CN104000973A - Traditional Chinese medicine composition for treating colpitis and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating colpitis and preparation method thereof Download PDFInfo
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- CN104000973A CN104000973A CN201410208508.0A CN201410208508A CN104000973A CN 104000973 A CN104000973 A CN 104000973A CN 201410208508 A CN201410208508 A CN 201410208508A CN 104000973 A CN104000973 A CN 104000973A
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Abstract
A traditional Chinese medicine composition for treating colpitis is characterized by being prepared from the following raw materials: angelica, poria, motherwort herb, epimedium, pinellia, cinnamon, red ginseng, atractylodes, radices sileris, sargentgloryvine stem, radix paeoniae rubra, radix astragali and peach kernel. The traditional Chinese medicine composition IS mainly used for treatment of colpitis, is exact in curative effect, has the dampness clearing, antibacterial, insecticidal and antipruritic effects, has non-irritating, non-allergic and non-toxic and side effects, and is highly safe and comfortable.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly, the present invention relates to a kind ofly for curing mainly colpitic Chinese medicine composition, the invention still further relates to the preparation method of described Chinese medicine composition.
Background technology
The difficult miscellaneous diseases of gynecological and chronic condition of disease affect people's orthobiosis, but can not effect a radical cure very soon.Gynecological inflammation mainly refers to women genitals's inflammation, comprise vaginitis, cervicitis, pelvic inflammatory disease that a variety of causes causes, often there is pruritus vulvae, scorching hotly swell and ache, the symptom such as vaginal congest, leucorrhea bean dregs sample, leucorrhea amount are many, dyspareunia, frequent micturition, urgent micturition, dysurea, lower abdomen falling inflation, when serious, affect women's quality of life, inflammation repeated infection also can be encroached on other organs of female reproduction, even may threaten to life.
According to the relevant statistics of World Health Organization (WHO), show, women's gynecological inflammation prevalence is high, with regard to its degree, married woman or the women of child-bearing age's the state of an illness is even more serious, the cause of disease is more complicated, the course of disease is more very long, wherein has more than 5% women, because the state of an illness serious affected normal study, work or life.
Traditional Chinese medical herbal treatment gynaecopathia is to start with from Overall View, depressed liver-energy dispersing and QI regulating, strengthening the body resistance, blood circulation promoting and blood stasis dispelling, hard masses softening and resolving, heat-clearing and toxic substances removing, endocrine regulation is lived the logical blood of gas comprehensively, enlivens internal organs, and meridians are this, QI and blood is for using, QI and blood is the material base of human body, and internal organs are source of generating QI and blood, play be in charge of blood generation, have under one's command and move, regulate blood and balanced action, gas is the motive power of blood.With regard to women, blood is the material base of menstruation, if visceral dysfunction, qi and blood circulation will be affected, and involves sea of blood function, can cause various gynopathic generations, as ovarian cyst etc.Chinese traditional treatment can be exempted mental pressure and the mental burden that operation brings to patient, endocrine regulation, and enhancing immunity etc., take medicine conveniently, do not operate on, and do not hinder vigour, and painful risk is little, and expense is low, effective fast.Chronic pelvic inflammatory disease is department of obstetrics and gynecology commonly encountered diseases, frequently-occurring disease, is to cause chronic pelvic pain, ectopic pregnancy and infertile main cause.The multiple young women of being born in clinically, this disease cause of disease is complicated, and Relapse rate is treated thornyly, has a strong impact on patient's healthy and life quality.
Theory of Chinese medical science thinks, the main damp of gynecological inflammation is for suffering from, and has again inside and outside minute, and main pathogenesis can be summarized as liver spleen renal dysfunction, and damp injures to appoint is with two arteries and veins, makes conception vessel lose solid, dai channel and fails to keep an appointment.Specifically can divide again that dampness-heat of the liver, deficiency of YIN folder is wet, turbid damp pents up.Gynecological inflammation as vaginitis and pudendal pruritus belong to the traditional Chinese medical science " pudendal pruritus ", " leukorrheal diseases " category.< < Yizong Jinjian > > thinks, married woman's pudendal pruritus, and how because of parasite caused by accumulation of damp-heat in the body, insect poison is had an itch.< < Complete Effective Prescriptions for Women > > says: Mr. and Mrs people pudendal pruritus person is that worm-eaten is done.Three worms are between the intestines and stomach, and because of deficiency of five ZANG-organs, three worms actions, in ulceration at external genitals.Its worm makes heat, micro-for itching, heavy be bitterly also.Leukorrhagia too much refers to woman's leukorrhagia amount showed increased, and color, matter, abnormal smells from the patient are abnormal, or with part and General Symptoms person.< < female section brief points > > propose leukorrhagia be too much by taste virtual loss, yang-energy, sunk due to, advocate spleen invigorating yang invigorating leukorrhagia stopping.
