CN104080789A - 作为布鲁顿酪氨酸激酶抑制剂的环状分子 - Google Patents
作为布鲁顿酪氨酸激酶抑制剂的环状分子 Download PDFInfo
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- CN104080789A CN104080789A CN201380007581.5A CN201380007581A CN104080789A CN 104080789 A CN104080789 A CN 104080789A CN 201380007581 A CN201380007581 A CN 201380007581A CN 104080789 A CN104080789 A CN 104080789A
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- ISDIBDPXVWNENH-UHFFFAOYSA-N C=CC(N(C1)CC1(CC1)CCC1[n](c1c2c(N)ncn1)nc2-c(cc1)ccc1Oc1ccccc1)=O Chemical compound C=CC(N(C1)CC1(CC1)CCC1[n](c1c2c(N)ncn1)nc2-c(cc1)ccc1Oc1ccccc1)=O ISDIBDPXVWNENH-UHFFFAOYSA-N 0.000 description 1
- 0 CC1C=CC(c2n[n](C3CCCC[C@]4(*CC*CCCC4)CCCCC3)c3c2c(N)ncn3)=CC1 Chemical compound CC1C=CC(c2n[n](C3CCCC[C@]4(*CC*CCCC4)CCCCC3)c3c2c(N)ncn3)=CC1 0.000 description 1
- YYVUOZULIDAKRN-UHFFFAOYSA-N Nc1ncnc2c1c(-c(cc1)ccc1Oc1ccccc1)n[nH]2 Chemical compound Nc1ncnc2c1c(-c(cc1)ccc1Oc1ccccc1)n[nH]2 YYVUOZULIDAKRN-UHFFFAOYSA-N 0.000 description 1
- LSEBXPBCIBOTIM-UHFFFAOYSA-N Nc1ncnc2c1c(-c(cc1)ccc1Oc1ccccc1)n[n]2C(C1)CC11CNCCC1 Chemical compound Nc1ncnc2c1c(-c(cc1)ccc1Oc1ccccc1)n[n]2C(C1)CC11CNCCC1 LSEBXPBCIBOTIM-UHFFFAOYSA-N 0.000 description 1
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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Abstract
Description
化合物 | ALK抑制,IC50 |
实施例1 | 98.5% |
实施例2 | 80.1% |
实施例3 | 96.4% |
实施例4A | 85.7% |
实施例4B | 97.9% |
Claims (17)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261632781P | 2012-01-31 | 2012-01-31 | |
US61/632,781 | 2012-01-31 | ||
PCT/CA2013/000085 WO2013113097A1 (en) | 2012-01-31 | 2013-01-30 | Cyclic molecules as bruton's tyrosine kinase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104080789A true CN104080789A (zh) | 2014-10-01 |
CN104080789B CN104080789B (zh) | 2016-05-11 |
Family
ID=48904331
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201380007581.5A Active CN104080789B (zh) | 2012-01-31 | 2013-01-30 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
Country Status (6)
Country | Link |
---|---|
US (1) | US9458162B2 (zh) |
EP (1) | EP2809673B1 (zh) |
JP (1) | JP5985658B2 (zh) |
CN (1) | CN104080789B (zh) |
CA (1) | CA2863239C (zh) |
WO (1) | WO2013113097A1 (zh) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106588914A (zh) * | 2015-10-16 | 2017-04-26 | 陈剑 | 具有取代吡啶并咪唑类衍生物,其制备及其在医药上的应用 |
WO2018033091A1 (zh) * | 2016-08-17 | 2018-02-22 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制酪氨酸激酶活性的稠合双环类化合物 |
CN108368086A (zh) * | 2015-12-16 | 2018-08-03 | 勃林格殷格翰国际有限公司 | 可用于治疗自身免疫疾病的二吡唑基衍生物 |
CN109310671A (zh) * | 2016-01-21 | 2019-02-05 | 淄博百极常生制药有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
CN110494433A (zh) * | 2017-03-22 | 2019-11-22 | 廖细斌 | 布鲁顿酪氨酸激酶抑制剂 |
WO2020015735A1 (zh) * | 2018-07-20 | 2020-01-23 | 正大天晴药业集团股份有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
CN110944999A (zh) * | 2017-08-01 | 2020-03-31 | 勃林格殷格翰国际有限公司 | 中间体化合物和方法 |
CN111454268A (zh) * | 2019-01-18 | 2020-07-28 | 明慧医药(上海)有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
US10793566B2 (en) | 2016-01-21 | 2020-10-06 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
CN113329748A (zh) * | 2018-10-10 | 2021-08-31 | 福马治疗股份有限公司 | 抑制脂肪酸合酶(fasn) |
