CN111481654A

CN111481654A - Composition for rapidly relieving pain and treating or preventing rennet pain and preparation medicine and method thereof

Info

Publication number: CN111481654A
Application number: CN202010365068.5A
Authority: CN
Inventors: 黄汉林; 陈伟
Original assignee: Huanghanlin Medical Clinic Of Traditional Chinese Medicine In Longhu District Shantou City
Current assignee: Huanghanlin Medical Clinic Of Traditional Chinese Medicine In Longhu District Shantou City
Priority date: 2020-04-30
Filing date: 2020-04-30
Publication date: 2020-08-04

Abstract

A composition for rapidly relieving pain and treating or preventing rennet pain is composed of the following raw material medicines in parts by weight: 33-60 parts of lysimachia christinae hance, 5-12 parts of pyrrosia lingua, 5-9 parts of endothelium corneum gigeriae galli, 3-10 parts of raw oyster, 3-10 parts of lygodium japonicum, 6-12 parts of astragalus membranaceus, 5-8 parts of radix paeoniae alba, 3-8 parts of fructus aurantii, 8-12 parts of lalang grass rhizome, 2-5 parts of akebiaquinata, 3-6 parts of rhizoma alismatis, 2-6 parts of peach kernel, 2-8 parts of cowherb seed and 1-5 parts of rhizoma zingiberis.

Description

Composition for rapidly relieving pain and treating or preventing rennet pain and preparation medicine and method thereof

Technical Field

The invention relates to a composition for rapidly relieving pain and treating or preventing rennet pain, a medicine prepared from the composition and a corresponding preparation method, and belongs to the technical field of traditional Chinese medicines for treating renal colic caused by renal calculus.

Background

Patients with nephrolithiasis often have low back pain of varying degrees. Generally manifested as distending pain or dull pain, and acute attacks as angina. When the calculus is large, the movement amplitude is small, and the calculus can press, rub or cause hydrops on the inner side of renal pelvis or renal calyx, which is manifested by soreness and discomfort of waist, or dull pain when the physical activity is increased; the severe pain suddenly occurs in the back, waist or costal abdomen, and radiates to the lower abdomen, inner thigh and pudendum along the ureter, can be accompanied with dysuria, nausea, vomiting, profuse sweat and hematuria and the like, small stones can be separated from the renal pelvis and move into the ureter along with flowing urine to block the excretion of the urine in the ureter to generate pressure, the stones squeeze and stimulate the ureter wall to cause the intense spasm and contraction of the smooth muscle of the ureter, the nerve endings of the ureter wall generate intense pain due to the sudden urine squeezing, stone stimulation and intense spasm, the spasm and contraction of the ureter further wraps the stones tightly, so that the urine cannot be discharged out of the body, the pressure of the ureter is suddenly increased due to the continuous increase of urine in the kidney and the bladder, spasm and contraction are increasingly serious, the ureter is punctured by the calculus which is more compressed, and acute angina is more serious under multiple actions.

The commonly adopted treatment method for the nephrolithiasis in modern medicine is as follows: treatment with antibiotics when symptoms of infection develop; draining the renal effusion by renal puncture; when renal colic occurs, the nonsteroidal analgesic and anti-inflammatory drugs are taken for mild pain, and are matched with spasmolytic drugs for treatment; injecting analgesic medicine when the pain is severe; if the calculus is large, the extracorporeal lithotripsy is performed. Because various treatment methods are separately treated, the synchronous effect cannot be generated, so the treatment effect is poor and certain side effects are caused. The sources of the kidney stone pain are smooth muscle spasm, stone stimulation and puncture wound, and the nerve ending is pressed by urine. The injection of analgesic drugs can not relieve the three factors, so that the analgesic effect is not obvious or even ineffective. Since acute renal colic often causes pain to the patient, the treatment is first of all an urgent task to relieve the pain of the patient. However, the modern medicine does not have a treatment method for quickly relieving renal colic caused by calculi at present, and the treatment effect of applying the spasmolytic pain-relieving medicine on relieving acute renal colic is not obvious.

