CN108925806A - It is a kind of to help the sea cucumber gel drink swallowed and its preparation process and purposes - Google Patents
It is a kind of to help the sea cucumber gel drink swallowed and its preparation process and purposes Download PDFInfo
- Publication number
- CN108925806A CN108925806A CN201810956391.2A CN201810956391A CN108925806A CN 108925806 A CN108925806 A CN 108925806A CN 201810956391 A CN201810956391 A CN 201810956391A CN 108925806 A CN108925806 A CN 108925806A
- Authority
- CN
- China
- Prior art keywords
- sea cucumber
- swallowed
- drink
- gel
- aqueous solution
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000251511 Holothuroidea Species 0.000 title claims abstract description 159
- 238000002360 preparation method Methods 0.000 title claims abstract description 20
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 156
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 76
- 241000206575 Chondrus crispus Species 0.000 claims abstract description 49
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims abstract description 49
- 235000019700 dicalcium phosphate Nutrition 0.000 claims abstract description 49
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims abstract description 44
- 239000004302 potassium sorbate Substances 0.000 claims abstract description 44
- 235000010241 potassium sorbate Nutrition 0.000 claims abstract description 44
- 229940069338 potassium sorbate Drugs 0.000 claims abstract description 44
- 239000001814 pectin Substances 0.000 claims abstract description 42
- 229920001277 pectin Polymers 0.000 claims abstract description 42
- 235000010987 pectin Nutrition 0.000 claims abstract description 42
- 239000000213 tara gum Substances 0.000 claims abstract description 39
- 235000010491 tara gum Nutrition 0.000 claims abstract description 39
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims abstract description 33
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims abstract description 33
- 239000000811 xylitol Substances 0.000 claims abstract description 33
- 235000010447 xylitol Nutrition 0.000 claims abstract description 33
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims abstract description 33
- 229960002675 xylitol Drugs 0.000 claims abstract description 33
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 claims abstract description 32
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 claims abstract description 32
- 239000002994 raw material Substances 0.000 claims abstract description 30
- MVORZMQFXBLMHM-QWRGUYRKSA-N Gly-His-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)CN)CC1=CN=CN1 MVORZMQFXBLMHM-QWRGUYRKSA-N 0.000 claims abstract description 28
- 108010038983 glycyl-histidyl-lysine Proteins 0.000 claims abstract description 28
- 239000003814 drug Substances 0.000 claims abstract description 27
- 239000000203 mixture Substances 0.000 claims abstract description 20
- 230000009748 deglutition Effects 0.000 claims abstract description 11
- 239000007864 aqueous solution Substances 0.000 claims description 92
- 239000007788 liquid Substances 0.000 claims description 42
- 238000003756 stirring Methods 0.000 claims description 38
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
- 239000000243 solution Substances 0.000 claims description 29
- 230000001954 sterilising effect Effects 0.000 claims description 28
- 238000001816 cooling Methods 0.000 claims description 25
- 238000010438 heat treatment Methods 0.000 claims description 25
- 238000011049 filling Methods 0.000 claims description 24
- 239000011265 semifinished product Substances 0.000 claims description 24
- 238000005507 spraying Methods 0.000 claims description 23
- 238000002156 mixing Methods 0.000 claims description 22
- 239000004615 ingredient Substances 0.000 claims description 13
- 239000003651 drinking water Substances 0.000 claims description 12
- 235000020188 drinking water Nutrition 0.000 claims description 12
- 238000005303 weighing Methods 0.000 claims description 12
- 208000019505 Deglutition disease Diseases 0.000 claims description 10
- 239000007921 spray Substances 0.000 claims description 8
- 238000004806 packaging method and process Methods 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 4
- 235000005979 Citrus limon Nutrition 0.000 claims description 2
- 244000131522 Citrus pyriformis Species 0.000 claims description 2
- 238000004659 sterilization and disinfection Methods 0.000 claims description 2
- 235000013305 food Nutrition 0.000 abstract description 23
- 230000000694 effects Effects 0.000 abstract description 15
- 230000009747 swallowing Effects 0.000 abstract description 15
- 235000019640 taste Nutrition 0.000 abstract description 6
- 230000007794 irritation Effects 0.000 abstract description 4
- 230000000857 drug effect Effects 0.000 abstract description 3
- 239000000499 gel Substances 0.000 description 157
- 239000000047 product Substances 0.000 description 23
- 238000012360 testing method Methods 0.000 description 17
- 230000006870 function Effects 0.000 description 12
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 11
- 239000011591 potassium Substances 0.000 description 11
- 229910052700 potassium Inorganic materials 0.000 description 11
- 239000000084 colloidal system Substances 0.000 description 10
- 229940079593 drug Drugs 0.000 description 10
- 238000004090 dissolution Methods 0.000 description 9
- 239000001257 hydrogen Substances 0.000 description 9
- 229910052739 hydrogen Inorganic materials 0.000 description 9
- 239000003826 tablet Substances 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 239000003292 glue Substances 0.000 description 8
- UUTKICFRNVKFRG-WDSKDSINSA-N (4R)-3-[oxo-[(2S)-5-oxo-2-pyrrolidinyl]methyl]-4-thiazolidinecarboxylic acid Chemical compound OC(=O)[C@@H]1CSCN1C(=O)[C@H]1NC(=O)CC1 UUTKICFRNVKFRG-WDSKDSINSA-N 0.000 description 7
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 7
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 7
- 239000011575 calcium Substances 0.000 description 7
- 229910052791 calcium Inorganic materials 0.000 description 7
- 239000007919 dispersible tablet Substances 0.000 description 7
- 229960005489 paracetamol Drugs 0.000 description 7
- 229960001163 pidotimod Drugs 0.000 description 7
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 238000013329 compounding Methods 0.000 description 6
- 150000002431 hydrogen Chemical class 0.000 description 6
- 230000007062 hydrolysis Effects 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- 230000004060 metabolic process Effects 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 235000016709 nutrition Nutrition 0.000 description 6
- 239000000843 powder Substances 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 230000002195 synergetic effect Effects 0.000 description 6
- 238000001514 detection method Methods 0.000 description 5
- 238000002386 leaching Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 230000035764 nutrition Effects 0.000 description 5
- 241000167880 Hirundinidae Species 0.000 description 4
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 4
- 229910052698 phosphorus Inorganic materials 0.000 description 4
- 239000011574 phosphorus Substances 0.000 description 4
- 235000019605 sweet taste sensations Nutrition 0.000 description 4
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
- NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 3
- 229910001424 calcium ion Inorganic materials 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- 239000012530 fluid Substances 0.000 description 3
- 230000002496 gastric effect Effects 0.000 description 3
- 229910001414 potassium ion Inorganic materials 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-L sulfate group Chemical group S(=O)(=O)([O-])[O-] QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 3
- 239000013589 supplement Substances 0.000 description 3
- 238000010257 thawing Methods 0.000 description 3
- 230000008719 thickening Effects 0.000 description 3
- YUFFSWGQGVEMMI-JLNKQSITSA-N (7Z,10Z,13Z,16Z,19Z)-docosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCCCC(O)=O YUFFSWGQGVEMMI-JLNKQSITSA-N 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- 235000007627 Caesalpinia Nutrition 0.000 description 2
- 241000522234 Caesalpinia Species 0.000 description 2
- 235000021294 Docosapentaenoic acid Nutrition 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000032683 aging Effects 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 238000006664 bond formation reaction Methods 0.000 description 2
- 230000001055 chewing effect Effects 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000018044 dehydration Effects 0.000 description 2
- 238000006297 dehydration reaction Methods 0.000 description 2
