CN104055954A - Traditional Chinese medicine combination for preventing bovine pasteurellosis - Google Patents
Traditional Chinese medicine combination for preventing bovine pasteurellosis Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine combination for preventing bovine pasteurellosis. The traditional Chinese medicine combination is an orally-taken preparation prepared by active pharmaceutical ingredients comprising, by weight, 40 parts to 80 parts of honeysuckle, 40 parts to 80 parts of fructus forsythiae, 20 parts to 60 parts of burdock, 40 parts to 80 parts of isatis roots, 40 parts to 80 parts of subprostrate sophora, 30 parts to 70 parts of the root bark of the peony tree, 60 parts to 100 parts of dried radix rehmanniae, 40 parts to 80 parts of scutellaria baicalensis, 30 parts to 70 parts of coptis chinensis, 40 parts to 80 parts of pollen, 30 parts to 70 parts of oriental wormwood, 30 parts to 70 parts of gardenia, 40 parts to 80 parts of blackberry lily, 30 parts to 70 parts of puffball, 30 parts to 70 parts of mint and 10 parts to 50 parts of liquorice. The bulk pharmaceutical chemicals of the traditional Chinese medicine combination are wide in source, low in cost, easy to obtain, safe and reliable. The traditional Chinese medicine combination is small in toxic and side effect, free of medicine tolerance and stable in treatment effect, significantly lowers the average incidence of bovine pasteurellosis in the same cattle herd, has the good preventing effect on bovine pasteurellosis, and is a good trauma medicine which is safe, high in quality and stable.
Description
Technical field
The invention belongs to the animal and veterinary field that learns a skill, relate to a kind of Chinese medicine composition that prevents bovine pasteurellosis.
Background technology
Bovine pasteurellosis is a kind of acute, the infectious diseases common to human beings and animals being caused by pasteurella multocida.Primary disease is without obvious seasonality, mainly take septicemia and inflammatory hemorrhage clinically as principal character, and (being again " hueppe's disease ") not only can cause the various physiological functions disorders of cattle, growth promoter to be obstructed, and mortality rate raises, and can also to people, infect by number of ways, even cause death.Primary disease sickness rate can reach 20%-60%, and fatality rate reaches more than 80%, once occur, therapeutic effect is very poor.Therefore, having a strong impact on cattle and becoming the healthy of the sound development of industry and people, OIE (OIE) and the national Ministry of Agriculture classify it as respectively category-B epidemic disease and two class epidemic diseases.According to the antigenic specificity of thalline surface capsular polysaccharide, this disease pathogen-pasteurella multocida can be divided into A, B, D, E and F5 pod membrane serotype.Because host's preferendum, the pathogenic characteristic of each serotype is not quite similar, therefore, between different pod membrane serotype, cross protection is poor.China is Major Epidemic pod membrane serum Type B in the past, and existing vaccine strain is also Type B pasteurella multocida.Since two thousand eight, domesticly in succession in Tianjin, Jilin, the Inner Mongol, Ningxia, Shandong, Xinjiang and Gansu, from suffer from pulmonis Bovis seu Bubali tissue, be separated to cattle source pod membrane serum A type pasteurella multocida homotype pathogen.Because cows do not have immunity, it is popular that emerging cattle source pod membrane serum A type pasteurella multocida is endemicity in above provinces and cities, and cause high M & M, to cattle-raising, causes great economic loss.According to investigations: at present, the whole sickness rate in Hexi Corridor that is positioned at western part, Gansu Province reaches 1.72%, mortality rate 1.12%, fatality rate 65.52%; With group's sickness rate average out to, more than 56%, fatality rate reaches more than 80%.
The method of existing prevention bovine pasteurellosis is mainly that application cattle pasteurellosis bacillus inactivated vaccine carries out immunity inoculation and premorbid is used antibiotic in advance.But vaccine strain is Type B pasteurella multocida, pathogenic strain is A type pasteurella multocida, and because cross protection between different pod membrane serotype is poor, so preventive effect is very poor, does not substantially have preventive effect; And use in advance antibiotic easily to cause body to produce drug resistance and drug residue, be unfavorable for producing free-pollution beef.
