CN106333962A - Composition for increasing bone density - Google Patents
Composition for increasing bone density Download PDFInfo
- Publication number
- CN106333962A CN106333962A CN201610984989.3A CN201610984989A CN106333962A CN 106333962 A CN106333962 A CN 106333962A CN 201610984989 A CN201610984989 A CN 201610984989A CN 106333962 A CN106333962 A CN 106333962A
- Authority
- CN
- China
- Prior art keywords
- compositionss
- bone density
- composition
- calcium carbonate
- chondroitin sulfate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/10—Carbonates; Bicarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7008—Compounds having an amino group directly attached to a carbon atom of the saccharide radical, e.g. D-galactosamine, ranimustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Inorganic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a composition for increasing bone density. On the basis of 1000 particles of the composition, active ingredients for manufacturing the composition are 125-150 g of calcium carbonate, 165-190 g of D-glucosamine hydrochloride and 25-45 g of chondroitin sulfate. The composition can effectively increase the bone density and prevent and treat osteoporosis.
Description
Technical field
The invention belongs to technical field of health care food is and in particular to a kind of compositionss of increase bone density.
Background technology
A kind of phenomenon of the low calcium deficiency of bone density.When human body daily intakes calcium amount less than 600 milligram hours, especially child,
Anemia of pregnant woman, wet nurse, old man these need colony more than common people for the calcium amount, skeleton and tooth not only cannot calcium supply, she also to moves
Maintain daily physiological need with calcium therein, then cause bone density to reduce.
Bone density declines or bone loss, is as the age and increases and unconsciously occur, women can lose half with
On bone amount, male can lose bone amount 30%～40%.Estrogen is to preventing bone loss and delay skeleton aging to have important work
With.With the loss of bone amount, skeletal structure becomes sparse porous, careless slightly is easy for fracturing.Fracture has a strong impact on the life of people
In bioplasm amount, or even threat to life, such as fracture of femoral neck 1 year, died has 20%～25%, there are about three in survival patient/
Two can not walk, and can't take care of oneself.For this reason, bone loss and osteoporosises should be prevented as early as possible.Thus, the low person to bone density,
If less than 30 years old crowd, although blood calcium, in normal reference range, also should suitably increase the food of rich calcium, except just maintaining
Often outside physiological need, also to make up conventional loss.It is thus desirable to food increases the compositionss of bone density.
Content of the invention
According to above the deficiencies in the prior art, the technical problem to be solved is to propose a kind of increase bone density
Compositionss, provide its preparation method simultaneously.
In order to solve above-mentioned technical problem, the technical solution used in the present invention is: a kind of compositionss increasing bone density, its
It is characterised by, in terms of 1000 described compositionss, the active component making said composition is: Calcium Carbonate 125-150g, d- amino
Glucosamine salt hydrochlorate 165-190g, chondroitin sulfate 25-45g.
As a kind of preferred implementation of the present invention program, in terms of 1000 described compositionss, make said composition
Active component is: Calcium Carbonate 130-145g, d- glucosamine hydrochloride 170-185g, chondroitin sulfate 30-40g.
As a kind of preferred implementation of the present invention program, in terms of 1000 described compositionss, make said composition
Active component is: Calcium Carbonate 135-140g, d- glucosamine hydrochloride 175-180g, chondroitin sulfate 32-38g.
Described pharmaceutical composition in addition to the active ingredient (s, also includes adjuvant magnesium stearate.Said composition makes hard capsule, soft
Capsule, granule and tablet.Preparation method is: Calcium Carbonate, d- glucosamine hydrochloride, chondroitin sulfate pulverized respectively,
Cross 80 mesh sieves, weighing respectively after pulverizing, add magnesium stearate, above-mentioned fine powder mix homogeneously is total mixed powder, fills to capsule,
The pharmaceutical composition being uniformly mixed.
Using the natural whiting fired for shell of Calcium Carbonate.