- 239000012738 dissolution medium Substances 0.000 description 2
- 238000011978 dissolution method Methods 0.000 description 2
- 238000007922 dissolution test Methods 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 229930182830 galactose Natural products 0.000 description 2
- 239000003349 gelling agent Substances 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 230000036039 immunity Effects 0.000 description 2
- 238000000338 in vitro Methods 0.000 description 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 230000000050 nutritive effect Effects 0.000 description 2
- 230000008855 peristalsis Effects 0.000 description 2
- 230000000152 swallowing effect Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 1
- 240000001592 Amaranthus caudatus Species 0.000 description 1
- 235000009328 Amaranthus caudatus Nutrition 0.000 description 1
- 241000894006 Bacteria Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- 244000003240 Caesalpinia gilliesii Species 0.000 description 1
- 235000014161 Caesalpinia gilliesii Nutrition 0.000 description 1
- -1 Carbon sugar alcohol Chemical class 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- YTBSYETUWUMLBZ-UHFFFAOYSA-N D-Erythrose Natural products OCC(O)C(O)C=O YTBSYETUWUMLBZ-UHFFFAOYSA-N 0.000 description 1
- YTBSYETUWUMLBZ-IUYQGCFVSA-N D-erythrose Chemical compound OC[C@@H](O)[C@@H](O)C=O YTBSYETUWUMLBZ-IUYQGCFVSA-N 0.000 description 1
- 206010056474 Erythrosis Diseases 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- 102000004877 Insulin Human genes 0.000 description 1
- 108090001061 Insulin Proteins 0.000 description 1
- 206010035669 Pneumonia aspiration Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 235000010358 acesulfame potassium Nutrition 0.000 description 1
- 229960004998 acesulfame potassium Drugs 0.000 description 1
- 239000000619 acesulfame-K Substances 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical group O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 1
- 235000012735 amaranth Nutrition 0.000 description 1
- 239000004178 amaranth Substances 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 201000009807 aspiration pneumonia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000019658 bitter taste Nutrition 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- OIQPTROHQCGFEF-UHFFFAOYSA-L chembl1371409 Chemical compound [Na+].[Na+].OC1=CC=C2C=C(S([O-])(=O)=O)C=CC2=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 OIQPTROHQCGFEF-UHFFFAOYSA-L 0.000 description 1
- 235000015165 citric acid Nutrition 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 239000013065 commercial product Substances 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004051 gastric juice Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 229940125396 insulin Drugs 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000002609 medium Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 229940085605 saccharin sodium Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 230000009758 senescence Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 235000014347 soups Nutrition 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 150000005846 sugar alcohols Chemical class 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 230000007761 synergistic anti-cancer Effects 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/231—Pectin; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/20—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents
- A23L29/206—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin
- A23L29/256—Foods or foodstuffs containing additives; Preparation or treatment thereof containing gelling or thickening agents of vegetable origin from seaweeds, e.g. alginates, agar or carrageenan
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Dispersion Chemistry (AREA)
- Non-Alcoholic Beverages (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Help the sea cucumber gel drink swallowed and its preparation process and purposes the present invention relates to a kind of, solve the prior art without training function of deglutition, promote to swallow that effect is poor, easily causes caused by accidentally inhaling that relative risk is high, it is inconvenient to take and nutriment and energy content is low, package and the technical issues of cover medicine irritation taste effect difference and influence drug effect performance.The present invention provides a kind of sea cucumber gel drink for helping and swallowing, weighed in every 1000ml drink raw material components composition include: 1.0~5.0g of sea cucumber Gly-His-Lys, 10~30g of xylitol, 10~50g of antierythrite, 1.0~4.0g of pectin, 2.0~8.0g of carragheen, 1.5~3.5g of tara gum, 0.2~1.0g of citric acid, 0.1~1.0g of calcium monohydrogen phosphate, 0.1~0.5g of potassium sorbate, remaining be water；Its preparation process and purposes are also provided simultaneously.The present invention is widely used in field of food.
Description
Technical field
The invention belongs to field of food, and in particular to a kind of to help the sea cucumber gel drink swallowed and its preparation process and use
On the way.
Background technique
At this stage, with the propulsion of aging society, the number of chewing or dysphagia person caused by the age increases is just
Increasing.These have the easy inlet type diet for chewing or swallowing people's intake of problem by fine cutting conventional food preparation
Or the paste diet standby by using mixed mechanism.The prior art is in nursing facility, and all the time, daily is to mince food materials
Or crush to be cooked, in addition to common food, the food minced is provided, chops extremely broken food, mixing food, paste food
Object, aqueous liquid foodstuff etc..The food minced is supplied to extensively in nursing facility etc. to be swallowed, the People that masticatory function reduces.
But in recent years, the food minced is noted the risk that can improve aspiration pneumonia morbidity.In addition, also have report point out with it is general
Logical food increases instead compared to Masticatory frequency.In this way, gradually learning that the food minced may not diet easier than common food.And
Paste like food is made in order to crush food materials, needs to cooperate the moisture such as a large amount of soup, therefore, adds excessive water intake, i.e.,
Make intake weight identical with common food, is also substantially decrement, causes to absorb calorie reduction, nutrition cannot supplement.
It is directly swallowed with water in addition, the people for swallowing problem takes drugs preparation, throat has the senses of discomfort such as foreign body sensation, can make
Difficult at medication, compliance is low, and therapeutic effect is not achieved.Bitter taste, sour and astringent, pungent etc. of the existing gel products for taken medicine object
Irritation taste but can not achieve package effect well, and after coating medicine, drug discharges slowly in vivo, final to influence clothes
Drug effect fruit.
Summary of the invention
The object of the invention is in order to overcome the above-mentioned deficiencies of the prior art, swallow principle according to human body, provide one kind
Raw material composition advantages of simple, ingredient is natural, proportion is appropriate, performance is stable, promotes to swallow significant effect, significantly reduces and accidentally attract
Risk, take safe ready, heat full of nutrition is high, can promote trained function of deglutition, package and covers medicine irritation
Nature and flavor road significant effect and do not influence drug effect performance help the sea cucumber gel drink swallowed and its preparation process.
The technical proposal for solving the technical problem of the invention is:
A kind of to help the sea cucumber gel drink swallowed, it includes: sea cucumber Gly-His-Lys that raw material components composition is weighed in every 1000ml drink
1.0~5.0g, 10~30g of xylitol, 10~50g of antierythrite, 1.0~4.0g of pectin, 2.0~8.0g of carragheen, Caesalpinia spinosaKuntze
1.5~3.5g of glue, 0.2~1.0g of citric acid, 0.1~1.0g of calcium monohydrogen phosphate, 0.1~0.5g of potassium sorbate, remaining be water.
Preferably, weighing in every 1000ml drink in raw material components composition further includes 0.1~1.0g of edible essence.
Preferably, raw material components composition is weighed in every 1000ml drink are as follows: sea cucumber Gly-His-Lys 3.0g, xylitol 20g, erythrose
Alcohol 30g, pectin 2.5g, carragheen 5.0g, tara gum 2.5g, citric acid 0.6g, calcium monohydrogen phosphate 0.5g, potassium sorbate 0.3g,
Edible essence 0.4g, remaining be water.
