CN104042705B - One treats prostatitic Chinese medicine composition and preparation method and application - Google Patents
One treats prostatitic Chinese medicine composition and preparation method and application Download PDFInfo
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- CN104042705B CN104042705B CN201410294732.6A CN201410294732A CN104042705B CN 104042705 B CN104042705 B CN 104042705B CN 201410294732 A CN201410294732 A CN 201410294732A CN 104042705 B CN104042705 B CN 104042705B
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Abstract
The invention provides one and treat prostatitic Chinese medicine composition, it is extracted by the crude drug of following parts by weight and prepares: Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 15-25 part, star show flower 10-20 part, Radix Salviae Miltiorrhizae 14-18 part, Flos Carthami 10-15 part, Herba Patriniae 30-40 part, Semen Vaccariae 8-16 part, Fructus Rubi 10-15 part, Ootheca Mantidis 15-25 part form, energy clearing away heat and promoting diuresis, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, treatment prostatitis, and disclose preparation method and purposes.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to one and be used for the treatment of prostatitic Chinese medicine composition and preparation method and application.
Background technology
Prostatitis is the commonly encountered diseases of Urology Surgery, and in Urology Surgery male patient, the right side of fifty group accounts for first place.Prostatitis is divided into four class five kinds, i.e. acute bacterial prostatitis, chronic bacterial prostatitis, chronic Pelvic Pain Syndrome (inflammatory and non-inflammatory), silent prostatitis.Wherein nonbacterial prostatitis is common far beyond bacterial prostatitis.The medicine that past is commonly used as Sulfamethoxazole Compound (SMZ-TMP) has a broad antifungal spectrum, but can not concentrate in prostate, and continuous use 2 months curative effects are still unsatisfied with.Many opinions quinolones for oral administration is as ofloxacin (ofloxacin) or levofloxacin (levofloxacin) at present.If invalid continuation was with 8 weeks.Recurrence and strain is constant, use preventive dose instead to reduce acute attack, symptom gone down.If prolonged application antibiotic brings out serious side reaction, as pseudomembranous enterocolitis, diarrhoea, intestinal Resistant strain is grown, then need to change therapeutic scheme.Another program first uses tetracycline, if symptom alleviates, extend to 28 days, symptom does not subtract, and uses quinolones instead.Lack real effective patent medicine in the market.
Summary of the invention
Goal of the invention: in order to solve the problem, the object of the present invention is to provide one to be used for the treatment of prostatitic Chinese medicine composition and preparation method and application.
Technical scheme: the object of the invention is by following scheme realize:
One treats prostatitic Chinese medicine composition, and it is extracted by the crude drug of following parts by weight and prepares: Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 15-25 part, star show flower 10-20 part, Radix Salviae Miltiorrhizae 14-18 part, Flos Carthami 10-15 part, Herba Patriniae 30-40 part, Semen Vaccariae 8-16 part, Fructus Rubi 10-15 part, Ootheca Mantidis 15-25 part.
The prostatitic Chinese medicine composition of described treatment, it by following parts by weight crude drug extract prepare: Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 20 parts, star show spend 15 parts, Radix Salviae Miltiorrhizae 16 parts, 12 parts, Flos Carthami, Herba Patriniae 35 parts, Semen Vaccariae 12 parts, Fructus Rubi 10 parts, Ootheca Mantidis 20 parts.
The prostatitic Chinese medicine composition of described treatment, preparation method comprises the steps: to get Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), star show flower, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Patriniae, Semen Vaccariae, Fructus Rubi, Ootheca Mantidis medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
The application of the prostatitic Chinese medicine composition of described treatment in preparation treatment prostatitis medicine.
Raw Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) of the present invention is the root of comfrey Herba Carpesii Cernui.Star show flower is Gentianaceae agueweed red Radix Gentianae GentianarhodanthaFranch., with root and all herbal medicine.All the other are pharmacopeia kind.
Beneficial effect:
From theory of Chinese medical science, in we, Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) clearing away heat and promoting diuresis, star show flower anti-inflammatory analgetic are monarch drug, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Patriniae blood circulation promoting and blood stasis dispelling, Semen Vaccariae, Fructus Rubi hard masses softening and resolving, be ministerial drug altogether, Ootheca Mantidis controlling nocturnal emission with astringent drugs reducing urination, reinforcing the kidney and supporting YANG, for adjuvant, all medicines are harmonious, and play clearing away heat and promoting diuresis, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving effect altogether, are used for the treatment of prostatitis.Formulation of the present invention is reasonable, and compatibility is rigorous, through long-term clinical verification, and determined curative effect.Consist of Chinese crude drug, have no side effect, low price.
Detailed description of the invention
Form by the following examples, foregoing of the present invention is described in further detail again, but this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following example, all technology realized based on foregoing of the present invention all belong to scope of the present invention.
One, preparation embodiment 1: get Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 20g, star show flower 15g, Radix Salviae Miltiorrhizae 16g, Flos Carthami 12g, Herba Patriniae 35g, Semen Vaccariae 12g, Fructus Rubi 10g, Ootheca Mantidis 20g medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add starch and make capsule.