Summary of the invention
The present invention is directed to bovine pasteurellosis sickness rate, fatality rate high, large to animal husbandry and person health hazard, use vaccine prevention weak effect, use antibiotic prophylaxis easily to cause body to produce the problem of drug resistance and drug residue, a kind of Chinese medicine composition that prevents bovine pasteurellosis is provided.
In order to address the above problem the present invention, adopt following technical scheme:
The present invention prevents the Chinese medicine composition of bovine pasteurellosis, is with Flos Lonicerae, Fructus Forsythiae, and Fructus Arctii, Radix Isatidis, Radix Sophorae Tonkinensis, Cortex Moutan, the Radix Rehmanniae, Radix Scutellariae, Rhizoma Coptidis, pollen, Herba Artemisiae Scopariae, Fructus Gardeniae, Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Herba Menthae, Radix Glycyrrhizae is the oral preparations that crude drug is made.
In pharmaceutical formulation of the present invention
Flos Lonicerae, nature and flavor: sweet; Cold.Effect: heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly: toxic-heat and blood stasis, carbuncle furuncle, sore throat and multi-infection disease.
Fructus Forsythiae, nature and flavor: hardship; Be slightly cold.Effect: heat-clearing and toxic substances removing, mass dissipating and swelling eliminating, dispelling wind and heat pathogens; Cure mainly: heating, vexed, laryngopharynx swelling and pain, macule, erysipelas, scrofula, carbuncle pyogenic infections from tumour or sore, acute nephritis.
Fructus Arctii, nature and flavor: pungent; Bitter; Cold.Effect: dispelling wind and heat pathogens, removing toxic substances rash, sore-throat relieving fall apart swollen; Cure mainly: wind heat or cough due to lung-heat, cough up phlegm not smooth, laryngopharynx swelling and pain, macule is not saturating, and at the measles initial stage, rash goes out not smooth, rubella pruritus, sore swollen toxin, mumps.
Radix Isatidis, nature and flavor: hardship; Cold.Effect: heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly: acute enteritis, bacillary dysentery, hepatitis etc.
Radix Sophorae Tonkinensis, nature and flavor: hardship; Cold; Poisonous.Effect: heat-clearing and toxic substances removing, relieving sore throat and diminishing swelling; Cure mainly: laryngopharynx swelling and pain, jaundice due to damp-heat, cough due to lung-heat, carbuncle sore tumefacting virus.
Cortex Moutan, nature and flavor: hardship; Pungent; Be slightly cold.Effect: clearing away heat and cooling blood, promoting blood circulation to remove blood stasis; Cure mainly: carbuncle sore tumefacting virus, falls and flutters the pain of injury, rheumatism pyretic arthralgia.
The Radix Rehmanniae, nature and flavor: sweet; Bitter; Be slightly cold.Effect: nourishing YIN and clearing away heat, removing heat from blood are enriched blood; Cure mainly:
Spit blood, metrorrhagia, hematuria, has blood in stool, blood deficiency and yellow complexion, dizzy cardiopalmus.
Radix Scutellariae, nature and flavor: sweet; Tepor.Effect: benefit is defended consolidating superficial resistance, tonifying Qi and lifting yang, promoting pus discharge and tissue regeneration strengthening, inducing diuresis to remove edema; Cure mainly: the deficiency of vital energy is weak, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, from juice night sweat, blood deficiency and yellow complexion, carbuncle of yin nature is unrestrained swollen, deficiency of vital energy edema, interior-heat is quenched one's thirst.
Rhizoma Coptidis, nature and flavor: hardship; Cold.Effect: heat clearing and damp drying, eliminating fire and detoxication; Cure mainly: damp and hot, feel sick, vomiting, stomachache, dysentery, jaundice.
Pollen, nature and flavor: sweet; Temperature.Effect: the QI invigorating of dispeling the wind, astringing to arrest bleeding; Cure mainly: have a dizzy spell, stomachache, chronic dysentery, all skin ulcers are wet rotten, wound hemorrhage.
