CN104068306A - Health food for improving bone density and preparation method of health food - Google Patents
Health food for improving bone density and preparation method of health food Download PDFInfo
- Publication number
- CN104068306A CN104068306A CN201410274352.6A CN201410274352A CN104068306A CN 104068306 A CN104068306 A CN 104068306A CN 201410274352 A CN201410274352 A CN 201410274352A CN 104068306 A CN104068306 A CN 104068306A
- Authority
- CN
- China
- Prior art keywords
- calcium
- health food
- bone density
- parts
- mix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000037182 bone density Effects 0.000 title claims abstract description 91
- 235000013402 health food Nutrition 0.000 title claims abstract description 64
- 238000002360 preparation method Methods 0.000 title claims abstract description 24
- 239000000463 material Substances 0.000 claims abstract description 50
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 48
- 239000011248 coating agent Substances 0.000 claims abstract description 46
- 238000000576 coating method Methods 0.000 claims abstract description 46
- VSGNNIFQASZAOI-UHFFFAOYSA-L calcium acetate Chemical compound [Ca+2].CC([O-])=O.CC([O-])=O VSGNNIFQASZAOI-UHFFFAOYSA-L 0.000 claims abstract description 43
- 235000011092 calcium acetate Nutrition 0.000 claims abstract description 43
- 229920001287 Chondroitin sulfate Polymers 0.000 claims abstract description 38
- 239000001639 calcium acetate Substances 0.000 claims abstract description 36
- 229960005147 calcium acetate Drugs 0.000 claims abstract description 36
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims abstract description 31
- 229940059329 chondroitin sulfate Drugs 0.000 claims abstract description 31
- 239000008187 granular material Substances 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 28
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 24
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 24
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 24
- 239000011718 vitamin C Substances 0.000 claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 23
- 239000004480 active ingredient Substances 0.000 claims abstract description 14
- 230000001965 increasing effect Effects 0.000 claims abstract description 14
- -1 tabletting Substances 0.000 claims abstract description 6
- 239000000203 mixture Substances 0.000 claims description 88
- 229920002451 polyvinyl alcohol Polymers 0.000 claims description 61
- 239000002245 particle Substances 0.000 claims description 38
- 235000020985 whole grains Nutrition 0.000 claims description 38
- CHVZQMAANSUXJU-JJKGCWMISA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanamide;hydrochloride Chemical class Cl.NC(=O)[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO CHVZQMAANSUXJU-JJKGCWMISA-N 0.000 claims description 35
- 229920000881 Modified starch Polymers 0.000 claims description 27
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 claims description 25
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 25
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 25
- 239000007921 spray Substances 0.000 claims description 25
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 24
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 24
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims description 22
- 239000007888 film coating Substances 0.000 claims description 21
- 238000009501 film coating Methods 0.000 claims description 21
- 239000011812 mixed powder Substances 0.000 claims description 16
- 239000000686 essence Substances 0.000 claims description 15
- 239000007788 liquid Substances 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- 239000008188 pellet Substances 0.000 claims description 12
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 239000002253 acid Substances 0.000 claims description 7
- 229940107200 chondroitin sulfates Drugs 0.000 claims description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 6
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims description 6
- 235000005979 Citrus limon Nutrition 0.000 claims description 6
- 244000131522 Citrus pyriformis Species 0.000 claims description 6
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 6
- 239000002202 Polyethylene glycol Substances 0.000 claims description 6
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000853 adhesive Substances 0.000 claims description 6
- 230000001070 adhesive effect Effects 0.000 claims description 6
- 239000003963 antioxidant agent Substances 0.000 claims description 6
- 230000003078 antioxidant effect Effects 0.000 claims description 6
- 235000006708 antioxidants Nutrition 0.000 claims description 6
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 6
- 235000009508 confectionery Nutrition 0.000 claims description 6
- 239000003085 diluting agent Substances 0.000 claims description 6
- 239000000284 extract Substances 0.000 claims description 6
- 239000000945 filler Substances 0.000 claims description 6
- 239000000576 food coloring agent Substances 0.000 claims description 6
- 235000003599 food sweetener Nutrition 0.000 claims description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 claims description 6
- 239000000314 lubricant Substances 0.000 claims description 6
- 239000004014 plasticizer Substances 0.000 claims description 6
- 229920001223 polyethylene glycol Polymers 0.000 claims description 6
- 239000000375 suspending agent Substances 0.000 claims description 6
- 239000003765 sweetening agent Substances 0.000 claims description 6
- 229940088594 vitamin Drugs 0.000 claims description 6
- 229930003231 vitamin Natural products 0.000 claims description 6
- 235000013343 vitamin Nutrition 0.000 claims description 6
- 239000011782 vitamin Substances 0.000 claims description 6
- 150000003722 vitamin derivatives Chemical class 0.000 claims description 6
- 229920002472 Starch Polymers 0.000 claims description 5
- 239000008107 starch Substances 0.000 claims description 5
- 235000019698 starch Nutrition 0.000 claims description 5
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims description 3
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 3
- KKAJSJJFBSOMGS-UHFFFAOYSA-N 3,6-diamino-10-methylacridinium chloride Chemical compound [Cl-].C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 KKAJSJJFBSOMGS-UHFFFAOYSA-N 0.000 claims description 3
- AHRFRRASJMTTQU-UHFFFAOYSA-N 6-methyl-2,2-dioxooxathiazin-4-one;potassium Chemical compound [K].CC1=CC(=O)NS(=O)(=O)O1 AHRFRRASJMTTQU-UHFFFAOYSA-N 0.000 claims description 3
- 108010011485 Aspartame Proteins 0.000 claims description 3
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 claims description 3
- 239000005711 Benzoic acid Substances 0.000 claims description 3
- SEBIKDIMAPSUBY-ARYZWOCPSA-N Crocin Chemical compound C([C@H]1O[C@H]([C@@H]([C@@H](O)[C@@H]1O)O)OC(=O)C(C)=CC=CC(C)=C\C=C\C=C(/C)\C=C\C=C(C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O2)O)O1)O)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SEBIKDIMAPSUBY-ARYZWOCPSA-N 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- 239000004375 Dextrin Substances 0.000 claims description 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 3
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims description 3
- 235000016623 Fragaria vesca Nutrition 0.000 claims description 3
- 240000009088 Fragaria x ananassa Species 0.000 claims description 3
- 235000011363 Fragaria x ananassa Nutrition 0.000 claims description 3
- 229930091371 Fructose Natural products 0.000 claims description 3
- 239000005715 Fructose Substances 0.000 claims description 3
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
- 241000168517 Haematococcus lacustris Species 0.000 claims description 3
- XINCECQTMHSORG-UHFFFAOYSA-N Isoamyl isovalerate Chemical compound CC(C)CCOC(=O)CC(C)C XINCECQTMHSORG-UHFFFAOYSA-N 0.000 claims description 3
- 229920003081 Povidone K 30 Polymers 0.000 claims description 3
- 235000021355 Stearic acid Nutrition 0.000 claims description 3
- 239000004383 Steviol glycoside Substances 0.000 claims description 3
- 239000004376 Sucralose Substances 0.000 claims description 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 3
- 240000000851 Vaccinium corymbosum Species 0.000 claims description 3
- 235000003095 Vaccinium corymbosum Nutrition 0.000 claims description 3
- 235000017537 Vaccinium myrtillus Nutrition 0.000 claims description 3
- 229930003427 Vitamin E Natural products 0.000 claims description 3
- 244000273928 Zingiber officinale Species 0.000 claims description 3
- 235000006886 Zingiber officinale Nutrition 0.000 claims description 3
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims description 3
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 claims description 3
- 239000000605 aspartame Substances 0.000 claims description 3
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims description 3
- 235000010357 aspartame Nutrition 0.000 claims description 3
- 229960003438 aspartame Drugs 0.000 claims description 3
- 235000013793 astaxanthin Nutrition 0.000 claims description 3
- 239000001168 astaxanthin Substances 0.000 claims description 3
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 claims description 3
- 229940022405 astaxanthin Drugs 0.000 claims description 3
- 235000013871 bee wax Nutrition 0.000 claims description 3
- 239000012166 beeswax Substances 0.000 claims description 3
- 235000010233 benzoic acid Nutrition 0.000 claims description 3
- 229960004365 benzoic acid Drugs 0.000 claims description 3
- 235000013734 beta-carotene Nutrition 0.000 claims description 3
- 239000011648 beta-carotene Substances 0.000 claims description 3
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 claims description 3
- 229960002747 betacarotene Drugs 0.000 claims description 3
- 239000001055 blue pigment Substances 0.000 claims description 3
- 235000021014 blueberries Nutrition 0.000 claims description 3
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 3
- 235000012730 carminic acid Nutrition 0.000 claims description 3
- 235000015165 citric acid Nutrition 0.000 claims description 3
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 3
- 238000004040 coloring Methods 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- FPAFDBFIGPHWGO-UHFFFAOYSA-N dioxosilane;oxomagnesium;hydrate Chemical compound O.[Mg]=O.[Mg]=O.[Mg]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O FPAFDBFIGPHWGO-UHFFFAOYSA-N 0.000 claims description 3
- 239000008157 edible vegetable oil Substances 0.000 claims description 3
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims description 3
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 3
- 239000001530 fumaric acid Substances 0.000 claims description 3
- 235000011087 fumaric acid Nutrition 0.000 claims description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 3
- 239000009627 gardenia yellow Substances 0.000 claims description 3
- 235000008397 ginger Nutrition 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 239000007887 hard shell capsule Substances 0.000 claims description 3
- 239000004310 lactic acid Substances 0.000 claims description 3
- 235000014655 lactic acid Nutrition 0.000 claims description 3
- 235000012680 lutein Nutrition 0.000 claims description 3
- 239000001656 lutein Substances 0.000 claims description 3
- 229960005375 lutein Drugs 0.000 claims description 3
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 claims description 3
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 claims description 3
- QUIOHQITLKCGNW-TYYBGVCCSA-L magnesium;(e)-but-2-enedioate Chemical compound [Mg+2].[O-]C(=O)\C=C\C([O-])=O QUIOHQITLKCGNW-TYYBGVCCSA-L 0.000 claims description 3
- 235000015091 medicinal tea Nutrition 0.000 claims description 3
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical class COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 3