Disclosure of Invention

In the process of diagnosing and treating the renal calculus for a long time, the inventor intensively researches a composition for rapidly relieving pain and treating or preventing the symptoms of the renal sprain by applying the principles of combination of syndrome differentiation and disease differentiation and emergency treatment of traditional Chinese medicine on the basis of referring to modern western medicine. The medicinal effects of the composition can be synergistic, synchronous physiological effects are generated, the effect is strong, the composition is close to pathogenesis, ureterospasm can be quickly relieved, the diuretic effect is realized, the ureteral pressure is reduced, so that renal colic is stopped, and the colic is completely relieved 1-1.5 hours after patients suffering from acute renal colic take the composition clinically. It is effective in treating dull pain and distending pain caused by renal calculus. The composition can gradually dissipate and drain the calculus after being taken for a period of time, and the acute renal colic of a patient does not relapse, so that the cause of the calculus can be radically treated.

In order to achieve the purpose, the invention is implemented by adopting the following technical means:

a composition for rapidly relieving pain and treating or preventing rennet pain is composed of the following raw material medicines in parts by weight:

33-60 parts of lysimachia christinae hance, 5-12 parts of pyrrosia lingua, 5-9 parts of raw chicken's gizzard-membrane, 3-10 parts of raw oyster, 3-10 parts of lygodium japonicum, 6-12 parts of astragalus membranaceus, 5-8 parts of radix paeoniae alba, 3-8 parts of fructus aurantii, 8-12 parts of lalang grass rhizome, 2-5 parts of akebiaquinata, 3-6 parts of rhizoma alismatis, 2-6 parts of peach kernel, 2-8 parts of cowherb seed and 1-5 parts of dried ginger.

Preferably, the traditional Chinese medicine composition is characterized by comprising the following raw material medicines in parts by weight:

40-50 parts of desmodium, 8-12 parts of pyrrosia lingua, 6-9 parts of raw chicken's gizzard-membrane, 4-9 parts of raw oyster, 4-9 parts of spora lygodii, 6-12 parts of astragalus membranaceus, 5-7 parts of radix paeoniae alba, 4-7 parts of fructus aurantii, 6-10 parts of lalang grass rhizome, 2-4 parts of akebia stem, 4-6 parts of rhizoma alismatis, 3-6 parts of peach kernel, 4-8 parts of cowherb seed and 2-4 parts of dried ginger.

More preferably, for patients with acute renal colic with relatively severe symptoms, the pharmaceutical composition suitable for the patients with acute renal colic can be prepared from the following raw material medicines in parts by weight:

40 parts of longhairy antenoron herb, 6 parts of pyrrosia lingua, 6 parts of raw chicken's gizzard-membrane, 5 parts of raw oyster, 5 parts of climbing fern spore, 7 parts of astragalus membranaceus, 5 parts of white paeony root, 3 parts of fructus aurantii, 10 parts of lalang grass rhizome, 2 parts of akebia stem, 3 parts of rhizoma alismatis, 3 parts of peach kernel, 3 parts of cowherb seed and 2 parts of dried ginger.

More preferably, for patients with acute renal colic with relatively mild symptoms, the pharmaceutical composition suitable for the patients with acute renal colic can be prepared from the following raw material medicines in parts by weight:

45 parts of longhairy antenoron herb, 9 parts of pyrrosia lingua, 6 parts of raw chicken's gizzard-membrane, 6 parts of raw oyster, 7 parts of climbing fern spore, 10 parts of astragalus membranaceus, 5 parts of white paeony root, 5 parts of fructus aurantii, 8 parts of lalang grass rhizome, 3 parts of akebia stem, 4 parts of rhizoma alismatis, 4 parts of peach kernel, 6 parts of cowherb seed and 3 parts of dried ginger.

