CN104543674A - Health food for improving bone and joint health as well as preparation method thereof - Google Patents
Health food for improving bone and joint health as well as preparation method thereof Download PDFInfo
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- CN104543674A CN104543674A CN201510002075.8A CN201510002075A CN104543674A CN 104543674 A CN104543674 A CN 104543674A CN 201510002075 A CN201510002075 A CN 201510002075A CN 104543674 A CN104543674 A CN 104543674A
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
The invention discloses a health food for improving bone and joint health as well as a preparation method for the health food. The health food for improving the bone and joint health comprises the following components in parts by weight: 10-15 parts of glucosamine hydrochloride, 4-12 parts of chondroitin sulfate, 10-12.6 parts of calcium carbonate, 4-8 parts of collagen protein and 1-5 parts of membrana follicularis ovi hydrolysate. Proved by experience, the health food has the health function of improving the bone and joint health.
Description
Technical field
The present invention relates to health product, particularly relate to and a kind ofly improve health food of B&J health and preparation method thereof.
Background technology
Along with developing rapidly of national economy, medical and health cause constantly perfect, living standards of the people are improving constantly, and the average life span constantly extends, and aged tendency of population also becomes clear day by day.This colony of middle-aged and elderly people is going from strength to strength, and according to their physiological characteristics, body and function engender old and feeble phenomenon, and various disease also comes quiet, and osteoporosis, osteoarthritis are all the diseases threatening middle-aged and elderly people health.
Osteoporosis (osteoporosis, OP) is a kind of with bone amount minimizing, and osseous tissue fine structure destroys the one systematicness systemic skeletal disease causing skeletal fragility increase and fracture risk to increase to feature.
Osteoarthritis (osteoarthritis, OA) is the non-specific arthritis of one being narrowed feature with articular cartilage damage, subchondral osteonecrosis and joint space, is a kind of prompting aging and gradual chronic disease.
Osteoporosis can accelerate osteoarticular pathological changes, and osteoarthritis also can accelerate osteoporotic process, and the two presents complementary positive correlation.Osteoporosis and osteoarthritis are all increase relevant a kind of degeneration illness with the age, very common and can cause serious consequence in old people.Along with the aging of population, its sickness rate is more and more higher, is also the main cause causing its arthralgia and DB.
Therefore, research and development has the health food simultaneously improving B&J healthy functions, and to preventing and improving middle-aged and elderly people osteoporosis, osteoarthritis, the quality of the life improving middle-aged and elderly people is significant.
Summary of the invention
The present invention is directed to the deficiency in the middle of prior art, a kind of health food that can improve B&J health is provided.
The health food improving B&J health of the present invention, comprises each component of following weight portion:
Glucosamine hydrochloride 10 ~ 15 parts,
Chondroitin sulfate 4 ~ 12 parts,
Calcium carbonate 10 ~ 12.6 parts,
Bone collagen 4 ~ 8 parts,
Membrana Follicularis ovi hydrolysate 1 ~ 5 part.
Preferably, the health food of described improvement B&J health, also comprises the adjuvant of following weight portion:
Microcrystalline Cellulose 1.625 ~ 1.9 parts,
Carboxymethylstach sodium 0.9 ~ 2.25 part,
PVP K30 0.1 ~ 0.15 part,
Hypromellose 0.15 ~ 0.18 part,
Magnesium stearate 0.225 ~ 0.45 part,
Film coating agent 0.135 ~ 1.35 part.