Object of the present invention overcomes that Western medicine side effect is large exactly, curative effect not significantly or the reason such as form of Chinese drug, the deficiency of the technology such as curative effect is unstable, according to traditional Chinese medical science prescription and preparation principle, Chinese medicine composition is developed meticulously, the advantage such as provide a kind of pointed strong, good effect, the cycle is short, price is low, have no side effect, can make again patient take like a shot, can treat preferably colpitic pure Chinese medicinal preparation.At anti-inflammation simultaneously, regulate intravaginal environment, improve vaginal mucosa resistance, evident in efficacy.In addition, visible in clinical observation, Chinese medicine composition itching-relieving action of the present invention is especially obvious, and after patient is reflected medication, antipruritic effect is fast, and it is comfortable that part is felt.Chinese medicine composition of the present invention is not found toxic and side effects in using, and is prevent and treat colpitic good medicine, is worthy of popularization.
Summary of the invention
For solving the problems of the technologies described above, the invention provides a kind of colpitic Chinese medicine composition for the treatment of, it is characterized in that being prepared from by following raw material components: Radix Angelicae Sinensis, Poria, Herba Leonuri, Herba Epimedii, the Rhizoma Pinelliae, Cortex Cinnamomi, Radix Ginseng Rubra, Rhizoma Atractylodis, Radix Saposhnikoviae, Caulis Sargentodoxae, Radix Paeoniae Rubra, the Radix Astragali, Semen Persicae.
Wherein, Radix Angelicae Sinensis 10-30 weight portion, Poria 15-30 weight portion, Herba Leonuri 10-20 weight portion, Herba Epimedii 10-25 weight portion, Rhizoma Pinelliae 15-25 weight portion, Cortex Cinnamomi 10-20 weight portion, Radix Ginseng Rubra 5-15 weight portion, Rhizoma Atractylodis 10-20 weight portion, Radix Saposhnikoviae 15-25 weight portion, Caulis Sargentodoxae 10-20 weight portion, Radix Paeoniae Rubra 10-20 weight portion, Radix Astragali 15-30 weight portion, Semen Persicae 15-30 weight portion.
Preferably, Radix Angelicae Sinensis 20-30 weight portion, Poria 22-30 weight portion, Herba Leonuri 16-20 weight portion, Herba Epimedii 18-25 weight portion, Rhizoma Pinelliae 21-25 weight portion, Cortex Cinnamomi 14-20 weight portion, Radix Ginseng Rubra 9-15 weight portion, Rhizoma Atractylodis 14-20 weight portion, Radix Saposhnikoviae 19-25 weight portion, Caulis Sargentodoxae 13-20 weight portion, Radix Paeoniae Rubra 16-20 weight portion, Radix Astragali 21-30 weight portion, Semen Persicae 22-30 weight portion.
Further preferably, Radix Angelicae Sinensis 20 weight portions, Poria 22 weight portions, Herba Leonuri 16 weight portions, Herba Epimedii 18 weight portions, the Rhizoma Pinelliae 21 weight portions, Cortex Cinnamomi 14 weight portions, Radix Ginseng Rubra 9 weight portions, Rhizoma Atractylodis 14 weight portions, Radix Saposhnikoviae 19 weight portions, Caulis Sargentodoxae 13 weight portions, Radix Paeoniae Rubra 16 weight portions, the Radix Astragali 21 weight portions, Semen Persicae 22 weight portions.
For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of colpitic Chinese medicine composition, and preparation process is:
A. each component in described raw material components is mixed in proportion, puts into 10 times of water gagings, heating and refluxing extraction 2 times, each 45 minutes～1.5 hours, extract active ingredient, 2 extracting solution are merged standing;
B. the medicinal residues of crossing through water extraction in step a are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 30 minutes～45 minutes, merges standing by 2 extracting solution again;
C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is ℃-70 ℃, puts into oven for drying by extractum and make powder, sieves, and every 100g powder adds refined honey 90～110g, makes big honeyed pills, obtains.
The present invention also provides the application of above-mentioned raw materials component in the colpitic Chinese medicine composition of preparation treatment.
Beneficial effect of the present invention:
Technical problem to be solved by this invention is, a kind of colpitic Chinese medicine composition for the treatment of is provided, described Chinese medicine composition is mainly used in colpitic treatment clinically, determined curative effect, there is damp eliminating, antibacterial, parasite killing, antipruritic effect, to mucocutaneous nonirritant, without anaphylaxis, have no side effect, have safety and the comfort of height.