D- glucosamine hydrochloride used is by natural chitin extraction, is a kind of marine biological preparation, energy
Promote the synthesis of human body mucopolysaccharide, improve the viscosity of knuckle synovia, the metabolism of articular cartilage can be improved；There is promotion antibiotic note
Penetrate the effect of efficiency, for synthesizing water-solubility cancer therapy drug NSC-178248, it has the cancer resistance of nitrosoureas compound, with
When there is the suppression less feature of bone marrow toxicity again, to melanoma, pulmonary carcinoma, renal carcinoma etc. shows certain curative effect；Supplement amino Portugal
Grape sugar culture-medium, can strengthen the n- glycosylation of secretory protein, and the cell of impact such as garland cellss and stem cell
System's variation；Glucamine, a kind of amino sugar, is the precursor of biosynthesiss hexose amine route, may result in formation udp-n- acetyl ammonia
Base glucose (udp-glcnac), is used subsequently to mucopolysaccharide, in the preparation of proteoglycan and glycolipid class.Glucosamine hydrochloric acid
Salt is that medical circle is considered as only so far material that can at all treat joint disease, and glucosamine should be soft with sulphuric acid
Ossein uses cooperatively, and has a pain relieving, promotes effect of regenerating bone or cartilage, can be from improving joint prob at all.
Chondroitin sulfate, as the medicine for the treatment of joint disease, is used cooperatively with glucosamine, has pain relieving, promotes soft
Effect of osteanagenesis, can be from improving joint prob at all.One of critical function of chrondroitin is exactly as conveyance conduit, weight
The oxygen wanted, for being delivered to joint with nutrient, helps remove IA waste, carbon dioxide and waste is excluded simultaneously.
Because articular cartilage has no blood supply, therefore all of oxygenation, nourishing and lubrication are all derived from synovial fluid.Chondroitin sulfate pair
Corneal collagen fiber has protective effect, can promote the growth of fiber in substrate, strengthens permeability, improves blood circulation, accelerates
Metabolism, promotes the absorption of penetrating fluid and the elimination of inflammation；Its polyanion has strong water-retaining property, can improve cornea group
The water metabolism knitted, corneal has stronger affinity, can form one layer of ventilative water-retaining film in anterior corneal surface, improve eye dryness
Symptom.By promoting the generation of substrate, the migration for cell provides framework, is conducive to the migration of corneal epithelial cell, thus promoting
Enter the healing of corneal wound, the absorption of transudate and the elimination of inflammation.
The medicine have the advantages that the present invention is by mentioned component rational proportion, it is effectively increased bone density, prevent and treat bone
Matter is loose.
Specific embodiment
Below by the description to embodiment, for example involved shape of each component of the specific embodiment of the present invention, structure
Make, the mutual alignment between each several part and annexation, the effect of each several part and operation principle, manufacturing process and the side of operating with
Method etc., is described in further detail, completeer to help those skilled in the art that the inventive concept of the present invention, technical scheme are had
Whole, accurate and deep understanding.
Embodiment 1
Calcium Carbonate 135g, d- glucosamine hydrochloride 173g, chondroitin sulfate 37g, magnesium stearate 5g.
Concrete preparation method is as follows: Calcium Carbonate, d- glucosamine hydrochloride, chondroitin sulfate is pulverized respectively, pulverizes
Cross 80 mesh sieves, weighing respectively afterwards, add magnesium stearate, above-mentioned fine powder mix homogeneously is total mixed powder, fills to capsule, obtain
The pharmaceutical composition of mix homogeneously.
Embodiment 2
Calcium Carbonate 140g, d- glucosamine hydrochloride 170g, chondroitin sulfate 35g, magnesium stearate 5g, preparation method is same
On.
Embodiment 3
Calcium Carbonate 130g, d- glucosamine hydrochloride 180g, chondroitin sulfate 146g, magnesium stearate 4g, preparation method
Ibid.
Embodiment 4
Calcium Carbonate 135g, d- glucosamine hydrochloride 172g, chondroitin sulfate 40g, magnesium stearate 3g, preparation method is same
On.