Present invention also offers a kind of preparation method of the health food for described improvement B&J health, comprise the following steps:
S10, to sieve
Each raw material is crossed 60 mesh sieves respectively;
S20, granulation, drying, granulate
PVP K30 purified water is dissolved, is mixed with PVP K30 solution, for subsequent use; Hypromellose purified water is dissolved, is mixed with hypromellose cellulose solution, for subsequent use;
Calcium carbonate is mixed with hypromellose cellulose solution, soft material processed, granulate after 20 mesh sieves, obtained wet granular A; Glucosamine hydrochloride is mixed with PVP K30 solution, soft material processed, granulate after 20 mesh sieves, obtained wet granular B;
By wet granular A, wet granular B 60 ~ 70 DEG C of dryings, cross 20 mesh sieve granulate respectively, obtain granule C, granule D;
S30, always to mix
By granule C, granule D, all the other each supplementary material mix homogeneously, obtain total mixture;
S40, tabletting
Total mixture is carried out tabletting and obtains label;
S50, coating
By film coating agent purified water or dissolve with ethanol solution, stir, obtained coating solution; Again with coating solution to label film coating, obtain coated tablet.
Described Membrana Follicularis ovi hydrolysate is purchased from Jiangsu Fu Dan biological medicine company limited, and commodity are called ESM-P polypeptide powder.
The health food instructions of taking that can improve B&J health of the present invention is, oral, every day 2 times, each 2 or 3 (every sheet 0.75 gram).
Osteoporosis (osteoporosis, OP) is a kind of with bone amount minimizing, and osseous tissue fine structure destroys the one systematicness systemic skeletal disease causing skeletal fragility increase and fracture risk to increase to feature.Osteoarthritis (osteoarthritis, OA) is the non-specific arthritis of one being narrowed feature with articular cartilage damage, subchondral osteonecrosis and joint space, is a kind of prompting aging and gradual chronic disease.Osteoporosis can accelerate osteoarticular pathological changes, and osteoarthritis also can accelerate osteoporotic process, and the two presents complementary positive correlation.
Each component below in conjunction with health food of the present invention is described the mechanism that it improves B&J health.
Calcium carbonate
Calcium is the element that in human body mineral, content is maximum, is the necessary element of New bone formation in whole vital stage process of reconstruction.To the formation of sclerotin, maintain NE that is neural and muscle, reduce blood capillary and membrane passage etc. and there is important function.The calcium of 99% is present in skeleton and tooth in vivo, and the calcium of 1% is present in soft tissue and extracellular fluid, and serum calcium levels is 9-11mg/100ml, and under the adjustment of parathyroid hormone, calcitonin and vitamin D etc., its content keeps relative stability.If long-term low calcium diet, absorb less than enough calcium from food, the calcium concentration in blood will decline, in body parathyroid hormone will make skeleton and tooth separate out calcium for, to maintain calcium concentration certain in blood.Calcium in skeleton and tooth will run off gradually, makes osteopenia, causes osteoporosis and odontoseisis.
Supplementary calcium preparation is an osteoporotic Primary Care.Its mechanism mainly reduces bone conversion, suppresses the excessive secretion of parathyroid hormone, has protective effect to bone density, and can promote the formation of bone and keep bone strength.
Because calcium can suppress the secretion of parathyroid hormone, so there is anti-bone resorption.In circulation, parathyroid hormone level is seasonal variety, and appropriateness rises in the winter time, and is proportionate with the serum osteocalcin same period (mark that sclerotin upgrades).But when circulate in parathyroid hormone increase to over normal range time, then there is the bone loss of cortical bone.And the change of calcium intake within normal range time, the appropriateness of blood parathyroid hormone level can be caused to change, therefore with supplementing calcium preparation to suppress parathyroid hormone level, thus the effect of the bone mass of stabilization of bony cortex can be played.
Glucosamine hydrochloride
Glucosamine is a kind of natural amino monosaccharide, it is the composition of poly-glucosamine in cartilage matrix and synovial fluid, chondrocyte synthetic proteins polysaccharide can be stimulated, supplement the loss of cartilage matrix, suppress the enzyme of damaged cartilage as collagenase and phospholipase A2, and the generation of the super oxyradical of damaged cartilage cell can be prevented, thus promote the repair and reconstruction of cartilage matrix, improve joint motion, alleviating pain.