Herba Artemisiae Scopariae, nature and flavor: hardship; Pungent; Be slightly cold.Effect: clearing away heat-damp and promoting diuresis, jaundice eliminating; Cure mainly: jaundice oliguria, eczema pruritus, infectious jaundice type hepatitis.
Fructus Gardeniae, nature and flavor: hardship; Cold.Effect: clearing away heat-fire, removing heat from blood, removing toxic substances, dampness removing; Cure mainly: vexed insomnia, restlessness is not peaceful, jaundice due to damp-heat, heat in blood is told nosebleed.
Rhizoma Belamcandae, nature and flavor: hardship; Cold.Effect: heat-clearing and toxic substances removing, expectorant infections, throat; Cure mainly: laryngopharynx swelling and pain, abundant expectoration cough with asthma.
Lasiosphaera Seu Calvatia, nature and flavor: pungent; Flat.Effect: removing heat from the lung and relieving sorethroat, removing toxic substances, hemostasis; Cure mainly: sore throat pharyngalgia, cough with aphonia, spits blood, epistaxis, traumatic hemorrhage.
Herba Menthae, nature and flavor: pungent; Cool.Effect: disperse wind heat, the clear sharp head, sore-throat relieving, rash; Cure mainly: wind heat, headache, laryngopharynx swelling and pain, rubella pruritus.
Radix Glycyrrhizae, nature and flavor: sweet; Flat.Effect: invigorating the spleen and replenishing QI, nourishing the lung to arrest cough, heat-clearing and toxic substances removing, alleviation pain relieving, the mitigation property of medicine; Cure mainly: weakness of the spleen and stomach, shortness of breath and fatigue, severe palpitation, cough expectorant is few, pathopyretic ulcer, medicine food is poisoning, gastral cavity abdomen shoot, limb pain twin.
The present invention is reasonably combined above-mentioned 16 kinds of crude drug, and the drug effect of each crude drug is played altogether, the collaborative effect that realizes heat clearing away, removing toxic substances, pathogenic fire purging, removing heat from blood, hemostasis, dissipating blood stasis, thus play the object of preventing bovine pasteurellosis.
The present invention prevents the Chinese medicine composition of bovine pasteurellosis, and each crude drug is filled a prescription in following scope, all can play the effect of good prevention bovine pasteurellosis:
Prevent a Chinese medicine composition for bovine pasteurellosis, by the crude drug of following weight portion, made: Flos Lonicerae 40-80 part, Fructus Forsythiae 40-80 part, Fructus Arctii 20-60 part, Radix Isatidis 40-80 part, Radix Sophorae Tonkinensis 40-80 part, Cortex Moutan 30-70 part, Radix Rehmanniae 60-100 part, Radix Scutellariae 40-80 part, Rhizoma Coptidis 30-70 part, pollen 40-80 part, Herba Artemisiae Scopariae 30-70 part, Fructus Gardeniae 30-70 part, Rhizoma Belamcandae 40-80 part, Lasiosphaera Seu Calvatia 30-70 part, Herba Menthae 30-70 part, Radix Glycyrrhizae 10-50 part.
Optimum ratio is: Flos Lonicerae 50-70 part, Fructus Forsythiae 50-70 part, Fructus Arctii 30-50 part, Radix Isatidis 50-70 part, Radix Sophorae Tonkinensis 50-70 part, Cortex Moutan 40-60 part, Radix Rehmanniae 70-90 part, Radix Scutellariae 50-70 part, Rhizoma Coptidis 40-60 part, pollen 50-70 part, Herba Artemisiae Scopariae 40-60 part, Fructus Gardeniae 40-60 part, Rhizoma Belamcandae 50-70 part, Lasiosphaera Seu Calvatia 40-60 part, Herba Menthae 40-60 part, Radix Glycyrrhizae 20-40 part.
Best proportioning is: 60 parts of Flos Loniceraes, 60 parts of Fructus Forsythiaes, 40 parts of cattle Fructus Arctiis, 60 parts of Radix Isatidis, 60 parts of Radix Sophorae Tonkinensiss, 50 parts of Cortex Moutans, 80 parts, the Radix Rehmanniae, 60 parts of Radix Scutellariaes, 50 parts of Rhizoma Coptidis, 60 parts of pollen, 50 parts of Herba Artemisiae Scopariaes, 50 parts of Fructus Gardeniaes, 60 parts of Rhizoma Belamcandae, 50 parts of Lasiosphaera Seu Calvatia, 50 parts of Herba Menthaes, 30 parts, Radix Glycyrrhizae.
