CN104042516A - Chinese herbal medicine composition with skin whitening effect as well as preparation method and application of Chinese herbal medicine composition - Google Patents
Chinese herbal medicine composition with skin whitening effect as well as preparation method and application of Chinese herbal medicine composition Download PDFInfo
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Abstract
The invention discloses a Chinese herbal medicine composition with a skin whitening effect. The Chinese herbal medicine composition is prepared from the following components in parts by weight: 8-40 parts of bletilla striata, 8-40 parts of rhizome of chuanxiong, 8-40 parts of radix puerariae, 8-40 parts of green tea and 5-20 parts of rhizome nardostachyos. The invention also discloses a preparation method of the Chinese herbal medicine composition with the skin whitening effect and an application of the Chinese herbal medicine composition with the skin whitening effect to cosmetics. The Chinese herbal medicine composition with the skin whitening effect has the beneficial effects that the Chinese herbal medicine composition capable of mainly inhibiting the synthesis of melanin and expression of relevant mRNA, synergically promoting metabolization of skin and promoting blood circulation can be used for effectively preventing and reducing the synthesis of skin melanin; the Chinese herbal medicine composition is a pure Chinese herbal extract so as to be safe in use, conform to the hygienic code of cosmetics and be used in a skin whitening cosmetic formula such as skin whitening and moisturizing lotions and skin whitening cleaning milk; researches on the three mechanisms including biological chemistry, cell biology and molecule biology prove that the Chinese herbal medicine composition with the skin whitening effect has the multilevel skin whitening effect through remarkably inhibiting tyrosinase, inhibiting melanin and inhibiting the gene synthesis of melanin correlated factor mRNA.
Description
Technical field
The present invention relates to a kind of Chinese herbal medicine extract, particularly one for skin-whitening and there is white-skinned face function herbal composite and its preparation method and application.
Background technology
The color of application on human skin is mainly to be determined by melanic amount, and melanin is the pigment of a kind of pitchy of existing in animal skin or hair.Melanic generation and endocrine disturbance, sun exposure are relevant; The factors such as ultraviolet, heredity, inflammatory mediator, improper diet cause Melanin Metabolism abnormal, and the black pigment of skin excessively rapid growth and skewness, cause local skin to cross black and pigmentation.Freckle removing and whitening is still the topic that Asia women is paid close attention to most.
Existing skin-whitening agents, often adopt the amino hydrargyrum of hydrogen peroxide, hydrogenation with and various phenol derivatives.Although these compounds can make melanin disintegrate rapidly, reach effect of quick whitening; But because of its corrosivity, cytotoxicity and anaphylaxis to skin, make it have great danger, disabled in the hygienic practice of many countries.Meet the cosmetics of " green, natural " in order to develop, some Chinese herbal medicine with better whitening effect are more and more subject to the favor of consumer.
The traditional Chinese medical science thinks, melanic generation and the dirty relation of liver,spleen,kidney three are very close, and drug of choice owner will be taking blood circulation promoting and blood stasis dispelling as guide, and dredging stasis blocking, makes mechanism of qi be able to smoothness, promotes facial blood circulation, improves skin of face metabolism, and facial pigmentation is dribbled.Chinese herbal medicine is applied to the clinical existing two dry history for many years of beauty treatment, has safety and the actual effect of height.
" Chinese combination of Chinese and Western medicine skin cypridology magazine " shows that the tea polyphenols of green tea can effectively absorb ultraviolet, suppresses melanocytic activation, and the activity of restraint of tyrosinase, has obvious whitening function." research and development of natural products " research finds that in Radix Puerariae, puerarin has obvious inhibitory action to tryrosinase.The Pseudobulbus Bletillae (Rhizoma Bletillae), " property of medicine opinion " cloud its: control skin ulcer on face, make us flesh sliding; It " washes one's face Compendium of Material Medica cloud black, speckle dispelling ".