A kind of preparation process for helping the sea cucumber gel drink swallowed of above-mentioned any one, comprising the following steps:
1) ingredient: number weighs sea cucumber Gly-His-Lys, xylitol, antierythrite, pectin, carragheen, Caesalpinia spinosaKuntze according to the required weight
Glue, citric acid, calcium monohydrogen phosphate, potassium sorbate, edible essence；
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
Suitable water is separately added into be dissolved, respectively be made calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, potassium sorbate aqueous solution,
Sea cucumber peptide aqueous solution, edible essence aqueous solution；
3) gel processed: the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum are uniformly mixed
Afterwards, it is then added in dense preparing tank after being dissolved with the water of its total weight 50%~80%, then step 2) is added into dense preparing tank
Calcium monohydrogen phosphate aqueous solution obtained after mixing evenly, then is heated after mixing evenly, obtains gelinite feed liquid；
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution after being finally settled at graduation mark with water, are stirred under heating equal to mixing
It is even, the sea cucumber gel drink semi-finished product swallowed must be helped；
5) filling sterilizing: the sea cucumber gel drink semi-finished product swallowed will be helped successively to carry out filling, sterilizing made from step 4)
Afterwards, the sea cucumber gel drink swallowed must be helped.
Preferably, further include step 6) spraying cooling: will step 5) is obtained helps the sea cucumber gel drink swallowed, with drinking
Water spray is cooling.
Preferably, in step 2), suitable coolant-temperature gage is 80~85 DEG C.
Preferably, heating stirring described in step 3): temperature is 70~80 DEG C of stirring 10min；It is heated described in step 4)
Stirring: temperature is 70~80 DEG C of stirring 15min.
Preferably, in step 5), the sterilization steps are that spray sterilizing 30min is carried out using 85 DEG C of water.
A kind of above-mentioned purposes for helping the sea cucumber gel drink swallowed, helps the sea cucumber gel drink swallowed to be used to help swallow
Patients with Difficult trains function of deglutition.
A kind of above-mentioned purposes for helping the sea cucumber gel drink swallowed helps the sea cucumber gel drink swallowed for packaging medicine
Mode help the patient to take medicine.
Beneficial effects of the present invention: compatibility science of the present invention, synergistic, mouthfeel is pure and fresh smooth, has significant promote
The effect swallowed has certain elasticity, inviscid, the stable Weak Gels shape between g., jelly-like and flow-like,
Safety convenient to take significantly reduces risk caused by accidentally inhaling；It can be used for packaging medicine and cover the irritation taste of drug, to help
Patient is helped to take medicine；Dysphagia patients training function of deglutition can also be helped；It may additionally facilitate metabolism, battalion with higher simultaneously
Support value.
(1) of the invention to help in the sea cucumber gel drink swallowed, pectin, carragheen, tara gum synergistic effect, a side
Face, do not have in tara gum molecular structure on galactolipin sweet dew sugar chain branch (galactose residue) region can and pectin dehydration
Galacturonic acid residues are firmly connect with the double-stranded hydrophilic colloid of carragheen with hydrogen bond formation simultaneously, form space
Network structure, make the sea cucumber gel drink swallowed that helps of the invention, gel physics it is in stable condition between solid gum and liquid
The elasticity of body glue intermediate state having centainly, the inviscid gel between g., jelly-like and flow-like, with semisolid
G., jelly-like has compared with liquid and takes safety, significantly reduces risk caused by accidentally inhaling.On the other hand, pectin, carragheen,
Tara gum synergy formed compounding colloid keep gel more stable and high resilience, and can effectively play its thickening, water holding,
Gelatification, so that gel tissue's compact structure, in good taste, water-retaining property is strong to be significantly improved with thawing resistance.
(2) in acidic food, carragheen is easily hydrolyzed；Under high temperature and low cation concn, hydrolysis degree increases.
Sulfate group knot in the calcium monohydrogen phosphate and potassium sorbate of addition in the present invention, on calcium ion and potassium ion and carragheen
It closes, the generation of hydrolysis phenomena can be prevented in this way.
(3) of the invention that the sea cucumber gel drink swallowed is helped to can be also used for packaging medicine, to help patient to take medicine, simultaneously
It may also help in dysphagia patients training function of deglutition.
(4) sea cucumber gel drink of the invention has mouthfeel smooth, is suitable for aphetite disorder crowd (containing psychological), pure and fresh
It is smooth to be conducive to swallow, it can be to aphetite disorder crowd extra-nutrition and amount of water.Xylitol and antierythrite and pectin, OK a karaoke club
It is synergistic that glue, tara gum form compounding colloid, on the one hand, increases sweet taste and heat, promotes human metabolism, makes high sea
It is easy-to-swallow to join gel drink；On the other hand, mild nice and cool mouthfeel is generated, sea cucumber gel drink mouthfeel smoothness is significantly improved
With pure and fresh degree, the performance swallowed is remarkably promoted.
(5) of the invention to help in the sea cucumber gel drink swallowed, carragheen has reacted emulsification with sea cucumber Gly-His-Lys, makes sea
Ginseng peptide emulsion compounds colloid stable bond with the formation of pectin, carragheen and tara gum synergy, gel is presented non-stick
Property, the system of satiny quality.Sea cucumber Gly-His-Lys can also promote body immunity Synergistic anti-cancer, may additionally facilitate gastrointestinal peristalsis, prolong
Slow aging；Children's docosapentaenoic acid is supplemented, the sea cucumber gel drink swallowed that helps of the invention is made, it is not only convenient, promote to swallow, also
Nutritive value with higher.
Specific embodiment
The present invention is further explained in the light of specific embodiments, to help the contents of the present invention are understood.The present invention
Used in method unless otherwise required, be conventional production method；Used raw material is unless otherwise required
Conventional commercial product.
Embodiment 1
Prepare a kind of sea cucumber gel drink for helping and swallowing, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, and it includes: sea cucumber that raw material components composition is weighed in every 1000ml drink
Gly-His-Lys 1.0g, xylitol 10g, antierythrite 10g, pectin 1.0g, carragheen 2.0g, tara gum 1.5g, citric acid 0.2g, phosphorus
Sour hydrogen calcium 0.1g, potassium sorbate 0.1g, edible essence 0.1g, remaining be water.
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
It is separately added into the water that suitable temperature is 80 DEG C to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sorb is made respectively
Sour aqueous solutions of potassium, sea cucumber peptide aqueous solution, edible essence aqueous solution.
3) gel processed: the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum are uniformly mixed
Afterwards, it is then added in dense preparing tank after being dissolved with the water of its total weight 50%, then is added made from step 2) into dense preparing tank
It after mixing evenly, then with temperature is to obtain gel after 70 DEG C of stirring 10min progress heating stirrings are uniform by calcium monohydrogen phosphate aqueous solution
Body feed liquid.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, then with temperature be 70 DEG C of heating stir
15min is mixed to being uniformly mixed, the sea cucumber gel drink semi-finished product swallowed must be helped.
5) filling sterilizing: the sea cucumber gel drink semi-finished product swallowed will be helped successively to carry out filling, use made from step 4)
After 85 DEG C of water carry out spray sterilizing 30min, the sea cucumber gel drink first product swallowed must be helped.