The invention also provides a preparation method of the composition for rapidly relieving pain and treating or preventing the symptoms of the winkle, the prepared dosage form is a medicinal pill, and the specific preparation method comprises the following steps:

step 1: proportioning the cleaned raw material medicines according to a weight part ratio, taking 50-75% of the herba lysimachiae raw material medicine by weight as a herba lysimachiae prefabricated raw material medicine, adding water to the herba lysimachiae prefabricated raw material medicine in a weight ratio of 1:12-17, decocting the herba lysimachiae prefabricated raw material medicine to obtain a liquid medicine, concentrating the liquid medicine to 20-30% of the original weight, removing medicine residues to obtain a herba lysimachiae extracting solution, adding honey to the herba lysimachiae extracting solution in a weight ratio of 2:1, and uniformly mixing to obtain a herba lysimachiae honey prepared extract;

step 2: pulverizing the rest herba Lysimachiae Christinae raw material and other raw materials into powder;

and step 3: and (3) pouring all the powder prepared in the step (2) into the liquid medicine prepared in the step (1), uniformly stirring, drying and preparing into a medicinal pill.

The invention also provides a preparation method of another medicine of the composition for rapidly relieving pain and treating or preventing the symptoms of the winkle, the prepared preparation formulation is a medicine extracting solution, and the specific preparation method comprises the following steps:

step 1: proportioning the cleaned raw material medicines according to the weight part ratio, taking 50-75% of the herba lysimachiae raw material medicine by weight as the herba lysimachiae prefabricated raw material medicine, adding water into the herba lysimachiae prefabricated raw material medicine by the weight ratio of 1:12-17, decocting the liquid medicine, concentrating to 20-30% of the original weight, and removing dregs of a decoction to obtain the herba lysimachiae extracting solution;

step 2: adding the rest herba Lysimachiae Christinae raw material medicine and other raw material medicines into the herba Lysimachiae Christinae extract in the step 1; further decocting and concentrating to 60% -70% of the original weight, and removing the dregs to obtain the medicine extract.

The invention also provides a preparation method of another medicine of the composition for rapidly relieving pain, treating or preventing the symptoms of the rennet pain, the preparation method is more convenient, and the method can be suitable for preparing various medicines:

step 1: mixing the cleaned and dried raw materials according to the weight part ratio, mixing together, and crushing to 300-500 meshes to prepare medicinal superfine powder;

step 2: and (3) preparing the medicine superfine powder prepared in the step (2) and a pharmaceutically acceptable carrier and/or excipient into a medicine.

The raw material medicine composition has the following compatibility thought and beneficial effects:

the raw material medicines of the composition are selected based on the standards of traditional Chinese medicine decoction pieces in Chinese pharmacopoeia. The treatment principle is that the formula for treating renal colic caused by renal calculus is combined by adopting four treatments of a heat-clearing and calculus-dissolving treatment group, a qi-tonifying and urgency-relieving treatment group, a diuresis and blood-activating treatment group and a middle-warming and body-strengthening treatment group, wherein:

the heat-clearing and calculus-removing treatment group comprises five traditional Chinese medicines of desmodium, pyrrosia lingua, endothelium corneum gigeriae galli, raw oyster and lygodium japonicum:

lysimachia christinae Hance is the essential herb for removing urinary calculus, and has the effects of clearing away damp-heat, removing urinary calculus and promoting urination. Modern pharmacology proves that polysaccharide components in the desmodium have an inhibiting effect on calcium oxalate crystallization causing lithangiuria. Can reduce supersaturation degree of calcium oxalate in urine, inhibit formation of calcium oxalate, relax vascular smooth muscle, improve smooth muscle spasm, promote blood circulation, and remove blood stasis. The prescription firstly uses large dose of longhairy antenoron herb, and the single medicine is decocted to obtain thick juice as an extracting solution, and the extracting solution is used for blending other medicinal materials in the prescription. Because of the herba lysimachiae fossil along with the increase of concentration and the stone effect of removing is showing more, reach the effect that makes lithangiuria top layer edges and corners soft scatter fast, reduce the amazing injury of calculus edges and corners to urethra smooth muscle to alleviate angina pectoris fast.

Pyrrosia leaf has the efficacy of promoting diuresis for treating stranguria, and can treat stranguria caused by urinary calculus, stranguria, hematuria and the like.

