CN104016951B - 靶向癌症干细胞的化合物和组合物 - Google Patents

靶向癌症干细胞的化合物和组合物 Download PDF

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CN104016951B
CN104016951B CN201410101861.9A CN201410101861A CN104016951B CN 104016951 B CN104016951 B CN 104016951B CN 201410101861 A CN201410101861 A CN 201410101861A CN 104016951 B CN104016951 B CN 104016951B
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polymorph
cancer
compound
furan
naphtho
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CN104016951A (zh
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李嘉强
D.勒格特
李有志
李微
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1Globe Biomedical Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/92Naphthofurans; Hydrogenated naphthofurans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/21Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • AHUMAN NECESSITIES
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A61P9/00Drugs for disorders of the cardiovascular system
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00Stock material or miscellaneous articles
    • Y10T428/29Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982Particulate matter [e.g., sphere, flake, etc.]

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  • Health & Medical Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Gynecology & Obstetrics (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
CN201410101861.9A 2010-03-19 2011-03-21 靶向癌症干细胞的化合物和组合物 Active CN104016951B (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US31588610P 2010-03-19 2010-03-19
US31589010P 2010-03-19 2010-03-19
US61/315890 2010-03-19
US61/315886 2010-03-19
US32581410P 2010-04-19 2010-04-19
US61/325814 2010-04-19

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CN104016951A CN104016951A (zh) 2014-09-03
CN104016951B true CN104016951B (zh) 2016-07-13

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CN201710613672.3A Active CN107311969B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物
CN201710134235.3A Pending CN106860443A (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物
CN201410101861.9A Active CN104016951B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的化合物和组合物

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CN201710613672.3A Active CN107311969B (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物
CN201710134235.3A Pending CN106860443A (zh) 2010-03-19 2011-03-21 靶向癌症干细胞的新的化合物和组合物

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EP (2) EP3295796A1 (enExample)
JP (11) JP2014098050A (enExample)
CN (3) CN107311969B (enExample)
CA (3) CA2959951A1 (enExample)
DK (1) DK3108750T3 (enExample)
ES (1) ES2689928T3 (enExample)
HU (1) HUE066482T2 (enExample)
NZ (2) NZ701237A (enExample)
PT (1) PT2547205T (enExample)
RU (2) RU2657750C1 (enExample)
SG (3) SG10201502079VA (enExample)

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JP5688840B2 (ja) 2007-09-10 2015-03-25 ボストン バイオメディカル, インコーポレイテッド 新規のStat3経路阻害剤及び癌幹細胞阻害剤
SG10201502079VA (en) * 2010-03-19 2015-06-29 Boston Biomedical Inc Novel compounds and compositions for targeting cancer stem cells
LT2547205T (lt) * 2010-03-19 2024-06-10 1Globe Biomedical Co., Ltd. Nauji tikslinio poveikio vėžio kamieninėms ląstelėms būdai
MX2015014181A (es) 2013-04-09 2016-05-24 Boston Biomedical Inc 2-acetilnafto [2,3-b]furano -4,9-diona para uso en el tratamiento del cáncer.
US20180140572A1 (en) * 2015-06-03 2018-05-24 Boston Biomedical, Inc. Compositions comprising a cancer stemness inhibitor and an immunotherapeutic agent for use in treating cancer
GB201515387D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions
GB201515391D0 (en) * 2015-08-28 2015-10-14 Amazentis Sa Compositions
JP6751658B2 (ja) 2016-11-15 2020-09-09 クラリオン株式会社 音声認識装置、音声認識システム
WO2018102427A1 (en) 2016-11-29 2018-06-07 Boston Biomedical, Inc. Naphthofuran derivatives, preparation, and methods of use thereof
CA3062656A1 (en) 2017-05-17 2018-11-22 Boston Biomedical, Inc. Methods for treating cancer

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WO2004026253A2 (en) * 2002-09-17 2004-04-01 Arqule, Inc. Novel lapacho compounds and methods of use thereof
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

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EP0945131A1 (de) * 1998-03-27 1999-09-29 Boehringer Ingelheim Pharma KG Perorale Wirkstoff-Suspension
WO2000044774A2 (en) * 1999-01-27 2000-08-03 The University Of South Florida Inhibition of stat3 signal transduction for human cancer therapy
AR042052A1 (es) * 2002-11-15 2005-06-08 Vertex Pharma Diaminotriazoles utiles como inhibidores de proteinquinasas
JP5288791B2 (ja) * 2005-01-28 2013-09-11 武田薬品工業株式会社 難水溶性物質含有微細化組成物
JP2006290871A (ja) * 2005-03-16 2006-10-26 Taheebo Japan Kk 抗癌性を示す化合物およびその中間体ならびにそれらの製造方法
TW200803854A (en) * 2005-09-30 2008-01-16 Smithkline Beecham Corp Pharmaceutical compositions
EP1860126A1 (en) * 2006-05-26 2007-11-28 INEOS Manufacturing Belgium NV Polyolefin powder
US8822482B2 (en) * 2008-07-08 2014-09-02 Beta Pharma, Inc. Icotinib hydrochloride, synthesis, crystalline forms, pharmaceutical compositions, and uses thereof
SG10201502079VA (en) * 2010-03-19 2015-06-29 Boston Biomedical Inc Novel compounds and compositions for targeting cancer stem cells
WO2011116398A1 (en) * 2010-03-19 2011-09-22 Boston Biomedical, Inc. Novel compounds and compositions for targeting cancer stem cells
LT2547205T (lt) * 2010-03-19 2024-06-10 1Globe Biomedical Co., Ltd. Nauji tikslinio poveikio vėžio kamieninėms ląstelėms būdai

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004026253A2 (en) * 2002-09-17 2004-04-01 Arqule, Inc. Novel lapacho compounds and methods of use thereof
WO2009036099A1 (en) * 2007-09-10 2009-03-19 Boston Biomedical, Inc. A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors

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Publication number Publication date
JP2016222723A (ja) 2016-12-28
JP2020063308A (ja) 2020-04-23
JP2022020002A (ja) 2022-01-27
CA2959951A1 (en) 2011-09-22
JP2018115209A (ja) 2018-07-26
JP2015232037A (ja) 2015-12-24
JP2014098048A (ja) 2014-05-29
JP2015098489A (ja) 2015-05-28
JP2020114888A (ja) 2020-07-30
EP3108750B1 (en) 2018-07-04
SG10201502079VA (en) 2015-06-29
CN104016951A (zh) 2014-09-03
PT2547205T (pt) 2024-05-27
EP3108750A1 (en) 2016-12-28
JP2018002744A (ja) 2018-01-11
HUE066482T2 (hu) 2024-08-28
RU2015142279A (ru) 2018-12-28
CA2959931A1 (en) 2011-09-22
CN107311969B (zh) 2022-01-28
DK3108750T3 (en) 2018-10-22
CN107311969A (zh) 2017-11-03
CA2993363A1 (en) 2011-09-22
RU2657750C1 (ru) 2018-06-15
JP6246169B2 (ja) 2017-12-13
JP2014098049A (ja) 2014-05-29
SG10201704745UA (en) 2017-07-28
JP2014098050A (ja) 2014-05-29
JP5993390B2 (ja) 2016-09-14
CN106860443A (zh) 2017-06-20
NZ701237A (en) 2016-04-29
EP3295796A1 (en) 2018-03-21
RU2015142279A3 (enExample) 2019-02-26
ES2689928T3 (es) 2018-11-16
SG10201706265PA (en) 2017-08-30
NZ712826A (en) 2017-03-31

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