of described treatment renal calculus, comprises the following steps:
(1) clean, pulverize: respectively by Folium Jasmini Nudiflori, Radix Dipsaci, Herba Taxilli, Olibanum, Myrrha, Radix Rehmanniae and Pericarpium Zanthoxyli, clean roguing, dry, pulverize;
(2) water extraction: take the various medical materials after pulverizing in proportion, mix homogeneously, added the water soaking of its quality 5-6 times amount after 1 hour, and heating decoction 2 hours, filters, and obtains first time Aqueous extracts; In the medicinal residues that filtration obtains, add the water of its quality 3-5 times amount, heating decocts 1-1.5 hour, filters, and obtains second time Aqueous extracts; Merge Aqueous extracts and second time Aqueous extracts for the first time, filter, be concentrated into the half of original volume, obtain concentrated solution;
(3) dry: to dry 1 hour under concentrated solution being placed on 80 DEG C of temperature, after stirring, dry under being then placed in 80 DEG C of temperature;
(4) molding: by dried mixture according to the metering of 1-2g/ grain, make capsule formulation according to the preparation for processing of capsule.
Embodiment 4
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of renal calculus, comprises Folium Jasmini Nudiflori 72 parts, Radix Dipsaci 21 parts, Herba Taxilli 19 parts, Olibanum 16 parts, Myrrha 14 parts, Radix Rehmanniae 17 parts and 7 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
The preparation method of the Chinese medicine composition of described treatment renal calculus, comprises the following steps:
(1) clean, pulverize: respectively by Folium Jasmini Nudiflori, Radix Dipsaci, Herba Taxilli, Olibanum, Myrrha, Radix Rehmanniae and Pericarpium Zanthoxyli, clean roguing, dry, pulverize;
(2) water extraction: take the various medical materials after pulverizing in proportion, mix homogeneously, added the water soaking of its quality 5-6 times amount after 1 hour, and heating decoction 2 hours, filters, and obtains first time Aqueous extracts; In the medicinal residues that filtration obtains, add the water of its quality 3-5 times amount, heating decocts 1-1.5 hour, filters, and obtains second time Aqueous extracts; Merge Aqueous extracts and second time Aqueous extracts for the first time, filter, be concentrated into the half of original volume, obtain concentrated solution;
(3) dry: to dry 1 hour under concentrated solution being placed on 80 DEG C of temperature, after stirring, dry under being then placed in 80 DEG C of temperature;
(4) molding: by dried mixture according to the metering of 1-2g/ grain, make capsule formulation according to the preparation for processing of capsule.
Embodiment 5
In the embodiment of the present invention, a kind of Chinese medicine composition for the treatment of renal calculus, comprises Folium Jasmini Nudiflori 74 parts, Radix Dipsaci 22 parts, Herba Taxilli 18 parts, Olibanum 15 parts, Myrrha 16 parts, Radix Rehmanniae 13 parts and 5 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
The preparation method of the Chinese medicine composition of described treatment renal calculus, comprises the following steps:
(1) clean, pulverize: respectively by Folium Jasmini Nudiflori, Radix Dipsaci, Herba Taxilli, Olibanum, Myrrha, Radix Rehmanniae and Pericarpium Zanthoxyli, clean roguing, dry, pulverize;
(2) water extraction: take the various medical materials after pulverizing in proportion, mix homogeneously, added the water soaking of its quality 5-6 times amount after 1 hour, and heating decoction 2 hours, filters, and obtains first time Aqueous extracts; In the medicinal residues that filtration obtains, add the water of its quality 3-5 times amount, heating decocts 1-1.5 hour, filters, and obtains second time Aqueous extracts; Merge Aqueous extracts and second time Aqueous extracts for the first time, filter, be concentrated into the half of original volume, obtain concentrated solution;
(3) dry: to dry 1 hour under concentrated solution being placed on 80 DEG C of temperature, after stirring, dry under being then placed in 80 DEG C of temperature;
(4) molding: by dried mixture according to the metering of 1-2g/ grain, make capsule formulation according to the preparation for processing of capsule.
The property of medicine and effect of Chinese medicine of the present invention are as follows:
Folium Jasmini Nudiflori: cold in nature, bitter in the mouth, GUIXIN, Liver Channel, have effect of heat clearing away, dampness removing, removing toxic substances.Main cold, fever, urine leaching pain, pruritus vulvae, toxic swelling malignant boil, traumatic injury, knife injury is hemorrhage.