The raw gizzard-membrane has the efficacy of resolving hard mass and removing stones to treat stranguria, and modern pharmacology proves that the raw gizzard-membrane can treat symptoms such as painful urination, stranguria caused by urinary stone or gall-stone. The clinically used endothelium corneum gigeriae galli contains gastric hormone, keratin, trace pepsin, amylase, various vitamins, trace elements, 18 amino acids and the like. The traditional cooked endothelium corneum Gigeriae Galli has effects of destroying contained elements during parching process, and reducing or eliminating calculus and treating stranguria. It can only be used for strengthening spleen and stomach and promoting digestion and resolving food stagnation. Therefore, the recipe should be annotated with raw endothelium corneum Gigeriae Galli.

Raw oyster can soften hardness and dissipate nodulation, resolve phlegm and eliminate scrofula. It has better effect of dispersing pathogen accumulation and removing stone by combining with Sheng Nei jin.

Hai jin Sha can clear damp-heat in bladder and relieve pain in urethra. It has the actions of inducing diuresis, treating stranguria and alleviating pain. Can be used for treating stranguria caused by urinary stone, pyretic stranguria, odynuria, bloody stranguria, etc.

And the qi-tonifying and urgency-relieving treatment group consists of three traditional Chinese medicines of astragalus, white paeony root and bitter orange. The group with qi tonifying and urgency relieving can rapidly relieve spasm of smooth muscle of renal pelvis, bladder wall and ureter, so as to loosen calculus, reduce irritation and injury of calculus to ureter wall, and relieve or even eliminate angina. The group with qi invigorating and urgency relieving effects can be used in combination with the group with diuresis promoting and blood circulation promoting effects for inducing diuresis for treating stranguria and relieving ureter pressure, and can rapidly relieve pain of acute renal colic.

Astragalus root, radix astragali tonifies qi of lung and spleen, raises yang and lifts sinking, and can treat visceral prolapse caused by qi deficiency; the lifting force is taken from the prescription to reduce the force of pressing ureteral calculus downwards by urine, and the qi is enough to stretch and expand the pipeline, thereby playing an important role in relieving ureterospasm.

Bai Shao is good at nourishing blood and liver and has the action of relieving spasm and spasm due to failure of nourishing tendons and vessels.

The bitter orange has the function of relieving the epigastric distention and regulating qi, and the modern pharmacology proves that the extract of the bitter orange has a bidirectional effect on the smooth muscle. Can excite smooth muscle, strengthen its contraction, accelerate peristalsis, reduce smooth muscle tension, and relieve tendon spasm.

And the diuresis-inducing and blood-circulation-promoting treatment group consists of five traditional Chinese medicines of lalang grass rhizome, akebia stem, rhizoma alismatis, peach kernel and cowherb seed. The group has the functions of promoting the flow of blood and dredging the vessels for the urine in the renal pelvis and the bladder, relieving the pressure in the renal pelvis and the bladder, and relieving the pain of the nerve endings on the inner wall of the ureter without being pressed by the urine and the friction and stimulation of stones. The urine is dredged, and the inner wall capillary of the ureter is not injured by the calculus, so the hematuria disappears.

Baimaogen has the effects of clearing heat, inducing diuresis, treating stranguria and stopping bleeding.

Akebia quinata has the functions of promoting blood circulation, removing blood stasis, activating collaterals, clearing damp-heat in bladder and obviously promoting urination.

Rhizoma alismatis has the effects of promoting diuresis and excreting dampness and clearing damp-heat in bladder, and can treat stranguria with astringency caused by heat accumulated in damp-heat, and modern pharmacology proves that rhizoma alismatis has a strong diuretic effect. The combination of the rhizoma imperatae and the akebia stem has larger efficacy of inducing diuresis and treating stranguria.

Peach kernel has the functions of breaking blood, removing blood stasis, moistening dryness and lubricating intestines, can dilate blood vessels, lubricate ureters, discharge urine and reduce pressure caused by calculus blockage.