" Chinese herbal medicine " magazine has been summed up having whitening function or having the natural plant composition of potential whitening function of finding in recent years.Publication number is that CN1493270A Chinese patent application discloses the apply some make up compositions of composition of a kind of skin-whitening, from Rhizoma Chuanxiong, to isolate 6,7-dihydro-3-butylphthalide A, suppresses the constituent of melanotropin activity and the constituent that skin-whitening applies some make up as effective ingredient.Publication number is that the Chinese patent application of CN1947696A discloses a kind of Chinese medicine formula with white-skinned face function, formed by the Rhizoma Atractylodis Macrocephalae, Poria, Radix Ampelopsis, the Radix Paeoniae Alba, the Pseudobulbus Bletillae (Rhizoma Bletillae), Rhizoma Seu Herba Bergeniae and Radix Glycyrrhizae, effectively improve skin quality, there is moisturizing whitening, the miraculous effects of delaying skin aging.Publication number provides a kind of Chinese herb compound freckle removing and whitening compositions and external preparation for CN102028752A Chinese patent application, there is removal or desalinate the effect of the mottle pigments such as chloasma, chloasma hepaticum, butterfly spot, sunburn, senile plaque, can improve the low and deep and inhomogeneous colour of skin, the moist skin of nutrition simultaneously, make skin high resilience, be used in conjunction with arbutin, Vc and derivant thereof etc., can strengthen freckle removing and whitening effect.
According to above analysis, existing whitening correlational study is found, no matter is folk prescription or compound skin-whitening Chinese herbal medicine, and its research mainly concentrates on inhibitory action to tryrosinase or in melanic inhibition or scavenging action.
Summary of the invention
The object of the invention is the deficiency existing for the above prior art, provide a kind of check melanin safely and effectively to generate and reduce melanin deposition there is white-skinned face function herbal composite.
Described in being to provide, another object of the present invention there is the preparation method of white-skinned face function herbal composite.
Described in being to provide, the 3rd object of the present invention there is the application of white-skinned face function herbal composite.
In order to realize foregoing invention object, the present invention is achieved through the following technical solutions: have white-skinned face function herbal composite, be made up of the component of following parts by weight:
Have the preparation method of white-skinned face function herbal composite, it step comprising is as follows:
(1) said components is pulverized, adding 10～30 times of volumetric concentrations of gross mass is that 35-70% ethanol water soaks 30～60min;
(2) temperature is controlled at 15～30 DEG C, and pressure control 0.2～70mpa carries out High Pressure Difference extraction, collects extracting solution centrifugalize and gets supernatant;
(3) supernatant separates through micro-filtration membrane, and it is concentrated that collection filtrate is carried out reverse osmosis membrane.
Have the application of white-skinned face function herbal composite in cosmetics, its addition is 0.5-20%.
A kind of lightening compositions, it comprises following parts by weight component:
A kind of cleawhite pack, it comprises following parts by weight component:
Compared with prior art, the invention has the beneficial effects as follows: can stress the expression of the synthetic and relevant mRNA of ground check melanin, the collaborative metabolism of strengthening skin, the herbal composite of blood circulation promoting, can effectively prevent and reduce the synthetic of dermal melanin; And be pure Chinese herbal medicine extract, use safety, meet cosmetics health specification, can be used in skin-lightening cosmetic formula, as body whitening crème, whitening cleansing milk etc.; Studies have shown that by biochemistry, cytobiology and the large mechanism of molecules three: have obvious restraint of tyrosinase, the gene of check melanin and check melanin correlation factor mRNA is synthetic, reaches at many levels whitening effect.
Brief description of the drawings
Fig. 1 is B16 cell appreciation rate: represent the increment effect of skin-whitening herbal composite to B16 cell.
Fig. 2 is B16 drug sensitivity testing suppression ratio: represent the responsive result of B16 cell to all kinds of determinands.
Fig. 3 is the structural representation of High Pressure Difference extractor.
Detailed description of the invention
In order to set forth better technology contents of the present invention, now lift preferred embodiment and be described as follows.
Embodiment 1
There is white-skinned face function herbal composite, made by the component of following parts by weight:
Embodiment 2
There is white-skinned face function herbal composite, made by the component of following parts by weight:
Embodiment 3
There is white-skinned face function herbal composite, made by the component of following parts by weight:
Embodiment 4
There is white-skinned face function herbal composite, made by the component of following parts by weight:
The above-mentioned preparation method with white-skinned face function herbal composite, it step comprising is as follows:
(1) said components is pulverized, mix homogeneously, the volumetric concentration that adds said components to mix 10 times of rear gross masses is that 35% ethanol water soaks 35min, can be to carry out in charging tank, need to stir;
(2) temperature is controlled at 15 DEG C, and pressure control 0.2～70mpa carries out High Pressure Difference extraction, collects extracting solution centrifugalize and carries out getting supernatant after solid-liquid separation;
(3) supernatant separates through micro-filtration membrane, and it is concentrated that collection filtrate is carried out reverse osmosis membrane.