The specific embodiment
The invention provides a kind of colpitic Chinese medicine composition for the treatment of, it is characterized in that being prepared from by following raw material components: Radix Angelicae Sinensis, Poria, Herba Leonuri, Herba Epimedii, the Rhizoma Pinelliae, Cortex Cinnamomi, Radix Ginseng Rubra, Rhizoma Atractylodis, Radix Saposhnikoviae, Caulis Sargentodoxae, Radix Paeoniae Rubra, the Radix Astragali, Semen Persicae.
Wherein, Radix Angelicae Sinensis 10-30 weight portion, Poria 15-30 weight portion, Herba Leonuri 10-20 weight portion, Herba Epimedii 10-25 weight portion, Rhizoma Pinelliae 15-25 weight portion, Cortex Cinnamomi 10-20 weight portion, Radix Ginseng Rubra 5-15 weight portion, Rhizoma Atractylodis 10-20 weight portion, Radix Saposhnikoviae 15-25 weight portion, Caulis Sargentodoxae 10-20 weight portion, Radix Paeoniae Rubra 10-20 weight portion, Radix Astragali 15-30 weight portion, Semen Persicae 15-30 weight portion.
Preferably, Radix Angelicae Sinensis 20-30 weight portion, Poria 22-30 weight portion, Herba Leonuri 16-20 weight portion, Herba Epimedii 18-25 weight portion, Rhizoma Pinelliae 21-25 weight portion, Cortex Cinnamomi 14-20 weight portion, Radix Ginseng Rubra 9-15 weight portion, Rhizoma Atractylodis 14-20 weight portion, Radix Saposhnikoviae 19-25 weight portion, Caulis Sargentodoxae 13-20 weight portion, Radix Paeoniae Rubra 16-20 weight portion, Radix Astragali 21-30 weight portion, Semen Persicae 22-30 weight portion.
Further preferably, Radix Angelicae Sinensis 20 weight portions, Poria 22 weight portions, Herba Leonuri 16 weight portions, Herba Epimedii 18 weight portions, the Rhizoma Pinelliae 21 weight portions, Cortex Cinnamomi 14 weight portions, Radix Ginseng Rubra 9 weight portions, Rhizoma Atractylodis 14 weight portions, Radix Saposhnikoviae 19 weight portions, Caulis Sargentodoxae 13 weight portions, Radix Paeoniae Rubra 16 weight portions, the Radix Astragali 21 weight portions, Semen Persicae 22 weight portions.
The present invention also provides a kind of preparation method for the treatment of colpitic Chinese medicine composition, and preparation process is:
A. each component in described raw material components is mixed in proportion, puts into 10 times of water gagings, heating and refluxing extraction 2 times, each 45 minutes～1.5 hours, extract active ingredient, 2 extracting solution are merged standing;
B. the medicinal residues of crossing through water extraction in step a are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 30 minutes～45 minutes, merges standing by 2 extracting solution again;
C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is ℃-70 ℃, puts into oven for drying by extractum and make powder, sieves, and every 100g powder adds refined honey 90～110g, makes big honeyed pills, obtains.
The present invention also provides the application of above-mentioned raw materials component in the colpitic Chinese medicine composition of preparation treatment.
The present invention develops Chinese medicine composition meticulously according to traditional Chinese medical science prescription and preparation principle, the advantage such as provide a kind of pointed strong, good effect, the cycle is short, price is low, have no side effect, can make again patient take like a shot, can treat preferably colpitic pure Chinese medicinal preparation.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1:
Get Radix Angelicae Sinensis 10g, Poria 15g, Herba Leonuri 10g, Herba Epimedii 10g, Rhizoma Pinelliae 15g, Cortex Cinnamomi 10g, Radix Ginseng Rubra 5g, Rhizoma Atractylodis 10g, Radix Saposhnikoviae 15g, Caulis Sargentodoxae 10g, Radix Paeoniae Rubra 10g, Radix Astragali 15g, Semen Persicae 15g, after chopping, put into 10 times of water gagings, heating and refluxing extraction 2 times, each 45 minutes, extract active ingredient, 2 extracting solution are merged standing; The medicinal residues of crossing with water extraction are put into 10 times of amount ethanol, and heating and refluxing extraction 2 times, each 30 minutes, merges standing by 2 extracting solution; Above-mentioned two kinds of extracting solution are merged, and decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03MPa, temperature remains on 60 ℃, and being concentrated into relative density is 1.20, and the extractum of temperature to 60 ℃, puts into oven for drying by extractum and make powder, sieves, and every 100g powder adds refined honey 90g, makes big honeyed pills, obtains.