- 229930189775 mogroside Natural products 0.000 claims description 3
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 3
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
- 238000005453 pelletization Methods 0.000 claims description 3
- 239000000049 pigment Substances 0.000 claims description 3
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 3
- 235000010241 potassium sorbate Nutrition 0.000 claims description 3
- 239000004302 potassium sorbate Substances 0.000 claims description 3
- 229940069338 potassium sorbate Drugs 0.000 claims description 3
- 239000001054 red pigment Substances 0.000 claims description 3
- 239000000377 silicon dioxide Substances 0.000 claims description 3
- 239000000661 sodium alginate Substances 0.000 claims description 3
- 235000010413 sodium alginate Nutrition 0.000 claims description 3
- 229940005550 sodium alginate Drugs 0.000 claims description 3
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 3
- 239000004299 sodium benzoate Substances 0.000 claims description 3
- 235000010234 sodium benzoate Nutrition 0.000 claims description 3
- 229960003885 sodium benzoate Drugs 0.000 claims description 3
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 claims description 3
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 claims description 3
- 239000007901 soft capsule Substances 0.000 claims description 3
- 235000010199 sorbic acid Nutrition 0.000 claims description 3
- 239000004334 sorbic acid Substances 0.000 claims description 3
- 229940075582 sorbic acid Drugs 0.000 claims description 3
- 239000008117 stearic acid Substances 0.000 claims description 3
- 235000019411 steviol glycoside Nutrition 0.000 claims description 3
- 229930182488 steviol glycoside Natural products 0.000 claims description 3
- 150000008144 steviol glycosides Chemical class 0.000 claims description 3
- 235000019202 steviosides Nutrition 0.000 claims description 3
- 235000019408 sucralose Nutrition 0.000 claims description 3
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 claims description 3
- 239000011975 tartaric acid Substances 0.000 claims description 3
- 235000002906 tartaric acid Nutrition 0.000 claims description 3
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims description 3
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 claims description 3
- 235000019165 vitamin E Nutrition 0.000 claims description 3
- 229940046009 vitamin E Drugs 0.000 claims description 3
- 239000011709 vitamin E Substances 0.000 claims description 3
- 235000014101 wine Nutrition 0.000 claims description 3
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 claims description 3
- 239000001052 yellow pigment Substances 0.000 claims description 3
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims description 3
- 239000011575 calcium Substances 0.000 abstract description 111
- 229910052791 calcium Inorganic materials 0.000 abstract description 111
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract description 110
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 38
- 239000005018 casein Substances 0.000 abstract description 35
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 abstract description 35
- 235000021240 caseins Nutrition 0.000 abstract description 35
- 238000010521 absorption reaction Methods 0.000 abstract description 32
- 230000000694 effects Effects 0.000 abstract description 25
- 238000002156 mixing Methods 0.000 abstract description 22
- 230000006872 improvement Effects 0.000 abstract description 2
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 abstract 2
- CBOJBBMQJBVCMW-BTVCFUMJSA-N (2r,3r,4s,5r)-2-amino-3,4,5,6-tetrahydroxyhexanal;hydrochloride Chemical compound Cl.O=C[C@H](N)[C@@H](O)[C@H](O)[C@H](O)CO CBOJBBMQJBVCMW-BTVCFUMJSA-N 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229960001911 glucosamine hydrochloride Drugs 0.000 abstract 1
- 235000019359 magnesium stearate Nutrition 0.000 abstract 1
- 229960005069 calcium Drugs 0.000 description 104
- 102400000112 Katacalcin Human genes 0.000 description 58
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 49
- 241000700159 Rattus Species 0.000 description 34
- 108010076119 Caseins Proteins 0.000 description 31
- 239000000243 solution Substances 0.000 description 31
- 235000018102 proteins Nutrition 0.000 description 27
- 108090000623 proteins and genes Proteins 0.000 description 27
- 102000004169 proteins and genes Human genes 0.000 description 27
- 210000000988 bone and bone Anatomy 0.000 description 26
- 229910000019 calcium carbonate Inorganic materials 0.000 description 24
- 208000001132 Osteoporosis Diseases 0.000 description 18
- 210000000689 upper leg Anatomy 0.000 description 18
- 239000000047 product Substances 0.000 description 17
- 239000002904 solvent Substances 0.000 description 17
- 239000011122 softwood Substances 0.000 description 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 14
- 238000002474 experimental method Methods 0.000 description 13
- 239000008367 deionised water Substances 0.000 description 12
- 229910021641 deionized water Inorganic materials 0.000 description 12
- 238000011049 filling Methods 0.000 description 10
- 238000000034 method Methods 0.000 description 10
- 238000012360 testing method Methods 0.000 description 10
- 241001465754 Metazoa Species 0.000 description 9
- 230000014759 maintenance of location Effects 0.000 description 9
- 239000008213 purified water Substances 0.000 description 9
- 238000003756 stirring Methods 0.000 description 9
- 108010033929 calcium caseinate Proteins 0.000 description 8
- 238000003304 gavage Methods 0.000 description 8
- 230000036541 health Effects 0.000 description 8
- 239000003814 drug Substances 0.000 description 7
- 230000002708 enhancing effect Effects 0.000 description 6
- 239000002689 soil Substances 0.000 description 6
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 5
- 230000037396 body weight Effects 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 231100000957 no side effect Toxicity 0.000 description 5
- 230000002265 prevention Effects 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 239000013589 supplement Substances 0.000 description 5
- 210000004051 gastric juice Anatomy 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- MRELNEQAGSRDBK-UHFFFAOYSA-N lanthanum(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[La+3].[La+3] MRELNEQAGSRDBK-UHFFFAOYSA-N 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 3
- 241000270295 Serpentes Species 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000006870 function Effects 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 230000004060 metabolic process Effects 0.000 description 3
- 239000011574 phosphorus Substances 0.000 description 3
- 229910052698 phosphorus Inorganic materials 0.000 description 3
- 238000011160 research Methods 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 3
- MSWZFWKMSRAUBD-UHFFFAOYSA-N 2-Amino-2-Deoxy-Hexose Chemical compound NC1C(O)OC(CO)C(O)C1O MSWZFWKMSRAUBD-UHFFFAOYSA-N 0.000 description 2
- QWJSAWXRUVVRLH-LREBCSMRSA-M 2-hydroxyethyl(trimethyl)azanium;(2r,3r)-2,3,4-trihydroxy-4-oxobutanoate Chemical compound C[N+](C)(C)CCO.OC(=O)[C@H](O)[C@@H](O)C([O-])=O QWJSAWXRUVVRLH-LREBCSMRSA-M 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 2
- DKHJWWRYTONYHB-UHFFFAOYSA-N CPP Chemical compound OC(=O)C(C)OC1=CC=C(Cl)C=C1 DKHJWWRYTONYHB-UHFFFAOYSA-N 0.000 description 2
- 229920002261 Corn starch Polymers 0.000 description 2
- 239000004470 DL Methionine Substances 0.000 description 2
- 206010017076 Fracture Diseases 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 102000003982 Parathyroid hormone Human genes 0.000 description 2
- 108090000445 Parathyroid hormone Proteins 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- MCMNRKCIXSYSNV-UHFFFAOYSA-N Zirconium dioxide Chemical compound O=[Zr]=O MCMNRKCIXSYSNV-UHFFFAOYSA-N 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000002146 bilateral effect Effects 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 239000002775 capsule Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000008120 corn starch Substances 0.000 description 2
- 229940099112 cornstarch Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000002124 endocrine Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000037406 food intake Effects 0.000 description 2
- 235000012631 food intake Nutrition 0.000 description 2
- 230000002496 gastric effect Effects 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000012423 maintenance Methods 0.000 description 2
- FFEARJCKVFRZRR-UHFFFAOYSA-N methionine Chemical compound CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 description 2
- 229930182817 methionine Natural products 0.000 description 2
- 235000006109 methionine Nutrition 0.000 description 2
- 230000008520 organization Effects 0.000 description 2
- 210000001672 ovary Anatomy 0.000 description 2
- 239000000199 parathyroid hormone Substances 0.000 description 2
- 229960001319 parathyroid hormone Drugs 0.000 description 2
- VLTRZXGMWDSKGL-UHFFFAOYSA-N perchloric acid Chemical compound OCl(=O)(=O)=O VLTRZXGMWDSKGL-UHFFFAOYSA-N 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 108010004034 stable plasma protein solution Proteins 0.000 description 2
- 238000012109 statistical procedure Methods 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 208000011580 syndromic disease Diseases 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 230000004584 weight gain Effects 0.000 description 2
- 235000019786 weight gain Nutrition 0.000 description 2
- MSWZFWKMSRAUBD-IVMDWMLBSA-N 2-amino-2-deoxy-D-glucopyranose Chemical compound N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O MSWZFWKMSRAUBD-IVMDWMLBSA-N 0.000 description 1
- 206010002091 Anaesthesia Diseases 0.000 description 1
- 208000008316 Arsenic Poisoning Diseases 0.000 description 1
- 208000020084 Bone disease Diseases 0.000 description 1
- 206010006002 Bone pain Diseases 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 description 1
- 206010013183 Dislocation of vertebra Diseases 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- BZQFBWGGLXLEPQ-UHFFFAOYSA-N O-phosphoryl-L-serine Natural products OC(=O)C(N)COP(O)(O)=O BZQFBWGGLXLEPQ-UHFFFAOYSA-N 0.000 description 1
- 206010057178 Osteoarthropathies Diseases 0.000 description 1
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 1
- 241001474977 Palla Species 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000271897 Viperidae Species 0.000 description 1
- CPGKMLVTFNUAHL-UHFFFAOYSA-N [Ca].[Ca] Chemical compound [Ca].[Ca] CPGKMLVTFNUAHL-UHFFFAOYSA-N 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 239000002250 absorbent Substances 0.000 description 1
- 230000002745 absorbent Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- 229960005143 amobarbital sodium Drugs 0.000 description 1
- 230000037005 anaesthesia Effects 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 238000003321 atomic absorption spectrophotometry Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000004221 bone function Effects 0.000 description 1
- 150000001669 calcium Chemical class 0.000 description 1
- 230000003913 calcium metabolism Effects 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- MWKXCSMICWVRGW-UHFFFAOYSA-N calcium;phosphane Chemical compound P.[Ca] MWKXCSMICWVRGW-UHFFFAOYSA-N 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000001055 chewing effect Effects 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 235000020247 cow milk Nutrition 0.000 description 1
- 108010061103 cyclic citrullinated peptide Chemical group 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000000326 densiometry Methods 0.000 description 1
- 238000001739 density measurement Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229910052805 deuterium Inorganic materials 0.000 description 1
