CN104056100A - Traditional Chinese medicine composition for treating pediatric asthma - Google Patents
Traditional Chinese medicine composition for treating pediatric asthma Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating pediatric asthma. The traditional Chinese medicine composition is prepared from raw traditional Chinese medicinal materials and medicinal auxiliaries, wherein the raw traditional Chinese medicinal materials comprises the following components in parts by weight: 30-42 parts of rhizoma fagopyri dibotryis, 15-26 parts of folium mori, 21-30 parts of bamboo leaves, 21-30 parts of lotus leaves, 5-8 parts of fructus schisandrae chinensis, and 6-12 parts of semen raphani. Verified by clinical application, the traditional Chinese medicine composition is obvious in curative effect, reliable in action, mild in drug properties, free from toxic and side effects, the asthma symptoms of pediatric patients are completely relieved after one to two courses administration, neither cough nor asthma exits, and the lung auscultation is normal.
Description
Technical field
The invention belongs to Chinese medicine technical field, be specifically related to a kind of Chinese medicine composition for the treatment of infantile asthma.
Background technology
The commonly encountered diseases childhood period that infantile asthma being and frequently-occurring disease are the chronic ill reactive disorders of air flue being participated in by the inflammation cells such as eosinophilic granulocyte, mastocyte and T lymphocyte and cytokine.And bronchial asthma can occur during regardless of season, especially in season in severe winter, and climate temperature is fallen ill while sharply changing more.Mostly because of physical weakness, or touch following factor and have the infant of latent phlegm can bring out primary disease to lung: meet sense wind and cold.Direct stimulation is depressed, or environment cataclysm, inhales people's dust and diet etc.Because development in children is not yet ripe, premunition is low, belongs to the body of the young sun of young the moon, and its internal organs are tender and lovely, and shape gas does not fill, and how empty lung spleen is, and easily empty easily real, and with the passing of time phlegm stagnancy is easy to heat-transformation, in clinical manifestation, mostly is intermingling cold and heat, deficiency and excess and deposits.Children's's internal organs are grown also immaturity.Because human body skin belongs to lung, be responsible for, lungs are tender and lovely, and it is poor that skin is defended outer function, skin space between skin and muscles is not fine and close, and wind and cold, wind heat are invaded human body by fur or mouth and nose, suffer from a deficiency of the kidney, spleen, lung, the dirty functional disorder of kidney three cause phlegm retention to form, and pathogen is taken advantage of a weak point, and pathogen enters lung meridian priming latent phlegm, phlegm rising following QI, obstruction of QI due to retention of phlegm, fights mutually sharp, obstructing airway, ascending or descending movement of vital Qi is unfavorable, and consequently many suctions of exhalation lacks, breath dyspnea with rapid and short breath, throat croup expectorant toot.Symptom is: rapid breathing, suddenly, uncomfortable in chest rough, larynx has been asked wheezing sound in outbreak, must not pant put down sleeping.Generally be paroxysmal outbreak, or occur the symptom such as obnubilation of agitation, perspiration, expectoration, livid purple, pale complexion, weight.
The treatment of asthma is turned to the treatment to airway inflammation by alleviating airway smooth muscle spasm, take hormone Inhalation in Treating as main, but hormone therapy has certain side effect, can cause the adverse consequencess such as upgrowth and development of children obstacle.Through inventor's long-term practice, draw, Chinese medicine is controlled infantile asthma and is had better effect, obtains good effect.
Summary of the invention
The object of the invention is to by folk remedy is furtherd investigate and explored, thereby a kind of Chinese medicine composition for the treatment of infantile asthma is provided.
The object of the present invention is achieved like this:
A kind of Chinese medicine composition for the treatment of infantile asthma, by traditional Chinese medicinal material raw materials and pharmaceutically acceptable auxiliaries, be prepared from, by weight, described Chinese crude drug comprises: Rhizoma Fagopyri Dibotryis 30-42 part, Folium Mori 15-26 part, Folium Bambusae 21-30 part, Folium Nelumbinis 21-30 part, Fructus Schisandrae Chinensis 5-8 part, Semen Raphani 6-12 part.
Preferably, treat as mentioned above the Chinese medicine composition of infantile asthma, wherein by weight, described traditional Chinese medicinal material raw materials is comprised of Rhizoma Fagopyri Dibotryis 34-37 part, Folium Mori 18-22 part, Folium Bambusae 24-26 part, Folium Nelumbinis 24-26 part, Fructus Schisandrae Chinensis 6-7 part and Semen Raphani 8-10 part.
In a most preferred embodiment of the present invention, treat as mentioned above the Chinese medicine composition of infantile asthma, wherein by weight, described traditional Chinese medicinal material raw materials is comprised of 9 parts of 35 parts of Rhizoma Fagopyri Dibotryiss, 20 parts, Folium Mori, 25 parts, Folium Bambusae, 25 parts, Folium Nelumbinis, 6 parts of Fructus Schisandrae Chinensis and Semen Raphanis.