The cowherb seed is good at promoting blood circulation and activating blood circulation to pass through the channels, and can be used for treating the syndromes of unsmooth circulation, amenorrhea and dysmenorrheal caused by blood stasis and qi stagnation. Its property of herbs goes downward, which indicates that it enters abdomen zang-fu organs well. It also has the action of promoting lactation, and can promote blood circulation, induce diuresis and treat stranguria, and can be used for treating various stranguria symptoms, dysuria and other symptoms. Therefore, it can dredge the blood in the renal pelvis and bladder wall to promote diuresis. Modern pharmacology proves that the cowherb seed can obviously reduce the blood viscosity and improve the high-viscosity state in the blood rheology so as to improve the microcirculation blood volume, and the efficacy can evacuate water through capillaries to play a role in diuresis. With the combination of Tao ren, it can strengthen the actions of activating blood and resolving stasis.

And fourthly, the treatment group for warming middle-jiao and strengthening body resistance selects one traditional Chinese medicine of dried ginger. Because of the many cold herbs in the recipe, it is easy to hurt the yang qi of spleen and stomach. The dried ginger is pungent and warm and has strong heat, and can warm the middle energizer of the spleen and stomach to transform cold and qi of various medicines, enhance the function of the spleen and stomach and better attract the effective components of various medicines. Cold leading to contraction can make the blood vessels obstructed. Gan Jiang warms yang and relaxes blood vessels to help promote blood circulation and induce diuresis. The qi rising from Huang Qi is assisted by the yang-heat of gan Jiang, so Huang Qi has more obvious effect.

In clinic, patients with kidney stones and suffering from renal colic can be cured by the prescription. Particularly, after the acute renal colic patient takes the prescription, the symptoms of the renal colic can be obviously relieved within 40 minutes to 1.5 hours without the coordination of other pain-relieving and spasmolytic medicines.

After the medicine prepared by the composition is taken by patients with renal calculus, the clinical application proves that the medicines with different dosage forms have quick effect in treating renal calculus. Generally, a patient with kidney stone insists on taking the medicine for 1 to 3 months, and middle and small particle stones can be decomposed and discharged from the urethra; the prescription can also improve the calculus forming mechanism, can effectively prevent substances such as calcium salt, uric acid, cysteine and the like from being concentrated and precipitated in renal pelvis and renal calyx, and has the effect of treating both symptoms and root causes.

Detailed Description

The essence of the present invention will be further described in detail with reference to examples of the present invention, which are provided for illustration only and are not intended to limit the present invention.

Example 1

Step 1: 120g of longhairy antenoron herb, 18g of pyrrosia lingua, 18g of raw chicken's gizzard-membrane, 15g of raw oyster shell, 15g of climbing fern spore, 21g of astragalus, 15g of white paeony root, 9g of bitter orange, 30g of lalang grass rhizome, 6g of akebia stem, 9g of rhizoma alismatis, 9g of peach kernel, 9g of cowherb seed and 6g of dried ginger are subjected to pre-compatibility, and after cleaning, drying, sterilization and other cleaning procedures are respectively carried out, 75% by weight of longhairy antenoron herb raw material medicine of 90g is taken as the prefabricated raw material medicine of the longhairy antenoron herb, 1300g of water is added, decoction is concentrated to 25% by weight, dregs of decoction are removed to obtain longhairy antenoron herb extracting solution, and the medicinal solution and;

step 2: pulverizing the rest 30g herba Lysimachiae Christinae raw material and other raw materials into powder;

Example 2

Step 1: 140g of longhairy antenoron herb, 20g of pyrrosia lingua, 25g of raw chicken's gizzard-membrane, 18g of raw oyster shell, 18g of climbing fern spore, 25g of astragalus, 18g of white paeony root, 16g of bitter orange, 30g of lalang grass rhizome, 9g of akebia stem, 12g of rhizoma alismatis, 10g of peach kernel, 12g of cowherb seed and 9g of dried ginger are subjected to pre-compatibility, cleaning procedures such as cleaning, drying, sterilization and the like are respectively carried out, 65% by weight of the raw medicinal material of the longhairy antenoron herb is taken as the prefabricated raw medicinal material of the longhairy antenoron herb, 1400g of water is added, decoction is carried out and concentration is carried out until the original weight is 22%, dregs of decoction are removed to obtain a longhairy antenor;

step 2: pulverizing the rest 49g herba Lysimachiae Christinae raw material and other raw materials into powder;