Said ratio is weight portion meter all.
The present invention prevents the preparation method of bovine pasteurellosis Chinese medicine composition: get the Flos Lonicerae of above-mentioned weight proportion, Fructus Forsythiae, cattle Fructus Arctii, Radix Isatidis, Radix Sophorae Tonkinensis, Cortex Moutan, the Radix Rehmanniae, Radix Scutellariae, Rhizoma Coptidis, pollen, Herba Artemisiae Scopariae, Fructus Gardeniae, Rhizoma Belamcandae, Lasiosphaera Seu Calvatia, Herba Menthae, Radix Glycyrrhizae, adds total raw material drug weight 2-4 water doubly to decoct, maintain the temperature at 84 ℃-100 ℃ and decoct 1-3 hour, wherein to boil be 0.5 hour to water, and drop goes out to obtain medicinal liquid.
Usage: give with group's cows temperature of drying in the air of not falling ill and gavage, once a day, use 1-5 days.
Below by clinical experiment, the effect of chemoprophylaxis bovine pasteurellosis of the present invention is further described.
1. clinical efficacy of medicine observing is added up
Test drug: the oral preparations of filling a prescription and preparing by the present invention; Experimental animal: cattle; Ill domestic animal symptom: diarrhoea, dry cough, has blood in stool, dyspnea, the foam sample nose liquid of bleeding; Average attack rate with normal cattle in group is more than 60%.
1.1. experimental animal: 49 examples, ill domestic animal: 1 example, ill domestic animal symptom: diarrhoea, dry cough, has blood in stool, the foam sample nose liquid of bleeding.
Therapeutic Method: give the same group of cows perfusions of not falling ill, the temperature of drying in the air gavages, and once a day, with 1 day, average attack rate was 32%.
1.2. experimental animal: 64 examples, ill domestic animal: 1 example, ill domestic animal symptom: dyspnea, diarrhoea, has blood in stool, blood sample nose liquid.
Therapeutic Method: give the same group of cows perfusions of not falling ill, the temperature of drying in the air gavages, and once a day, with 2 days, average attack rate was 23%.
1.3. experimental animal: 44 examples, ill domestic animal: 1 example, ill domestic animal symptom: cough, the foam sample nose liquid of bleeding, diarrhoea.
Therapeutic Method: give the same group of cows perfusions of not falling ill, the temperature of drying in the air gavages, and once a day, with 3 days, average attack rate was 15%.
1.4. experimental animal: 79 examples, ill domestic animal: 1 example, ill domestic animal symptom: the foam sample nose liquid of bleeding, diarrhoea, has blood in stool.
Therapeutic Method: give the same group of cows perfusions of not falling ill, the temperature of drying in the air gavages, and once a day, with 4 days, average attack rate was 14.6%.
1.5. experimental animal: 83 examples, ill domestic animal: 1 example, ill domestic animal symptom: cough, dyspnea, diarrhoea, blood sample nose liquid.
Therapeutic Method: give the same group of cows perfusions of not falling ill, the temperature of drying in the air gavages, and once a day, with 5 days, average attack rate was 14.8%.
Above-mentioned clinical trial shows, by methods such as epidemiology, clinical symptoms, pathological change and laboratory inspections, make a definite diagnosis after cattle pasteurellosis bacillus, to with group all in incubation period, do not occur that the cattle of clinical symptoms gavages Chinese medicine by invented Chinese medicinal formulae, can make by 60%, to drop to 15% left and right with the average attack rate of group cattle bovine pasteurellosis, bovine pasteurellosis is played to good preventive effect.In addition, crude drug wide material sources of the present invention, cheap and easy to get, safe and reliable, toxic and side effects is little, has no drug resistance, and stable curative effect, is a kind of safety, high-quality, stable good medicine for oral administration.