It should be noted that, traditional Chinese medicinal material raw materials of the present invention has following source: Rhizoma Fagopyri Dibotryis is selected the dry rhizome of polygonaceae plant Rhizoma Fagopyri Dibotryis Fagopyrum dibotrys (D.Don) Hara.Folium Mori are selected the dried leaves of moraceae plants Mulberry Morus alba L..Folium Bambusae is selected the dried leaves of grass phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle.Folium Nelumbinis is selected the dried leaves of nymphaeaceae plant lotus Nelumbo nuciferaGaertn..Fructus Schisandrae Chinensis is selected the dry mature fruit of Magnoliacea plant schisandra chinensis Schisandra sphenanthera Rehd.et Wils..Semen Raphani is selected the dry mature seed of crucifer Radix Raphani Raphanus sativus L..
Further preferably, the Chinese medicine composition of described treatment infantile asthma, wherein said Chinese medicine composition is oral formulations; Described oral formulations comprises oral liquid, tablet, granule, capsule etc.
Chinese medicine composition involved in the present invention verifies through clinical practice, and it is evident in efficacy, reliable effect, and the property of medicine is gentle, does not occur toxic and side effects, and medication 1-2 is after the course for the treatment of, and Asthma symptom is alleviated completely, does not cough and does not breathe heavily, and auscultation of lung is without extremely.In addition, the component of this medicine all adopts natural raw material of Chinese medicine, and its preparation is easy, medicine source is wide, cost is low, so production cost is low, and patient spends few, has good economic benefit.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.
Embodiment 1: the preparation of Chinese medicine oral liquid
Take Rhizoma Fagopyri Dibotryis 0.35kg, Folium Mori 0.20kg, Folium Bambusae 0.25kg, Folium Nelumbinis 0.25kg, Fructus Schisandrae Chinensis 0.06kg, Semen Raphani 0.09kg, clean roguing, add water and cover powder 2cm, soak 1-1.2h, pull medical material out and put multi-functional extraction and decoct with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 6 times of amounts of medical material, decoct 1h, get twice decocting liquid and merge, filter the concentrated solution that while being concentrated into 90 ℃, relative density is 1.10; Concentrated solution is set to 0 to-5 ℃ of deepfreeze 24h, cold preservation liquid is added to 0.3% filter aid kieselguhr, filter, filtrate reconcentration containing 3.0g crude drug amount, then adds appropriate cane sugar powder and 0.2% potassium sorbate to every milliliter, stirs, set to 0 a ℃ deepfreeze 24h, cold preservation liquid is filtered, obtain oral liquid.
Embodiment 2: the preparation of Chinese medicine granules
Take Rhizoma Fagopyri Dibotryis 0.30kg, Folium Mori 0.18kg, Folium Bambusae 0.21kg, Folium Nelumbinis 0.30kg, Fructus Schisandrae Chinensis 0.08kg, Semen Raphani 0.12kg, clean roguing, add water and cover powder 2cm, soak 1-1.2h, pulling medical material out puts multi-functional extraction and decocts with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 6 times of amounts of medical material, decoct 1h, getting twice decocting liquid merges, filter, filtrate is at 0.08MPa, the extractum that when concentrating under reduced pressure becomes to 65 ℃ under 65 ℃ of conditions, relative density is 1.15g/mL, extractum is put in stainless steel disc, vacuum drying (60 ℃ following) becomes dried cream powder broken, add cane sugar powder, make 40 order granule powder packing, every bag 20g.
Embodiment 3: the preparation of Chinese medicine granules
Take Rhizoma Fagopyri Dibotryis 0.42kg, Folium Mori 0.25kg, Folium Bambusae 0.25kg, Folium Nelumbinis 0.25kg, Fructus Schisandrae Chinensis 0.08kg, Semen Raphani 0.08kg, clean roguing, add water and cover powder 2cm, soak 1-1.2h, pulling medical material out puts multi-functional extraction and decocts with water secondary in filling with, add up for the first time the water of 8 times of amounts of medical material, decoct 2h, get decocting liquid, filter, add up for the second time the water of 6 times of amounts of medical material, decoct 1h, getting twice decocting liquid merges, filter, filtrate is at 0.08MPa, the extractum that when concentrating under reduced pressure becomes to 65 ℃ under 65 ℃ of conditions, relative density is 1.15g/mL, extractum is put in stainless steel disc, vacuum drying (60 ℃ following) becomes dried cream powder broken, add cane sugar powder, make 40 order granule powder packing, every bag 20g.