6) spraying cooling: will help the sea cucumber gel drink first product swallowed made from step 5), after drinking water spraying cooling,
The sea cucumber gel drink swallowed must be helped.
Embodiment 2
Prepare a kind of sea cucumber gel drink for helping and swallowing, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, and it includes: sea cucumber that raw material components composition is weighed in every 1000ml drink
Gly-His-Lys 5.0g, xylitol 30g, antierythrite 50g, pectin 4.0g, carragheen 8.0g, tara gum 3.5g, citric acid 1.0g, phosphorus
Sour hydrogen calcium 1.0g, potassium sorbate 0.5g, edible essence 1.0g, remaining be water.
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
It is separately added into the water that suitable temperature is 85 DEG C to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sorb is made respectively
Sour aqueous solutions of potassium, sea cucumber peptide aqueous solution, edible essence aqueous solution.
3) gel processed: the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum are uniformly mixed
Afterwards, it is then added in dense preparing tank after being dissolved with the water of its total weight 80%, then is added made from step 2) into dense preparing tank
It after mixing evenly, then with temperature is to obtain gel after 80 DEG C of stirring 10min progress heating stirrings are uniform by calcium monohydrogen phosphate aqueous solution
Body feed liquid.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, then with temperature be 80 DEG C of heating stir
15min is mixed to being uniformly mixed, the sea cucumber gel drink semi-finished product swallowed must be helped.
5) filling sterilizing: the sea cucumber gel drink semi-finished product swallowed will be helped successively to carry out filling, use made from step 4)
After 85 DEG C of water carry out spray sterilizing 30min, the sea cucumber gel drink first product swallowed must be helped.
6) spraying cooling: will help the sea cucumber gel drink first product swallowed made from step 5), after drinking water spraying cooling,
The sea cucumber gel drink swallowed must be helped.
Embodiment 3
Prepare a kind of sea cucumber gel drink for helping and swallowing, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, and it includes: sea cucumber that raw material components composition is weighed in every 1000ml drink
Gly-His-Lys 2.0g, xylitol 12g, antierythrite 15g, pectin 1.5g, carragheen 3.0g, tara gum 2.0g, citric acid 0.4g, phosphorus
Sour hydrogen calcium 0.2g, potassium sorbate 0.2g, edible essence 0.2g, remaining be water.
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
It is separately added into the water that suitable temperature is 82 DEG C to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sorb is made respectively
Sour aqueous solutions of potassium, sea cucumber peptide aqueous solution, edible essence aqueous solution；
3) gel processed: the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum are uniformly mixed
Afterwards, it is then added in dense preparing tank after being dissolved with the water of its total weight 60%, then is added made from step 2) into dense preparing tank
It after mixing evenly, then with temperature is to obtain gel after 70 DEG C of stirring 10min progress heating stirrings are uniform by calcium monohydrogen phosphate aqueous solution
Body feed liquid.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, then with temperature be 75 DEG C of heating stir
15min is mixed to being uniformly mixed, the sea cucumber gel drink semi-finished product swallowed must be helped.
5) filling sterilizing: the sea cucumber gel drink semi-finished product swallowed will be helped successively to carry out filling, use made from step 4)
After 85 DEG C of water carry out spray sterilizing 30min, the sea cucumber gel drink first product swallowed must be helped.
6) spraying cooling: will help the sea cucumber gel drink first product swallowed made from step 5), after drinking water spraying cooling,
The sea cucumber gel drink swallowed must be helped.
Embodiment 4
Prepare a kind of sea cucumber gel drink for helping and swallowing, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, and it includes: sea cucumber that raw material components composition is weighed in every 1000ml drink
Gly-His-Lys 4.0g, xylitol 25g, antierythrite 40g, pectin 3.0g, carragheen 7.0g, tara gum 3.0g, citric acid 0.8g, phosphorus
Sour hydrogen calcium 0.8g, potassium sorbate 0.4g, edible essence 0.8g, remaining be water.
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
It is separately added into the water that suitable temperature is 85 DEG C to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sorb is made respectively
Sour aqueous solutions of potassium, sea cucumber peptide aqueous solution, edible essence aqueous solution.
3) gel processed: the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum are uniformly mixed
Afterwards, it is then added in dense preparing tank after being dissolved with the water of its total weight 70%, then is added made from step 2) into dense preparing tank
It after mixing evenly, then with temperature is to obtain gel after 80 DEG C of stirring 10min progress heating stirrings are uniform by calcium monohydrogen phosphate aqueous solution
Body feed liquid.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, then with temperature be 75 DEG C of heating stir
15min is mixed to being uniformly mixed, the sea cucumber gel drink semi-finished product swallowed must be helped.
5) filling sterilizing: the sea cucumber gel drink semi-finished product swallowed will be helped successively to carry out filling, use made from step 4)
After 85 DEG C of water carry out spray sterilizing 30min, the sea cucumber gel drink first product swallowed must be helped.
6) spraying cooling: will help the sea cucumber gel drink first product swallowed made from step 5), after drinking water spraying cooling,
The sea cucumber gel drink swallowed must be helped.
Embodiment 5
Prepare a kind of sea cucumber gel drink for helping and swallowing, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, raw material components composition is weighed in every 1000ml drink are as follows: sea cucumber peptide
Powder 3.0g, xylitol 20g, antierythrite 30g, pectin 2.5g, carragheen 5.0g, tara gum 2.5g, citric acid 0.6g, phosphoric acid
Hydrogen calcium 0.5g, potassium sorbate 0.3g, edible essence 0.4g, remaining be water.
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
It is separately added into the water that suitable temperature is 83 DEG C to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sorb is made respectively
Sour aqueous solutions of potassium, sea cucumber peptide aqueous solution, edible essence aqueous solution.
3) gel processed: the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum are uniformly mixed
Afterwards, it is then added in dense preparing tank after being dissolved with the water of its total weight 65%, then is added made from step 2) into dense preparing tank
It after mixing evenly, then with temperature is to obtain gel after 75 DEG C of stirring 10min progress heating stirrings are uniform by calcium monohydrogen phosphate aqueous solution
Body feed liquid.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, then with temperature be 75 DEG C of heating stir
15min is mixed to being uniformly mixed, the sea cucumber gel drink semi-finished product swallowed must be helped.
5) filling sterilizing: the sea cucumber gel drink semi-finished product swallowed will be helped successively to carry out filling, use made from step 4)
After 85 DEG C of water carry out spray sterilizing 30min, the sea cucumber gel drink first product swallowed must be helped.
6) spraying cooling: will help the sea cucumber gel drink first product swallowed made from step 5), after drinking water spraying cooling,
The sea cucumber gel drink swallowed must be helped.
Control group 1
Prepare a kind of gel drink, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, raw material components composition is weighed in every 1000ml drink are as follows: sea cucumber peptide
Powder 3.0g, xylitol 20g, antierythrite 30g, carragheen 5.0g, tara gum 2.5g, citric acid 0.6g, calcium monohydrogen phosphate 0.5g,
Potassium sorbate 0.3g, edible essence 0.4g, remaining be water.
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
It is separately added into the water that suitable temperature is 83 DEG C to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sorb is made respectively
Sour aqueous solutions of potassium, sea cucumber peptide aqueous solution, edible essence aqueous solution.