- 229950006137 dexfosfoserine Drugs 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 229940011871 estrogen Drugs 0.000 description 1
- 239000000262 estrogen Substances 0.000 description 1
- 230000027119 gastric acid secretion Effects 0.000 description 1
- 229960002442 glucosamine Drugs 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 210000003692 ilium Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229910052746 lanthanum Inorganic materials 0.000 description 1
- FZLIPJUXYLNCLC-UHFFFAOYSA-N lanthanum atom Chemical compound [La] FZLIPJUXYLNCLC-UHFFFAOYSA-N 0.000 description 1
- 238000004900 laundering Methods 0.000 description 1
- 235000020997 lean meat Nutrition 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 230000007102 metabolic function Effects 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 235000008935 nutritious Nutrition 0.000 description 1
- 238000009806 oophorectomy Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 230000002188 osteogenic effect Effects 0.000 description 1
- 230000001009 osteoporotic effect Effects 0.000 description 1
- 230000036407 pain Effects 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- BZQFBWGGLXLEPQ-REOHCLBHSA-N phosphoserine Chemical compound OC(=O)[C@@H](N)COP(O)(O)=O BZQFBWGGLXLEPQ-REOHCLBHSA-N 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000005180 public health Effects 0.000 description 1
- 230000000384 rearing effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000007670 refining Methods 0.000 description 1
- 108010048734 sclerotin Proteins 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- BNHGKKNINBGEQL-UHFFFAOYSA-M sodium;5-ethyl-5-(3-methylbutyl)pyrimidin-3-ide-2,4,6-trione Chemical compound [Na+].CC(C)CCC1(CC)C(=O)NC(=O)[N-]C1=O BNHGKKNINBGEQL-UHFFFAOYSA-M 0.000 description 1
- 239000012086 standard solution Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 238000011121 vaginal smear Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/18—Peptides; Protein hydrolysates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/30—Foods or foodstuffs containing additives; Preparation or treatment thereof containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Inorganic Chemistry (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses health food for improving bone density and a preparation method of the health food. The health food comprises active ingredients and auxiliary materials, wherein the active ingredients comprise the following components by weight parts: 30-48 parts of calcium acetate, 5-20 parts of casein calcium peptide, 10-35 parts of glucosamine hydrochloride, 10-30 parts of chondroitin sulfate and 1-5 parts of vitamin C. The preparation method of tablets comprises the following steps: mixing raw materials, granulating, drying, arranging granules, mixing arranged granules with vitamin C and magnesium stearate, tabletting, and coating. The health food is very high in absorption rate; by adding casein calcium peptide with a specific ratio, the calcium absorption of a human body is promoted; casein calcium peptide is short in peptide chain, small in molecular weight, good in water solubility, excellent in thermal stability and can be easily absorbed by a human body; due to casein calcium peptide with the specific ratio, very high calcium absorption capability of the human body can be kept, the calcium absorption capability of middle-aged and elderly people with relatively poor digestion-absorption function can be increased, and the bone density improvement effect is remarkable.
Description
Technical field
The invention belongs to field of health care food, relate to a kind of health food that increases bone density and preparation method thereof.
Background technology
Osteoporosis (osteoporosis, OP) is a kind of general osteopathy that bone amount is low, bone micro-structure destroys, bone fragility increases, easily generation fracture is feature of take
[1].Osteoporosis and the fracture incidence causing thereof occupy the 7th of common disease, and China's patients with osteoporosis has 6,000 ten thousand~8,000 ten thousand.Along with the aggravation of aging population and the increase of resident's life expectancy, osteoporosis with its high incidence, high disability rate, high mortality and having a strong impact on resident's life and health, becomes a serious public health problem gradually.
Modern study shows that the elderly is due to loss of tooth and gastric acid secretion deficiency or gastric anacidity, and digestive function reduces, and the ability of bone received is poor, and the picked-up of nutrition reduces, and how nutritious shortage, causes calcium, electrolytes and minerals insufficiency of intake.And China's custom meals belong to low calcium recipe, calcium source mainly relies on cereal and vegetables, the elderly's absence of tooth is more, vegetables, fruit, lean meat are difficult for chewing, intake reduces, and presents " negative calcium balance ", and feedback parathyroid hormone (PTH) secretion is risen, cause bone calcium to dissolve, blood calcium rises.Serium inorganic phosphorus content and age are obvious negative, and the elderly, because serium inorganic phosphorus reduces, increases the ratio of calcium phosphorus, causes the reduction of osteogenic action.Due to above these features, the elderly is lower to calcareous absorptivity, is osteoporosis group of people at high risk.In recent years on market, the health food or the pharmaceutical preparation that occur a large amount of preventions, improvement or auxiliary curing osteoporosis, but there is no these features for the elderly, the absorptivity of general product is not high or side effect is larger, and too much the calcareous of picked-up may be combined containing careless acid and form calcinm oxalate calculus with vegetables of taking in etc. owing to not being fully absorbed, larger to harm.Enhancing bone density product on market, one class is directly to replenish the calcium into the body of assigning to calcareous absorption, thereby reach the object that strengthens bone density, absorptivity is generally all lower, this type of strengthens bone density product has considerable part all to adopt calcium carbonate etc. need to consume the calcareous of hydrochloric acid in gastric juice, poorly water-soluble, be unfavorable for absorbing, and can make the elderly's hydrochloric acid in gastric juice more lack.One class is to supplement calcium or do not supplement calcium, and by adjusting endocrine, promote the absorption of calcium, this type of strengthens bone density product and adopts the drug ingedients such as estrogen, Chinese medicine, and the elderly poor for physique, endocrine disturbance easily occurs is also improper, has certain side effect.One class is supplement calcium, supplement sorbefacient simultaneously, this type of strengthens bone density product and is selecting under suitable calcareous and prerequisite that optimization of C/C composites forms, absorptivity is higher, but because the suitable calcium source of pin the elderly's not feature selecting and calcium promote absorbent, as a lot of enhancing bone density products, adopt the poorly water-solubles such as calcium carbonate, consume the calcareous of hydrochloric acid in gastric juice; As adopt vitamin D as accelerating agent of calcium absorption, because the metabolism time of vitamin D in human body is longer, and a lot of the elderly's metabolic function is relatively poor, easily accumulates in vivo, causes poisoningly, more harm than good equally, and side effect easily occurs.Therefore, need a kind of with strong points, absorptivity is high, have no side effect, be applicable to the enhancing bone density product that the elderly takes.
CPP (CPP), is to take bovine casein as raw material, and what by biotechnology, make has a bioactive polypeptide.Experimental results demonstrate that CPP can effectively promote the absorption of human body to calcium.Chinese patent (CN102178933A) discloses a kind of preparation for Prevention and Treatment of Osteoporosis and osteoarthropathy, wherein adopts calcium carbonate, aminoglucose hydrochloride, chondroitin sulfate, CPP, ossein, neo dohyfral D3 isoreactivity composition.Chinese patent (CN102133395A) discloses a kind of skeleton health-care product or pharmaceutical composition and preparation method thereof, said composition comprises calcium carbonate, neo dohyfral D3, CPP, chondroitin sulfate, aminoglucose hydrochloride and ossein isoreactivity composition and alleviates bone pain recovery bone function raising immunity for increasing bone density, obviously solves the symptoms such as osteoporosis.Chinese patent (CN101904866A) discloses a kind of osteoporotic pharmaceutical composition and preparation method thereof for the treatment of, and said composition contains D-Glucosamine Hydrochloride, calcium carbonate, neo dohyfral D3 and chondroitin sulfate isoreactivity composition.Chinese patent (CN101322551A) discloses a kind of for strengthening the composition of bone density and repairing articular cartilage, and wherein said composition contains chondroitin sulfate, Glucosamine and calcium agent isoreactivity composition.As can be seen here, CPP (CPP) is the active component of common increase bone density.
Through large quantity research, discovery CCP (CCP) is compared and can more effectively be promoted human body to the combination of calcium, absorption with CPP (CPP).And through formula screening, select the CCP (CCP) of specified quantitative, its formula effect is very obvious, and effect significantly.CCP (CCP) is a kind of phosphoric acid silk amino acid residue biologically active polypeptide that contains equally, is caseic calcium salt (calcium caseinate) refining forming after enzyme hydrolysis in cow's milk.When CCP enters after small intestine, the phosphorus in structure can be combined and make calcium keep solvable state with the calcium of little ilium, to promote the absorption of calcium and the formation of sclerotin.The peptide chain of CCP (CCP) for being formed by phosphoserine in casein, peptide chain average molecular mass is less by approximately 3000, and peptide chain is shorter, soluble in water, is conducive to absorption of human body.Can more effectively promote the absorption of human body to calcium, guarantee higher calcium absorptivity.In addition, CCP (CCP) heat endurance is strong, at 120 ℃ of aqueous solution heating, 30min, without precipitation, can guarantee, under high temperature reconstitutes mode, to keep its activity.CCP (CCP) and CPP (CPP) can promote the absorption of calcium equally, effect is suitable, CCP (CCP) is compared with CPP (CPP), peptide chain is shorter, molecular weight is less, water-soluble better, heat endurance is stronger.Therefore in increasing bone density health food, the alternative CPP (CPP) of available CCP (CCP) can more effectively promote human body to the combination of calcium, absorption.CCP (CCP) safe without toxic side effect in addition.Therefore, CCP (CCP) can apply to strengthen in the health food of bone density, strengthens the elderly to calcareous absorption.The application that CCP (CCP) strengthens bone density product the elderly is less.Chinese patent (CN102824627A) discloses a kind of snake bone calcium capsule pulvis and preparation method thereof, and snake bone calcium capsule pulvis contains that the compositions such as pallas pit viper vertebrae, black high and steep snake vertebrae, CCP can be used for course of therapy and prevention of osteoporosis is evident in efficacy.But in recent years, find to come supplement calcium easily to cause arsenic poisoning with Animal Bone, be not suitable for the elderly, have certain risk.