Osteoblast is as the key player participating in bone metabolism, and its differentiation and maturation, functional activity and apoptosis determine formation and the mineralization degree of bone in metabolic process.Research in recent years shows, glucosamine has the effect improving osteoblast activity, promote osteoblastic proliferation.
Glucosamine is general in vitro to be existed with the form of sulphuric acid, hydrochloric acid, N-acetylate, and they dissociate completely in gastric acid, absorb in small intestinal with glucosamine original shape, just have nothing to do with initial acid group, show identical activity once by absorption.
Chondroitin sulfate
Chondroitin sulfate is the class mucopolysaccharide be extensively present in humans and animals cartilaginous tissue, the class acidic mucopolysaccharide obtained primarily of cartilaginous tissue separation and purification such as animal larynx bone, nasal septum, tracheas, the structure of chondroitin sulfate is made up of D-glucuronic acid and N-2 acyl-D chondrosaminicacid sulfuric ester.Its composition is about containing 50-70 disaccharidase ultimate unit, and molecular weight is 1-5 ten thousand.According to the difference of alduronic acid kind and sulfuric ester position in its molecular structure, be mainly divided into three types: chondroitin sulfate A, chondroitin sulfate B, chondroitin sulfate C etc.There is composition as natural in connective tissue in chondroitin sulfate, can be used for lubrication and support joint by bound water molecule, make joint motion freely; and there is promotion osteoblastic proliferation, promote bone doped calcium, induction new bone formation; protection cartilage, antiinflammatory, the multiple biological activity such as blood fat reducing.In recent years, chondroitin sulfate, as a kind of novel active composition, is subject to people's attention gradually and welcomes.
Bone collagen
Bone collagen is also called as tectine matter, is skeleton, articular cartilage, epiphysial cartilage and bone trabecular main constituent, has 70% ~ 86% to be bone collagen in skeleton Organic substance.Bone collagen in osteocyte is the adhesive of hydroxyapatite, and itself and hydroxyapatite together constitute the main body of skeleton.Bone collagen is mainly distributed in spongy bone in skeleton, and collagen content increases, and bone trabecula can be made thickening, and toughness increases.Collagen is full of the net of duck eye just as in skeleton, and it can keep the mineral such as calcium, phosphorus that will run off firmly here.The characteristic amino acid hydroxyproline of collagen protein is the vehicle of transport calcium to osteocyte.Research shows, if collagen protein is less in bone, even if supplement calcareous how also little for preventing osteoporosis effect again.Therefore, while replenishing the calcium, take in a certain amount of collagen protein, be conducive to absorption and the deposition of calcium.
Membrana Follicularis ovi hydrolysate
Membrana Follicularis ovi derives from the eggshell inner membrance of Phasianidae animal man chicken.Membrana Follicularis ovi is about containing protein 90%, liposome 3%, saccharide 2%, aminoacid kind more than 20, and egg shell membrane is based on collagen protein, keratin, the compound protein that combines with mucopolysaccharide class.Contain and constituent identical or close in knee cartilage substrate and joint fluid, as glucosamine, hyaluronic acid, chondroitin sulfate, collagen protein etc.Clinical trial confirms, oral Membrana Follicularis ovi can improve the gonalgia of Human Osteoarthritis and stiff symptom, and safe and effective.Membrana Follicularis ovi hydrolysate may secrete inflammatory mediator with its suppression OA to the protective effect of articular cartilage, and reduces the destruction of inflammatory mediator to cartilage matrix, promotes that chondrocyte synthesis secretion proteoglycan is relevant.
The primary raw material of this product is calcium carbonate, glucosamine hydrochloride and chondroitin sulfate, bone collagen and Membrana Follicularis ovi hydrolysate.Calcium carbonate is conventional calcium source, can effectively prevent bone calcium loss by replenishing the calcium, and increases bone doped calcium, increases bone amount, to prevent and delaying osteoporosis plays an important role; Glucosamine hydrochloride and chondroitin sulfate can promote osteoblastic proliferation, improve osteoblast activity, finally reach the function improving B&J health, bone collagen is conducive to absorption and the deposition of calcium, Membrana Follicularis ovi hydrolysate contains and constituent identical or close in knee cartilage substrate and joint fluid, as glucosamine, hyaluronic acid, chondroitin sulfate, collagen protein etc., the gonalgia of Human Osteoarthritis and stiff symptom can be improved, above five kinds of raw materials share, and can effectively improve B&J health.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is further elaborated.
