CN104055921A - Pharmaceutical composition for treating oral lichen planus and application of pharmaceutical composition - Google Patents
Pharmaceutical composition for treating oral lichen planus and application of pharmaceutical composition Download PDFInfo
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- CN104055921A CN104055921A CN201410252120.0A CN201410252120A CN104055921A CN 104055921 A CN104055921 A CN 104055921A CN 201410252120 A CN201410252120 A CN 201410252120A CN 104055921 A CN104055921 A CN 104055921A
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- 206010030983 oral lichen planus Diseases 0.000 title claims abstract description 25
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 24
- 239000002994 raw material Substances 0.000 claims abstract description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract description 3
- 239000003814 drug Substances 0.000 claims description 24
- 241000628997 Flos Species 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 9
- 241001530126 Scrophularia Species 0.000 claims description 5
- 230000000694 effects Effects 0.000 abstract description 9
- 230000006378 damage Effects 0.000 abstract description 3
- 239000000203 mixture Substances 0.000 abstract description 3
- 241000220317 Rosa Species 0.000 abstract 1
- 241000124033 Salix Species 0.000 abstract 1
- 210000004400 mucous membrane Anatomy 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 21
- 239000000865 liniment Substances 0.000 description 16
- 229940040145 liniment Drugs 0.000 description 16
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 15
- 238000003756 stirring Methods 0.000 description 14
- 239000000843 powder Substances 0.000 description 9
- 239000000243 solution Substances 0.000 description 9
- 229960004756 ethanol Drugs 0.000 description 8
- 239000012567 medical material Substances 0.000 description 8
- 201000010099 disease Diseases 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 7
- 210000004877 mucosa Anatomy 0.000 description 7
- 239000008213 purified water Substances 0.000 description 7
- 229960000935 dehydrated alcohol Drugs 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- -1 hydroxypropyl Chemical group 0.000 description 5
- JLKDVMWYMMLWTI-UHFFFAOYSA-M potassium iodate Chemical compound [K+].[O-]I(=O)=O JLKDVMWYMMLWTI-UHFFFAOYSA-M 0.000 description 5
- 235000006666 potassium iodate Nutrition 0.000 description 5
- 229940093930 potassium iodate Drugs 0.000 description 5
- 239000001230 potassium iodate Substances 0.000 description 5
- 239000000706 filtrate Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 210000000214 mouth Anatomy 0.000 description 4
- 239000007921 spray Substances 0.000 description 4
- 238000005507 spraying Methods 0.000 description 4
- 210000002200 mouth mucosa Anatomy 0.000 description 3
- 239000002674 ointment Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 206010020565 Hyperaemia Diseases 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 241000207844 Scrophulariaceae Species 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 2
- 239000012984 antibiotic solution Substances 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 239000003862 glucocorticoid Substances 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 201000011486 lichen planus Diseases 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229960001727 tretinoin Drugs 0.000 description 2
- 206010003694 Atrophy Diseases 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
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- 108090000790 Enzymes Proteins 0.000 description 1
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- 208000034493 Mucous membrane disease Diseases 0.000 description 1
- 241000405911 Rehmannia glutinosa Species 0.000 description 1
- 240000008254 Rosa chinensis Species 0.000 description 1
- 244000020191 Salix babylonica Species 0.000 description 1
- 235000002493 Salix babylonica Nutrition 0.000 description 1
- 241001121987 Scrophularia ningpoensis Species 0.000 description 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 1
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- 239000008280 blood Substances 0.000 description 1
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- 230000001404 mediated effect Effects 0.000 description 1
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- 230000035935 pregnancy Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a pharmaceutical composition for treating oral lichen planus and application of the pharmaceutical composition. The composition is prepared from traditional Chinese medicinal raw materials and excipients. The traditional Chinese medicinal raw materials comprise the following components in parts by weight: 25-40 parts of radix scrophulariae, 25-40 parts of monthly rose, 12-20 parts of dried rehamnnia root and 5-12 parts of willow root. The pharmaceutical composition is used for treating oral lichen planus in an external application way; after medicating for 4 weeks, the damage area of mucous membrane of the patient is obviously reduced and the pain is obviously relieved; the effective rate reaches 94.7%; the curative effect of the pharmaceutical composition is obviously better than the conventional treatment.
Description
Technical field
The invention belongs to Chinese medicine technical field, in particular to a kind of pharmaceutical composition and application thereof for the treatment of oral lichen planus.