Embodiment 5
Calcium Carbonate 137.2g, d- glucosamine hydrochloride 175g, chondroitin sulfate 35g, magnesium stearate 2.8g, preparation side
Method is ibid.
Below by way of experimental statuss beneficial effects of the present invention to be described:
Carry out human feeding trial, the bone density of test body, test-meal group: the present invention for oral administration, given the test agent gives the time
120 days, the age of experimenter was identical, ate identical food, equal daily schedule, wherein test-meal group 40 during testing
People.Matched group 5 people.
The bone density of human body before and after experiment is measured.Matched group 5 people's bone density no significant change, 40 people of test-meal group
In have 35 people's bone densities increase, 5 people's bone density no significant changes.
Test result indicate that, the present invention has the effect increasing human bone mineral density.
Above the present invention is exemplarily described it is clear that the present invention implements is not subject to the restrictions described above,
As long as employing the improvement of various unsubstantialities that method of the present invention design and technical scheme are carried out, or not improved by this
Bright design and technical scheme directly apply to other occasions, all within protection scope of the present invention.The protection of the present invention
Scope should be defined by the protection domain that claims are limited.
Claims (6)
1. a kind of compositionss increasing bone density are it is characterised in that in terms of 1000 described compositionss, make the work of said composition
Property composition is: Calcium Carbonate 125-150g, d- glucosamine hydrochloride 165-190g, chondroitin sulfate 25-45g.
2. the compositionss increasing bone density according to claim 1 are it is characterised in that in terms of 1000 described compositionss,
The active component making said composition is: Calcium Carbonate 130-145g, d- glucosamine hydrochloride 170-185g, chondroitin sulfate
30-40g.
3. the compositionss increasing bone density according to claim 2 are it is characterised in that in terms of 1000 described compositionss,
The active component making said composition is: Calcium Carbonate 135-140g, d- glucosamine hydrochloride 175-180g, chondroitin sulfate
32-38g.
4. the compositionss of the increase bone density according to claim 1-3 any one are it is characterised in that with described in 1000
Compositionss meter, described pharmaceutical composition also includes adjuvant magnesium stearate 3-5g in addition to the active ingredient (s.
5. the compositionss increasing bone density according to claim 4 are it is characterised in that said composition makes hard capsule, soft
Capsule, granule and tablet.
6. the compositionss increasing bone density according to claim 1 are it is characterised in that the preparation method of compositionss is: will
Calcium Carbonate, d- glucosamine hydrochloride, chondroitin sulfate are pulverized respectively, cross 80 mesh sieves, weighing respectively after pulverizing, add Hard Fat
Sour magnesium, above-mentioned fine powder mix homogeneously is total mixed powder, fills to capsule, the pharmaceutical composition being uniformly mixed.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610984989.3A CN106333962A (en) | 2016-10-29 | 2016-10-29 | Composition for increasing bone density |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610984989.3A CN106333962A (en) | 2016-10-29 | 2016-10-29 | Composition for increasing bone density |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN106333962A true CN106333962A (en) | 2017-01-18 |
Family
ID=57841117
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610984989.3A Pending CN106333962A (en) | 2016-10-29 | 2016-10-29 | Composition for increasing bone density |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN106333962A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924343A (en) * | 2017-03-16 | 2017-07-07 | 桦南仙紫食品科技有限公司 | Ammonia sugar calcium purple perilla soft capsule and preparation method |
| CN108685943A (en) * | 2018-07-19 | 2018-10-23 | 深圳极醇健康产业股份有限公司 | A kind of tablet and preparation method thereof increasing bone density |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903220A (en) * | 2006-07-12 | 2007-01-31 | 江中药业股份有限公司 | Health-care food with function of improving skeletal density and its prepn. method |