3) it gel processed: after mixing by the weighed xylitol of step 1), antierythrite, carragheen and tara gum, uses
The water of its total weight 65% is then added in dense preparing tank after being dissolved, then phosphoric acid hydrogen made from step 2) is added into dense preparing tank
It after mixing evenly, then with temperature is to obtain gelinite material after 75 DEG C of stirring 10min progress heating stirrings are uniform by calcium aqueous solution
Liquid.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, then with temperature be 75 DEG C of heating stir
15min is mixed to being uniformly mixed, obtains gel drink semi-finished product.
5) filling sterilizing: by gel drink semi-finished product made from step 4) successively carry out it is filling, sprayed using 85 DEG C of water
After leaching sterilizing 30min, gel drink first product is obtained.
6) spraying cooling: by sea cucumber gel drink first product made from step 5), after drinking water spraying cooling, gel drink is obtained
Product.
Control group 2
Prepare a kind of gel drink, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, raw material components composition is weighed in every 1000ml drink are as follows: sea cucumber peptide
Powder 3.0g, xylitol 20g, antierythrite 30g, pectin 2.5g, tara gum 2.5g, citric acid 0.6g, calcium monohydrogen phosphate 0.5g, mountain
Potassium sorbate 0.3g, edible essence 0.4g, remaining be water.
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
It is separately added into the water that suitable temperature is 83 DEG C to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sorb is made respectively
Sour aqueous solutions of potassium, sea cucumber peptide aqueous solution, edible essence aqueous solution.
3) gel processed: after mixing by the weighed xylitol of step 1), antierythrite, pectin and tara gum, it is used
The water of total weight 65% is then added in dense preparing tank after being dissolved, then calcium monohydrogen phosphate made from step 2) is added into dense preparing tank
It after mixing evenly, then with temperature is to obtain gelinite feed liquid after 75 DEG C of stirring 10min progress heating stirrings are uniform by aqueous solution.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, then with temperature be 75 DEG C of heating stir
15min is mixed to being uniformly mixed, obtains gel drink semi-finished product.
5) filling sterilizing: by gel drink semi-finished product made from step 4) successively carry out it is filling, sprayed using 85 DEG C of water
After leaching sterilizing 30min, gel drink first product is obtained.
6) spraying cooling: by gel drink first product made from step 5), after drinking water spraying cooling, gel drink is obtained.
Control group 3
Prepare a kind of sea cucumber gel drink for helping and swallowing, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, raw material components composition is weighed in every 1000ml drink are as follows: sea cucumber peptide
Powder 3.0g, xylitol 20g, antierythrite 30g, pectin 2.5g, carragheen 5.0g, citric acid 0.6g, calcium monohydrogen phosphate 0.5g, sorb
Sour potassium 0.3g, edible essence 0.4g, remaining be water.
2) prepared by aqueous solution: by the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence
It is separately added into the water that suitable temperature is 83 DEG C to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sorb is made respectively
Sour aqueous solutions of potassium, sea cucumber peptide aqueous solution, edible essence aqueous solution.
3) gel processed: after mixing by the weighed xylitol of step 1), antierythrite, pectin and carragheen, total with it
The water of weight 65% is then added in dense preparing tank after being dissolved, then calcium monohydrogen phosphate water made from step 2) is added into dense preparing tank
It after mixing evenly, then with temperature is to obtain gelinite feed liquid after 75 DEG C of stirring 10min progress heating stirrings are uniform by solution.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) is to being uniformly mixed, then to sequentially add potassium sorbate made from step 2) thereto water-soluble
Liquid, sea cucumber peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, then with temperature be 75 DEG C of heating stir
15min is mixed to being uniformly mixed, obtains gel drink semi-finished product.
5) filling sterilizing: by gel drink semi-finished product made from step 4) successively carry out it is filling, sprayed using 85 DEG C of water
After leaching sterilizing 30min, gel drink first product is obtained.
6) spraying cooling: will help the sea cucumber gel drink first product swallowed made from step 5), after drinking water spraying cooling,
Obtain gel drink.
Control group 4
Prepare a kind of sea cucumber gel drink for helping and swallowing, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, raw material components composition is weighed in every 1000ml drink are as follows: sea cucumber peptide
Powder 3.0g, xylitol 20g, antierythrite 30g, pectin 2.5g, carragheen 5.0g, tara gum 2.5g, citric acid 0.6g, phosphoric acid
Hydrogen calcium 0.5g, edible essence 0.4g, remaining be water.
2) prepared by aqueous solution: the weighed calcium monohydrogen phosphate of step 1), citric acid, sea cucumber Gly-His-Lys, edible essence are separately added into
Suitable temperature is that 83 DEG C of water is dissolved, and it is water-soluble that calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, sea cucumber peptide are made respectively
Liquid, edible essence aqueous solution.
3) gel processed: the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum are uniformly mixed
Afterwards, it is then added in dense preparing tank after being dissolved with the water of its total weight 65%, then is added made from step 2) into dense preparing tank
It after mixing evenly, then with temperature is to obtain gel after 75 DEG C of stirring 10min progress heating stirrings are uniform by calcium monohydrogen phosphate aqueous solution
Body feed liquid.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) to be uniformly mixed, then sequentially add thereto sea cucumber peptide aqueous solution made from step 2) and
Edible essence aqueous solution, after being finally settled at graduation mark with water, then it is equal to mixing for 75 DEG C of heating stirring 15min with temperature
It is even, the sea cucumber gel drink semi-finished product swallowed must be helped.
5) filling sterilizing: by gel drink semi-finished product made from step 4) successively carry out it is filling, sprayed using 85 DEG C of water
After leaching sterilizing 30min, gel drink first product is obtained.
6) spraying cooling: will help the sea cucumber gel drink first product swallowed made from step 5), after drinking water spraying cooling,
Obtain gel drink.
Control group 5
Prepare a kind of gel drink, comprising the following steps:
1) ingredient: weighing raw material components according to the required weight, raw material components composition is weighed in every 1000ml drink are as follows: xylitol
20g, antierythrite 30g, pectin 2.5g, carragheen 5.0g, tara gum 2.5g, citric acid 0.6g, calcium monohydrogen phosphate 0.5g, sorb
Sour potassium 0.3g, edible essence 0.4g, remaining be water.
2) prepared by aqueous solution: the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, edible essence are separately added into
Suitable temperature is that 83 DEG C of water is dissolved, and it is water-soluble that calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, potassium sorbate are made respectively
Liquid, edible essence aqueous solution.
3) gel processed: the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum are uniformly mixed
Afterwards, it is then added in dense preparing tank after being dissolved with the water of its total weight 65%, then is added made from step 2) into dense preparing tank
It after mixing evenly, then with temperature is to obtain gel after 75 DEG C of stirring 10min progress heating stirrings are uniform by calcium monohydrogen phosphate aqueous solution
Body feed liquid.
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, is slowly added thereto
Aqueous citric acid solution made from step 2) then sequentially adds potassium sorbate aqueous solution made from step 2) to being uniformly mixed thereto
It after being finally settled at graduation mark with water, then with temperature is 75 DEG C of heating stirring 15min equal to mixing with edible essence aqueous solution
It is even, obtain gel drink semi-finished product.
5) filling sterilizing: by gel drink semi-finished product made from step 4) successively carry out it is filling, sprayed using 85 DEG C of water
After leaching sterilizing 30min, gel drink first product is obtained.