Radix Dipsaci: slightly warm in nature, bitter in the mouth, pungent, return liver, kidney channel, there is invigorating the liver and kidney, bone and muscle strengthening, blood circulation regulating, continuous injured, effect of only metrorrhagia.For aching pain in waist and back; Podomere flaccidity syndrome and arthralgia syndrome; Fall flutter wound, damage muscle folding bone, red, metrorrhagia is leaked in fetal movement, seminal emission, leukorrhagia, carbuncle skin ulcer swell.
Herba Taxilli: property is put down, bitter in the mouth, sweet, returns liver, kidney channel, has invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, effect of antiabortive unit.Be mainly used to soreness of waist and knee joint; Muscles and bones flaccidity is weak; Limbs are hemiplegia; Rheumatic arthralgia; Head is wrong dizzy; Frequent fetal movement, metrostaxis.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, metrorrhagia through many, blood leaking in gestation, frequent fetal movement; Hypertension.
Olibanum: warm in nature, acrid in the mouth, hardship, GUIXIN, liver, spleen channel, have regulating qi and activating blood, analgesic therapy, chases after effect of poison.For regulating qi and activating blood, analgesic therapy, chases after poison.Control coagulation of QI-blood, trusted subordinate's pain, carbuncle pyogenic infections from tumour or sore, traumatic injury, dysmenorrhea, postnatal blood stasis twinge.
Myrrha: property is put down, and bitter in the mouth, GUIXIN, liver, spleen channel, have the effects such as promoting blood circulation to remove blood stasis, pain relieving, detumescence and promoting granulation.Cure mainly breast abdomen stasis of blood pain, dysmenorrhea, amenorrhea, lump in the abdomen, traumatic injury, carbuncle skin infection, acute appendicitis, conjunctival congestion and swelling pain.
Radix Rehmanniae: cold in nature, sweet in the mouth, GUIXIN, liver, kidney channel, have clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat is quenched one's thirst, and spits blood, and epistaxis sends out speckle dermexanthesis.
Pericarpium Zanthoxyli: warm in nature, acrid in the mouth, returns spleen, stomach, kidney channel, has warming middle-JIAO to relieve pain, effect of killing parasites for relieving itching.For coldness and pain in the epigastrium, vomiting is had loose bowels, abdominal pain due to worm stagnation, ascariasis; External treatment eczema pruritus.
The present invention with the Folium Jasmini Nudiflori of heat clearing away, dampness removing, removing toxic substances for principal agent, with the Radix Dipsaci of invigorating the liver and kidney, bone and muscle strengthening and Herba Taxilli for accessory drugs, in addition the Olibanum of GUIXIN, liver, spleen channel, Myrrha and Radix Rehmanniae, there is the Pericarpium Zanthoxyli of warming middle-JIAO to relieve pain, all medicines share, and play inducing menstruation to relieve menalgia, relieving stranguria by diuresis, blood stasis-eliminating and stagnation-dissipating, calculus effect altogether.
The present invention has effect of anti-inflammatory analgetic, blood circulation promoting and blood stasis dispelling, promoting QI to circulate and dispersing the agglomeration of the pathogens, diuresis and expelling stone, is applicable to the renal calculus patient of the symptoms such as waist is ached, the whole body is weak, it is not smooth to urinate, hematuria, and evident in efficacy, has no side effect, with low cost; Compatibility science of the present invention, obviously can alleviate the pain of renal calculus patient, make ureter, the spasm of urethra alleviated, and impels urinary function normal, has calculus evident in efficacy, analgesic efficacy.
Animal acute toxicity test is carried out to foregoing invention embodiment, get Mouse and rat half and half, be divided into 5 groups, wherein first group of oral medicine of the present invention giving embodiment 1 preparation of 5000mg/kg, medicine of the present invention prepared by second group of oral embodiment 2 giving 5000mg/kg, medicine of the present invention prepared by the 3rd group of oral embodiment 3 giving 5000mg/kg, medicine of the present invention prepared by the 4th group of oral embodiment 4 giving 5000mg/kg, medicine of the present invention prepared by the 5th group of oral embodiment 5 giving 5000mg/kg, once a day, 7 days are continued.To observation post administration 2 weeks, there is no dead mouse.The test dose adopted in animal acute toxicity test is all greater than more than 20 times of people's oral dose every day, and the toxicity that result shows this medicine is very micro-.Therefore, clinical trial is carried out to the patient being diagnosed as renal calculus.