Summary of the invention
The present invention is in order to solve above-described variety of issue and defect, the invention provides a kind of with strong points, absorptivity is high, have no side effect, be applicable to the enhancing bone density product that the elderly takes.
The object of the present invention is to provide a kind of health food that increases bone density.
Another object of the present invention is to provide a kind of preparation method who increases the health food of bone density.
The technical solution used in the present invention is:
Increase a health food for bone density, active ingredient and auxiliary material, consist of, its active ingredient is comprised of the raw material of following parts by weight: 30~48 parts of calcium acetates; 5~20 parts of CCPs; 10~35 parts of aminoglucose hydrochlorides; 10~30 parts of chondroitin sulfates; 1~5 part of vitamin C.
Further, a kind of health food that increases bone density, is comprised of active ingredient and auxiliary material, and its active ingredient is comprised of the raw material of following parts by weight: 44 parts of calcium acetates; 8 parts of CCPs; 20 parts of aminoglucose hydrochlorides; 10 parts of chondroitin sulfates; 3 parts of vitamin Cs.
Further, the formulation of above-mentioned health food is tablet, pulvis, granule, medicinal tea, hard shell capsules, soft capsule or oral liquid.
Further, above-mentioned auxiliary material is gross weight 1~35%, and it is selected from least one in filler, adhesive, sweetener, acid, flavoring essence, food coloring, lubricant, anticorrisive agent, suspending agent, diluent and plasticizer, antioxidant.
Further, above-mentioned filler is selected from least one in fructose, antierythrite, hydroxyl isomaltulose, sweet mellow wine, starch, dextrin;
Above-mentioned adhesive is selected from least one in hydroxypropyl methylcellulose, pregelatinized starch, PVP;
Above-mentioned sweetener be selected from Sucralose, steviol glycoside, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt, Aspartame, mogroside, knob sweet at least one;
Above-mentioned acid is selected from least one in citric acid, lactic acid, tartaric acid, fumaric acid;
Above-mentioned flavoring essence is selected from least one in orange essence, lemon extract, strawberry essence, blueberry essence, flavoring apple essence;
Above-mentioned food coloring is selected from least one in burnt sugar coloring, lemon yellow pigment, light blue pigment, carmine pigment, sunset yellow, allured red pigment, ginger color, Gardenia Yellow;
Above-mentioned lubricant is selected from least one in talcum powder, dolomol, silica, stearic acid, magnesium fumarate;
The above-mentioned anticorrisive agent of stating is selected from least one in Sodium Benzoate, benzoic acid, sorbic acid, potassium sorbate, metagin class;
Above-mentioned suspending agent is selected from least one in sodium carboxymethylcellulose, sodium alginate, polyethylene glycol, PVP K30, beeswax;
Above-mentioned diluent is selected from least one in water, edible vegetable oil, polyethylene glycol;
Above-mentioned plasticizer is selected from least one in glycerine, sorbierite;
Above-mentioned antioxidant is selected from least one in vitamin C, vitamin E etc., Co-Q10, beta carotene, lutein, epiphysin, luteole, angle xanthin, tuna flavine, astaxanthin, haematococcus pluvialis extract.
The preparation method of tablet who increases the health food of bone density, comprises the following steps:
1) by above-mentioned formula, take each raw material;
2) mix: after CCP, pregelatinized starch are fully mixed, then add calcium acetate, aminoglucose hydrochloride, chondroitin sulfate, mix;
3) granulate: the ethanolic solution that is 40~60% by volumetric concentration spray in above-mentioned mixed powder until hold mixture can be agglomerating, finger is light presses loosely, in every kilogram of mixed powder, sprays 0.1~0.20kg volumetric concentration and be 40~60% ethanolic solution; Then with 16 eye mesh screens, granulate;
4) dry: the wet granular that previous step is made is dried, and baking temperature is 55~65 ℃, when pellet moisture content is 3~4.5%, takes out dry particle, is cooled to room temperature;
5) whole grain: dried dry particle is crossed to 16 mesh sieves with pelletizing machine and carry out whole grain;
6) always mixed: first the part particle after whole grain to be increased progressively and mixed with vitamin C equivalent, then add particle and the dolomol after the whole grain of residue, mix, obtain always mixed material;
7) compressing tablet: will always mix material and carry out obtaining plain sheet after compressing tablet with tablet press machine;
8) dressing: Hydroxypropyl methylcellulose and Macrogol 4000 are made into the film coating liquid of 10% (w/v), more plain sheet is carried out to dressing with coating solution in coating pan, gained coating tablet is the health food that increases bone density.
The invention has the beneficial effects as follows:
1. crucial innovative point of the present invention is that product absorptivity of the present invention is very high, by adding the CCP of specific proportioning, promote the absorption of human body to calcium, CCP peptide chain is short, molecular weight is little, good water solubility, heat endurance are strong, be easy to absorption of human body, the calcium caseinate Toplink of specified quantitative makes the absorbability that human body is very high to calcareous maintenance, can make weak the elderly of digestion and absorption function originally strengthen calcareous absorbability, the absorptivity very high to calcareous maintenance, strengthens bone density successful.
2. crucial innovative point of the present invention is that product of the present invention is with strong points.The elderly that the present invention is gastric anacidity from the feature of middle-aged and old physique etc. provides formula more targetedly, makes the elderly unaffected to the absorption effect of calcium, better reaches the effect that strengthens bone density.
The present invention formula safely, have no side effect, without medicine, Animal Bone etc., bring side effect.
4. the present invention takes stopgap measures and effects a permanent cure, and by combining, carrys out the syndromes such as ostalgia that releasing osteoporosis brings, inflammation with the conventional safe drugs composition chondroitin sulfate of osteoporosis, aminoglucose hydrochloride.In the time of for the elderly's prevention or releasing osteoporosis disease, effectively lower the senses of discomfort such as pain.
The present invention pointed strong, absorptivity is high, have no side effect, take stopgap measures and effect a permanent cure, be applicable to the feature that the elderly takes.
6. its composition of mainly filling a prescription of the present invention comprises calcium acetate, CCP, chondroitin sulfate, aminoglucose hydrochloride.The present invention carrys out the picked-up of specific aim strengthening the elderly to calcium by not consuming the calcium acetate of hydrochloric acid in gastric juice, good water solubility as calcium source, by adding the CCP of specified quantitative to promote the absorption of the elderly to calcium, guarantee higher calcium absorptivity, calcium acetate and CCP synergy increase bone density; And combine with osteoporosis common drug composition chondroitin sulfate, aminoglucose hydrochloride and carry out the syndromes such as ostalgia that releasing osteoporosis brings, inflammation.The present invention takes stopgap measures and effects a permanent cure, pointed strong, absorptivity is high, have no side effect, be applicable to the feature that the elderly takes.Be exactly more than the good technique effect that the present invention produces, for the elderly's prevention or releasing osteoporosis disease, strengthen bone density.
The specific embodiment
Increase a health food for bone density, its raw material by following parts by weight is made: active ingredient and auxiliary material, consist of, its active ingredient is comprised of the raw material of following parts by weight: 30~48 parts of calcium acetates; 5~20 parts of CCPs; 10~35 parts of aminoglucose hydrochlorides; 10~30 parts of chondroitin sulfates; 1~5 part of vitamin C.
Preferably, a kind of health food that increases bone density, is comprised of active ingredient and auxiliary material, and its active ingredient is comprised of the raw material of following parts by weight: 44 parts of calcium acetates; 8 parts of CCPs; 20 parts of aminoglucose hydrochlorides; 10 parts of chondroitin sulfates; 3 parts of vitamin Cs.
Increase a health food for bone density, its formulation is tablet, pulvis, granule, medicinal tea, hard shell capsules, soft capsule or oral liquid.
Preferably, described auxiliary material is gross weight 1~35%, and it is selected from least one in filler, adhesive, sweetener, acid, flavoring essence, food coloring, lubricant, anticorrisive agent, suspending agent, diluent and plasticizer, antioxidant.
Described filler is preferably at least one in fructose, antierythrite, hydroxyl isomaltulose, sweet mellow wine, starch, dextrin;
Described adhesive is preferably at least one in hydroxypropyl methylcellulose, pregelatinized starch, PVP;
Described sweetener be preferably Sucralose, steviol glycoside, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt, Aspartame, mogroside, knob sweet at least one;
Described acid is preferably at least one in citric acid, lactic acid, tartaric acid, fumaric acid;
Described flavoring essence is preferably at least one in orange essence, lemon extract, strawberry essence, blueberry essence, flavoring apple essence;
Described food coloring is preferably at least one in burnt sugar coloring, lemon yellow pigment, light blue pigment, carmine pigment, sunset yellow, allured red pigment, ginger color, Gardenia Yellow;
Described lubricant is preferably at least one in talcum powder, dolomol, silica, stearic acid, magnesium fumarate;
Described anticorrisive agent is preferably at least one in Sodium Benzoate, benzoic acid, sorbic acid, potassium sorbate, metagin class;
Described suspending agent is preferably at least one in sodium carboxymethylcellulose, sodium alginate, polyethylene glycol, PVP K30, beeswax;
Described diluent is preferably at least one in water, edible vegetable oil, polyethylene glycol;
Described plasticizer is preferably at least one in glycerine, sorbierite;
Described antioxidant is preferably at least one in vitamin C, vitamin E etc., Co-Q10, beta carotene, lutein, epiphysin, luteole, angle xanthin, tuna flavine, astaxanthin, haematococcus pluvialis extract.