Embodiment 1
The Ricipe for health care food that can improve B&J health of the present embodiment is:
Glucosamine hydrochloride 13.5 parts,
Chondroitin sulfate 9 parts,
Calcium carbonate 12.6 parts,
Bone collagen 4 parts,
Membrana Follicularis ovi hydrolysate 1 part.
Microcrystalline Cellulose 1.885 parts,
Carboxymethylstach sodium 2.25 parts,
PVP K30 0.135 part,
Hypromellose 0.18 part,
Magnesium stearate 0.45 part,
Film coating agent 1.35 parts.
The health food that can improve B&J health of the present embodiment is prepared according to following steps:
S10, to sieve
Each raw material is crossed 60 mesh sieves respectively;
S20, granulation, drying, granulate
PVP K30 purified water is dissolved, is mixed with PVP K30 solution, for subsequent use; Hypromellose purified water is dissolved, is mixed with hypromellose cellulose solution, for subsequent use;
Calcium carbonate is mixed with hypromellose cellulose solution, soft material processed, granulate after 20 mesh sieves, obtained wet granular A; Glucosamine hydrochloride is mixed with PVP K30 solution, soft material processed, granulate after 20 mesh sieves, obtained wet granular B;
By wet granular A, wet granular B 60 ~ 70 DEG C of dryings, cross 20 mesh sieve granulate respectively, obtain granule C, granule D;
S30, always to mix
By granule C, granule D, all the other each supplementary material mix homogeneously, obtain total mixture;
S40, tabletting
Total mixture is carried out tabletting and obtains label;
S50, coating
By film coating agent 70wt% (wt mass percent) dissolve with ethanol, stir, obtained coating solution; Again with coating solution to label film coating, obtain coated tablet.
Embodiment 2
The Ricipe for health care food that can improve B&J health of the present embodiment is:
Glucosamine hydrochloride 10 parts,
Chondroitin sulfate 12 parts,
Calcium carbonate 10 parts,
Bone collagen 8 parts,
Membrana Follicularis ovi hydrolysate 2 parts.
Microcrystalline Cellulose 1.625 parts,
Carboxymethylstach sodium 0.9 part,
PVP K30 0.1 part,
Hypromellose 0.15 part,
Magnesium stearate 0.225 part,
Film coating agent 0.135 part.
The preparation method can improving the health food of B&J health of the present embodiment is with embodiment 1.
Embodiment 3
The Ricipe for health care food that can improve B&J health of the present embodiment is:
Glucosamine hydrochloride 15 parts,
Chondroitin sulfate 4 parts,
Calcium carbonate 11 parts,
Bone collagen 6 parts,
Membrana Follicularis ovi hydrolysate 5 parts.
Microcrystalline Cellulose 1.9 parts,
Carboxymethylstach sodium 1.35 parts,
PVP K30 0.15 part,
Hypromellose 0.15 part,
Magnesium stearate 0.45 part,
Film coating agent 0.135 part.
The preparation method can improving the health food of B&J health of the present embodiment is with embodiment 1.
The film coating agent used in embodiment 1 ~ 3 is hypromellose or coating pre-mixing agent.
Increase bone density test
1 materials and methods
1.1 samples: the health food in embodiment 1, human body recommended dose be 4.5g/ day/people.
1.2 experimental animals and raising: SPF level female sd inbred rats 60.Animal feeding: animal is raised in barrier level (IVC) Animal House.In whole experimentation, animal freely ingests and drinks deionized water, room temperature 20 DEG C ~ 26 DEG C, relative humidity 40% ~ 70%.