The above-mentioned preparation method with white-skinned face function herbal composite, it step comprising is as follows: (1) pulverizes said components, mix homogeneously, adding said components to mix rear 30 times of volumetric concentrations of gross mass is that 70% ethanol water soaks 60min;
(2) temperature is controlled at 30 DEG C, and pressure control 0.2～70mpa carries out High Pressure Difference extraction, collects extracting solution centrifugalize and gets supernatant;
(3) supernatant separates through micro-filtration membrane, and it is concentrated that collection filtrate is carried out reverse osmosis membrane.
Preferably, the above-mentioned preparation method with white-skinned face function herbal composite, it step comprising is as follows: (1) pulverizes said components, mix homogeneously, and adding said components to mix rear 25 times of volumetric concentrations of gross mass is that 50% ethanol water soaks 50min;
(2) temperature is controlled at 30 DEG C, and pressure control 0.2～70mpa carries out High Pressure Difference extraction, collects extracting solution centrifugalize and gets supernatant;
(3) supernatant separates through micro-filtration membrane, and it is concentrated that collection filtrate is carried out reverse osmosis membrane.
Wherein, said components can be crushed to 30-150 order, can improve extraction efficiency.Described micro-filtration membrane can Ceramics film, and its filter opening footpath is between 0.1-1 micron.Described reverse osmosis membrane is Tao Shi reverse osmosis membrane preferably, failure rate is low and long service life.
It is change the powerful mechanical force producing and form high velocity stream at 0.2～70mpa of 0.1-0.3S moment pressure reduction that described High Pressure Difference is extracted, make material to be extracted under machinery and permeable pressure head condition, content be mixed with solvent phase, thereby make intracellular extracts active ingredients out.
Preferably, High Pressure Difference extraction is to change the powerful mechanical force producing and form high velocity stream at 0.5～50mpa of 0.S moment pressure reduction to extract; Can raise the efficiency like this and can keep extract activity
Wherein, High Pressure Difference is extracted and can in High Pressure Difference extractor, be carried out.Described High Pressure Difference extractor as shown in Figure 3, is made up of extraction chamber 1, rewinding chamber 2, extracting solution tank battery 3, air compression station 4, dog-house 5, agitator 6, solvent aerosol apparatus 7, condenser 8, freezing water station 9, solvent storage tank 10, condensate buffering tank 11, vacuum station 12, temperature set station 13, extraction slag storage tank 14, temperature detecting controller 20, pressure testing and controlling device 30; Described extraction chamber 1 and described rewinding chamber 2 share a pressure vessel with heat preservation sandwich layer also by leaf filter interval, the built-in described agitator 6 in described extraction chamber 1; Described extraction chamber 1 and described rewinding chamber 2 can be split can be also the standalone of disjunctor, between described extraction chamber 1 and described rewinding chamber 2, cut apart with filter, described filter is board-like or the combination of rolling, filled type, pillar or different types filter; The top of described extraction chamber 1 is provided with described dog-house 5, and described solvent aerosol apparatus 7 is installed, and solvent aerosol apparatus 7 is by pipeline communication solvent storage tank 10; Described rewinding chamber 2 is extracted slag storage tank 14 by 1 bottom, extraction chamber described in pipeline communication extracting solution tank battery 3 by pipeline communication; Described condensate buffering tank 11 passes through pipeline communication with vacuum station 12; The compressed air reservoir of 1 top, described extraction chamber and air compression station 4 passes through pipeline communication; Pressure vessel interlayer is set up circulating line with the temperature adjusting liquid storage tank of temperature set station 13 and is connected; Described extraction chamber 1 is provided with temperature detecting controller 20 and pressure testing and controlling device 30.Set up pipeline by the vacuum orifice on condensate buffering tank 11 with the vacuum buffer tank of vacuum station 12 and be connected, while making to operate, can make as required the vacuum in rewinding chamber 2 be up to 50Pa; Set up pipeline by the compressed air inlet at top, extraction chamber with the compressed air reservoir of air compression station 4 and be connected, while making to operate, can make as required the indoor pressure of rewinding be up to 35MPa; Set up circulating line by the temperature adjusting liquid import and export of interlayer with the temperature adjusting liquid storage tank of temperature set station 13 and be connected, temperature adjusting liquid temperature general control, at-35 DEG C～50 DEG C, can make the indoor temperature of extraction chamber and rewinding be controlled at-25 DEG C～40 DEG C as required while making to operate; Set up information gathering and the transmission path of control system by the valve on pressure testing and controlling device 30, temperature detecting controller 20 and the pipeline at 1 top, extraction chamber, these information will be conducive to the procedure design and application of automatic control operation.High Pressure Difference extractor is attached is furnished with cleaning, decontamination system.