Background technology
Oral lichen planus (oral lichenplanus, OLP) is cell-mediated inflammatory skin, mucous membrane disease of a kind of agnogenic T, is one of oral mucosa commonly encountered diseases.Modern medicine is not clear and definite to the oral lichen planus cause of disease yet, and thinking may be abnormal with Nervous and Mental Factors, infection, medicine, chronic lesion, systemic disease, enzyme, cryptorrhea or qi depression to blood stasis etc. are relevant.This disease is apt to occur in middle age, and women is more than male.Current local therapeutic approaches comprises antibiotic solution rinsing the mouth, the interior injection of infringement or external glucocorticoid, 0.1% tretinoin ointment.But long-term external glucocorticoid often produces the untoward reaction such as local atrophy, infection, telangiectasis, and the curative effect of antibiotic solution rinsing the mouth and 0.1% tretinoin ointment is all undesirable.
Because oral lichen planus is often with vesicle, ulceration, the erosion of oral mucosa, when the conscious obvious spontaneous pain of patient or feed, exciting pain, clinical symptoms weight, treat more difficult, traditional Therapeutic Method weak curative effect, easily recurrence, often increases heavy stress to patient.Meanwhile, because its cause of disease is complicated, unstable condition, Chang Fanfu outbreak, at present both at home and abroad all without effective especially medicine and method.
Summary of the invention
In view of the deficiencies in the prior art, the object of the present invention is to provide a kind of pharmaceutical composition and application thereof for the treatment of oral lichen planus.
Pharmaceutical composition of the present invention is to complete on the basis of secret prescription handed down in the family from generation to generation, and its concrete technical scheme is as follows:
Treat a pharmaceutical composition for oral lichen planus, by traditional Chinese medicinal material raw materials and excipient, be prepared from, by weight, described Chinese crude drug comprises: Radix Scrophulariae 25-40 part, Flos Rosae Chinensis 25-40 part, Radix Rehmanniae 12-20 part, Radix Salicis Babylonicae 5-12 part.
Preferably, treat as mentioned above the pharmaceutical composition of oral lichen planus, by weight, described traditional Chinese medicinal material raw materials is comprised of Radix Scrophulariae 30-35 part, Flos Rosae Chinensis 30-35 part, Radix Rehmanniae 14-18 part and Radix Salicis Babylonicae 6-10 part.
In a most preferred embodiment of the present invention, treat as mentioned above the pharmaceutical composition of oral lichen planus, by weight, described traditional Chinese medicinal material raw materials is comprised of 8 parts of 32 parts of Radix Scrophulariaes, 32 parts of Flos Rosae Chinensiss, 16 parts, the Radix Rehmanniae and Radix Salicis Babylonicae.
Pharmaceutical composition of the present invention is preferably external preparation; As ointment, liniment, liniment etc.
By clinical experimental study, find, the pharmaceutical composition being comprised of above-mentioned Chinese crude drug has significant curative effect aspect treatment oral lichen planus patients.Therefore, second object of the present invention is to provide a kind of new pharmaceutical use, i.e. the application of above-mentioned pharmaceutical composition in the medicine of preparation treatment oral lichen planus.Especially, the application of above-mentioned pharmaceutical composition in the external used medicine of preparation treatment oral lichen planus.
The source of Chinese crude drug that the present invention adopts is as follows: Radix Scrophulariae is selected from the dry root of dicotyledon Scrophulariaceae Scrophulariaceae Radix Scrophulariae Scrophularia ningpoensisHemsl..Flos Rosae Chinensis is selected the dried floral into rosaceous plant Chinese rose.The Radix Rehmanniae is selected from the dried root of Scrophulariaceae herbaceos perennial Radix Rehmanniae Rehmannia glutinosa Libosch., also claims Radix Rehmanniae.Radix Salicis Babylonicae is selected root and the root hair of Salicaceous Plants Salix babylonica L..
The preparation method of Chinese medicine liniment of the present invention comprises the steps: to take by recipe quantity the Radix Scrophulariae 25-40 part cleaning up, Flos Rosae Chinensis 25-40 part, Radix Rehmanniae 12-20 part and Radix Salicis Babylonicae 5-12 part, merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder; In clear paste powder, add Tween-20, glycerol, partial purification water to stir, make to dissolve completely; Add afterwards hydroxypropyl emthylcellulose, stirring is spent the night, and it is dissolved completely; Then add dehydrated alcohol, stir; After this purified water that takes a morsel is dissolved potassium iodate, and joins in previous step material and mix, and stirs; By remaining purified water, add to full dose, stir; Fill, packing, obtain Chinese medicine liniment.