The preparation method of tablet who increases the health food of bone density, comprises the following steps:
Step 1: take each raw material by above-mentioned formula;
Step 2: mix
After CCP, pregelatinized starch are fully mixed, then add calcium acetate, aminoglucose hydrochloride, chondroitin sulfate, mix.
Step 3: granulate
The ethanolic solution that is 40~60% by volumetric concentration spray in above-mentioned mixed powder until hold mixture can be agglomerating, finger is light presses loosely, in every kilogram of mixed powder, sprays 0.1~0.20kg volumetric concentration and be 40~60% ethanolic solution; Then with 16 eye mesh screens, granulate.
Step 4: dry
The wet granular that previous step is made is dried, and baking temperature is 55~65 ℃, when pellet moisture content is 3~4.5%, takes out dry particle, is cooled to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with pelletizing machine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, then add remainder particulate and dolomol, mix, obtain always mixed material.
Step 7: compressing tablet
To always mix material carries out obtaining plain sheet after compressing tablet with tablet press machine.
Step 8: dressing
Hydroxypropyl methylcellulose and Macrogol 4000 are made into the film coating liquid of 10% (w/v), more plain sheet is carried out to dressing with coating solution in coating pan, gained coating tablet is the health food that increases bone density.
The using method of the increase bone density health food of casein containing protein calcium peptide: a specification 1g/ sheet, every day twice, sooner or later respectively once, once two, oral.
Below in conjunction with specific experiment example, the present invention is further illustrated, but be not limited to this.
Embodiment 1:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 44%; CCP 8%; Aminoglucose hydrochloride 20%; Chondroitin sulfate 10%; Vitamin C 3%; Pregelatinized starch 12%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: take raw material
Meter takes following raw material by weight: 44 parts of calcium acetates; 8 parts of CCPs; 20 parts of aminoglucose hydrochlorides; 10 parts of chondroitin sulfates; 3 parts of vitamin Cs; 12 parts of pregelatinized starch; 1 part of dolomol; 1.5 parts of Hydroxypropyl methylcelluloses; 0.5 part of Macrogol 4000.
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix and mix for 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By volumetric concentration be 50% ethanolic solution spray in above-mentioned mixed powder until hold mixture can be agglomerating, finger is light presses loosely, in every kilogram of mixed powder, sprays 0.1~0.20kg concentration and be 50% ethanolic solution; Then with oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
The wet granular that previous step is made is placed in CTCI heated-air circulation oven and is dried, and it is 55~65 ℃ that baking temperature is controlled, and when pellet moisture content is 3~4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
Particle after the whole grain of vitamin C and equivalent is mixed, then add remainder particulate and dolomol, and be placed in three-dimensional motion mixer always mixed 20 minutes, it is fully mixed, obtain always mixed material.
Step 7: compressing tablet
To always mix material carries out obtaining plain sheet after compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
Film coating material Hydroxypropyl methylcellulose and Macrogol 4000 are slowly joined to the film coating liquid that is made into 10% (w/v) in the purified water under stirring, again plain sheet is added in coating pan, open hot blast, preheating 10min, start coating pan, retention tab bed tempertaure sprays into coating solution at 40~45 ℃.Gained coating tablet is the health food of increase bone density of the present invention.
Embodiment 2:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 42.3%; CCP 7.5%; Aminoglucose hydrochloride 22%; Chondroitin sulfate 17%; Catergen .8%; Pregelatinized starch 2%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: weigh
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By 50% ethanolic solution, spray into softwood processed in above-mentioned mixed powder, until that softwood is held is agglomerating, finger is light press loose; With oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
Wet granular is placed in to CTCI heated-air circulation oven and is dried, it is 55 ℃~65 ℃ that baking temperature is controlled, and pellet moisture is controlled at 3%-4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, more always mix 20 minutes with remainder particulate, dolomol and the above-mentioned three-dimensional motion mixer that is placed in, obtain always mixed material.
Step 7: compressing tablet
To always mix material and carry out compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
By film coating material Hydroxypropyl methylcellulose and Macrogol 4000, slowly join the film coating liquid that is made into 10% in the purified water under stirring.Plain sheet is added in coating pan again, open hot blast, preheating 10min, starts coating pan, and retention tab bed tempertaure sprays into coating solution at 40-45 ℃.Coating tablet be the increase bone density tablet health food of a kind of casein containing protein calcium of the present invention peptide.
Embodiment 3:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 44.8%; CCP 8.4%; Aminoglucose hydrochloride 23%; Chondroitin sulfate 16%; Catergen .8%; Pregelatinized starch 2%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: weigh
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By 50% ethanolic solution, spray into softwood processed in above-mentioned mixed powder, until that softwood is held is agglomerating, finger is light press loose; With oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
Wet granular is placed in to CTCI heated-air circulation oven and is dried, it is 55 ℃~65 ℃ that baking temperature is controlled, and pellet moisture is controlled at 3%-4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, more always mix 20 minutes with remainder particulate, dolomol and the above-mentioned three-dimensional motion mixer that is placed in, obtain always mixed material.
Step 7: compressing tablet
To always mix material and carry out compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
By film coating material Hydroxypropyl methylcellulose and Macrogol 4000, slowly join the film coating liquid that is made into 10% in the purified water under stirring.Plain sheet is added in coating pan again, open hot blast, preheating 10min, starts coating pan, and retention tab bed tempertaure sprays into coating solution at 40-45 ℃.Coating tablet be the increase bone density tablet health food of a kind of casein containing protein calcium of the present invention peptide.
Embodiment 4:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 40%; CCP 9.5%; Aminoglucose hydrochloride 19%; Chondroitin sulfate 20%; Catergen .2%; Pregelatinized starch 8.3%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: weigh
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By 50% ethanolic solution, spray into softwood processed in above-mentioned mixed powder, until that softwood is held is agglomerating, finger is light press loose; With oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
Wet granular is placed in to CTCI heated-air circulation oven and is dried, it is 55 ℃~65 ℃ that baking temperature is controlled, and pellet moisture is controlled at 3%-4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, more always mix 20 minutes with remainder particulate, dolomol and the above-mentioned three-dimensional motion mixer that is placed in, obtain always mixed material.
Step 7: compressing tablet
To always mix material and carry out compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
By film coating material Hydroxypropyl methylcellulose and Macrogol 4000, slowly join the film coating liquid that is made into 10% in the purified water under stirring.Plain sheet is added in coating pan again, open hot blast, preheating 10min, starts coating pan, and retention tab bed tempertaure sprays into coating solution at 40-45 ℃.Coating tablet be the increase bone density tablet health food of a kind of casein containing protein calcium of the present invention peptide.
Embodiment 5:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 47.6%; CCP 5%; Aminoglucose hydrochloride 22%; Chondroitin sulfate 18%; Catergen .4%; Pregelatinized starch 2%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: weigh
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By 50% ethanolic solution, spray into softwood processed in above-mentioned mixed powder, until that softwood is held is agglomerating, finger is light press loose; With oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
Wet granular is placed in to CTCI heated-air circulation oven and is dried, it is 55 ℃~65 ℃ that baking temperature is controlled, and pellet moisture is controlled at 3%-4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, more always mix 20 minutes with remainder particulate, dolomol and the above-mentioned three-dimensional motion mixer that is placed in, obtain always mixed material.
Step 7: compressing tablet
To always mix material and carry out compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
By film coating material Hydroxypropyl methylcellulose and Macrogol 4000, slowly join the film coating liquid that is made into 10% in the purified water under stirring.Plain sheet is added in coating pan again, open hot blast, preheating 10min, starts coating pan, and retention tab bed tempertaure sprays into coating solution at 40-45 ℃.Coating tablet be the increase bone density tablet health food of a kind of casein containing protein calcium of the present invention peptide.
Embodiment 6:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 30%: CCP 7.5%; Aminoglucose hydrochloride 35%; Chondroitin sulfate 18%; Vitamin C 4%; Pregelatinized starch 2.5%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: weigh
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By 50% ethanolic solution, spray into softwood processed in above-mentioned mixed powder, until that softwood is held is agglomerating, finger is light press loose; With oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
Wet granular is placed in to CTCI heated-air circulation oven and is dried, it is 55 ℃~65 ℃ that baking temperature is controlled, and pellet moisture is controlled at 3%-4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, more always mix 20 minutes with remainder particulate, dolomol and the above-mentioned three-dimensional motion mixer that is placed in, obtain always mixed material.
Step 7: compressing tablet
To always mix material and carry out compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
By film coating material Hydroxypropyl methylcellulose and Macrogol 4000, slowly join the film coating liquid that is made into 10% in the purified water under stirring.Plain sheet is added in coating pan again, open hot blast, preheating 10min, starts coating pan, and retention tab bed tempertaure sprays into coating solution at 40-45 ℃.Coating tablet be the increase bone density tablet health food of a kind of casein containing protein calcium of the present invention peptide.
Embodiment 7:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 48%; CCP 6.8%; Aminoglucose hydrochloride 23.2%; Chondroitin sulfate 14%; Vitamin C 3%; Pregelatinized starch 2%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: weigh
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By 50% ethanolic solution, spray into softwood processed in above-mentioned mixed powder, until that softwood is held is agglomerating, finger is light press loose; With oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
Wet granular is placed in to CTCI heated-air circulation oven and is dried, it is 55 ℃~65 ℃ that baking temperature is controlled, and pellet moisture is controlled at 3%-4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, more always mix 20 minutes with remainder particulate, dolomol and the above-mentioned three-dimensional motion mixer that is placed in, obtain always mixed material.
Step 7: compressing tablet
To always mix material and carry out compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
By film coating material Hydroxypropyl methylcellulose and Macrogol 4000, slowly join the film coating liquid that is made into 10% in the purified water under stirring.Plain sheet is added in coating pan again, open hot blast, preheating 10min, starts coating pan, and retention tab bed tempertaure sprays into coating solution at 40-45 ℃.Coating tablet be the increase bone density tablet health food of a kind of casein containing protein calcium of the present invention peptide.