Clinical data:
1, clinical criteria.With reference to " the new Chinese medicine guideline of clinical investigations " first volume that in 1993 Ministry of Health of the People's Republic of China develops and publishes.1. medical history and symptom: the kidney having typical case to break out or ureteral colic, companion's naked eyes or microscopic hematuria; Or only have waist and belly dull pain, sour swollen discomfort, or there is calculus history; Bladder, calculus of urethra then have dysuria, and urine stream interrupts, urine retention and terminal hematuria etc.2. sign: pain or tenderness are kowtowed in acute attack Shi Shen district or ureter position; Giant hydronephrosis, renal abscess patient, can lay one's hand on and enclosed mass; Large vesical calculus often can be touched in per rectum touch; Hind urethra calculus, rectal touch can touch; Penis inspection can touch to obtain anterior urethra calculus.3. x-ray inspection: the lithangiuria of 95% develops on plain film, therefore plain film can show size, form, the number of calculus, and can stone composition according to a preliminary estimate.Plain film is negative, the person that still can not get rid of lithangiuria completely, excretory urography or ascending urography need be made, to understand the position that has that it's too late of calculus, and renal pelvis, renal calices, ureter anatomic form can be understood further, and with or without hydronephrosis and degree thereof, excess of the kidney matter thickness, renal function quality, upper urinary tract is with or without birth defect and other organic disease.4., after uroscopy: urine R-RBC often increases, especially angor outbreak or after motion, sometimes salt crystalloid can be there is, visible more leukocyte or pus cell during accompanying infection.5. ING inspection: existence and the degree thereof that can reflect renal function situation and upper urinary.6. ultrasound investigation: the degree of the existence of auxiliary diagnosis calculus and size thereof, position, hydrops.
2, case selection:
Case 200 example meeting above-mentioned clinical criteria is included in clinical trial altogether in, is divided into treatment group and matched group at random, treatment group and each 100 examples of matched group.Man 66 example, female 34 example in treatment group; Minimum 20 years old of age, maximum 65 years old, 48 years old mean age.Matched group man 68 example, female 32 example; Minimum 18 years old of age, maximum 67 years old.Two groups of M-Fs, age size are all without significant difference.
3, medicament selection:
Treatment group takes medicine of the present invention, every day 2 times, each 1 time sooner or later, each 3g, after meal half an hour warm water delivery service; It within 15 days, is 1 course for the treatment of; Matched group takes allopurinol tablet, be grown up one time 1 ~ 3,2 ~ 3 times on the one, when half an hour ante cibum or stomachache attack, chew rear clothes.
4, curative effect determinate standard:
(1) cure: B ultrasonic display renal calculus is discharged, and noresidue in body, graft function is normal.
(2) effective: B ultrasonic display renal calculus reduces, and renal function obviously improves.
(3) effective: B ultrasonic display renal calculus reduces to some extent, renal function improves or worsens without continuation.
(4) invalid: symptom, sign are without improvement, and renal function is without improvement.
5, clinical test results:
Select in the treatment group of medicine of the present invention, cure 60 examples, effective 21 examples, effective 12 examples, invalid 7 examples, cure rate 60%, total effective rate 93%.
48 examples are cured, effective 15 examples, effective 19 examples, invalid 18 examples, cure rate 48%, total effective rate 82% in matched group.
Contrast therapy group and matched group, the cure rate for the treatment of group and total effective rate, apparently higher than matched group, illustrate that medicine of the present invention has significant effect for the treatment of renal calculus.
Model case is illustrated:
Revive certain, female, 32 years old, From Shandong Rizhao people, the frequent lumbago of patient, through ultrasound diagnosis, have 2 calculus in kidney, one of them calculus is 0.8cm × 0.5cm, another is 0.7cm × 0.6cm, and after taking 1 course for the treatment of of medicine of the present invention, through ultrasound diagnosis, in its kidney, calculus is discharged substantially; After continuing to take 1 course for the treatment of, through ultrasound diagnosis, in its kidney, calculus is all discharged.
Slowly certain, male, 26 years old, Zhejiang Hangzhou people, back lumbar part angor on the left of patient, and to thigh root radiation, acute face dolorosa, groan, cold sweat, look into left lower quadrant tenderness (++), kidney district tenderness, left side (+), percussion pain (++).Ultrasound diagnosis: the no echo area of visible 1.2cm × 2.7cm in left sinus renalis, left ureter epimere is expanded, the strong echo group of interior visible diameter 0.4cm, rear accompanying sound shadow.Routine urinalysis: albumen trace, leukocyte 3-4/np, erythrocyte 18-25/np, is diagnosed as stranguria caused by urinary stone.After taking 1 course for the treatment of of medicine of the present invention, discharge the calculus of one piece of Semen Glycines size with urine; After continuing to take 3 courses for the treatment of, patients symptomatic, sign disappear, and X-ray, B ultrasonic display calculus shade disappears.