Chinese medicine liniment of the present invention treatment oral lichen planus, medication in the time of 4 weeks patient's mucosa damage area and obviously reduce, pain is obviously alleviated, effective percentage reaches 94.7%, its curative effect is apparently higher than conventional therapy.
The specific embodiment
Be below specific embodiments of the invention, technical scheme of the present invention is done to further description, but protection scope of the present invention is not limited to these embodiment.Every do not deviate from the change of the present invention design or be equal to substitute include within protection scope of the present invention.
The preparation of embodiment 1 Chinese medicine liniment
Take 32 parts of Radix Scrophulariaes, 32 parts of Flos Rosae Chinensiss, 8 parts of 16 parts, the Radix Rehmanniae and Radix Salicis Babylonicae, merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder, standby;
According to following formula, prepare burden: clear paste powder 1g, hydroxypropyl emthylcellulose 2g, polysorbas20 2g, glycerol 1g, dehydrated alcohol 20g, potassium iodate 0.02g, purified water adds to 100g.In clear paste powder, add Tween-20, glycerol, partial purification water to stir, make to dissolve completely; Add afterwards hydroxypropyl emthylcellulose, stirring is spent the night, and it is dissolved completely; Then add dehydrated alcohol, stir; After this purified water that takes a morsel is dissolved potassium iodate, and joins in previous step material and mix, and stirs; By remaining purified water, add to 100g, stir; Fill, packing, obtain Chinese medicine liniment.
The preparation of embodiment 2 Chinese medicine liniment
Take 38 parts of Radix Scrophulariaes, 30 parts of Flos Rosae Chinensiss, 20 parts, the Radix Rehmanniae, 10 parts of Radix Salicis Babylonicae, merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder, standby;
According to following formula, prepare burden: clear paste powder 1g, hydroxypropyl emthylcellulose 2g, polysorbas20 3g, glycerol 1g, dehydrated alcohol 30g, potassium iodate 0.025g, adds to 100g by purified water.Method for making, with embodiment 1, obtains liniment.
The preparation of embodiment 3 Chinese medicine liniment
Take 25 parts of Radix Scrophulariaes, 28 parts of Flos Rosae Chinensiss, 12 parts, the Radix Rehmanniae, 6 parts of Radix Salicis Babylonicae, merge, decoct with water twice, adding for the first time water is 10 times of amounts of medical material weight, decoct 1.5h, adding for the second time water is 8 times of amounts of medical material weight, decoct 1.5h, collecting decoction, 0.07MPa, the extractum that while being evaporated to 65 ℃ at 60-70 ℃, relative density is 1.15, adding 95% (v/v) ethanol makes to reach 75% (v/v) containing alcohol amount, stir, standing 24 hours, filter, filtrate is at 0.07MPa, when under 65 ℃ of conditions, concentrating under reduced pressure becomes to 65 ℃, relative density is 1.25, and reclaim ethanol, obtain concentrated solution, by concentrated solution spraying, dry (condition is that inlet temperature is 100 ℃, leaving air temp is 80 ℃, temperature of charge is 80 ℃, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s.), pulverized 80 mesh sieves, obtain clear paste powder, standby;
According to following formula, prepare burden: clear paste powder 5g, hydroxypropyl emthylcellulose 3g, polysorbas20 15g, glycerol 5g, dehydrated alcohol 45g, potassium iodate 0.5g, adds to 100g by purified water.Method for making, with embodiment 1, obtains Chinese medicine liniment.
The effectiveness study of embodiment 4 Chinese medicine liniment to oral cavity patients with lichen planus
Oral lichen planus patient's 38 examples, male 22 examples wherein, female's 16 examples; 24～78 years old age, average (46.5 ± 5.2) year.All patients all have the typical mucosa infringement of lichen planus, and make a definite diagnosis through pathology.Exclusion standard: the concurrent oral mucosa disease that other significantly may affect the treatment and evaluate in affected part; 2 persons of Zhou Nei local application; Gestation or women breast-feeding their children.By medical order, patient is divided into matched group (19 example) and test group (19 example) at random.Two groups aspect sex, age and disease degree without significantly lower difference, there is comparability.