When operation, step is as follows:
1. reinforced: to open dog-house 5, start and stir dress device 6, dry material to be extracted is dropped in extraction chamber by charge door.
2. evacuation: after material finishes, close dog-house 5, start freezing water station 9 and make chilled water enter condenser 8 circulation, start vacuum station, will be evacuated in extraction chamber 1 by condensate buffering tank 11, reach after the vacuum needing, keep certain hour.
3. add solvent: by solvent aerosol apparatus 7, the solvent in solvent storage tank 10 is measured on demand and quantitatively sprayed in extraction chamber 1, keep certain hour.
4. subtract vacuum: start air compression station 4, logical compressed air enters in extraction chamber 1, makes indoor vacuum drop to gradually 0.0MPa.
5. pressurization: continue to pass into compressed air, make extraction chamber's 1 internal pressure rise to gradually the highest 35MPa, extracting solution is entered in rewinding chamber 2.
6. repeatedly carry out operating procedure 2～5, until extracting solution does not show selected index components identification.
7. opening extraction chamber's bottom valve is expelled to extraction slag to extract in slag storage tank 14.
Embodiment 5
(1) composite good above-mentioned raw materials proportionally, is pulverized, and the powder after pulverizing is placed in 200L charging tank, then adds 10～20 times of pure water, is controlled at about 90 DEG C stirs and extract 60～120min in temperature;
(2) said extracted liquid carries out solid-liquid separation by centrifuge.Supernatant carries out that microfiltration is concentrated, and centrifugal slag adds 10～20 times of pure water again, is controlled under the condition of 90 DEG C of left and right stirs and extract 60～120min in temperature;
(3) said extracted liquid concentrates by centrifuge again, makes its solid-liquid separation;
(4) centrifugal liquid is carried out clarified separation processing by micro-filtration membrane again;
(5) the isolated supernatant of microfiltration is connected to reverse osmosis membrane system by pipeline, and it is carried out to concentration, can obtain extract.
What the present invention obtained has white-skinned face function herbal composite, according to the standard of " 2010 editions cosmetics health specifications ", the repeatedly irritation test, acute ocular irritation test and the health physics and chemistry that have carried out whitening compound detect, and indices result all meets the requirement of cosmetics specification.
Have the application of white-skinned face function herbal composite in the cosmetics such as cream frost, water preparation, emulsion, its preferred addition is 1-10%.Most preferred, the addition with white-skinned face function herbal composite is 5%.
Embodiment 6
A kind of lightening compositions, it comprises following parts by weight component:
Embodiment 7
A kind of lightening compositions, it comprises following parts by weight component:
Embodiment 8
A kind of lightening compositions, it comprises following parts by weight component:
The preparation method of above-mentioned a kind of lightening compositions is as follows:
(1) first disodiumedetate is added in water and stirred, be incubated half an hour after being heated to 80-90 degree Celsius simultaneously;
(2) in (1) step water, add successively polyglycereol, hydrogenated starch hydrolysate, carrageenan and hyaluronate sodium, be stirred to completely after dissolving and start cooling;
(3) after temperature drops to 45-55 degree Celsius, add Aloe extract, trehalose, vitamin E and dextran, stir;
(4) add after cooling the temperature to 35-45 degree Celsius have white-skinned face function herbal composite and, stir;
(5) finally add that to regulate pH value with sodium hydroxide be 7-8, stir.