Clinical practice example: the effectiveness study of Chinese medicinal formulae to infantile asthma
Through children with bronchial asthma disease 54 examples of clinical definite, clinical manifestation is obvious with wheezing between cough, tachypnea, larynx, dyspnea even, and two fullness of the lung cloth wheezing sounds are feature.In all cases, male's 31 examples, women's 23 examples; 4～13 years old age, 8.9 ± 2.0 years old mean age; The course of disease 3～18 days.54 routine infants are divided into each 27 examples of Chinese drug-treated group and matched group at random, two groups at aspects such as sex, age, the course of disease, the state of an illness without significant difference, there is comparability.
Chinese drug-treated group gives Chinese medicine decoction, prescription: Rhizoma Fagopyri Dibotryis 35g, Folium Mori 20g, Folium Bambusae 25g, Folium Nelumbinis 25g, Fructus Schisandrae Chinensis 6g, Semen Raphani 9g.Add 2L decocting in water and open the rear slow fire 1.5h that boils medicine, then concentrated medicament is to 100ml.4～7 years old each 20ml, 7 years old above each 30ml.Every day 3 times, decoction being taken warmly after sugaring 30 minutes ante cibum.Matched group adopts conventional relieving cough and resolving phlegm, relievings asthma, anti-infective therapy.All treating for two groups 10 days was 1 course for the treatment of, treated altogether for 1～2 course for the treatment of, observe the curative effect.The criterion of clinical efficacy is as follows:
Cure: medication 1-2 is after the course for the treatment of, and infant symptom is alleviated completely, do not cough and do not breathe heavily, auscultation of lung is without extremely;
Effective: symptom SPR, do not breathe heavily, even during climate change have cough with asthma, continues to take medicine and alleviate very soon;
Invalid: after 2 courses for the treatment of of medication, the state of an illness is without improvement.
Therapeutic outcome is in Table 1.According to the curative effect statistical result of table 1, can find out, test group is cured effective 28 examples (90.32%), and total effective rate is 96.77%; And matched group is cured effective 9 examples (29.03%), total effective rate is 67.74%.Obviously, test group is obviously better than matched group.
Table 1 liang group curative effect comparison (example)
Claims (5)
1. a Chinese medicine composition for the treatment of infantile asthma, it is characterized in that: by traditional Chinese medicinal material raw materials and pharmaceutically acceptable auxiliaries, be prepared from, by weight, described Chinese crude drug comprises: Rhizoma Fagopyri Dibotryis 30-42 part, Folium Mori 15-26 part, Folium Bambusae 21-30 part, Folium Nelumbinis 21-30 part, Fructus Schisandrae Chinensis 5-8 part, Semen Raphani 6-12 part.
2. treat according to claim 1 the Chinese medicine composition of infantile asthma, it is characterized in that: by weight, described traditional Chinese medicinal material raw materials is comprised of Rhizoma Fagopyri Dibotryis 34-37 part, Folium Mori 18-22 part, Folium Bambusae 24-26 part, Folium Nelumbinis 24-26 part, Fructus Schisandrae Chinensis 6-7 part and Semen Raphani 8-10 part.
3. treat according to claim 2 the Chinese medicine composition of infantile asthma, it is characterized in that: by weight, described traditional Chinese medicinal material raw materials is comprised of 9 parts of 35 parts of Rhizoma Fagopyri Dibotryiss, 20 parts, Folium Mori, 25 parts, Folium Bambusae, 25 parts, Folium Nelumbinis, 6 parts of Fructus Schisandrae Chinensis and Semen Raphanis.
4. according to the Chinese medicine composition for the treatment of infantile asthma described in claim 1 or 2 or 3, it is characterized in that: described Chinese medicine composition is oral formulations.
5. treat according to claim 4 the Chinese medicine composition of infantile asthma, it is characterized in that: described oral formulations comprises oral liquid, tablet, granule, capsule.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857707A (en) * | 2006-03-16 | 2006-11-08 | 李玉海 | Chinese medicine mixture for treating infantile dyspneic cough |
| CN102580003A (en) * | 2012-03-14 | 2012-07-18 | 赵莹 | Chinese medicinal oral liquid for treating infantile asthma and preparation method thereof |
| CN102988832A (en) * | 2012-12-03 | 2013-03-27 | 刘瑞青 | Traditional Chinese medicine composition used for treating asthma of children |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1857707A (en) * | 2006-03-16 | 2006-11-08 | 李玉海 | Chinese medicine mixture for treating infantile dyspneic cough |
| CN102580003A (en) * | 2012-03-14 | 2012-07-18 | 赵莹 | Chinese medicinal oral liquid for treating infantile asthma and preparation method thereof |
| CN102988832A (en) * | 2012-12-03 | 2013-03-27 | 刘瑞青 | Traditional Chinese medicine composition used for treating asthma of children |
Non-Patent Citations (1)
| Title |
|---|
| 国家中医药管理局专业技术资格考试专家委员会 编写: "《中医儿科专业》", 31 December 2011, 中国中医药出版社 * |
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