CN104039134A - 细胞组学血管健康概况分析的系统和方法 - Google Patents

细胞组学血管健康概况分析的系统和方法 Download PDF

Info

Publication number
CN104039134A
CN104039134A CN201280039113.1A CN201280039113A CN104039134A CN 104039134 A CN104039134 A CN 104039134A CN 201280039113 A CN201280039113 A CN 201280039113A CN 104039134 A CN104039134 A CN 104039134A
Authority
CN
China
Prior art keywords
subject
mps
flow cytometry
biological sample
risk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201280039113.1A
Other languages
English (en)
Chinese (zh)
Inventor
E·R·莫勒
J·S·摩尔
L·张
W·罗杰斯
A·D·班特雷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pennsylvania Penn
Original Assignee
University of Pennsylvania Penn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pennsylvania Penn filed Critical University of Pennsylvania Penn
Publication of CN104039134A publication Critical patent/CN104039134A/zh
Pending legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/32—Cardiovascular disorders

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280039113.1A 2011-06-10 2012-06-10 细胞组学血管健康概况分析的系统和方法 Pending CN104039134A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161495955P 2011-06-10 2011-06-10
US61/495,955 2011-06-10
US201261650353P 2012-05-22 2012-05-22
US61/650,353 2012-05-22
PCT/US2012/041792 WO2012170974A1 (en) 2011-06-10 2012-06-10 System and method of cytomic vascular health profiling

Publications (1)

Publication Number Publication Date
CN104039134A true CN104039134A (zh) 2014-09-10

Family

ID=47296510

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201280039113.1A Pending CN104039134A (zh) 2011-06-10 2012-06-10 细胞组学血管健康概况分析的系统和方法

Country Status (7)

Country Link
US (1) US20140357505A1 (enExample)
EP (1) EP2717681A4 (enExample)
JP (1) JP6059211B2 (enExample)
CN (1) CN104039134A (enExample)
AU (1) AU2012267489B2 (enExample)
CA (1) CA2838436A1 (enExample)
WO (1) WO2012170974A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531772A (zh) * 2015-05-07 2018-01-02 肿瘤免疫股份有限公司 Cd24用于降低低密度脂蛋白胆固醇水平的用途
CN116359488A (zh) * 2021-12-27 2023-06-30 北京积水潭医院 检测血液样本中不同类型微颗粒含量的方法

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015134791A2 (en) * 2014-03-07 2015-09-11 University Of Washington - Center For Commercialization Non-invasive biomarker of antibody-mediated allograft rejection
JP2015123503A (ja) * 2014-08-21 2015-07-06 千住金属工業株式会社 真空はんだ処理装置及びその制御方法
JP2018505392A (ja) * 2014-12-10 2018-02-22 ネオゲノミクス ラボラトリーズ， インコーポレイテッド 自動化されたフローサイトメトリ分析方法及びシステム
FR3030039B1 (fr) * 2014-12-12 2018-03-16 Commissariat A L'energie Atomique Et Aux Energies Alternatives Caracterisation et reproduction d'un jugement d'expert pour une classification binaire
CA3012985A1 (en) 2015-01-27 2016-08-04 Kardiatonos, Inc. Biomarkers of vascular disease
WO2017162722A1 (en) * 2016-03-22 2017-09-28 INSERM (Institut National de la Santé et de la Recherche Médicale) Free functional annexin levels in plasma as a biomarker of cardiovascular risk
JPWO2020138351A1 (enExample) * 2018-12-28 2020-07-02
CN114674729B (zh) * 2022-03-02 2023-11-21 迈克医疗电子有限公司 脉冲识别方法、装置、存储介质、设备及血液细胞分析仪
CN120778688A (zh) * 2025-07-09 2025-10-14 广州市微米生物科技有限公司 一种流式检测试剂在肿瘤疾病的出血风险等级分类产品中的应用

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050032140A1 (en) * 2003-06-27 2005-02-10 Oklahoma Medical Research Foundation Methods for predicting susceptibility to cardiovascular disease
US20050272098A1 (en) * 2004-04-23 2005-12-08 Tramontano Anthony F Quantitation of endothelial microparticles
US20060057072A1 (en) * 2002-11-15 2006-03-16 Toren Finkel Method for diagnosis and treatment of vascular disease
US20060078553A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Diverse multi-unit complexes including a tRNA synthetase fragment
US20090233999A1 (en) * 1999-09-06 2009-09-17 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
US20100203058A1 (en) * 2009-02-11 2010-08-12 Indiana University Research And Technology Corporation Diagnostics and therapeutics based on circulating progenitor cells

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011000874A1 (en) * 2009-07-01 2011-01-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting cardiovascular mortality risk

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090233999A1 (en) * 1999-09-06 2009-09-17 Novogen Research Pty Ltd Compositions and therapeutic methods involving isoflavones and analogues thereof
US20060057072A1 (en) * 2002-11-15 2006-03-16 Toren Finkel Method for diagnosis and treatment of vascular disease
US20050032140A1 (en) * 2003-06-27 2005-02-10 Oklahoma Medical Research Foundation Methods for predicting susceptibility to cardiovascular disease
US20050272098A1 (en) * 2004-04-23 2005-12-08 Tramontano Anthony F Quantitation of endothelial microparticles
US20060078553A1 (en) * 2004-10-07 2006-04-13 Paul Glidden Diverse multi-unit complexes including a tRNA synthetase fragment
US20100203058A1 (en) * 2009-02-11 2010-08-12 Indiana University Research And Technology Corporation Diagnostics and therapeutics based on circulating progenitor cells