Matched group patient uses 2% sodium bicarbonate solution and 0.2% liquor hibitane every day rinsing the mouth alternately for several times.The local Chinese medicine liniment (being prepared from by the prescription of above-described embodiment 1 and technique) that uses of test group, dips liniment with cotton swab and is directly applied to affected part, every day 2 times, within 4 weeks, is 1 course for the treatment of.Treatment finishes rear further consultation.The standard of curative effect evaluation is as follows.
Recovery from illness: mucosa infringement disappears completely, transference cure;
Effective: mucosa infringement is disappeared more than 70%, rotten to the corn face healing, hyperemia disappears or dwindles more than 2/3, only has a little white stripes, and nothing is subjective symptoms obviously;
Take a turn for the better: mucosa infringement disappears 30%～70%, hyperemia, rotten to the corn reduction of area is little, and white stripes reduces, and subjective symptoms alleviates;
Invalid: mucosa infringement disappear less than 30% or the state of an illness unchanged.
Recovery from illness, effective, take a turn for the better and all to count effectively.Two groups of curative effects compare in Table 1, by table 1, can find out, patient adopts liniment of the present invention to carry out topical therapeutic, has obtained better curative effect.After drug withdrawal 4 weeks, matched group has 5 example recurrences, and test group all has 2 example recurrences.
Table 1 liang group curative effect comparison
By above research, can draw, Chinese medicine liniment of the present invention treatment oral lichen planus, medication in the time of 4 weeks patient's mucosa damage area and obviously reduce, pain is obviously alleviated, effective percentage reaches 94.7%, apparently higher than matched group.
Claims (6)
1. a pharmaceutical composition for the treatment of oral lichen planus, it is characterized in that: by traditional Chinese medicinal material raw materials and excipient, be prepared from, by weight, described traditional Chinese medicinal material raw materials comprises: Radix Scrophulariae 25-40 part, Flos Rosae Chinensis 25-40 part, Radix Rehmanniae 12-20 part and Radix Salicis Babylonicae 5-12 part.
2. treat according to claim 1 the pharmaceutical composition of oral lichen planus, it is characterized in that: by weight, described traditional Chinese medicinal material raw materials is comprised of Radix Scrophulariae 30-35 part, Flos Rosae Chinensis 30-35 part, Radix Rehmanniae 14-18 part and Radix Salicis Babylonicae 6-10 part.
3. treat according to claim 1 the pharmaceutical composition of oral lichen planus, it is characterized in that: by weight, described traditional Chinese medicinal material raw materials is comprised of 8 parts of 32 parts of Radix Scrophulariaes, 32 parts of Flos Rosae Chinensiss, 16 parts, the Radix Rehmanniae and Radix Salicis Babylonicae.
4. according to the pharmaceutical composition for the treatment of oral lichen planus described in claim 1 or 2 or 3, it is characterized in that: described pharmaceutical composition is external preparation.
5. the application of the pharmaceutical composition described in claim 1 or 2 or 3 in the medicine of preparation treatment oral lichen planus.
6. the application of the pharmaceutical composition described in claim 1 or 2 or 3 in the external used medicine of preparation treatment oral lichen planus.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104606314A (en) * | 2015-03-04 | 2015-05-13 | 马宁 | Traditional Chinese medicine for treating oral lichen planus and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895513A (en) * | 2006-06-23 | 2007-01-17 | 陈文渊 | Medicine for treating oral lichen planus |
| CN101708278A (en) * | 2009-12-08 | 2010-05-19 | 中国人民解放军第三军医大学第二附属医院 | Medicament for treating oral plane lichen and preparation method thereof |
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2014
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1895513A (en) * | 2006-06-23 | 2007-01-17 | 陈文渊 | Medicine for treating oral lichen planus |
| CN101708278A (en) * | 2009-12-08 | 2010-05-19 | 中国人民解放军第三军医大学第二附属医院 | Medicament for treating oral plane lichen and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 白晓丽等: "中西医结合治疗口腔扁平苔藓20例疗效观察", <<内蒙古中医药>> * |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104606314A (en) * | 2015-03-04 | 2015-05-13 | 马宁 | Traditional Chinese medicine for treating oral lichen planus and preparation method thereof |
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