The specific embodiment
Below by specific embodiment, the preparation of medicine of the present invention is described further.
embodiment 1
The formula of Chinese medicine composition: in weight portion
40 parts of Flos Loniceraes, 40 parts of Fructus Forsythiaes, 20 parts of Fructus Arctiis, 40 parts of Radix Isatidis, 40 parts of Radix Sophorae Tonkinensiss, 30 parts of Cortex Moutans, 60 parts, the Radix Rehmanniae, 40 parts of Radix Scutellariaes, 30 parts of Rhizoma Coptidis, 40 parts of pollen, 30 parts of Herba Artemisiae Scopariaes, 30 parts of Fructus Gardeniaes, 40 parts of Rhizoma Belamcandae, 30 parts of Lasiosphaera Seu Calvatia, 30 parts of Herba Menthaes, 10 parts, Radix Glycyrrhizae.
Preparation method: each crude drug of getting above-mentioned weight proportion adds the water of 2 times of total raw material drug weight to decoct, maintains the temperature under 84 ℃ of-100 ℃ of degree and decocts 1 hour, and drop goes out to obtain medicinal liquid.
embodiment 2
The formula of Chinese medicine composition: in weight portion
50 parts of Flos Loniceraes, 50 parts of Fructus Forsythiaes, 30 parts of Fructus Arctiis, 50 parts of Radix Isatidis, 50 parts of Radix Sophorae Tonkinensiss, 40 parts of Cortex Moutans, 70 parts, the Radix Rehmanniae, 50 parts of Radix Scutellariaes, 50 parts of Rhizoma Coptidis, 50 parts of pollen, 40 parts of Herba Artemisiae Scopariaes, 40 parts of Fructus Gardeniaes, 50 parts of Rhizoma Belamcandae, 40 parts of Lasiosphaera Seu Calvatia, 40 parts of Herba Menthaes, 20 parts, Radix Glycyrrhizae.
Preparation method: each crude drug of getting above-mentioned weight proportion adds the water of 2 times of total raw material drug weight to decoct, maintains the temperature under 84 ℃ of-100 ℃ of degree and decocts 2 hours, and drop goes out to obtain medicinal liquid.
embodiment 3
The formula of Chinese medicine composition: in weight portion
60 parts of Flos Loniceraes, 60 parts of Fructus Forsythiaes, 40 parts of Fructus Arctiis, 60 parts of Radix Isatidis, 60 parts of Radix Sophorae Tonkinensiss, 50 parts of Cortex Moutans, 80 parts, the Radix Rehmanniae, 60 parts of Radix Scutellariaes, 50 parts of Rhizoma Coptidis, 60 parts of pollen, 50 parts of Herba Artemisiae Scopariaes, 50 parts of Fructus Gardeniaes, 60 parts of Rhizoma Belamcandae, 50 parts of Lasiosphaera Seu Calvatia, 50 parts of Herba Menthaes, 30 parts, Radix Glycyrrhizae.
Preparation method: each crude drug of getting above-mentioned weight proportion adds the water of 3 times of total raw material drug weight to decoct, maintains the temperature under 84 ℃ of-100 ℃ of degree and decocts 2.5 hours, and drop goes out to obtain medicinal liquid.
embodiment 4
The formula of Chinese medicine composition: in weight portion
70 parts of Flos Loniceraes, 70 parts of Fructus Forsythiaes, 50 parts of Fructus Arctiis, 70 parts of Radix Isatidis, 70 parts of Radix Sophorae Tonkinensiss, 60 parts of Cortex Moutans, 90 parts, the Radix Rehmanniae, 70 parts of Radix Scutellariaes, 60 parts of Rhizoma Coptidis, 70 parts of pollen, 60 parts of Herba Artemisiae Scopariaes, 60 parts of Fructus Gardeniaes, 70 parts of Rhizoma Belamcandae, 60 parts of Lasiosphaera Seu Calvatia, 60 parts of Herba Menthaes, 40 parts, Radix Glycyrrhizae.
