CN104069240A

CN104069240A - Traditional Chinese medicine gargle for preventing chemotherapy-induced stomatitis

Info

Publication number: CN104069240A
Application number: CN201410286973.6A
Authority: CN
Inventors: 刘玉莲
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-06-16
Filing date: 2014-06-16
Publication date: 2014-10-01
Anticipated expiration: 2034-06-16
Also published as: CN104069240B

Abstract

The invention discloses traditional Chinese medicine gargle for preventing chemotherapy-induced stomatitis. The marrow hemopoietic function is inhibited by chemotherapy drugs, the leukocyte is reduced, the resistance of patients is reduced, gastrointestinal reaction is added, salivary secretion is reduced, the self-cleaning effect of an oral cavity is weakened, bacteria are rapidly reproduced in the oral cavity, fermentation and acid production effects are enhanced, oral mucosa is damaged and oral ulcer is formed. The gargle disclosed by the invention is prepared from the following traditional Chinese medicines with the effects of clearing heat and dry dampness and removing toxicity: brittle falsepimpernel herb, small-leaved desmodium, pilosella-leaved drymoglossum herb, wideword parnassia herb, thymifoious euphorbia herb and catchweed bedstraw herb. Proven by clinical tests, the gargle has the advantages that the ulcer morbidity of treatment groups is obviously lower than those of control groups; the gargle is low in treatment cost and less in side effect.

Description

The Chinese medical collutory of stomatitis due to a kind of Prophylactic chemotherapy

Technical field

The present invention relates to a kind of Chinese medicine composition, relate in particular to the Chinese medical collutory of stomatitis due to a kind of Prophylactic chemotherapy.

Background technology

One of modal complication when stomatitis is malignant tumor patient chemotherapy, not only affects patient's feed, even hinders next step treatment, as infects, and also can cause the serious consequences such as septicemia.I find through clinical observation for many years, utilize stomatitis due to Chinese medical collutory Prophylactic chemotherapy to have good curative effect.

Summary of the invention

The Chinese medical collutory that the object of this invention is to provide stomatitis due to a kind of Prophylactic chemotherapy.Chemotherapeutics suppresses hemopoietic function of bone marrow, make leukopenia, patient's resistance reduces, and adds gastrointestinal reaction, patient's feed, drinking-water reduce, salivation reduces, and oral cavity self-cleaning action weakens, and antibacterial is breeding rapidly in oral cavity, fermentation, acid production strengthen, intraoral microenvironment changes, and has weakened the defense function in oral cavity, and oral pH reduces and to cause oral mucosa impaired and form oral ulcer.The traditional Chinese medical science thinks that aphtha of the mouth and tongue is due to internal organs intenseness of heat, and heat is taken advantage of heart spleen, and gas rushes due to the dispute, and controlling should heat clearing and damp drying, removing toxic substances is main.

The object of the invention is to be achieved through the following technical solutions, the Chinese medical collutory of stomatitis is made by the Chinese medicine of following weight portion due to this Prophylactic chemotherapy: Herba Linderniae Crustaceae 3-9 part, Herba desmodii microphylli 9-15 part, Drymoglossum Herba Drymoglossi 15-30 part, Herba parnassiae 7-10 part, Herba Euphorbiae Thymifoliae 25-30 part, Herba Galii Teneri 10-15 part.

Preferred: 6 parts of Herba Linderniae Crustaceaes, 12 parts of Herba desmodii microphyllis, 22.5 parts of Drymoglossum Herba Drymoglossis, 8.5 parts of Herba parnassiaes, 27 parts of Herba Euphorbiae Thymifoliaes, 12.5 parts of Herba Galii Teneris

Preparation method: make decoction by traditional preparation method decocting.

In side: Herba Linderniae Crustaceae, Herba desmodii microphylli, Drymoglossum Herba Drymoglossi: clearing away heat-damp and promoting diuresis, removing toxic substances; Herba parnassiae, Herba Euphorbiae Thymifoliae: clearing away heat and cooling blood, removing toxic substances and promoting subsidence of swelling; Herba Galii Teneri: clearing away damp-heat, dissipating blood stasis for subsidence of swelling.