1.3 feedstuffs: low calcium feedstuff, is provided by institute of lab animals of Sichuan Academy of Medical Sciences.Low calcium feed formula (gram %): casein 10.0, analysis for soybean powder 15.0, wheat flour 54.0, Oleum Arachidis hypogaeae semen 4.0, cellulose 2.0, AIN
_ 76salt-mixture 2.6, AIN
-76mixed vitamin 1.0, choline chloride 0.2, DL-methionine 0.2, starch 11.0, actual measurement per kilogram feedstuff calcium content is 789.5mg, adds CaC0
3feed calcium content is made to reach actual measurement 1500mg/kg, as low calcium feedstuff.
1.4 key instruments and reagent: atomic absorption spectrophotometer, DPX-L Dual-energy X-rays absorptionmetry, electronics Libra.
1.5 experimental techniques: rat after seven days, according to body weight, is divided into following five groups with normal feedstuff adaptability feed at random:
Low calcium matched group, high dose calcium carbonate group, health food three dosage groups that can increase bone density of the present invention: 375mg/kg.bw group, 750mg/kg.bw group and 1500mg/kg.bw group (being equivalent to 5,10,20 times of human intaking amount 75mg/kg.bw respectively), every treated animal 12.Five treated animals are all with low calcium feedstuff feed.Low calcium matched group is with distilled water gavage; Three dosage groups are with (the preparation of gavage liquid: get respectively and close brightness board nutritious calcium tablet (fragrant citrus taste) 3.75g, 7.5g, 15.0g of the sample liquid gavage of preparation, adding distil water is settled to 100ml, is mixed with the gavage liquid of 375mg/kg.bw, 750mg/kg.bw, 1500mg/kg.bw group); High dose calcium carbonate control group per os pours into the calcium carbonate of 375mg/kg.bw, and this dosage is equivalent to this health food high dose group calcium level.All animal gavage amounts are 10ml/kg.bw; Once a day, continuous gavage 90 days, weighs weekly and adjusts gavage amount by body weight.Test last femoral artery sacrificed by exsanguination animal, take out right side femur, in 105 DEG C of baking ovens, bake to constant weight, weigh bone weight.Bian DPX-L Dual-energy X-rays absorptionmetry measures fl bone density (g/cm
2), its concrete assay method scans whole fl with DPX-L Dual-energy X-rays absorptionmetry, represents this bone bone density with the mean bone density of bone.The right femur calcium content of Bian atomic absorption spectroscopy determination.
1.6 experimental data statistics: use PEMS3.1 statistical package, variance analysis is done to the group difference of each index.
2 results
The impact that 2.1 health foods of the present invention weigh rat body weight, bone, in table 1.
The impact that table 1 weighs rat body weight, bone
From table 1, body weight there was no significant difference (P>0.05) before each group experiment; After experiment, each group body weight also there was no significant difference (P>0.05).Three dosage groups have rising trend with the right femur bone of high dose calcium carbonate group is heavy compared with low calcium matched group, but not statistically significant (P>0.05).
2.2 health foods of the present invention on the impact of rat bone density and bone calcium, in table 2.
Table 2 is on the impact of rat bone density and calcium content of bone
★: compare P<0.05 with low calcium matched group; ★ ★: compare P<0.01 with low calcium matched group
From table 2, the bone density of high dose calcium carbonate group is significantly higher than low calcium matched group (P<0.05), the bone density of health food of the present invention middle and high dosage group is significantly higher than low calcium matched group (P<0.01, P<O.05), and without significant difference (P>0.05) between high dose group fl bone density and high dose calcium carbonate control group.There was no significant difference (P>0.05) between the right femur calcium content of three dosage groups and high dose calcium carbonate group and low calcium matched group.