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CURTIS ET AL.: "Relationship of Microparticles to Progenitor Cells as a Measure of Vascular Health in a Diabetic Population", 《CYTOMETRY PART B (CLINICAL CYTOMETRY)》, vol. 78, no. 5, 31 December 2010 (2010-12-31), pages 329 - 337 *
K. T. TAN ET AL.: "Clinically apparent atherosclerotic disease in diabetes is associated with an increase in platelet microparticle levels", 《DIABETIC MEDICINE》, vol. 22, no. 12, 31 December 2005 (2005-12-31), pages 1657 - 1662, XP055154571, DOI: 10.1111/j.1464-5491.2005.01707.x *
KOGA H ET AL.: "Elevated Levels of VE-Cadherin–Positive Endothelial Microparticles in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease", 《JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY》, vol. 45, no. 10, 31 December 2005 (2005-12-31), pages 1622 - 1630, XP029658785, DOI: 10.1016/j.jacc.2005.02.047 *
ROGERS ET AL.: "Cytometric Fingerprinting: Quantitative Characterization of Multivariate Distributions", 《CYTOMETRY PART A》, vol. 73, no. 5, 31 December 2008 (2008-12-31), pages 430 - 441 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107531772A (zh) * 2015-05-07 2018-01-02 肿瘤免疫股份有限公司 Cd24用于降低低密度脂蛋白胆固醇水平的用途
CN107531772B (zh) * 2015-05-07 2021-09-21 肿瘤免疫股份有限公司 Cd24用于降低低密度脂蛋白胆固醇水平的用途
CN116359488A (zh) * 2021-12-27 2023-06-30 北京积水潭医院 检测血液样本中不同类型微颗粒含量的方法

Also Published As

Publication number Publication date
JP6059211B2 (ja) 2017-01-11
AU2012267489B2 (en) 2017-03-16
CA2838436A1 (en) 2012-12-13
WO2012170974A1 (en) 2012-12-13
JP2014517313A (ja) 2014-07-17
EP2717681A1 (en) 2014-04-16
US20140357505A1 (en) 2014-12-04
EP2717681A4 (en) 2015-01-07
AU2012267489A1 (en) 2014-01-09

Similar Documents

Publication Publication Date Title
AU2012267489B2 (en) System and method of cytomic vascular health profiling
Ibrahim et al. Association of immature platelets with adverse cardiovascular outcomes
Urrechaga et al. Role of leucocytes cell population data in the early detection of sepsis
Kurtzman et al. Personalized cytomic assessment of vascular health: evaluation of the vascular health profile in diabetes mellitus
Yifan et al. Development and validation of a random forest diagnostic model of acute myocardial infarction based on ferroptosis-related genes in circulating endothelial cells
Mullier et al. Platelet microparticle generation assay: a valuable test for immune heparin-induced thrombocytopenia diagnosis
JP2015514227A (ja) 結核バイオマーカーおよびその使用
Zhang et al. Expanded CD14hiCD16− Immunosuppressive monocytes predict disease severity in patients with acute pancreatitis
Filh Hematological parameters as prognostic biomarkers in patients with cardiovascular diseases
Tőkés-Füzesi et al. Role of microparticles derived from monocytes, endothelial cells and platelets in the exacerbation of COPD
JP2022548905A (ja) Ｄｍａｒｄに対する患者の応答を予測する方法
CN110702917A (zh) 血清淀粉样蛋白p在制备抑郁症诊断治疗相关产品的用途
CN107238712A (zh) 血浆s100a12在st段抬高型心肌梗死预后中的应用
CN111323521A (zh) 色氨酸分解代谢中的犬尿氨酸/色氨酸比值的改变在st段抬高型心肌梗死预后中的应用
US20220187311A1 (en) Methods for the detection and quantification of circulating endothelial cells
Siwaponanan et al. Enumeration and phenotyping of circulating microvesicles by flow cytometry and nanoparticle tracking analysis: Plasma versus serum
CN114966056B (zh) 筛查急性主动脉夹层的试剂盒和系统
EP2534491B1 (en) Compositons and methods for predicting cardiovascular events
US12196763B2 (en) Compositions and methods for predicting post-surgical cardiovascular events
De Simone et al. Circulating endothelial cell levels in psoriatic patients and their modification after an anti‐TNF‐alpha (Etanercept) treatment
Rogers et al. V ascular H ealth P rofile predicts cardiovascular outcomes in patients with diabetes
Maréchal et al. Neutrophil dynamics in acute coronary syndrome
Wang et al. Mucosal‐associated invariant T cells correlate with myocardial ischaemia and remodelling in coronary artery disease
US12078645B2 (en) Method for diagnosing disseminated intravascular coagulation (DIC)
Guo et al. Clinical significance of inflammation-coagulation-autoantibody triad in systemic sclerosis-associated interstitial lung disease: a retrospective study

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20140910