WO2022253250A1 (zh) * | 2021-06-01 | 2022-12-08 | 正大天晴药业集团股份有限公司 | 含有并环或螺环的布鲁顿酪氨酸激酶降解剂 |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014025976A1 (en) | 2012-08-10 | 2014-02-13 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as bruton's tyrosine kinase (btk) inhibitors |
WO2014151620A1 (en) | 2013-03-14 | 2014-09-25 | Boehringer Ingelheim International Gmbh | 5-thiazolecarboxamide dervatives and their use as btk inhibitors |
WO2014152114A1 (en) * | 2013-03-15 | 2014-09-25 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as btk inhibitors |
EP3099674B1 (en) * | 2014-01-29 | 2018-10-24 | Boehringer Ingelheim International Gmbh | Pyrazole compounds as btk inhibitors |
JP6162904B2 (ja) * | 2014-02-03 | 2017-07-12 | カディラ ヘルスケア リミティド | 新規複素環式化合物 |
BR112017000470B1 (pt) * | 2014-07-07 | 2022-11-29 | Jiangsu Hengrui Medicine Co., Ltd | Compostos, composição farmacêutica e uso do composto ou da composição |
TWI578574B (zh) * | 2014-07-14 | 2017-04-11 | 新世紀光電股份有限公司 | 發光元件結構 |
WO2016106629A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Btk inhibitors |
WO2016106652A1 (en) * | 2014-12-31 | 2016-07-07 | Merck Sharp & Dohme Corp. | Biarylether imidazopyrazine btk inhibitors |
WO2017031138A1 (en) * | 2015-08-17 | 2017-02-23 | Infinite Arthroscopy Inc, Limited | Light source |
EP3414234B1 (en) * | 2015-10-14 | 2022-06-29 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
WO2017123695A1 (en) | 2016-01-13 | 2017-07-20 | Boehringer Ingelheim International Gmbh | Isoquinolones as btk inhibitors |
CN107021963A (zh) | 2016-01-29 | 2017-08-08 | 北京诺诚健华医药科技有限公司 | 吡唑稠环类衍生物、其制备方法及其在治疗癌症、炎症和免疫性疾病上的应用 |
CN115746000A (zh) | 2016-03-11 | 2023-03-07 | 嘉兴和剂药业有限公司 | 用于调节布鲁顿酪氨酸激酶的化合物及方法 |
KR102558066B1 (ko) | 2016-03-28 | 2023-07-25 | 인사이트 코포레이션 | Tam 억제제로서 피롤로트리아진 화합물 |
CA2939286A1 (en) * | 2016-08-17 | 2018-02-17 | Pharmascience Inc. | Spirocyclic containing compounds and pharmaceutical uses thereof |
CN110545826A (zh) | 2016-12-03 | 2019-12-06 | 朱诺治疗学股份有限公司 | 用于与激酶抑制剂组合使用治疗性t细胞的方法和组合物 |
CN106831787B (zh) * | 2017-01-20 | 2018-10-23 | 成都倍特药业有限公司 | 用作布鲁顿酪氨酸激酶抑制剂的化合物及其制备方法和应用 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030153752A1 (en) * | 1998-09-18 | 2003-08-14 | Hirst Gavin C. | Pyrrolopyrimidines as therapeutic agents |
CN101610676A (zh) * | 2006-09-22 | 2009-12-23 | 药品循环公司 | 布鲁顿酪氨酸激酶的抑制剂 |
CN101883774A (zh) * | 2007-10-16 | 2010-11-10 | 惠氏有限责任公司 | 噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途 |
CN102159214A (zh) * | 2008-07-16 | 2011-08-17 | 药品循环公司 | 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2002526500A (ja) * | 1998-09-18 | 2002-08-20 | ビーエーエスエフ アクチェンゲゼルシャフト | プロテインキナーゼ阻害剤としてのピロロピリミジン |
US6921763B2 (en) * | 1999-09-17 | 2005-07-26 | Abbott Laboratories | Pyrazolopyrimidines as therapeutic agents |
JP2007520559A (ja) * | 2004-02-03 | 2007-07-26 | アボット・ラボラトリーズ | 治療薬としてのアミノベンゾオキサゾール類 |
AU2009270984A1 (en) | 2008-07-16 | 2010-01-21 | Schering Corporation | Bicyclic Heterocycle Derivatives and methods of use thereof |
BR112012005400A2 (pt) | 2009-09-10 | 2016-04-05 | Irm Llc | derivados do tipo éter de heteroarilas bicíclicas |
JP2013512215A (ja) * | 2009-11-25 | 2013-04-11 | ノバルティス アーゲー | 二環式ヘテロアリールのベンゼン縮合6員酸素含有ヘテロ環誘導体 |
KR20140036269A (ko) * | 2011-07-01 | 2014-03-25 | 바이엘 인텔렉쳐 프로퍼티 게엠베하 | Alk1 억제제로서의 히드록시메틸아릴-치환된 피롤로트리아진 |