3 brief summaries
The fl bone density of health food of the present invention middle and high dosage group is significantly higher than low calcium matched group (P<0.01, P<0.05), high dose group fl bone density compares without significant difference (P>0.05) with high dose calcium carbonate control group.By evaluation criterion: health food of the present invention has increase bone substance density improving function.
Improve osteoarthrosis test
1 clinical data
Object of study is Beijing person in middle and old age Osteoarthritis.Number 20 example.Screening conditions: do not take any D-glucosamine chrondroitin series products confirms to have osteoarthritis middle-older patient through Clinical Laboratory.Data statistics tests and assesses 8: during rest, pain, fortune oxycinesia, articular pain, arthroncus, joint deadlock in morning, locomotor activity, crouching play obstacle, stair activity, have one or more symptom improver to be effectively with user is every.
The instructions of taking of 2 patients and statistical effect
2.1 instructions of taking: take the health food 2 times/d in embodiments of the invention 1,3 pieces/times.
2.2 take effect follows the tracks of statistical data in Table 3-table 5.
Table 3 patient takes health food 28d symptom of the present invention and improves data statistics
Table 4 patient takes health food 28d total effective rate of the present invention statistics
Table 5 patient takes the health food of the present invention osteoarthritis symptoms of 2 months and improves statistics
3 brief summaries
Health food of the present invention has the function improving osteoarthritic inflammation.
The sequencing of above embodiment, only for ease of describing, does not represent the quality of embodiment.
Last it is noted that above embodiment is only in order to illustrate technical scheme of the present invention, be not intended to limit; Although with reference to previous embodiment to invention has been detailed description, those of ordinary skill in the art is to be understood that: it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature; And these amendments or replacement, do not make the essence of appropriate technical solution depart from the spirit and scope of various embodiments of the present invention technical scheme.
Claims (3)
1. improve a health food for B&J health, it is characterized in that, comprise each component of following weight portion:
Glucosamine hydrochloride 10 ~ 15 parts,
Chondroitin sulfate 4 ~ 12 parts,
Calcium carbonate 10 ~ 12.6 parts,
Bone collagen 4 ~ 8 parts,
Membrana Follicularis ovi hydrolysate 1 ~ 5 part.
2. the health food improving B&J health according to claim 1, is characterized in that, also comprises the adjuvant of following weight portion:
Microcrystalline Cellulose 1.625 ~ 1.9 parts,
Carboxymethylstach sodium 0.9 ~ 2.25 part,
PVP K30 0.1 ~ 0.15 part,
Hypromellose 0.15 ~ 0.18 part,
Magnesium stearate 0.225 ~ 0.45 part,
Film coating agent 0.135 ~ 1.35 part.
3. a preparation method for the health food of the improvement B&J health described in claim 1 or 2, is characterized in that, comprise the following steps:
S10, to sieve
Each raw material is crossed 60 mesh sieves respectively;
S20, granulation, drying, granulate
PVP K30 purified water is dissolved, is mixed with PVP K30 solution, for subsequent use; Hypromellose purified water is dissolved, is mixed with hypromellose cellulose solution, for subsequent use;
Calcium carbonate is mixed with hypromellose cellulose solution, soft material processed, granulate after 20 mesh sieves, obtained wet granular A; Glucosamine hydrochloride is mixed with PVP K30 solution, soft material processed, granulate after 20 mesh sieves, obtained wet granular B;
By wet granular A, wet granular B 60 ~ 70 DEG C of dryings, cross 20 mesh sieve granulate respectively, obtain granule C, granule D;
S30, always to mix
By granule C, granule D, all the other each supplementary material mix homogeneously, obtain total mixture;
S40, tabletting
Total mixture is carried out tabletting and obtains label;
S50, coating
By film coating agent purified water or dissolve with ethanol solution, stir, obtained coating solution; Again with coating solution to label film coating, obtain coated tablet.