Preparation embodiment 2: get Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 15g, star show flower 20g, Radix Salviae Miltiorrhizae 14g, Flos Carthami 15g, Herba Patriniae 30g, Semen Vaccariae 16g, Fructus Rubi 10g, Ootheca Mantidis 25g medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add starch, pelletizing press sheet makes tablet.
Preparation embodiment 3: get Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 25g, star show flower 10g, Radix Salviae Miltiorrhizae 18g, Flos Carthami 10g, Herba Patriniae 40g, Semen Vaccariae 8g, Fructus Rubi 15g, Ootheca Mantidis 15g medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, spray drying condition is: inlet temperature is 100 DEG C, leaving air temp is 80 DEG C, temperature of charge is 70 DEG C, atomizing pressure is 0.2 MPa, spray velocity is 5ml/s, add starch, granule is made in granulation.
Two, the present invention is to prostatitic clinical trial data
The physical data of experimental subject: adopt the present invention to treat 60 examples altogether, the oldest person 32 years old, age reckling 19 years old is male entirely.
Diagnostic criteria:
1. urine can be had secondary slightly many, when urinating, in urethra, have burn feeling and urine meaning to feel not to the utmost.
2. can there be sacrum portion, perineum, lower abdomen, inguinal region, urethra, testis discomfort, distending pain.Can concurrent iritis, arthritis, neuritis.
3. can there is sexual disorder as libido decline, premature ejaculation, seminal emission.
4. prostate touch can be normal, also can air spots, and quality is uneven, can have local tenderness.
5. prostatic fluid microscopy, every high power field leukocyte is more than more than 10, and lecithin reduces or disappears.
6. urine and prostatic fluid split fix cultivation and colony counting (Meares-stamey inspection technique) marginal to making a definite diagnosis.If VB1 and VB2 is negative, or <3000 bacterium number/ml, and EPS or VB, more than 5000 bacterium number/ml, when namely VB3 is more than VB12 times, just diagnosable is bacterial prostatitis; 4 specimen such as VB1 are all aseptic, and when medical history, symptom, prostate touch and massage of prostate liquid meet prostatitis diagnosis, diagnosable is aseptic prostatitis.
Therapeutic Method: usage and dosage: adopt the capsule prepared by the embodiment of the present invention 1, its usage and consumption are each 8, and every day 3 times, warm water takes, and one week are a course for the treatment of, treat for 4 courses for the treatment of altogether.
The standard of curative effect evaluation:
Cure: clinical manifestation transference cure, sign is improved completely, happy, in high spirits.
Effective: clinical manifestation transference cure, sign makes moderate progress, and mood and spirit are better.
Invalid: clinical manifestation symptom does not disappear, sign and symptom are improved not obvious or without improvement.
Experimental result: in accept for medical treatment 60 routine cases, through treatment in 1 month, wherein cures 29 examples, effective 25 examples, and invalid 6 examples, total effective rate reaches 90%.Show that the present invention has extremely significant effect to treatment prostatitis patient.
Claims (4)
1. the prostatitic Chinese medicine composition for the treatment of, it is characterized in that, it is extracted by the crude drug of following parts by weight and prepares: Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 15-25 part, star show flower 10-20 part, Radix Salviae Miltiorrhizae 14-18 part, Flos Carthami 10-15 part, Herba Patriniae 30-40 part, Semen Vaccariae 8-16 part, Fructus Rubi 10-15 part, Ootheca Mantidis 15-25 part.
2. treat prostatitic Chinese medicine composition as claimed in claim 1, it is characterized in that, it by following parts by weight crude drug extract prepare: Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis) 20 parts, star show spend 15 parts, Radix Salviae Miltiorrhizae 16 parts, 12 parts, Flos Carthami, Herba Patriniae 35 parts, Semen Vaccariae 12 parts, Fructus Rubi 10 parts, Ootheca Mantidis 20 parts.
3. treat prostatitic Chinese medicine composition as claimed in claim 1, it is characterized in that, preparation method comprises the steps: to get Radix Cynoglossi Amabillis (Herba Cynoglossi Amabilis), star show flower, Radix Salviae Miltiorrhizae, Flos Carthami, Herba Patriniae, Semen Vaccariae, Fructus Rubi, Ootheca Mantidis medical material merges, decoct with water twice, amount of water is 10 times amount of medical material weight, decoct 2h, collecting decoction, when being concentrated into 65 DEG C, relative density is 1.10, adding ethanol makes the percent by volume of alcohol content reach 65%, stir, leave standstill, filter, during filtrate reduced in volume to 65 DEG C, relative density is 1.20 and reclaims ethanol, by concentrated solution spraying dry, add adjuvant and make capsule, tablet, granule.
4. described in claim 1, treat the application of prostatitic Chinese medicine composition in preparation treatment prostatitis medicine.
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| CN201410294732.6A CN104042705B (en) | 2014-06-26 | 2014-06-26 | One treats prostatitic Chinese medicine composition and preparation method and application |
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| CN201410294732.6A CN104042705B (en) | 2014-06-26 | 2014-06-26 | One treats prostatitic Chinese medicine composition and preparation method and application |
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| CN104042705A CN104042705A (en) | 2014-09-17 |
| CN104042705B true CN104042705B (en) | 2015-12-09 |
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