6) spraying cooling: by gel drink first product made from step 5), after drinking water spraying cooling, gel drink is obtained.
It is further illustrated below by human trial report of the invention the effect of helping the sea cucumber gel drink swallowed.
1. object
Tested material: by 1~embodiment of the embodiment of the present invention 5 to preparation method produce help the sea cucumber gel swallowed drink
Product as test specimen, 1~control group of control group 5 the gel drink produced to preparation method sample as a control group,
The given preparation method parameter of middle 1~control group of control group 5 is identical as the given preparation method parameter of embodiment 5, compared with Example 5
Only raw material components are different for it, and pectin is not added in control group 1 wherein, and carragheen is not added in control group 2, does not add in control group 3
Enter tara gum, potassium sorbate is not added in control group 4, sea cucumber Gly-His-Lys are not added in control group 5, commercially available help of control group 6 is swallowed
Gel (Japanese Long Jiao dissipates).
2. test method and result
2.1 embodiment of the present invention 1 help the sea cucumber gel drink swallowed to be detected with Nip's tester, and various indexs meet
The GB7718-2011 " prepackaged food label general rule " and GB28050-2011 of Ministry of Health of the People's Republic of China's approval publication
" prepackaged food nutritional labeling general rule " is 6.30 (>=3.0) through pH value in detection project；Lead content, total arsenic, copper, benzoic acid,
Sunset yellow, lemon yellow, dehydroactic acid, Sucralose, saccharin sodium, honey element (in terms of cyclohexylsulfamic), acetyl para-aminobenzenesulfonic acid
Potassium (acesulfame potassium), amaranth, brilliant blue items testing result are to be not detected；Total plate count, mould, yeast, is caused a disease at coliform
Bacterium (salmonella, staphylococcus aureus etc.) items testing result is met the requirements of the standard；Energy 80KJ/100ml, nutrition
Content of material is met the requirements of the standard, and be can be used as aphetite disorder person and is provided the safe nutrition food of nutrition and heat.
2.2 of the invention help the sea cucumber gel drink swallowed to be used to help dysphagia patients and help to swallow and train swallow function
The pilot project and result of energy.
2.2.1 detection training replys the study subject for swallowing effect and foretastes method: selecting 55~85 years old by randomly assigne
Patient 220 with dysphagia are used as subject, and stochastic averagina is divided into 11 groups, and every group 9 points of difference every morning are given
Feeding 300ml test specimen is given, after 1 month time, is given a mark to respective function of deglutition recovery situation, hence it is evident that improves 8~10
Point, improve 4~7 points, does not improve 1~3 point, the results are shown in Table 1.
2.2.2 detection helps the study subject for swallowing effect and foretastes method: having within 55~85 years old by randomly assigne selection and gulps down
Swallow patient 100 of dysfunction and be used as subject, after foretasting 20ml test specimen respectively, to it is each foretaste sample and help swallow function
Energy situation is given a mark, hence it is evident that help swallows effect and makes 8~10 scores, and helpful effect of swallowing makes 4~7 scores, not helpful to swallow
Effect makes 1~3 score, the results are shown in Table 1.
2.2.3 1~embodiment of the embodiment of the present invention 5 to preparation method produce help the sea cucumber gel drink swallowed make
For test specimen, 1~control group of control group 5 the gel drink produced to preparation method sample, detection are sentenced as a control group
Disconnected gel physical aspect classification, the results are shown in Table 1.
Table 1 helps the sea cucumber gel drink swallowed to be used to help dysphagia patients and helps the test for swallowing and training function of deglutition
Project and result
It helps the sea cucumber gel drink swallowed to be used to help dysphagia patients by table 1 and helps the examination for swallowing and training function of deglutition
Project and result are tested it is found that of the invention helps the sea cucumber gel drink generally Weak Gels state swallowed, holding configuration is steady
Fixed, 1~embodiment of embodiment 5 helps helping for the sea cucumber gel drink swallowed to swallow effect and training reply is swallowed significant effect and is higher than
1~control group of control group 6, wherein 1~control group of control group 2 be frozen glue state, control group 3 be colloidal dispersed gel, sufficiently
Prove it is of the invention help in the sea cucumber gel drink swallowed, pectin, carragheen, tara gum synergistic effect, make of the invention help
The sea cucumber gel drink swallowed, gel physics it is in stable condition there is certain bullet between solid gum and liquid glue intermediate state
Property, the inviscid Weak Gels shape between g., jelly-like and flow-like has with semisolid g., jelly-like compared with liquid
Safety is taken, risk caused by accidentally inhaling is significantly reduced.On the other hand, pectin, carragheen, tara gum synergy form compounding
Colloid keeps gel more stable and high resilience, and can effectively play its thickening, water holding, gelatification, so that gel tissue ties
Structure is fine and close, in good taste, and water-retaining property is strong and thawing resistance significantly improves, and training replys and swallows significant effect.
Control group 4 does not add potassium sorbate, helps and swallows effect and reply is trained to swallow effect lower than 1~embodiment of embodiment
5, it sufficiently proves in acidic food, carragheen easily hydrolyzes；Under high temperature and low cation concn, hydrolysis degree increases.
Sulfate group knot in the calcium monohydrogen phosphate and potassium sorbate of addition in the present invention, on calcium ion and potassium ion and carragheen
It closes, the generation of hydrolysis phenomena can be prevented in this way, further increase the stable state and performance of Weak Gels.It is suitable with mouthfeel
It is sliding, it is suitable for aphetite disorder crowd (containing psychological), it is pure and fresh smooth conducive to swallowing, it can supplement the nutrients to aphetite disorder crowd and suitable
Measure moisture.Xylitol and antierythrite are formed with pectin, carragheen, tara gum synergy compounds colloid synergy, and one
Aspect increases sweet taste and heat, promotes human metabolism, keeps high sea cucumber gel drink easy-to-swallow；On the other hand, temperature is generated
The nice and cool mouthfeel of sum significantly improves sea cucumber gel drink mouthfeel smoothness and pure and fresh degree, remarkably promotes the performance swallowed.
Control group 5 and control group 2 foretaste compared with data foretaste data with 1~embodiment of embodiment 5, it is known that of the invention helps
In the sea cucumber gel drink swallowed, carragheen has reacted emulsification with sea cucumber Gly-His-Lys, makes sea cucumber peptide emulsion and pectin, OK a karaoke club
Glue and tara gum synergy form compounding colloid stable bond, make gel that inviscid, the system of satiny quality be presented.
2.3. the of the invention examination for helping the sea cucumber gel drink swallowed and helping patient to take medicine for the mode of packaging medicine
Test project and result.
2.3.1 disintegrating property is tested:
With the buffer of disintegration time mensuration instrument water under the conditions of 37 DEG C, the hydrochloric acid solution of 0.1mol/L, pH6.8 respectively
Middle progress disintegration time limited test, is compared with gelling agent made from 1~embodiment of the embodiment of the present invention 5, as a result such as table 2:
Table 2 disintegration time limited (min) test result
Show that commercially available help swallows gel with water, simulated gastric fluid (0.1mol/L salt by table 2 disintegration time limited (min) test result
Acid solution) and simulated intestinal fluid (buffer of pH6.8) be medium, carry out disintegration time mensuration, 15min is not disintegrated completely.Such as
Fruit by it is commercially available help to swallow gel and be used for ancillary drug swallow, drug can be wrapped up by gel, can not normally be discharged, and can be released drug
It puts and absorbs behavior and make a significant impact, to influence therapeutic effect.And it is of the invention help the sea cucumber gel drink swallowed, in people
Disintegration completely, is disintegrated completely in 4min in water and simulated intestinal fluid in 1min in work gastric juice, can in alimentary canal rapid disintegration,
It will not influence the release and absorption of drug, of the invention helps the sea cucumber gel drink swallowed to can be used for packaging medicine, to help
Patient's medication, while may also help in dysphagia patients training function of deglutition.