Wang, female, 63 years old, Kunming, Yunnan people, patient fell ill before half a year, and gnawing pains take no rest always for right side of body, and anti-inflammatory analgetic of taking medicine is invalid.Clinical diagnosis finds right ureter epimere calculus, and renal calculus, with slight hydrops.After taking 2 courses for the treatment of of medicine of the present invention, recovery from illness, ultrasound diagnosis, without calculus thing, is followed up a case by regular visits to and is had no recurrence half a year.
Liu, man, 58 years old, jiangsu wuxi people.Patient suffers from the ictal stomachache of interval, interrupt with urinating and urodynamic violent, while can accompany terminal hematuria, clinical diagnosis is renal calculus.After taking 2 courses for the treatment of of medicine of the present invention, the state of an illness alleviates to some extent; After continuing to take 2 courses for the treatment of, recovery from illness, follows up a case by regular visits to and has no recurrence half a year.
Model, female, 39 years old, people from Baoji, patient suffered from renal calculus more than a year, and in ultrasound diagnosis kidney, calculus is 1.6cm × 1cm, calculus the smooth of the edge, and frequent lumbago, has some medicine when pain, and symptom can alleviate, and shows effect again after a while, again and again shows effect.After taking 1 course for the treatment of of medicine of the present invention, through ultrasound diagnosis, in its kidney, calculus is 1.1cm × 0.7cm, and lumbago obviously alleviates; Then after taking 2 courses for the treatment of, through ultrasound diagnosis, in its kidney, calculus is all discharged.
Hu, man, 53 years old, Ningbo of Zhejiang people, patient suffered from renal calculus more than 2 years, and waist and abdominal part often understand paroxysmal pain, and after aggravating activities, pain will be shown effect sometimes, there will be lancinating pain time serious, and pain can be radiated to groin sometimes.Through ultrasound diagnosis, there is 5, calculus in its kidney, wherein maximum 1.5cm × 0.6cm.After taking 1 course for the treatment of of medicine of the present invention, through ultrasound diagnosis, in its kidney, calculus is 5, but calculus obviously diminishes; Then after taking 1 course for the treatment of, through ultrasound diagnosis, in its kidney, calculus becomes 3, and calculus obviously diminishes; After again taking 1 course for the treatment of, through ultrasound diagnosis, in its kidney, calculus is all discharged.
To those skilled in the art, obviously the invention is not restricted to the details of above-mentioned one exemplary embodiment, and when not deviating from spirit of the present invention or basic feature, the present invention can be realized in other specific forms.Therefore, no matter from which point, all should embodiment be regarded as exemplary, and be nonrestrictive, scope of the present invention is limited by claims instead of above-mentioned explanation, and all changes be therefore intended in the implication of the equivalency by dropping on claim and scope are included in the present invention.
In addition, be to be understood that, although this description is described according to embodiment, but not each embodiment only comprises an independently technical scheme, this narrating mode of description is only for clarity sake, those skilled in the art should by description integrally, and the technical scheme in each embodiment also through appropriately combined, can form other embodiments that it will be appreciated by those skilled in the art that.
Claims (8)
1. treat a Chinese medicine composition for renal calculus, it is characterized in that, comprise Folium Jasmini Nudiflori 68-76 part, Radix Dipsaci 18-22 part, Herba Taxilli 18-22 part, Olibanum 14-16 part, Myrrha 14-16 part, Radix Rehmanniae 12-18 part and Pericarpium Zanthoxyli 5-7 part according to the raw material of mass fraction.