Embodiment 2:
Get Radix Angelicae Sinensis 30g, Poria 30g, Herba Leonuri 20g, Herba Epimedii 25g, Rhizoma Pinelliae 25g, Cortex Cinnamomi 20g, Radix Ginseng Rubra 15g, Rhizoma Atractylodis 20g, Radix Saposhnikoviae 25g, Caulis Sargentodoxae 20g, Radix Paeoniae Rubra 20g, Radix Astragali 30g, Semen Persicae 30g, after chopping, put into 10 times of water gagings, heating and refluxing extraction 2 times, each 1.5 hours, extract active ingredient, 2 extracting solution are merged standing; The medicinal residues of crossing with water extraction are put into 10 times of amount ethanol, and heating and refluxing extraction 2 times, each 45 minutes, merges standing by 2 extracting solution; Above-mentioned two kinds of extracting solution are merged, and decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.08MPa, temperature remains on 80 ℃, and being concentrated into relative density is 1.20, and the extractum of temperature to 70 ℃, puts into oven for drying by extractum and make powder, sieves, and every 100g powder adds refined honey 110g, makes big honeyed pills, obtains.
Embodiment 3:
Get Radix Angelicae Sinensis 20g, Poria 22g, Herba Leonuri 16g, Herba Epimedii 18g, Rhizoma Pinelliae 21g, Cortex Cinnamomi 14g, Radix Ginseng Rubra 9g, Rhizoma Atractylodis 14g, Radix Saposhnikoviae 19g, Caulis Sargentodoxae 13g, Radix Paeoniae Rubra 16g, Radix Astragali 21g, Semen Persicae 22g, after chopping, put into 10 times of water gagings, heating and refluxing extraction 2 times, each 1 hour, extract active ingredient, 2 extracting solution are merged standing; The medicinal residues of crossing with water extraction are put into 10 times of amount ethanol, and heating and refluxing extraction 2 times, each 40 minutes, merges standing by 2 extracting solution; Above-mentioned two kinds of extracting solution are merged, and decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.06MPa, temperature remains on 70 ℃, and being concentrated into relative density is 1.20, and the extractum of temperature to 65 ℃, puts into oven for drying by extractum and make powder, sieves, and every 100g powder adds refined honey 100g, makes big honeyed pills, obtains.
Embodiment 4:
In clinical experiment, selected 240 examples are diagnosed as colpitic patient, and between age 21-45 year, the mean age is 34.7 years old, and the course of disease is the shortest is half a year, and the longest is 5 years, average out to 1.57, random packet, test group 120 examples, matched group 120 examples.
Therapeutic Method: Chinese medicine composition prepared by the oral embodiment of the present invention 1-3 of test group, every day 2-3 time, each 22 weeks is 1 course for the treatment of.The oral fluconazol of matched group, every day 2-3 time, each 1-2 grain, 2 weeks is 1 course for the treatment of.
Diagnostic criteria: with reference to clinical criteria, and with symptom be divided into gently, in, severe.
Therapeutic outcome:
In the routine patient of test group 120, after 2 courses for the treatment of, cure 98 examples, cure rate accounts for 81.7%, 20 examples that take a turn for the better, and obvious effective rate accounts for 16.7%, and total effective rate is 98.3%, invalid 2 examples, inefficiency accounts for 1.7%.
In the routine patient of matched group 120, after 2 courses for the treatment of, cure 67 examples, cure rate accounts for 55.8%, 15 examples that take a turn for the better, and obvious effective rate accounts for 12.5%, and total effective rate is 68.3%, invalid 38 examples, inefficiency accounts for 31.7%.
Curative effect comparison: treatment group total effective rate and cure rate, apparently higher than matched group, are learned and processed by statistics, and difference all has very significant (P < 0.01).
Conclusion: traditional Chinese medicine composition for treating vaginitis of the present invention, at anti-inflammation simultaneously, regulate intravaginal environment, improve vaginal mucosa resistance, evident in efficacy.In addition, visible in clinical observation, Chinese medicine composition itching-relieving action of the present invention is especially obvious, and after patient is reflected medication, antipruritic effect is fast, and it is comfortable that part is felt.Chinese medicine composition of the present invention is not found toxic and side effects in using, and is prevent and treat colpitic good medicine, is worthy of popularization.
The above, be only preferred embodiment of the present invention, is not the present invention to be done to the restriction of other form, and any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the equivalent embodiment of equivalent variations.But every technical solution of the present invention content that do not depart from, any simple modification, equivalent variations and the remodeling above embodiment done according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.