EP2548877A1 (en) | 2011-07-19 | 2013-01-23 | MSD Oss B.V. | 4-(5-Membered fused pyridinyl)benzamides as BTK-inhibitors |
-
2013
- 2013-01-30 JP JP2014555045A patent/JP5985658B2/ja not_active Expired - Fee Related
- 2013-01-30 US US14/375,539 patent/US9458162B2/en active Active
- 2013-01-30 CN CN201380007581.5A patent/CN104080789B/zh active Active
- 2013-01-30 EP EP13743950.1A patent/EP2809673B1/en not_active Not-in-force
- 2013-01-30 WO PCT/CA2013/000085 patent/WO2013113097A1/en active Application Filing
- 2013-01-30 CA CA2863239A patent/CA2863239C/en not_active Expired - Fee Related
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030153752A1 (en) * | 1998-09-18 | 2003-08-14 | Hirst Gavin C. | Pyrrolopyrimidines as therapeutic agents |
CN101610676A (zh) * | 2006-09-22 | 2009-12-23 | 药品循环公司 | 布鲁顿酪氨酸激酶的抑制剂 |
CN101883774A (zh) * | 2007-10-16 | 2010-11-10 | 惠氏有限责任公司 | 噻吩并嘧啶和吡唑并嘧啶化合物及其用作mtor激酶和pi3激酶抑制剂的用途 |
CN102159214A (zh) * | 2008-07-16 | 2011-08-17 | 药品循环公司 | 用于实体肿瘤的治疗的布鲁顿酪氨酸激酶的抑制剂 |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106588914B (zh) * | 2015-10-16 | 2018-11-02 | 陈剑 | 具有取代吡啶并咪唑类衍生物,其制备及其在医药上的应用 |
CN106588914A (zh) * | 2015-10-16 | 2017-04-26 | 陈剑 | 具有取代吡啶并咪唑类衍生物,其制备及其在医药上的应用 |
CN108368086B (zh) * | 2015-12-16 | 2021-01-08 | 勃林格殷格翰国际有限公司 | 可用于治疗自身免疫疾病的二吡唑基衍生物 |
CN108368086A (zh) * | 2015-12-16 | 2018-08-03 | 勃林格殷格翰国际有限公司 | 可用于治疗自身免疫疾病的二吡唑基衍生物 |
US10793566B2 (en) | 2016-01-21 | 2020-10-06 | Zibo Biopolar Changsheng Pharmaceutical Co. Ltd. | Bruton's tyrosine kinase inhibitors |
CN109310671A (zh) * | 2016-01-21 | 2019-02-05 | 淄博百极常生制药有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
US11186578B2 (en) | 2016-08-17 | 2021-11-30 | Shenzhen Targetrx, Inc. | Substituted pyrrolo[3,2-d]pyrimidines and pyrazolo[4,3-d]pyrimidines as tyrosine kinase inhibitors |
CN108368119A (zh) * | 2016-08-17 | 2018-08-03 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制酪氨酸激酶活性的稠合双环类化合物 |
WO2018033091A1 (zh) * | 2016-08-17 | 2018-02-22 | 深圳市塔吉瑞生物医药有限公司 | 用于抑制酪氨酸激酶活性的稠合双环类化合物 |
US11554118B2 (en) | 2017-03-22 | 2023-01-17 | Xibin Liao | Bruton's tyrosine kinase inhibitors |
CN110494433A (zh) * | 2017-03-22 | 2019-11-22 | 廖细斌 | 布鲁顿酪氨酸激酶抑制剂 |
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CN110944999A (zh) * | 2017-08-01 | 2020-03-31 | 勃林格殷格翰国际有限公司 | 中间体化合物和方法 |
US11603354B2 (en) | 2017-08-01 | 2023-03-14 | Boehringer Ingelheim International Gmbh | Intermediate compounds and methods |
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WO2020015735A1 (zh) * | 2018-07-20 | 2020-01-23 | 正大天晴药业集团股份有限公司 | 布鲁顿酪氨酸激酶抑制剂 |
CN113329748A (zh) * | 2018-10-10 | 2021-08-31 | 福马治疗股份有限公司 | 抑制脂肪酸合酶(fasn) |
CN111454268A (zh) * | 2019-01-18 | 2020-07-28 | 明慧医药(上海)有限公司 | 作为布鲁顿酪氨酸激酶抑制剂的环状分子 |
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Also Published As
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JP2015509107A (ja) | 2015-03-26 |
JP5985658B2 (ja) | 2016-09-06 |
WO2013113097A1 (en) | 2013-08-08 |
US20150011530A1 (en) | 2015-01-08 |
CA2863239C (en) | 2016-09-13 |
CN104080789B (zh) | 2016-05-11 |
EP2809673A4 (en) | 2015-07-08 |
CA2863239A1 (en) | 2013-08-08 |
EP2809673B1 (en) | 2016-11-02 |
US9458162B2 (en) | 2016-10-04 |
EP2809673A1 (en) | 2014-12-10 |
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