2.3.2 gel is to drug-eluting measure of merit
In order to investigate the influence for helping the sea cucumber gel drink swallowed to drug dissolution, paracetamol tablets are selected
(0.3g) is used as test sample, directly puts paracetamol tablets into turn basket respectively, and paracetamol tablets are implemented
It helps after swallowing gelling agent package to be put into made from 1~embodiment of example 5 and turns basket, carry out dissolution test.According to dissolution method (in
Two the first methods of annex X C of state's pharmacopeia version in 2010), 1000ml is added water to as dissolution medium using dilute hydrochloric acid 24ml, revolving speed is
100r/min takes solution to filter when 5min, 10min, 15min, 30min, 45min, detection, calculates accumulation dissolution rate.
It the results are shown in Table 3.
The test that table 3 influences paracetamol tablets dissolution rate
Helping with 1~embodiment of embodiment 5 is shown by the test result that table 3 influences paracetamol tablets dissolution rate
After the sea cucumber gel drink package paracetamol tablets swallowed, compared with the tablet not wrapped up, in 5min, 10min, 15min
Later dissolution data does not make significant difference to the release in vitro of paracetamol tablets without significant changes.
2.3.3 in order to investigate the influence to quick releasing formulation, select dispersible tablet of pidotimod as test sample, it respectively will be right
Dispersible tablet of pidotimod, which is directly put into, turns basket, and will be helped made from 1~embodiment of embodiment 5 dispersible tablet of pidotimod and be swallowed
Sea cucumber gel drink package after be put into and turn basket, carry out dissolution test.According to dissolution method (Chinese Pharmacopoeia version two in 2010
Portion's the first method of annex X C), using water 900ml as dissolution medium, revolving speed 100r/min, when 5min, 10min, 15min,
It takes solution to filter, detects, calculate accumulation dissolution rate, the results are shown in Table 4.
The test that table 4 influences dispersible tablet of pidotimod dissolution rate
Helping with 1~embodiment of embodiment 5 is shown by the test result that table 4 influences dispersible tablet of pidotimod dissolution rate
After the sea cucumber gel drink package dispersible tablet of pidotimod swallowed, compared with the tablet not wrapped up, dissolution data becomes without significant
Change, does not make significant difference to the release in vitro of dispersible tablet of pidotimod.
In summary, of the invention that the sea cucumber gel drink swallowed is helped to can be used for packaging medicine, to help patient to take medicine,
It may also help in dysphagia patients training function of deglutition simultaneously.
3. result and conclusion
Of the invention helps in the sea cucumber gel drink swallowed, pectin, carragheen, tara gum synergistic effect, on the one hand, thorn
There is no the region of branch (galactose residue) can be with the dehydration gala of pectin in mysorethorn xanthan molecule structure on galactolipin sweet dew sugar chain
Uronic acid residue is firmly connect with the double-stranded hydrophilic colloid of carragheen with hydrogen bond formation simultaneously, forms the net in space
Network structure, makes the sea cucumber gel drink swallowed that helps of the invention, gel physics it is in stable condition between solid gum and liquid glue
The elasticity of intermediate state having centainly, inviscid semi-solid has with solid gum compared with liquid gel and takes peace
Entirely, risk caused by accidentally inhaling is significantly reduced.On the other hand, pectin, carragheen, tara gum synergy form compounding colloid and make
Gel is more stable and high resilience, and can effectively play its thickening, water holding, gelatification, so that gel tissue's compact structure,
In good taste, water-retaining property is strong and thawing resistance significantly improves.However in acidic food, carragheen is easily hydrolyzed；In high temperature and low
Under cation concn, hydrolysis degree increases.In the calcium monohydrogen phosphate and potassium sorbate of addition in the present invention, calcium ion and potassium ion
In conjunction with the sulfate group on carragheen, the generation of hydrolysis phenomena can be prevented in this way.
Sea cucumber gel drink of the invention has mouthfeel smooth, is suitable for aphetite disorder crowd (containing psychological), pure and fresh suitable
It is sliding to be conducive to swallow, it can be to aphetite disorder crowd extra-nutrition and amount of water.Xylitol and antierythrite and pectin, carragheen,
It is synergistic that tara gum synergy forms compounding colloid, on the one hand, and increase sweet taste and heat, promotes human metabolism,
Keep high sea cucumber gel drink easy-to-swallow；On the other hand, mild nice and cool mouthfeel is generated, sea cucumber gel drink mouthfeel is significantly improved
Smoothness and pure and fresh degree, remarkably promote the performance swallowed.
Xylitol sugariness is suitable with sucrose, is dissolved in absorbable amount of heat when water, is endothermic value in all sugar alcohol sweeteners
Maximum one kind, therefore when eating in solid form, it can pleasant refrigerant sense be generated in mouth.Metabolism is not adjusted by insulin,
Human body metabolism is complete, and calorific value 16.72kJ/g can be used as the heat energy of diabetes patient.Antierythrite is newly developed 4 of one kind
Carbon sugar alcohol can be made by glucose fermentation, be white crystalline powder, have tasty and refreshing sweet taste, stable at high temperature, in extensive PH model
Interior stabilization is enclosed, there is mild cooling feeling when orally-dissolvable.Of the invention helps in the sea cucumber gel drink swallowed, carragheen and sea
Ginseng Gly-His-Lys have reacted emulsification, and sea cucumber peptide emulsion and pectin, carragheen and tara gum synergy is made to form compound gel
Body stable bond makes gel that inviscid, the system of satiny quality be presented.Sea cucumber Gly-His-Lys can also promote body immunity collaboration
Anticancer may additionally facilitate gastrointestinal peristalsis, delay senescence；Supplement children's docosapentaenoic acid, make it is of the invention help the sea cucumber gel drink swallowed,
It is not only convenient, promote to swallow, nutritive value also with higher.
Only as described above, only specific embodiments of the present invention, when the model that cannot be limited the present invention with this and implement
It encloses, it is all according to equivalent changes and modifications within the scope of the patent application of the present invention, it is all covered by the present invention.
Claims (10)
1. a kind of help the sea cucumber gel drink swallowed, which is characterized in that weighing raw material components composition in every 1000ml drink includes:
1.0~5.0g of sea cucumber Gly-His-Lys, 10~30g of xylitol, 10~50g of antierythrite, 1.0~4.0g of pectin, carragheen 2.0~
8.0g, 1.5~3.5g of tara gum, 0.2~1.0g of citric acid, 0.1~1.0g of calcium monohydrogen phosphate, 0.1~0.5g of potassium sorbate, its
Yu Weishui.
2. a kind of the sea cucumber gel drink swallowed is helped according to claim 1, which is characterized in that every 1000ml drink
In weigh raw material components composition in further include 0.1~1.0g of edible essence.