Example 3

Step 1: 120g of longhairy antenoron herb, 18g of pyrrosia lingua, 18g of raw chicken's gizzard-membrane, 15g of raw oyster shell, 15g of climbing fern spore, 20g of astragalus, 15g of white paeony root, 8g of bitter orange, 24g of lalang grass rhizome, 7g of akebia stem, 10g of rhizoma alismatis, 8g of peach kernel, 9g of cowherb seed and 5g of dried ginger are subjected to pre-compatibility, and after cleaning, drying, sterilization and other cleaning procedures are respectively carried out, 75% of the weight of the longhairy antenoron herb raw material medicine is taken as the prefabricated longhairy antenoron herb raw material medicine, 1300g of water is added, the mixture is decocted and concentrated to 27%;

step 2: mixing the rest 30g of herba Lysimachiae Christinae raw material medicine and other raw material medicines, pouring all into the liquid medicine in step 1, further decocting and concentrating to 60% -70% of the original weight, and removing the residue to obtain medicine extract.

Example 4

Step 1: 140g of longhairy antenoron herb, 20g of pyrrosia lingua, 25g of raw chicken's gizzard-membrane, 18g of raw oyster shell, 18g of climbing fern spore, 25g of astragalus, 18g of white paeony root, 10g of bitter orange, 35g of lalang grass rhizome, 9g of akebia stem, 12g of rhizoma alismatis, 10g of peach kernel, 12g of cowherb seed and 9g of dried ginger are subjected to pre-compatibility, and after cleaning, drying, sterilization and other cleaning procedures are respectively carried out, 70% by weight of longhairy antenoron herb raw material medicine, namely 98g of longhairy antenoron herb raw material medicine, is taken as the prefabricated raw material medicine of longhairy antenoron herb, 1500g of.

Step 2: mixing the rest 42g of herba Lysimachiae Christinae raw material medicine and other raw materials, pouring into the liquid medicine of step 1, further decocting and concentrating to 60% -70% of the original weight, and removing the residue to obtain medicine extractive solution.

Example 5

Step 1: 135g of longhairy antenoron herb, 18g of pyrrosia lingua, 18g of raw chicken's gizzard-membrane, 15g of raw oyster shell, 15g of climbing fern spore, 21g of astragalus, 15g of white paeony root, 9g of bitter orange, 30g of cogongrass rhizome, 6g of akebia stem, 6g of rhizoma alismatis, 6g of peach kernel, 9g of cowherb seed and 6g of dried ginger are subjected to pre-compatibility, and after cleaning, drying, sterilization and other cleaning procedures are respectively carried out, 60% of the weight of the longhairy antenoron herb raw material is taken as the longhairy antenoron herb raw material, 1300g of water is added, the mixture is decocted and concentrated to 25% of the.

Step 2: mixing the rest 54g of herba Lysimachiae Christinae raw material medicine and other raw materials, pouring into the liquid medicine of step 1, further decocting and concentrating to 60% -70% of the original weight, and removing the residue to obtain medicine extractive solution.

Example 6

Step 1: 120g of longhairy antenoron herb, 18g of pyrrosia lingua, 18g of raw chicken's gizzard-membrane, 15g of raw oyster, 15g of spora lygodii, 21g of astragalus membranaceus, 15g of white paeony root, 9g of fructus aurantii, 20g of lalang grass rhizome, 6g of akebia stem, 9g of rhizoma alismatis, 9g of peach kernel, 9g of cowherb seed and 6g of dried ginger are subjected to pre-compatibility, and are respectively subjected to cleaning procedures such as cleaning, drying in the sun, sterilization and the like, and then are placed into a pulverizer to;

step 2: further pulverizing into 200 mesh medicinal micropowder, and encapsulating to obtain capsule.