2. the Chinese medicine composition for the treatment of renal calculus according to claim 1, is characterized in that, comprises Folium Jasmini Nudiflori 68 parts, Radix Dipsaci 18 parts, Herba Taxilli 22 parts, Olibanum 14 parts, Myrrha 16 parts, Radix Rehmanniae 18 parts and 5 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
3. the Chinese medicine composition for the treatment of renal calculus according to claim 1, is characterized in that, comprises Folium Jasmini Nudiflori 76 parts, Radix Dipsaci 19 parts, Herba Taxilli 21 parts, Olibanum 16 parts, Myrrha 15 parts, Radix Rehmanniae 12 parts and 6 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
4. the Chinese medicine composition for the treatment of renal calculus according to claim 1, is characterized in that, comprises Folium Jasmini Nudiflori 71 parts, Radix Dipsaci 20 parts, Herba Taxilli 20 parts, Olibanum 15 parts, Myrrha 15 parts, Radix Rehmanniae 15 parts and 6 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
5. the Chinese medicine composition for the treatment of renal calculus according to claim 1, is characterized in that, comprises Folium Jasmini Nudiflori 72 parts, Radix Dipsaci 21 parts, Herba Taxilli 19 parts, Olibanum 16 parts, Myrrha 14 parts, Radix Rehmanniae 17 parts and 7 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
6. the Chinese medicine composition for the treatment of renal calculus according to claim 1, is characterized in that, comprises Folium Jasmini Nudiflori 74 parts, Radix Dipsaci 22 parts, Herba Taxilli 18 parts, Olibanum 15 parts, Myrrha 16 parts, Radix Rehmanniae 13 parts and 5 parts, Pericarpium Zanthoxyli according to the raw material of mass fraction.
7. the preparation method of the Chinese medicine composition for the treatment of renal calculus according to claim 1, is characterized in that, comprise the following steps:
(1) clean, pulverize: respectively by Folium Jasmini Nudiflori, Radix Dipsaci, Herba Taxilli, Olibanum, Myrrha, Radix Rehmanniae and Pericarpium Zanthoxyli, clean roguing, dry, pulverize;
(2) water extraction: take the various medical materials after pulverizing in proportion, mix homogeneously, added the water soaking of its quality 5-6 times amount after 1 hour, and heating decoction 2 hours, filters, and obtains first time Aqueous extracts; In the medicinal residues that filtration obtains, add the water of its quality 3-5 times amount, heating decocts 1-1.5 hour, filters, and obtains second time Aqueous extracts; Merge Aqueous extracts and second time Aqueous extracts for the first time, filter, be concentrated into the half of original volume, obtain concentrated solution;
(3) dry: to dry 1 hour under concentrated solution being placed on 80 DEG C of temperature, after stirring, dry under being then placed in 80 DEG C of temperature;
(4) molding: by dried mixture according to the metering of 1-2g/ grain, make capsule formulation according to the preparation for processing of capsule.
8. one kind as arbitrary in claim 1-7 as described in Chinese medicine composition be applied in treatment renal calculus on.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857198A (en) * | 2015-06-17 | 2015-08-26 | 产俊涛 | Traditional Chinese medicinal composition for treating kidney stone and application of composition |
| CN105362401A (en) * | 2015-08-12 | 2016-03-02 | 彭刘平 | Traditional Chinese medicine for treating kidney calculi and application thereof |
| CN106421602A (en) * | 2016-10-26 | 2017-02-22 | 惠安县泰达商贸有限责任公司 | Traditional Chinese medicine preparation for treating kidney stone and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895444A (en) * | 2012-09-04 | 2013-01-30 | 刘长灵 | Traditional Chinese medicine composition for treating lithangiuria |
| CN104208358A (en) * | 2014-08-15 | 2014-12-17 | 石爱华 | Traditional Chinese medicine for treating renal calculi |
-
2015
- 2015-03-19 CN CN201510120548.4A patent/CN104758437A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102895444A (en) * | 2012-09-04 | 2013-01-30 | 刘长灵 | Traditional Chinese medicine composition for treating lithangiuria |
| CN104208358A (en) * | 2014-08-15 | 2014-12-17 | 石爱华 | Traditional Chinese medicine for treating renal calculi |
Non-Patent Citations (2)
| Title |
|---|
| 朱诗平等: "泌尿系结石四段辨治分析", 《山东中医药大学学报》 * |
| 陈清志: "排石1号方治疗泌尿系结石96例", 《新中医》 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104857198A (en) * | 2015-06-17 | 2015-08-26 | 产俊涛 | Traditional Chinese medicinal composition for treating kidney stone and application of composition |
| CN105362401A (en) * | 2015-08-12 | 2016-03-02 | 彭刘平 | Traditional Chinese medicine for treating kidney calculi and application thereof |
| CN106421602A (en) * | 2016-10-26 | 2017-02-22 | 惠安县泰达商贸有限责任公司 | Traditional Chinese medicine preparation for treating kidney stone and preparation method and application thereof |
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