Embodiment 8:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 41%; CCP 8.3%; Aminoglucose hydrochloride 23%; Chondroitin sulfate 17%; Catergen %; Pregelatinized starch 5.7%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: weigh
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By 50% ethanolic solution, spray into softwood processed in above-mentioned mixed powder, until that softwood is held is agglomerating, finger is light press loose; With oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
Wet granular is placed in to CTCI heated-air circulation oven and is dried, it is 55 ℃~65 ℃ that baking temperature is controlled, and pellet moisture is controlled at 3%-4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, more always mix 20 minutes with remainder particulate, dolomol and the above-mentioned three-dimensional motion mixer that is placed in, obtain always mixed material.
Step 7: compressing tablet
To always mix material and carry out compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
By film coating material Hydroxypropyl methylcellulose and Macrogol 4000, slowly join the film coating liquid that is made into 10% in the purified water under stirring.Plain sheet is added in coating pan again, open hot blast, preheating 10min, starts coating pan, and retention tab bed tempertaure sprays into coating solution at 40-45 ℃.Coating tablet be the increase bone density tablet health food of a kind of casein containing protein calcium of the present invention peptide.
Embodiment 9:
An increase bone density health food for casein containing protein calcium peptide, its primary raw material formula is by weight percentage as follows: calcium acetate 44%; CCP 8%; Aminoglucose hydrochloride 25%; Chondroitin sulfate 15%; Vitamin C 3%; Pregelatinized starch 2%; Dolomol 1%; Hydroxypropyl methylcellulose 1.5%; Macrogol 4000 0.5%.
A preparation method for the increase bone density health food of casein containing protein calcium peptide, comprises the following steps:
Step 1: weigh
Step 2: mix
CCP, pregelatinized starch are placed in trough type mixing machine, mix 10 minutes, then calcium acetate, aminoglucose hydrochloride, chondroitin sulfate are dropped in trough type mixing machine, mix 10 minutes, mix.
Step 3: granulate
By 50% ethanolic solution, spray into softwood processed in above-mentioned mixed powder, until that softwood is held is agglomerating, finger is light press loose; With oscillating granulator, filling 16 eye mesh screens granulates.
Step 4: dry
Wet granular is placed in to CTCI heated-air circulation oven and is dried, it is 55 ℃~65 ℃ that baking temperature is controlled, and pellet moisture is controlled at 3%-4.5%, takes out dry particle, lets cool to room temperature.
Step 5: whole grain
Dried dry particle is crossed to the whole grain of 16 mesh sieves with Fastgranulatemachine.
Step 6: always mixed
First the part particle after whole grain is increased progressively and mixed with vitamin C equivalent, more always mix 20 minutes with remainder particulate, dolomol and the above-mentioned three-dimensional motion mixer that is placed in, obtain always mixed material.
Step 7: compressing tablet
To always mix material and carry out compressing tablet with Highspeedrotarytabletpress.
Step 8: dressing
By film coating material Hydroxypropyl methylcellulose and Macrogol 4000, slowly join the film coating liquid that is made into 10% in the purified water under stirring.Plain sheet is added in coating pan again, open hot blast, preheating 10min, starts coating pan, and retention tab bed tempertaure sprays into coating solution at 40-45 ℃.Coating tablet be the increase bone density tablet health food of a kind of casein containing protein calcium of the present invention peptide.
The health food of the increase bone density of below being prepared by the present invention is made further effect detection.
One, the impact on bone density, bone mass and calcium content of bone
1 materials and methods
1.1 animals used as test: 110 of the clean level female sd inbred rats of weight (301.2 ± 6.9) g.
The sample (1g/ sheet) that 1.2 tested materials: embodiment 1~8 is prepared, human oral RD is every day 2 times, each two, become body mass press 60kg calculating, amounting to dosage is 0.0667gkg
-1.
1.3 instruments: SD-1000c bone mineral measuring instrument
1.4 method
With reference to the method for FDA Food and Drug Administration (FDA) and the World Health Organization (WHO) recommendation research osteoporosis, i.e. castration method modeling.The modeling of castration method is the best approach of the research osteoporosis of FDA Food and Drug Administration (FDA) and the World Health Organization (WHO) recommendation.
1.4.1 dosage is selected to give mode with tested material
13 groups are established in experiment: sham-operation group, solvent control group (oophorectomize+solvent control group), calcium carbonate control group (oophorectomize+calcium carbonate control group), calcium acetate control group (oophorectomize+calcium acetate control group), calcium caseinate control group (oophorectomize+calcium caseinate control group), 1 group of embodiment (oophorectomize+embodiment 1 sample sets), 2 groups of embodiment (oophorectomize+embodiment 2 sample sets), 3 groups of embodiment (oophorectomize+embodiment 3 sample sets), 4 groups of embodiment (oophorectomize+embodiment 4 sample sets), 5 groups of embodiment (oophorectomize+embodiment 5 sample sets), 6 groups of embodiment (oophorectomize+embodiment 6 sample sets), 7 groups of embodiment (oophorectomize+embodiment 7 sample sets), 8 groups of embodiment (oophorectomize+embodiment 8 sample sets).
According to the oral recommended amounts of human body, establish low middle high dose and be respectively 0.33,0.66,2.00gkg
-1(be equivalent to respectively human body RD 5,10,30 times), test dose select in dosage 0.66gkg
-1.
During sample preparation, embodiment group: get respectively corresponding embodiment sample 6.6g, grind, add deionized water to 100mL;
Calcium acetate control group: in the sample formula of hello use,, except not containing CCP, it is the same with embodiment 1 formula that other compositions are, and the quantity reducing according to CCP, the quantity of pregelatinized starch in corresponding adjustment formula, sample thief 6.6g, grinds, and adds deionized water to 100mL;
CCP control group, in the sample formula of hello use, except not containing calcium acetate, it is the same with embodiment 1 formula that other compositions are, and the quantity reducing according to calcium acetate, the quantity of pregelatinized starch in corresponding adjustment formula, sample thief 6.6g, grind, add deionized water to 100mL;
Calcium carbonate control group: per os gives 0.50gkg
-1calcium carbonate, get 5g calcium carbonate (calcium content is 40%) and add deionized water to 100mL;
Sham-operation group and solvent control group: give isopyknic deionized water, give respectively animal subject gavage, every day gavage once, every 100g weight rat oral gavage volume is 1.0mL.
From on-test, each treated animal all single cage is raised, and feeds and raises identical feed, and gavage gives the test solution that is subject to separately, drinks deionized water, records food-intake.Totally 12 weeks.
Above-mentioned feed formula (mass percent): low calcium casein 23.0%, DL-METHIONINE 0.3%, cornstarch 32.0%, sucrose 30.0%, fiber 5.0%, mixed mineral salt 3.5%, mixed vitamin 1.0%, two choline tartrate 0.2%.
1.4.2 oophorectomize: rat is with 30mgkg
-1dosage lumbar injection 1% amobarbital sodium solution, after anesthesia, carry out Bilateral oophorectomy, the penicillin of postoperative muscle injection 20,000 units, continuously 3d.
Sham-operation group: only excise the fat about 0.5g after opening abdominal cavity, retain bilateral ovaries.5d after rat ovary excision, carries out vaginal smear examination, rejects the incomplete rat of oophorectomize.
1.4.3 animal grouping: above-mentioned female castrated rats is divided into 1~9 group, sham-operation group, solvent control group, calcium carbonate control group, calcium acetate control group, calcium caseinate control group and embodiment sample at random by weight, amount to 13 groups, every group 10, single cage is fed, and feeds 12 weeks.
1.4.4 growth of animal index Weighing body quality and height weekly.
1.4.5 femur dry weight and bone densitometry: when experiment finishes, rat is put to death in cervical vertebra dislocation, peels off right femur, through 105 ℃, toast 8h to constant weight, be cooled to after room temperature, weigh key heavy and bone length, and measure the bone density (BMD) of femur midpoint and distal end.
1.4.6 calcium content of bone is measured: weigh after the gross mass of femur, through high-temperature baking, femur is made to bone ash, use 6molL
-1after dissolving with hydrochloric acid, with EDTA titration measuring calcium content of bone.
1.4.7 statistical procedures method: carry out variance analysis with SPPS (11.0) software, result represents with mean ± standard deviation
2 results
2.1 impacts of health product of the present invention on rat weight
Body weight to the rat after above-mentioned different disposal is measured, and measurement result, as shown in table 1 and continued 1, can be found out the inchoate aspect mass discrepancy not statistically significant (P > 0.05) of respectively organizing rat before experiment from table 1 and continued 1.Difference between the body weight of respectively organizing rat of latter the 4th week of experiment, the 8th weekend, experiment latter stage (the 12nd weekend) is also not obvious, not statistically significant (P > 0.05).
According to the body weight of table different disposal group rat, calculate and respectively organize the weight gain situation of rat when latter stage (the 12nd weekend) is tested in processing, result of calculation is as shown in continued 1, respectively organize as can be seen from the table the weight gain difference of rat when latter stage (the 12nd weekend) is tested in processing not obvious, not statistically significant (P > 0.05).
The impact of table 1 different disposal on rat body weight
Note: with the comparison of solvent control group,
*p > 0.05.
The impact of continued 1 different disposal on rat body weight
Note: with model control group comparison,
*p > 0.05.
2.2 impacts of health product of the present invention on the length of rat femur and bone density
To processing length and the bone density of the femur of the rat in (experiment latter stage) after 12 weeks, measure, measurement result is as shown in table 2, therefrom can find out the femur length difference not statistically significant (P > 0.05) of respectively organizing rat.
In bone density measurement result (table 2), the femur center bone density of sham-operation group and calcium carbonate control group, femur distal end bone density are all higher than solvent control group, but difference is not remarkable, not statistically significant (P > 0.05);
The femur center bone density of calcium acetate control group and calcium caseinate control group and the difference of solvent control group are not obvious, not statistically significant (P > 0.05); And this femur distal end bone density of two groups is all higher than solvent control group, there is significant difference, P < 0.05;
The rat femur center bone density of each embodiment group, femur distal end bone density, all higher than solvent control group, have significant difference, P < 0.05; But compare with solvent control group, only has the rat femur center bone density of 1 group of embodiment, the amplitude of femur distal end bone density increase is maximum.