Claims (6)
1. the colpitic Chinese medicine composition for the treatment of, is characterized in that being prepared from by following raw material components: Radix Angelicae Sinensis, Poria, Herba Leonuri, Herba Epimedii, the Rhizoma Pinelliae, Cortex Cinnamomi, Radix Ginseng Rubra, Rhizoma Atractylodis, Radix Saposhnikoviae, Caulis Sargentodoxae, Radix Paeoniae Rubra, the Radix Astragali, Semen Persicae.
2. according to the Chinese medicine composition of claim 1, wherein, Radix Angelicae Sinensis 10-30 weight portion, Poria 15-30 weight portion, Herba Leonuri 10-20 weight portion, Herba Epimedii 10-25 weight portion, Rhizoma Pinelliae 15-25 weight portion, Cortex Cinnamomi 10-20 weight portion, Radix Ginseng Rubra 5-15 weight portion, Rhizoma Atractylodis 10-20 weight portion, Radix Saposhnikoviae 15-25 weight portion, Caulis Sargentodoxae 10-20 weight portion, Radix Paeoniae Rubra 10-20 weight portion, Radix Astragali 15-30 weight portion, Semen Persicae 15-30 weight portion.
3. according to the Chinese medicine composition of claim 2, wherein, Radix Angelicae Sinensis 20-30 weight portion, Poria 22-30 weight portion, Herba Leonuri 16-20 weight portion, Herba Epimedii 18-25 weight portion, Rhizoma Pinelliae 21-25 weight portion, Cortex Cinnamomi 14-20 weight portion, Radix Ginseng Rubra 9-15 weight portion, Rhizoma Atractylodis 14-20 weight portion, Radix Saposhnikoviae 19-25 weight portion, Caulis Sargentodoxae 13-20 weight portion, Radix Paeoniae Rubra 16-20 weight portion, Radix Astragali 21-30 weight portion, Semen Persicae 22-30 weight portion.
4. according to the Chinese medicine composition of claim 1-3, wherein, Radix Angelicae Sinensis 20 weight portions, Poria 22 weight portions, Herba Leonuri 16 weight portions, Herba Epimedii 18 weight portions, the Rhizoma Pinelliae 21 weight portions, Cortex Cinnamomi 14 weight portions, Radix Ginseng Rubra 9 weight portions, Rhizoma Atractylodis 14 weight portions, Radix Saposhnikoviae 19 weight portions, Caulis Sargentodoxae 13 weight portions, Radix Paeoniae Rubra 16 weight portions, the Radix Astragali 21 weight portions, Semen Persicae 22 weight portions.
5. the preparation method of the Chinese medicine composition of any one in claim 1-4, is characterized in that, preparation process is:
A. each component in described raw material components is mixed in proportion, puts into 10 times of water gagings, heating and refluxing extraction 2 times, each 45 minutes～1.5 hours, extract active ingredient, 2 extracting solution are merged standing;
B. the medicinal residues of crossing through water extraction in step a are put into 10 times of amount ethanol, heating and refluxing extraction 2 times, each 30 minutes～45 minutes, merges standing by 2 extracting solution again;
C. above-mentioned two kinds of extracting solution are merged, decompression recycling ethanol to be concentrated into liquor strength be 0.6g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 ℃ 1.08; Be decompressed to 0.03-0.08MPa, temperature remains on 60-80 ℃, and being concentrated into relative density is 1.20, and the extractum that temperature to 60 is ℃-70 ℃, puts into oven for drying by extractum and make powder, sieves, and every 100g powder adds refined honey 90～110g, makes big honeyed pills, obtains.
6. the application of the raw material components of any one in the colpitic Chinese medicine composition of preparation treatment in claim 1-4.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189392A (en) * | 2014-09-05 | 2014-12-10 | 杜柏荣 | Traditional Chinese medicinal composition for treating skin itch and preparation method thereof |
| CN106806747A (en) * | 2017-01-10 | 2017-06-09 | 柳州市妇幼保健院 | A kind of Chinese medicine composition for treating vaginitis |
-
2014
- 2014-05-10 CN CN201410208508.0A patent/CN104000973A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 陈茹琴等: "当归芍药散加减治疗复发性念珠菌性阴道病观察", 《中医药临床杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104189392A (en) * | 2014-09-05 | 2014-12-10 | 杜柏荣 | Traditional Chinese medicinal composition for treating skin itch and preparation method thereof |
| CN106806747A (en) * | 2017-01-10 | 2017-06-09 | 柳州市妇幼保健院 | A kind of Chinese medicine composition for treating vaginitis |
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Application publication date: 20140827 |