| CN101904866A (en) * | 2010-09-07 | 2010-12-08 | 许阳 | Medicinal composition for treating osteoporosis and preparation method thereof |
| CN104543674A (en) * | 2015-01-04 | 2015-04-29 | 北京世纪合辉医药科技股份有限公司 | Health food for improving bone and joint health as well as preparation method thereof |
| CN105079028A (en) * | 2015-07-16 | 2015-11-25 | 北京世纪合辉医药科技股份有限公司 | Health care product capable of improving bones and joints and preparation method of health care product |
-
2016
- 2016-10-29 CN CN201610984989.3A patent/CN106333962A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903220A (en) * | 2006-07-12 | 2007-01-31 | 江中药业股份有限公司 | Health-care food with function of improving skeletal density and its prepn. method |
| CN101904866A (en) * | 2010-09-07 | 2010-12-08 | 许阳 | Medicinal composition for treating osteoporosis and preparation method thereof |
| CN104543674A (en) * | 2015-01-04 | 2015-04-29 | 北京世纪合辉医药科技股份有限公司 | Health food for improving bone and joint health as well as preparation method thereof |
| CN105079028A (en) * | 2015-07-16 | 2015-11-25 | 北京世纪合辉医药科技股份有限公司 | Health care product capable of improving bones and joints and preparation method of health care product |
Non-Patent Citations (1)
| Title |
|---|
| 潘卫三主编: "《工业药剂学》", 31 August 2015 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106924343A (en) * | 2017-03-16 | 2017-07-07 | 桦南仙紫食品科技有限公司 | Ammonia sugar calcium purple perilla soft capsule and preparation method |
| CN108685943A (en) * | 2018-07-19 | 2018-10-23 | 深圳极醇健康产业股份有限公司 | A kind of tablet and preparation method thereof increasing bone density |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101773539B (en) | Prescription with function for mitigating and curing osteoarthrosis | |
| CN101248882A (en) | Nutrition food product with promoting health of bones and bone arthrosis | |
| CN101695382A (en) | Calcium supplementing preparation with functions of improving bones and joints | |
| CN106235311A (en) | A kind of compositions promoting skeletal system health and application thereof | |
| CN102949710B (en) | Pharmaceutical composition or healthcare product for increasing bone mineral density and preparation method of pharmaceutical composition or healthcare product | |
| CN102085172B (en) | Skin care cosmetic taking American wild yam extract as main component and preparation method thereof | |
| CN102160614A (en) | Compound preparation for improving immunity of human bodies and enhancing bone density and application thereof | |
| KR20160026916A (en) | Multi-functional composition and preparation method and application thereof | |
| CN104814901B (en) | One kind prevention striae of pregnancy gel and preparation method thereof | |
| CN102077937A (en) | Special dietary seafood special for young and middle-aged women | |
| CN113133534A (en) | Tranquilizing and relieving sustained-release oral liquid and preparation method thereof | |
| CN106581130A (en) | Bone density increment tablet and preparation process thereof | |
| CN106333962A (en) | Composition for increasing bone density | |
| CN105079028A (en) | Health care product capable of improving bones and joints and preparation method of health care product | |
| CN102823862A (en) | Composition for qi-insufficiency constitution as well as preparation method and purpose of composition | |
| CN100363021C (en) | Use of cajan seed and its extract in preparing medicine for treating osteal arthritis | |
| CN108815505A (en) | Improve the composition that middle-aged and the old's bone density and osteoarticular function avoid waist-leg from knotting | |
| CN101129632A (en) | Medicament with function of nourishing kidney, warming Yang, preserving essence and benefiting element and method of producing the same | |
| CN110301647A (en) | The compound oligomeric peptide nutrient food of ground dragon protein | |
| CN108968075A (en) | It is a kind of improve bone health composition and its application | |
| CN108355038A (en) | The Chinese medicine bathing instant granular of improvement qi deficiency to blood stasis rheumatism and preparation and application method | |
| CN108175096A (en) | A kind of strong bone food | |
| CN103768434A (en) | Traditional Chinese medicine for enhancing laying rate of laying hens and preparation method thereof | |
| CN105213291A (en) | A kind of compound cold cream eliminating striae gravidarum and preparation method thereof | |
| CN101991757B (en) | Chinese medicinal composition for reinforcing kidney and supporting yang and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20170118 |