The above results explanation, only have the health food of increase bone density of the present invention rat femur center bone density and femur distal end bone density all to be there is to the effect of increase, obviously be better than the effect of other each control groups, and there is best increase bone density effect with the health food that in embodiment 1 prepared by specific proportioning.
The impact of table 2 different disposal on rat femur length and bone density
Note: with the comparison of solvent control group,
*p < 0.05,
*p < 0.01.
2.3 impacts of health product of the present invention on rat femur quality and calcium content of bone
To processing femoral shaft quality and the bone calcium of the rat in (experiment latter stage) after 12 weeks, measure, measurement result is as shown in table 3.
The impact of table 3 different disposal on rat femur quality and calcium content of bone
Note: with model control group comparison,
*p < 0.05,
*p < 0.01.。
As can be seen from Table 3:
Femoral shaft quality, the calcium content of bone of sham-operation group all, higher than solvent control group, have significant difference, P < 0.05;
The femoral shaft quality of calcium carbonate control group and calcium caseinate control group and the difference of solvent control group are not obvious, not statistically significant (P > 0.05); And this calcium content of bone of two groups is higher than solvent control group, there is significant difference, P < 0.05;
Femoral shaft quality, the calcium content of bone of calcium acetate control group all, higher than solvent control group, have significant difference, P < 0.05;
Rat femur dry mass, the calcium content of bone of each embodiment group all, higher than solvent control group, have significant difference, P < 0.05; But only have the rat bone calcium content of 1 group of embodiment to be more significantly higher than solvent control group, there is utmost point significant difference, P < 0.01.
The above results explanation, the health food of increase bone density of the present invention all has the effect of increase to rat femur dry mass, calcium content of bone, the effect that is better than calcium carbonate control group, calcium caseinate control group and calcium acetate control group, and with the health food that in embodiment 1 prepared by specific proportioning, there is the effect of best lifting rat bone calcium content.Illustrate that embodiment 1 sample increases rat bone density effect more obviously, effectively.
From above-mentioned experiment, the product of the present invention that main formula is made for calcium acetate, CCP, aminoglucose hydrochloride, chondroitin sulfate has the function of enhancing degree bone density, and the formula of specific proportioning composition, and its effect more obviously, effectively.
Two, calcium absorption experiment
1. principle
Under stable state, measure the calcium amount of discharging in calcium amount that rat takes in and ight soil, both differences are apparent absorption rate (%)=(the taking in calcium-excrement calcium) of the calcium calcium of apparent absorption/take in calcium * 100%.
2. instrument and reagent
Instrument: metabolism mouse cage, animal balance, atomic absorption spectrophotometer (tool flame method determinator deuterium lamp background deduction);
Reagent: perchloric acid (top grade is pure);
2% lanthana solution: take and analyze pure zirconia lanthanum (content > 99.99%) 25 grams, add 75% top grade pure hydrochloric acid, add deionized water to 1000ml;
Calcium standard solution: take 1.2486 grams and analyze calcium carbonate (purity is greater than 99.99%), add 50ml deionized water, add hydrochloric acid and make it to dissolve.Move in 1000ml volumetric flask, add 2% lanthana solution to scale.This solution 1.00ml is equivalent to 500ug calcium.Be stored in polyethylene bottle, 4 ℃ of preservations, face used time dilution.
3 experimental techniques
3.1 animals used as test: be born about 4 weeks ablactation rat.
3.2 basal feeds: low calcium formula (mass percent): low calcium casein 23.0%, DL-METHIONINE 0.3%, cornstarch 32.0%, sucrose 30.0%, fiber 5.0%, mixed mineral salt 3.5%, mixed vitamin 1.0%, two choline tartrate 0.2%.
3.3. zoopery grouping and dosage setting
Three dosage groups are established in experiment, and low middle high dose is respectively 0.33,0.66,2.00gkg
-1(be equivalent to respectively human body RD 5,10,30 times), establish low calcium control group (150mg/100g feed) and the identical calcium carbonate control group of tested material level corresponding with dosage group simultaneously.By low calcium basal feed preparation given the test agent each dosage group and calcium carbonate control group.
Low calcium basal feed, the i.e. feed in low calcium source, as food source, also as the tested material of low calcium control group, when tested material cannot gavage, feed can be used as the carrier of other given the test agent of gavage, and tested material is mixed in feed, is used for preparing each dosage group of given the test agent and each dosage calcium carbonate control group.
Low calcium control group: add appropriate amount of deionized water with low calcium basal feed, per os gives gavage
1 group of basic, normal, high dose delivery example: the quantity according to starch in the low calcium basal feed of the corresponding adjustment of the quantity of the given the test agent mixing, add appropriate amount of deionized water, per os gives gavage
Basic, normal, high dosage calcium carbonate control group: the quantity according to starch in the low calcium basal feed of the corresponding adjustment of the quantity of the calcium carbonate mixing, add appropriate amount of deionized water, per os gives gavage.
3.4 metabolism
Birth surrounding ablactation rat after one week laundering period, sub-cage rearing 4 weeks.Every group has do not move 8 of things of homogeneity.Drink deionized water, test and after 3 weeks, carry out calcium metabolism experiment in 3 days.Record 3 days food-intakes, collect 72 hours ight soil, measure calcium content in feed and ight soil.
The assay method of calcium in 3.5 fodder machine ight soil: atomic absorption spectrophotometry is measured.
3.6 calculate
Take in calcium (mg/d)=Calcium Content in Foodstuff (mg/g) * feed consumption (g/d)
Calcium content (mg/g) * ight soil discharge rate (g/d) in excrement calcium (mg/d)=ight soil
3.7 data processing
Statistical procedures for method SPPS (11.0) software carry out variance analysis, result represents with mean ± standard deviation
4 results
Test calculating embodiment 1 product calcium apparent absorption rate after 3 weeks, result of calculation is as shown in table 4, therefrom can find out that each dosage group apparent absorption rate of embodiment 1 sample and low calcium control group difference are little, the calcium carbonate control group of each dosage group apparent absorption rate of embodiment 1 sample and same calcium absorption level has significant difference (p < 0.05), each dosage group apparent absorption rate of embodiment 1 sample is all significantly higher than par calcium carbonate group, the results are shown in Table 4.
Table 4 embodiment 1 sample calcium apparent absorption rate
Note: with the comparison of low dosage calcium carbonate control group,
*p < 0.05; With the comparison of middle dosage calcium carbonate control group,
*p < 0.05; With the comparison of high dose calcium carbonate control group,
* *p < 0.05.
The formula of experimental result prompting embodiment 1 its specific proportioning of sample forms, and its calcium absorption efficiency is high.Solution provided by the invention, provides calcium acetate, CCP, the aminoglucose hydrochloride of certain content, the health food of chondroitin sulfate, has the health care of remarkable enhancing degree density.
Claims (6)
1. increase a health food for bone density, by active ingredient and auxiliary material, formed, it is characterized in that: its active ingredient is comprised of the raw material of following parts by weight: 30~48 parts of calcium acetates; 5~20 parts of CCPs; 10~35 parts of aminoglucose hydrochlorides; 10~30 parts of chondroitin sulfates; 1~5 part of vitamin C.
2. increase a health food for bone density, by active ingredient and auxiliary material, formed, it is characterized in that: its active ingredient is comprised of the raw material of following parts by weight: 44 parts of calcium acetates; 8 parts of CCPs; 20 parts of aminoglucose hydrochlorides; 10 parts of chondroitin sulfates; 3 parts of vitamin Cs.
3. a kind of health food that increases bone density according to claim 1 and 2, is characterized in that: its formulation is tablet, pulvis, granule, medicinal tea, hard shell capsules, soft capsule or oral liquid.
4. a kind of health food that increases bone density according to claim 1 and 2, it is characterized in that: described auxiliary material is gross weight 1~35%, it is selected from least one in filler, adhesive, sweetener, acid, flavoring essence, food coloring, lubricant, anticorrisive agent, suspending agent, diluent and plasticizer, antioxidant.
5. a kind of health food that increases bone density according to claim 4, is characterized in that:
Described filler is selected from least one in fructose, antierythrite, hydroxyl isomaltulose, sweet mellow wine, starch, dextrin;
Described adhesive is selected from least one in hydroxypropyl methylcellulose, pregelatinized starch, PVP;
Described sweetener be selected from Sucralose, steviol glycoside, 3,4-Dihydro-6-methyl-1,2,3-oxathiazin-4-one 2,2-dioxide potassium salt, Aspartame, mogroside, knob sweet at least one;
Described acid is selected from least one in citric acid, lactic acid, tartaric acid, fumaric acid;
Described flavoring essence is selected from least one in orange essence, lemon extract, strawberry essence, blueberry essence, flavoring apple essence;
Described food coloring is selected from least one in burnt sugar coloring, lemon yellow pigment, light blue pigment, carmine pigment, sunset yellow, allured red pigment, ginger color, Gardenia Yellow;
Described lubricant is selected from least one in talcum powder, dolomol, silica, stearic acid, magnesium fumarate;
Described anticorrisive agent is selected from least one in Sodium Benzoate, benzoic acid, sorbic acid, potassium sorbate, metagin class;
Described suspending agent is selected from least one in sodium carboxymethylcellulose, sodium alginate, polyethylene glycol, PVP K30, beeswax;
Described diluent is selected from least one in water, edible vegetable oil, polyethylene glycol;
Described plasticizer is selected from least one in glycerine, sorbierite;
Described antioxidant is selected from least one in vitamin C, vitamin E etc., Co-Q10, beta carotene, lutein, epiphysin, luteole, angle xanthin, tuna flavine, astaxanthin, haematococcus pluvialis extract.