3. a kind of the sea cucumber gel drink swallowed is helped according to claim 2, which is characterized in that every 1000ml drink
In weigh raw material components composition are as follows: sea cucumber Gly-His-Lys 3.0g, xylitol 20g, antierythrite 30g, pectin 2.5g, carragheen 5.0g,
Tara gum 2.5g, citric acid 0.6g, calcium monohydrogen phosphate 0.5g, potassium sorbate 0.3g, edible essence 0.4g, remaining be water.
4. a kind of preparation process for helping the sea cucumber gel drink swallowed, feature described in any one according to claim 1~3
It is, comprising the following steps:
1) ingredient: sea cucumber Gly-His-Lys, xylitol, antierythrite, pectin, carragheen, tara gum, lemon are weighed according to the required weight
Acid, calcium monohydrogen phosphate, potassium sorbate, edible essence；
2) prepared by aqueous solution: the weighed calcium monohydrogen phosphate of step 1), citric acid, potassium sorbate, sea cucumber Gly-His-Lys, edible essence are distinguished
Suitable water is added to be dissolved, calcium monohydrogen phosphate aqueous solution, aqueous citric acid solution, potassium sorbate aqueous solution, sea cucumber are made respectively
Peptide aqueous solution, edible essence aqueous solution；
3) it gel processed: after mixing by the weighed xylitol of step 1), antierythrite, pectin, carragheen and tara gum, uses
The water of its total weight 50%~80% is then added in dense preparing tank after being dissolved, then is added made from step 2) into dense preparing tank
Calcium monohydrogen phosphate aqueous solution after mixing evenly, then is heated after mixing evenly, obtains gelinite feed liquid；
4) it deploys: gelinite feed liquid made from step 3) in dense preparing tank being driven into dilute preparing tank, step is slowly added thereto
2) aqueous citric acid solution made from then sequentially adds potassium sorbate aqueous solution made from step 2), sea to being uniformly mixed thereto
Join peptide aqueous solution and edible essence aqueous solution, after being finally settled at graduation mark with water, is stirred under heating to being uniformly mixed, must help
The sea cucumber gel drink semi-finished product swallowed；
5) it filling sterilizing: after helping the sea cucumber gel drink semi-finished product swallowed successively to carry out filling, sterilizing made from step 4), obtains
Help the sea cucumber gel drink swallowed.
5. a kind of preparation process for helping the sea cucumber gel drink swallowed according to claim 4, which is characterized in that further include
Step 6) spraying cooling: the sea cucumber gel drink swallowed will be helped made from step 5), with drinking water spraying cooling.
6. a kind of preparation process for helping the sea cucumber gel drink swallowed according to claim 4, which is characterized in that step 2)
In, suitable coolant-temperature gage is 80~85 DEG C.
7. a kind of preparation process for helping the sea cucumber gel drink swallowed according to claim 4, which is characterized in that step 3)
Described in heating stirring: temperature be 70~80 DEG C of stirring 10min；Heating stirring described in step 4): temperature is 70~80 DEG C and stirs
Mix 15min.
8. a kind of preparation process for helping the sea cucumber gel drink swallowed according to claim 4, which is characterized in that step 5)
In, the sterilization steps are that spray sterilizing 30min is carried out using 85 DEG C of water.
9. a kind of purposes for helping the sea cucumber gel drink swallowed, feature described in any one exist according to claim 1~3
In described that the sea cucumber gel drink swallowed is helped to be used to help dysphagia patients training function of deglutition.
10. a kind of purposes for helping the sea cucumber gel drink swallowed, feature described in any one exist according to claim 1~3
In described to help the sea cucumber gel drink swallowed for the mode of packaging medicine to help patient to take medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810956391.2A CN108925806A (en) | 2018-08-21 | 2018-08-21 | It is a kind of to help the sea cucumber gel drink swallowed and its preparation process and purposes |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810956391.2A CN108925806A (en) | 2018-08-21 | 2018-08-21 | It is a kind of to help the sea cucumber gel drink swallowed and its preparation process and purposes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108925806A true CN108925806A (en) | 2018-12-04 |
Family
ID=64445634
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810956391.2A Pending CN108925806A (en) | 2018-08-21 | 2018-08-21 | It is a kind of to help the sea cucumber gel drink swallowed and its preparation process and purposes |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108925806A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112544954A (en) * | 2020-10-15 | 2021-03-26 | 麦孚营养科技（北京）有限公司 | Composition for improving eating safety of dysphagia patient and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170326068A1 (en) * | 2015-02-12 | 2017-11-16 | Morimoto-Pharma Co., Ltd. | Jelly for assisting in taking drug |
-
2018
- 2018-08-21 CN CN201810956391.2A patent/CN108925806A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170326068A1 (en) * | 2015-02-12 | 2017-11-16 | Morimoto-Pharma Co., Ltd. | Jelly for assisting in taking drug |
Non-Patent Citations (2)
| Title |
|---|
| 尹胜利等: "新型食品添加剂增稠剂-刺云实胶的特性及其在食品中的应用", 《中国食品添加剂》 * |
| 苏永昌等: "海参多肽果冻的制备工艺研究", 《渔业研究》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112544954A (en) * | 2020-10-15 | 2021-03-26 | 麦孚营养科技（北京）有限公司 | Composition for improving eating safety of dysphagia patient and preparation method and application thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101325374B1 (en) | Oral or enteral composition useful for recovery of physical functions | |
| CN107343657A (en) | High fat diet formula powder | |
| CN106135890A (en) | A kind of alimentation composition contributing to bony articulation health | |
| KR20080038376A (en) | Nutrient composition | |
| KR20170118788A (en) | Auxiliary jelly for medicines and manufacturing method thereof | |
| CN103859415A (en) | Polymerized whey protein-based panaxoside microcapsule and preparation method thereof | |
| CN107427058A (en) | Muscle synthesis accelerant | |
| CN106036678A (en) | Jellies capable of slow release of energy and preparation method of jellies | |
| JP5383244B2 (en) | Nutritional agent suitable for improving symptoms or nutritional status of cancer patients | |
| JP5106948B2 (en) | Oral administration adjuvant composition for pets | |
| CN109007478A (en) | A kind of blueberry gel drink and its preparation method and application | |
| WO2015137387A1 (en) | Muscle enhancing drug | |
| JP6084092B2 (en) | Thorough nutritional composition | |
| CN108925806A (en) | It is a kind of to help the sea cucumber gel drink swallowed and its preparation process and purposes | |
| CN110313617A (en) | A kind of aphetite disorder crowd medical usage formula food | |
| JP5527986B2 (en) | Pharmaceutical composition | |
| CN115067504B (en) | Special medical food for intestinal tract preparation and preparation method thereof | |
| WO2008053984A1 (en) | Health food containing aloe and agar | |
| JP2013208103A (en) | Regular diet-like jelly-in-jelly | |
| WO2016031292A1 (en) | Additive for orally administered composition | |
| CN107753417A (en) | Brain Fitness improvement composition | |
| US20070082108A1 (en) | Methods for reducing calorie intake | |
| CN109090319A (en) | Newborn mineral salt pressed candy | |
| JPH09175994A (en) | Calcium-containing liquid drug, calcium drink and its production | |
| CN113573598A (en) | Food product for inducing satiety and preparation thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181204 |
|
| RJ01 | Rejection of invention patent application after publication |