Example 7

Step 1: 120g of longhairy antenoron herb, 18g of pyrrosia lingua, 18g of raw chicken's gizzard-membrane, 15g of raw oyster, 15g of spora lygodii, 21g of astragalus membranaceus, 15g of white paeony root, 12g of fructus aurantii, 30g of lalang grass rhizome, 6g of akebia stem, 9g of rhizoma alismatis, 9g of peach kernel, 15g of cowherb seed and 6g of dried ginger are subjected to pre-compatibility, and are respectively subjected to cleaning procedures such as cleaning, drying in the sun, sterilization and the like, and then are placed into a pulverizer to be pulverized to reach;

step 2: the medicine superfine powder prepared in the step 2 of the simple preparation method is put into a wet granulator by the weight parts of 100-120 parts of medicine superfine powder, 10-18 parts of pregelatinized starch and 2-5 parts of crospovidone, is mixed, is dried, the water content is controlled to be below 2%, then 1-2 parts of magnesium stearate is added for continuous mixing, and tablets are prepared by a tablet press.

Example 8

Step 1: 120g of longhairy antenoron herb, 18g of pyrrosia lingua, 20g of raw chicken's gizzard-membrane, 15g of raw oyster, 15g of spora lygodii, 20g of astragalus membranaceus, 15g of white paeony root, 8g of fructus aurantii, 30g of lalang grass rhizome, 7g of akebia stem, 10g of rhizoma alismatis, 8g of peach kernel, 9g of cowherb seed and 5g of dried ginger are subjected to pre-compatibility, and are respectively subjected to cleaning procedures such as cleaning, drying in the sun, sterilization and the like, and then are placed into a pulverizer to;

step 2: further pulverizing to 150 mesh or less, and making into medicinal powder.

Representative examples of therapeutic applications

The first treatment example is as follows: aged women aged 48 years old this year, where they went to be Onchi city, Guangdong province, and renal calculus was found by color ultrasonography in Shaxi Huaqiao Hospital, Chao' an district, 12 months and 6 days in 2019, and the diagnosis was "double-kidney silt-like calculus". Mild hydronephrosis of the left kidney. The obstruction of the lower ureter is not eliminated. After the patient takes the medicine pill for one half-month treatment course according to the method of the example 1, the patient can review the medicine pill from 1 month to 8 days in 2020 to Shaxi Huaqiao hospital in Chao' an area, and the color ultrasound results show that the bladder of double kidney and double ureters has no obvious abnormality.

The second treatment example: forestry women, 57 years old, native to Guangdong province Chaozhou city people, who was diagnosed as "right ureteral calculus with right kidney effusion, infection, 2. double kidney multiple small calculus" in 19.11 months in 2017 at Shantou city center hospital, and "ureteroscopic right ureteral calculus ballistic calculus combined holmium laser lithotripsy" was performed in the hospital, and pain of patients after surgery was temporarily relieved, but discharge diagnosis was still "1. right ureteral calculus with right kidney effusion, infection, 2. double kidney multiple small calculus". The double kidney stones were diagnosed by the ultrasonic diagnosis at Chao' an district Huaqiao hospital in Chaozhou city at 12, 22 days in 2018, and the sizes of the stones were about 0.5x0.4cm (left kidney), 0.4x0.4cm (left kidney) and 0.4x0.4cm (right kidney), respectively. Because acute onset lumbar colic has no effect of relieving pain, the inventor is asked for a doctor to prepare the medicine extracting solution according to the method of example 4 to treat the patient, and the pain of the patient is relieved after 1 dose of the medicine is taken for about 40 minutes. The inventor takes the pills prepared by the method of example 2 for one treatment course, and the symptoms do not relapse.