6. the preparation method of the tablet of the arbitrary described a kind of health food that increases bone density of claim 1~5, is characterized in that: comprise the following steps:
1) by formula claimed in claim 1, take each raw material;
2) mix: after CCP, pregelatinized starch are fully mixed, then add calcium acetate, aminoglucose hydrochloride, chondroitin sulfate, mix;
3) granulate: the ethanolic solution that is 40~60% by volumetric concentration spray in above-mentioned mixed powder until hold mixture can be agglomerating, finger is light presses loosely, in every kilogram of mixed powder, sprays the ethanolic solution that 0.1~0.20kg concentration volume is 40~60%; Then with 16 eye mesh screens, granulate;
4) dry: the wet granular that previous step is made is dried, and baking temperature is 55 ~ 65 ℃, when pellet moisture content is 3~4.5%, takes out dry particle, is cooled to room temperature;
5) whole grain: dried dry particle is crossed to 16 mesh sieves with pelletizing machine and carry out whole grain;
6) always mixed: first the part particle after whole grain to be increased progressively and mixed with vitamin C equivalent, then add particle and the dolomol after the whole grain of residue, mix, obtain always mixed material;
7) compressing tablet: will always mix material and carry out obtaining plain sheet after compressing tablet with tablet press machine;
8) film coating liquid dressing: Hydroxypropyl methylcellulose and Macrogol 4000 are made into 10%(w/v), more plain sheet is carried out to dressing with coating solution in coating pan, gained coating tablet is the health food that increases bone density.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410274352.6A CN104068306B (en) | 2014-06-18 | 2014-06-18 | Health food for improving bone density and preparation method of health food |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201410274352.6A CN104068306B (en) | 2014-06-18 | 2014-06-18 | Health food for improving bone density and preparation method of health food |
Publications (2)
Publication Number | Publication Date |
---|---|
CN104068306A true CN104068306A (en) | 2014-10-01 |
CN104068306B CN104068306B (en) | 2017-05-17 |
Family
ID=51590225
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201410274352.6A Active CN104068306B (en) | 2014-06-18 | 2014-06-18 | Health food for improving bone density and preparation method of health food |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN104068306B (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104273541A (en) * | 2014-10-29 | 2015-01-14 | 成都健怡营销策划有限公司 | Health product for increasing bone mineral density |
CN104543674A (en) * | 2015-01-04 | 2015-04-29 | 北京世纪合辉医药科技股份有限公司 | Health food for improving bone and joint health as well as preparation method thereof |
CN105661509A (en) * | 2016-01-18 | 2016-06-15 | 烟台新时代健康产业有限公司 | Krill oil softgel for protecting bone health as well as preparation method and application thereof |
CN108719970A (en) * | 2018-04-24 | 2018-11-02 | 海南久惠生物科技有限公司 | A kind of composition, health products and preparation method thereof comprising it increasing bone density |
CN114586896A (en) * | 2022-03-31 | 2022-06-07 | 卫仕宠物营养研究院(芜湖)有限公司 | Calcium peptide nutritional composition freeze-dried particles for efficiently enhancing calcium absorption of pet dogs and preparation method thereof |
CN114634901A (en) * | 2022-05-18 | 2022-06-17 | 微康益生菌(苏州)股份有限公司 | Lactobacillus casei LC16 for promoting bone health and culture method and application thereof |
CN115804759A (en) * | 2022-12-09 | 2023-03-17 | 江苏扬新生物医药有限公司 | A granule containing coenzyme Q10 and calcium |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0670726A (en) * | 1991-09-26 | 1994-03-15 | Taiyo Kagaku Co Ltd | Readily absorbable mineral-containing food/beverage |
CN1543857A (en) * | 2003-11-13 | 2004-11-10 | 上海奥医高科技实业有限公司 | Health food having functions of postponing senescence and increasing bone mineral density |
CN1947724A (en) * | 2006-03-10 | 2007-04-18 | 北京阜康仁生物制药科技有限公司 | Compound amino-glucose hydrochloride, chondroitin sulfate effervescent, tablets prepn. method and use thereof |
CN103156881A (en) * | 2013-04-02 | 2013-06-19 | 黑龙江迪龙制药有限公司 | Compound pharmaceutical composition using glucosamine and sodium chondroitin sulfate as main medicaments |
CN103735572A (en) * | 2012-10-17 | 2014-04-23 | 山东明仁福瑞达制药股份有限公司 | Composition having bone mineral density increasing function, anti-inflammatory function and analgesia function, and preparation method of the composition |
-
2014
- 2014-06-18 CN CN201410274352.6A patent/CN104068306B/en active Active
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0670726A (en) * | 1991-09-26 | 1994-03-15 | Taiyo Kagaku Co Ltd | Readily absorbable mineral-containing food/beverage |
CN1543857A (en) * | 2003-11-13 | 2004-11-10 | 上海奥医高科技实业有限公司 | Health food having functions of postponing senescence and increasing bone mineral density |
CN1947724A (en) * | 2006-03-10 | 2007-04-18 | 北京阜康仁生物制药科技有限公司 | Compound amino-glucose hydrochloride, chondroitin sulfate effervescent, tablets prepn. method and use thereof |
CN103735572A (en) * | 2012-10-17 | 2014-04-23 | 山东明仁福瑞达制药股份有限公司 | Composition having bone mineral density increasing function, anti-inflammatory function and analgesia function, and preparation method of the composition |
CN103156881A (en) * | 2013-04-02 | 2013-06-19 | 黑龙江迪龙制药有限公司 | Compound pharmaceutical composition using glucosamine and sodium chondroitin sulfate as main medicaments |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104273541A (en) * | 2014-10-29 | 2015-01-14 | 成都健怡营销策划有限公司 | Health product for increasing bone mineral density |
CN104543674A (en) * | 2015-01-04 | 2015-04-29 | 北京世纪合辉医药科技股份有限公司 | Health food for improving bone and joint health as well as preparation method thereof |
CN105661509A (en) * | 2016-01-18 | 2016-06-15 | 烟台新时代健康产业有限公司 | Krill oil softgel for protecting bone health as well as preparation method and application thereof |
CN108719970A (en) * | 2018-04-24 | 2018-11-02 | 海南久惠生物科技有限公司 | A kind of composition, health products and preparation method thereof comprising it increasing bone density |
CN114586896A (en) * | 2022-03-31 | 2022-06-07 | 卫仕宠物营养研究院(芜湖)有限公司 | Calcium peptide nutritional composition freeze-dried particles for efficiently enhancing calcium absorption of pet dogs and preparation method thereof |
CN114634901A (en) * | 2022-05-18 | 2022-06-17 | 微康益生菌(苏州)股份有限公司 | Lactobacillus casei LC16 for promoting bone health and culture method and application thereof |
CN114634901B (en) * | 2022-05-18 | 2022-08-30 | 微康益生菌(苏州)股份有限公司 | Lactobacillus casei LC16 for promoting bone health and culture method and application thereof |
CN115804759A (en) * | 2022-12-09 | 2023-03-17 | 江苏扬新生物医药有限公司 | A granule containing coenzyme Q10 and calcium |
CN115804759B (en) * | 2022-12-09 | 2024-05-10 | 江苏扬新生物医药有限公司 | Granule containing coenzyme Q10 and calcium |
Also Published As
Publication number | Publication date |
---|---|
CN104068306B (en) | 2017-05-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN104068306A (en) | Health food for improving bone density and preparation method of health food | |
CN103251671B (en) | A kind of composition and method of making the same containing Chinese medicine increasing bone density | |
CN106135890A (en) | A kind of alimentation composition contributing to bony articulation health | |
CN106727481B (en) | Application of chlorogenic acid in preparation of appetite-enhancing drugs or health care products | |
CN107028191B (en) | Vitamin composition suitable for accurate nutrition of middle-aged and elderly people | |
CN113713084A (en) | Medicine and food dual purpose Chinese medicinal product for treating bone and joint pain and osteoporosis of middle aged and elderly people | |
CN103751327A (en) | Zinc gluconate VC (Vitamin C) effervescent tablet | |
CN102949710A (en) | Pharmaceutical composition or healthcare product for increasing bone mineral density and preparation method of pharmaceutical composition or healthcare product | |
CN111467481A (en) | Composition for improving and/or preventing osteoarthritis and application thereof | |
CN109247482A (en) | Diabetic's solid beverage and preparation method thereof | |
CN108096443B (en) | Medicine for eliminating toxins in livestock and poultry and improving immunity of organism, preparation method and application thereof | |
CN101716180B (en) | Combined medicament for supplementing zinc and calcium and preparation method thereof | |
CN105581331B (en) | A kind of nutritional composition for calcium supplement | |
CN101167754A (en) | Application of sea bone peptide in preparing medicine, health-care food or food for preventing osteoporosis | |
CN103211972A (en) | Kidney-tonifying composition and preparation method thereof | |
CN101720883A (en) | Application of xylooligosaccharide used as calcium absorption enhancer | |
CN100506085C (en) | Brown sugar health product capable of raising immunity of puerpera | |
US20150104539A1 (en) | Citrated folic acid compositions and methods for delivering folic acid to usp dissolution specifications | |
CN102626420B (en) | Mixed preparation containing strontium, calcium and vitamin D | |
CN105853459A (en) | Medicinal composition used for sows to prevent and treat diarrhea of newborn piglets, and compound traditional Chinese veterinary medicinal preparation method thereof | |
CN108925806A (en) | It is a kind of to help the sea cucumber gel drink swallowed and its preparation process and purposes | |
KR20100056329A (en) | Calcium compound and calcium compound fertilized rice for the prevention and treatment of osteoporosis | |
WO2014057296A1 (en) | Nutritional supplement for patients suffering from rheumatic diseases | |
CN116138459B (en) | Easily-dispersible and easily-absorbable calcium powder composition and preparation method thereof | |
ES2940465T3 (en) | Tungsten (VI) salts to stimulate fertility and reproduction and to improve the effectiveness of assisted reproductive techniques |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant | ||
CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: 510931 1 Xingye Road, Pearl Industrial Park, Conghua, Guangzhou, Guangdong. Patentee after: Vilnius guangsai (Guangdong) biological Polytron Technologies Inc Address before: 510931 1 Xingye Road, Pearl Industrial Park, Conghua, Guangzhou, Guangdong. Patentee before: Guangzhou Saijian Bio-tech Co., Ltd. |