Embodiment 9
A kind of cleawhite pack, it comprises following parts by weight component:
Embodiment 10
A kind of cleawhite pack, it comprises following parts by weight component:
Embodiment 11
A kind of cleawhite pack, it comprises following parts by weight component:
The preparation method of above-mentioned a kind of cleawhite pack is as follows:
(1) in water, add disodiumedetate (EDTA-2Na) to stir, be incubated half an hour after being heated to 80-90 degree Celsius simultaneously;
(2) add successively polyglycereol, hydrogenated starch hydrolysate, carrageenan and hyaluronate sodium, be stirred to completely after dissolving and start cooling with the rotating speed of 20-50rpm;
(3) after temperature drops to 45-55 degree Celsius, add antiseptic, Aloe extract, trehalose, vitamin E and dextran, stir;
(4) after temperature is down to 35-45 degree Celsius, add and there is white-skinned face function herbal composite, stir with the rotating speed of 20-50rpm;
(5) finally add that to regulate pH value with sodium hydroxide be 7-8, the rotating speed of 10-20rpm stirs.
Effect experiment
1, biochemistry level: above-described embodiment is carried out to effect experiment, use biochemical zymetology method to carry out the mensuration of external tyrosinase inhibition rate
Experimental technique: according to following table application of sample, mix, 37 DEG C of 37 DEG C of water bath heat preservations, in C1 and T1 pipe, adding concentration is that the L-3,4 dihydroxyphenylalanine of 100U/mL mixes.After 10min, make reference with C2 and survey the light absorption value of C1 at 475nm place, make reference with T2 and survey the light absorption value of T1 at 475nm place.Test parallel 3 times for every group, calculating mean value, utilizes the suppression ratio of formula calculation sample to tryrosinase.
Tyrosinase inhibition rate=(C1-T1)/C1
Table 1 is that the external biochemical enzyme process of embodiment 3 detects tryrosinase
Experimental result: the positive reference substance that biochemical zymetology method is used is β-arbutin, and this whitening inhibitor is widely used in skin-lightening cosmetic as conventional whitening additive.Experimental data shows that the skin-whitening herbal composite of 2% content is 54.1% to the suppression ratio of tryrosinase, β-the arbutin of 2% content is 34.8% to the suppression ratio of tryrosinase, other embodiment also have similar testing result, illustrate that skin-whitening of the present invention herbal composite has certain whitening effect.
2, cellular level: above-described embodiment is carried out to effect experiment, by melanic content in mouse melanoma B16 cell is detected, as depicted in figs. 1 and 2.
Experimental technique is as follows:
(1) B16 cell recovered and cultivated, detecting and the previous day cell is gone down to posterity, making its degree of converging is 30%-50%, uses the high sugared complete medium of DMEM-when detection.
Dosing in (2) second days is concentrated, sees that culture medium has obvious change color, and microscopic examination is when having black precipitate in cell, collecting cell.
(4) results 1 × 10
6cell, PBS washes twice, adds 200uL redistilled water that precipitation is suspended, and adds the ethanol of 1mL: ether (1: 1) mixed liquor, leaves standstill 20min, the centrifugal 5min of 3000r/min under room temperature.
(6) precipitation adds 1mol/L NaOH lml (containing 10%DMSO), spectrophotometer at 415nm on surveys absorbance after hatching 30min in 80 DEG C of water-baths.
Melanin synthesizes suppression ratio=(1-medicine concentrates class value/blank class value) × 100%
Experimental result:
Table 2 is the melanin suppression ratio of embodiment 3
Have white-skinned face function herbal composite melanin and detect and normally cultivate cell with experiment contrast group and compare, P < 0.05 has significant difference, proves that whitening compound recipe concentrates relative cell and secretes the melanin effect of having a significant effect; Compare with positive controls, P < 0.05 has significant difference, proves to have the obviously check melanin secretion of the concentrated B16 cell of white-skinned face function herbal composite.
3, human body level: above-described embodiment is carried out to human body skin test, the changes of contents by German dermal melanin tester Mexameter MX18 test dermal melanin after before use.
(1) test position: the bilateral forearm of trial volunteer is bent territory, lateral areas,
(2) experiment grouping: the skin of the bilateral forearm of trial volunteer being bent to side is divided into test side and blank side at random.
(3) experimental procedure: be first to collect each experimenter's forearm to bend the photo of side and measure tested front melanin content, issue experimenter being subject to trial product, make using method that each experimenter understands product (in the region of the selected 2*2cm of forearm, smear 1g raw material to absorbing completely, twice sooner or later of every day) at every turn.After test starts the 1st day, the 8th day, the 12nd day, the 17th day, the 21st day and the 25th day, use dermal melanin that German COURAGE+KHAZAKA electronic GmbH (CK) company produces and haemachrome tester Mexameter MX18 to measure haemachrome and the melanin value of target site skin.Target site dermal melanin is measured 3 times, gets its meansigma methods, uses the variation of front and back dermal melanin value to assess the effect of this product to skin-whitening by measurement products.