The third treatment example is as follows: mr.Wei, 60 years old this year, where it is in tidal range in Chaozhou city, Guangdong province, 4-19 days in 2020, awakens from sudden and severe pain in the upper right abdomen near the costal arch at 7 o' clock and 10 min in the morning, which makes the patient difficult to stand, accompanied by profuse sweating, difficult urination and difficult urination, and suffocating sensation in the lower abdomen. For the clinical diagnosis of the department of emergency treatment in the Shantou center, the pain is difficult to endure, and the pain is slightly relieved after 10 minutes because of the pain, and the pain is still difficult to endure within one hour. Emergency CT is shown as "1: double kidney stones, stones in right ureter and slight exudation around the stones. 2: left renal cyst. "renal colic is diagnosed. Adopts symptomatic treatment, pain is not reduced, dark yellow urine and dripping are not smooth, the urethra is scorched, and the feeling of oppression and distension is obvious. By introduction, the inventor prepares 3 doses of medicine extract immediately by the method of example 5 to treat the patient, 1 dose of medicine is taken at 9 o' clock at night, the urine discharge feeling is smooth after about 40 minutes, the urethra burning disappears, and the pain is obviously relieved. On day 2, except for lassitude and hypodynamia, the pain disappeared and the other symptoms were all lost; the tablets of example 7 are taken for a treatment course once a day, morning and evening, until the symptoms of renal colic do not recur.

Discussion of the related Art

Based on the curative effect evaluation and the representative application example, the medicine prepared by the composition can rapidly relieve ureterospasm to stop renal colic, and rapidly relieve pain of a patient after operation without relapse; the qi-tonifying and urgency-relieving group can quickly relieve the smooth muscle spasm of the renal pelvis, the bladder wall and the ureter, so that the calculus is loosened, the stimulation injury of the calculus to the ureter wall is reduced, and the angina is quickly relieved or even eliminated; the formula for promoting urination and activating blood circulation leads the urine in the renal pelvis and the bladder to be free of stranguria and catharsis by the force of activating blood and promoting blood circulation, the pressure in the renal pelvis and the bladder is reduced, and the nerve endings on the inner wall of the ureter are not pressed by the urine and rubbed and stimulated by stones, so that the pain is automatically stopped.

The group with qi tonifying and urgency relieving effects combines the group with diuresis promoting and blood circulation promoting effects of inducing diuresis for treating stranguria, relieving ureter pressure, assisting and rapidly discharging urine in bladder and ureter, and washing away small calculus to loosen it for easy discharge.

In the course of treatment, the medicine prepared by the composition can continuously reduce the supersaturation degree of endogenous calcium oxalate and other calcium salts, urate and cysteine, inhibit the generation of crystal particles and clear away damp heat so as to achieve the effects of dissolving stones, treating stranguria and relieving pain; the functions of clearing heat, promoting urination and treating stranguria and stopping bleeding are matched with the formula for promoting urination and activating blood circulation, so that the inner wall capillary of the ureter is not injured by calculus, and the formula for warming the middle-jiao and strengthening the body resistance can prevent various cold medicines from damaging the spleen and stomach; warming yang and dredging collaterals to promote blood circulation and promote diuresis; the channel warming and bleeding stopping can stop bleeding and promote the postoperative recovery of patients, and the effect of preventing the regeneration of kidney stone is achieved, so as to achieve the effect of treating both principal and secondary aspects of diseases.

Claims

1. The composition for rapidly relieving pain and treating or preventing the symptoms of the winkle is characterized by comprising the following raw material medicines in parts by weight:

2. The composition for rapidly relieving pain, treating or preventing rennetorpain as claimed in claim 1, which is composed of the following raw material medicines in parts by weight:

3. The composition for rapidly relieving pain, treating or preventing rennetorpain as claimed in claim 2, which is composed of the following raw material medicines in parts by weight:

4. The composition for rapidly relieving pain, treating or preventing rennetorpain as claimed in claim 2, which is composed of the following raw material medicines in parts by weight:

5. A medicament prepared from the composition as claimed in any one of claims 1 to 4.

6. A process for the preparation of a medicament according to claim 5, characterized by the following steps:

and step 3: and (3) pouring all the powder prepared in the step (2) into the longhairy antenoron herb honey extract prepared in the step (1), uniformly stirring, drying and preparing into a medicinal pill.

7. A process for the preparation of a medicament according to claim 5, characterized by the following steps:

8. A process for the preparation of a medicament according to claim 5, characterized by the following steps:

step 1: mixing the cleaned and dried raw materials according to the weight part ratio, mixing together, and crushing to 300-mesh and 500-mesh powder to prepare the medicine superfine powder;