CN104066442B - 基于半氟化烷烃的稳定蛋白质组合物 - Google Patents

基于半氟化烷烃的稳定蛋白质组合物 Download PDF

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Publication number
CN104066442B
CN104066442B CN201380006417.2A CN201380006417A CN104066442B CN 104066442 B CN104066442 B CN 104066442B CN 201380006417 A CN201380006417 A CN 201380006417A CN 104066442 B CN104066442 B CN 104066442B
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protein
polypeptide
composition
suspension
proteins
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CN104066442A (zh
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伯恩哈德·金特
巴斯蒂安·泰辛格
索尼娅·泰辛格
迪特尔·谢勒
克莱夫·威尔逊
安东尼·佩蒂格鲁
安妮特·休蒂格
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Novaliq GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/23—Calcitonins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/38—Albumins
    • A61K38/385—Serum albumin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4826—Trypsin (3.4.21.4) Chymotrypsin (3.4.21.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21001—Chymotrypsin (3.4.21.1)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201380006417.2A 2012-01-23 2013-01-22 基于半氟化烷烃的稳定蛋白质组合物 Active CN104066442B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12152159 2012-01-23
EP12152159.5 2012-01-23
PCT/EP2013/051163 WO2013110621A1 (en) 2012-01-23 2013-01-22 Stabilised protein compositions based on semifluorinated alkanes

Publications (2)

Publication Number Publication Date
CN104066442A CN104066442A (zh) 2014-09-24
CN104066442B true CN104066442B (zh) 2018-05-18

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US (2) US9757460B2 (https=)
EP (1) EP2806886B1 (https=)
JP (1) JP6084987B2 (https=)
KR (1) KR101989648B1 (https=)
CN (1) CN104066442B (https=)
AU (1) AU2013211645B2 (https=)
BR (1) BR112014017719A8 (https=)
CA (1) CA2862974C (https=)
DK (1) DK2806886T3 (https=)
ES (1) ES2625538T3 (https=)
MX (1) MX361681B (https=)
PL (1) PL2806886T3 (https=)
PT (1) PT2806886T (https=)
WO (1) WO2013110621A1 (https=)

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CA2862974A1 (en) 2013-08-01
WO2013110621A1 (en) 2013-08-01
BR112014017719A8 (pt) 2017-07-11
BR112014017719A2 (https=) 2017-06-20
DK2806886T3 (en) 2017-06-06
AU2013211645B2 (en) 2017-06-15
US9757460B2 (en) 2017-09-12
PT2806886T (pt) 2017-03-24
US20140369993A1 (en) 2014-12-18
MX361681B (es) 2018-12-13
USRE49758E1 (en) 2023-12-19
EP2806886B1 (en) 2017-03-01
MX2014008929A (es) 2015-06-02
ES2625538T3 (es) 2017-07-19
CN104066442A (zh) 2014-09-24
JP2015504082A (ja) 2015-02-05
AU2013211645A1 (en) 2014-07-17
PL2806886T3 (pl) 2017-08-31
JP6084987B2 (ja) 2017-02-22
KR101989648B1 (ko) 2019-06-14
EP2806886A1 (en) 2014-12-03
CA2862974C (en) 2021-11-16

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