Preparation method: each crude drug of getting above-mentioned weight proportion adds the water of 3 times of total raw material drug weight to decoct, maintains the temperature under 84 ℃ of-100 ℃ of degree and decocts 2.5 hours, and drop goes out to obtain medicinal liquid.
embodiment 5
The formula of Chinese medicine composition: in weight portion
80 parts of Flos Loniceraes, 80 parts of Fructus Forsythiaes, 60 parts of Fructus Arctiis, 80 parts of Radix Isatidis, 80 parts of Radix Sophorae Tonkinensiss, 70 parts of Cortex Moutans, 100 parts, the Radix Rehmanniae, 80 parts of Radix Scutellariaes, 70 parts of Rhizoma Coptidis, 80 parts of pollen, 70 parts of Herba Artemisiae Scopariaes, 70 parts of Fructus Gardeniaes, 80 parts of Rhizoma Belamcandae, 70 parts of Lasiosphaera Seu Calvatia, 70 parts of Herba Menthaes, 50 parts, Radix Glycyrrhizae.
Preparation method: each crude drug of getting above-mentioned weight proportion adds the water of 3 times of total raw material drug weight to decoct, maintains the temperature under 84 ℃ of-100 ℃ of degree and decocts 3 hours, and drop goes out to obtain medicinal liquid.
Claims (3)
1. a Chinese medicine composition that prevents bovine pasteurellosis, is characterized in that: be the oral preparations that the crude drug by following weight portion is prepared from: Flos Lonicerae 40-80 part, Fructus Forsythiae 40-80 part, Fructus Arctii 20-60 part, Radix Isatidis 40-80 part, Radix Sophorae Tonkinensis 40-80 part, Cortex Moutan 30-70 part, Radix Rehmanniae 60-100 part, Radix Scutellariae 40-80 part, Rhizoma Coptidis 30-70 part, pollen 40-80 part, Herba Artemisiae Scopariae 30-70 part, Fructus Gardeniae 30-70 part, Rhizoma Belamcandae 40-80 part, Lasiosphaera Seu Calvatia 30-70 part, Herba Menthae 30-70 part, Radix Glycyrrhizae 10-50 part.
2. a kind of Chinese medicine composition that prevents bovine pasteurellosis according to claim 1, is characterized in that: the weight proportion of described each crude drug is: Flos Lonicerae 50-70 part, Fructus Forsythiae 50-70 part, Fructus Arctii 30-50 part, Radix Isatidis 50-70 part, Radix Sophorae Tonkinensis 50-70 part, Cortex Moutan 40-60 part, Radix Rehmanniae 70-90 part, Radix Scutellariae 50-70 part, Rhizoma Coptidis 40-60 part, pollen 50-70 part, Herba Artemisiae Scopariae 40-60 part, Fructus Gardeniae 40-60 part, Rhizoma Belamcandae 50-70 part, Lasiosphaera Seu Calvatia 40-60 part, Herba Menthae 40-60 part, Radix Glycyrrhizae 20-40 part.
3. a kind of Chinese medicine composition that prevents bovine pasteurellosis according to claim 1, is characterized in that: the weight proportion of described each crude drug is: 60 parts of Flos Loniceraes, 60 parts of Fructus Forsythiaes, 40 parts of cattle Fructus Arctiis, 60 parts of Radix Isatidis, 60 parts of Radix Sophorae Tonkinensiss, 50 parts of Cortex Moutans, 80 parts, the Radix Rehmanniae, 60 parts of Radix Scutellariaes, 50 parts of Rhizoma Coptidis, 60 parts of pollen, 50 parts of Herba Artemisiae Scopariaes, 50 parts of Fructus Gardeniaes, 60 parts of Rhizoma Belamcandae, 50 parts of Lasiosphaera Seu Calvatia, 50 parts of Herba Menthaes, 30 parts, Radix Glycyrrhizae.
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105663873A (en) * | 2016-03-31 | 2016-06-15 | 李佃场 | Traditional Chinese medicine composition for controlling bovine pasteurellosis and preparation method |
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| CN102188601A (en) * | 2011-04-28 | 2011-09-21 | 完颜德杰 | Chinese medicinal powder for treating mixed infection of swine diseases |
| CN103599439A (en) * | 2013-10-18 | 2014-02-26 | 赵刚 | Traditional Chinese medicine composition for treating swine plague |
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