Clinical data

1. physical data in January, 2010-2012 Wo section in year June accepts tumour patient 64 examples of chemotherapy, male 30 examples, female's 34 examples, 31 years old～68 years old age, 42 years old mean age in hospital; Wherein, malignant lymphoma 34 examples, breast carcinoma 28 examples, pulmonary carcinoma 2 examples, all patients all make a definite diagnosis through pathologic finding.Chemotherapy regimen: malignant lymphoma gives CHOP (cyclophosphamide, vincristine, amycin, prednisone); Breast carcinoma gives CMF (cyclophosphamide, methotrexate, fluorouracil), and pulmonary carcinoma gives CAP (cyclophosphamide, amycin, cisplatin) scheme chemotherapy.Chemotherapeutics consumption and usage operative norm scheme.64 routine patients are divided into treatment group and matched group at random, every group of each 32 examples, two groups of patient genders, age, sick kind, chemotherapy regimen used, healths are learned processing not statistically significant by statistics, have comparability.

2. diagnostic criteria 0 is spent: oral mucosa is normal.I degree: erythema, pain appear in oral mucosa; II degree: erythema, ulcer appear in oral mucosa, can enter general diet; III degree: stomatocace, can only eat by influent stream; IV degree: occur ulcer, patient can not take food.

3. the routine patient of Therapeutic Method treatment group 32 starts to use Chinese medical collutory of the present invention from chemotherapy first day, take Herba Linderniae Crustaceae 6g, Herba desmodii microphylli 12g, Drymoglossum Herba Drymoglossi 22.5g, Herba parnassiae 8.5g, Herba Euphorbiae Thymifoliae 27g, Herba Galii Teneri 12.5g, add water 400ml～500ml and decoct into 200ml～300ml, dress aseptic bottle is standby.Gargle every day 5 times, three after the meal and respectively gargle once for 10 o'clock, 16 o'clock.The method of gargling: advise patient to suck collutory 30ml at every turn, rinsing the mouth 3min, and stir at tooth, cheek, each face of palate with tongue, drum spues after gargling, to chemotherapy one end cycle.Matched group 32 example Dobell's solution rinsing the mouth, time, the same experimental group of method.Two groups of patients equal every day early, respectively brush teeth 1 evening, smoking cessation, wine and pungent irritable food.Make regular check on oral cavity and have or not ulcer and other discomforts, once there is ulcer, except continuation is gargled by above-mentioned time and method, stop early, brush teeth evening, changes and do mouth care each 1 time sooner or later, ulcer surface ice-glazed sulphur is loose, observe at any time ulcer surface healing state, listen attentively to patient main suit.

4. the scorching incidence rate of two groups of patient's mouths of therapeutic outcome adopts χ ²check, treatment group stomatitis incidence rate (9.38%) is starkly lower than matched group (25%), and two groups relatively have statistical significance (P < 0.01).Concrete correction data is in Table 1.

The table 1 liang scorching incidence rate comparison of group patient's mouth

Note: with treatment group comparison, P < 0.05.

5. untoward reaction: untoward reaction does not occur during treatment, and patient all can tolerate.

The specific embodiment

Embodiment mono-: take Herba Linderniae Crustaceae 6g, Herba desmodii microphylli 12g, Drymoglossum Herba Drymoglossi 22.5g, Herba parnassiae 8.5g, Herba Euphorbiae Thymifoliae 27g, Herba Galii Teneri 12.5g, by traditional preparation method decocting, make decoction.

Embodiment bis-: take Herba Linderniae Crustaceae 3g, Herba desmodii microphylli 9g, Drymoglossum Herba Drymoglossi 15g, Herba parnassiae 10g, Herba Euphorbiae Thymifoliae 25g, Herba Galii Teneri 15g, by traditional preparation method decocting, make decoction.

Embodiment tri-: take Herba Linderniae Crustaceae 9g, Herba desmodii microphylli 15g, Drymoglossum Herba Drymoglossi 30g, Herba parnassiae 7g, Herba Euphorbiae Thymifoliae 30g, Herba Galii Teneri 10g, by traditional preparation method decocting, make decoction.

Claims

1. a Chinese medical collutory for stomatitis due to Prophylactic chemotherapy, is characterized in that this Chinese medical collutory made by the Chinese medicine of following weight portion: Herba Linderniae Crustaceae 3-9 part, Herba desmodii microphylli 9-15 part, Drymoglossum Herba Drymoglossi 15-30 part, Herba parnassiae 7-10 part, Herba Euphorbiae Thymifoliae 25-30 part, Herba Galii Teneri 10-15 part.

2. the Chinese medical collutory of stomatitis due to a kind of Prophylactic chemotherapy according to claim 1, is characterized in that this Chinese medical collutory made by the Chinese medicine of following weight portion: 6 parts of Herba Linderniae Crustaceaes, 12 parts of Herba desmodii microphyllis, 22.5 parts of Drymoglossum Herba Drymoglossis, 8.5 parts of Herba parnassiaes, 27 parts of Herba Euphorbiae Thymifoliaes, 12.5 parts of Herba Galii Teneris.