Experimental result:
Table 3 is the human body melanin content testing result of embodiment 3
Experimental result: the positive reference substance that biochemical zymetology method is used is β-arbutin, and this whitening inhibitor is widely used in skin-lightening cosmetic as conventional whitening additive.Experimental data shows that the skin-whitening herbal composite of 2% content is 54.1% to the suppression ratio of tryrosinase, β-the arbutin of 2% content is 34.8% to the suppression ratio of tryrosinase, other embodiment also have similar testing result, illustrate that skin-whitening of the present invention herbal composite has certain whitening effect.
The present invention detects the relevant composition-factor mRNA of melanin, carries out white-skinned face function evaluation respectively from biochemistry level, cellular level, molecular level and human body level.This herbal composite raw material pure natural, safe and non-stimulating, there is market potential widely.
Above-mentioned other embodiment of the present invention detect through said method, also have the similar data of beneficial effect described above, again no longer burdensome.
Above-described embodiment is preferably embodiment of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and principle, substitutes, combination, simplify; all should be equivalent replacement mode, within being included in protection scope of the present invention.
Claims (5)
1. there is white-skinned face function herbal composite, it is characterized in that, made by the component of following parts by weight:
2. as claimed in claim 1 have a white-skinned face function herbal composite, it is characterized in that, it step comprising is as follows:
(1) said components is pulverized, adding 10～30 times of volumetric concentrations of gross mass is that 35-70% ethanol water soaks 30～60min;
(2) temperature is controlled at 15～30 DEG C, and pressure control 0.2～70mpa carries out High Pressure Difference extraction, collects extracting solution centrifugalize and gets supernatant;
(3) supernatant separates through micro-filtration membrane, and it is concentrated that collection filtrate is carried out reverse osmosis membrane.
3. have the application of white-skinned face function herbal composite in cosmetics, its addition is 0.5-20%.
4. a lightening compositions, is characterized in that, it comprises following parts by weight component:
5. a cleawhite pack, is characterized in that, it comprises following parts by weight component:
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| CN104886593A (en) * | 2015-06-02 | 2015-09-09 | 无限极（中国）有限公司 | A skin whitening compound and an application thereof |
| CN105030562A (en) * | 2015-03-30 | 2015-11-11 | 广州市络捷生物科技有限公司 | Anti-allergic compound polysaccharide composition, preparation method and application thereof |
| CN105997657A (en) * | 2016-06-21 | 2016-10-12 | 安徽诚亚生物科技有限公司 | Moisturizing and whitening traditional Chinese medicine composition |
| CN109718184A (en) * | 2019-03-12 | 2019-05-07 | 北温草生物科技(上海)有限公司 | A kind of combined extracts of plant whitening agent |
| CN112890779A (en) * | 2021-01-28 | 2021-06-04 | 贵州省农作物品种资源研究所 | Preparation of whitening and whitening effect evaluation method of whitening and whitening gelatin dry powder |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105030562A (en) * | 2015-03-30 | 2015-11-11 | 广州市络捷生物科技有限公司 | Anti-allergic compound polysaccharide composition, preparation method and application thereof |
| CN105030562B (en) * | 2015-03-30 | 2019-01-04 | 广州市络捷生物科技有限公司 | A kind of antiallergy complex polysaccharide composition and its preparation method and application |
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| US10098372B2 (en) | 2015-06-02 | 2018-10-16 | Infinitus (China) Company Ltd | Whitening composition and the use thereof |
| CN105997657A (en) * | 2016-06-21 | 2016-10-12 | 安徽诚亚生物科技有限公司 | Moisturizing and whitening traditional Chinese medicine composition |
| CN109718184A (en) * | 2019-03-12 | 2019-05-07 | 北温草生物科技(上海)有限公司 | A kind of combined extracts of plant whitening agent |
| CN112890779A (en) * | 2021-01-28 | 2021-06-04 | 贵州省农作物品种资源研究所 | Preparation of whitening and whitening effect evaluation method of whitening and whitening gelatin dry powder |
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| CN104042516B (en) | 2016-10-12 |
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