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105770850A (en) * | 2016-04-25 | 2016-07-20 | 南京邦康生物技术有限公司 | Health care product for adjuvant treatment of osteoarticular diseases and preparation method of health care product |
CN106213492A (en) * | 2016-07-22 | 2016-12-14 | 山东博奥克生物科技有限公司 | A kind of lifter motion function also increases health-oriented products and the preparation method of bone density |
CN106333962A (en) * | 2016-10-29 | 2017-01-18 | 芜湖市诺康生物科技有限公司 | Composition for increasing bone density |
CN109007821A (en) * | 2018-08-07 | 2018-12-18 | 青岛明月海藻生物科技有限公司 | A kind of gel jelly and preparation method thereof improving articulation health |
CN109480213A (en) * | 2018-12-13 | 2019-03-19 | 北京康比特体育科技股份有限公司 | A kind of sport nutrition matched combined object with joint maintenance and maintenance |
CN110946994A (en) * | 2019-12-30 | 2020-04-03 | 东营广元生物科技股份有限公司 | Composition for increasing bone mineral density and preparation method thereof |
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Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102949710A (en) * | 2012-05-08 | 2013-03-06 | 北京润康普瑞生物技术有限公司 | Pharmaceutical composition or healthcare product for increasing bone mineral density and preparation method of pharmaceutical composition or healthcare product |
CN104068306A (en) * | 2014-06-18 | 2014-10-01 | 广州市赛健生物科技有限公司 | Health food for improving bone density and preparation method of health food |
CN104188999A (en) * | 2014-08-13 | 2014-12-10 | 哈药集团制药六厂 | Composition capable of increasing bone density and improving functions of skeletons and joints and preparation method thereof |
CN104206949A (en) * | 2014-08-04 | 2014-12-17 | 江苏康缘阳光药业有限公司 | Composition for improving osteoporosis and increasing bone mineral density, preparation method of same and application of the same in preparation of health-caring product |
-
2015
- 2015-01-04 CN CN201510002075.8A patent/CN104543674A/en active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102949710A (en) * | 2012-05-08 | 2013-03-06 | 北京润康普瑞生物技术有限公司 | Pharmaceutical composition or healthcare product for increasing bone mineral density and preparation method of pharmaceutical composition or healthcare product |
CN104068306A (en) * | 2014-06-18 | 2014-10-01 | 广州市赛健生物科技有限公司 | Health food for improving bone density and preparation method of health food |
CN104206949A (en) * | 2014-08-04 | 2014-12-17 | 江苏康缘阳光药业有限公司 | Composition for improving osteoporosis and increasing bone mineral density, preparation method of same and application of the same in preparation of health-caring product |
CN104188999A (en) * | 2014-08-13 | 2014-12-10 | 哈药集团制药六厂 | Composition capable of increasing bone density and improving functions of skeletons and joints and preparation method thereof |
Non-Patent Citations (1)
Title |
---|
李奕修等: "灌胃凤凰衣水解物对膝骨关节炎模型大鼠影响的实验研究", 《中国中医骨伤科杂志》 * |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105770850A (en) * | 2016-04-25 | 2016-07-20 | 南京邦康生物技术有限公司 | Health care product for adjuvant treatment of osteoarticular diseases and preparation method of health care product |
CN106213492A (en) * | 2016-07-22 | 2016-12-14 | 山东博奥克生物科技有限公司 | A kind of lifter motion function also increases health-oriented products and the preparation method of bone density |
CN106333962A (en) * | 2016-10-29 | 2017-01-18 | 芜湖市诺康生物科技有限公司 | Composition for increasing bone density |
CN109007821A (en) * | 2018-08-07 | 2018-12-18 | 青岛明月海藻生物科技有限公司 | A kind of gel jelly and preparation method thereof improving articulation health |
CN109480213A (en) * | 2018-12-13 | 2019-03-19 | 北京康比特体育科技股份有限公司 | A kind of sport nutrition matched combined object with joint maintenance and maintenance |
CN110946994A (en) * | 2019-12-30 | 2020-04-03 | 东营广元生物科技股份有限公司 | Composition for increasing bone mineral density and preparation method thereof |
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