CN104000600A - Percutaneous biological optical detecting device and percutaneous jaundice detector - Google Patents
Percutaneous biological optical detecting device and percutaneous jaundice detector Download PDFInfo
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- CN104000600A CN104000600A CN201410268575.1A CN201410268575A CN104000600A CN 104000600 A CN104000600 A CN 104000600A CN 201410268575 A CN201410268575 A CN 201410268575A CN 104000600 A CN104000600 A CN 104000600A
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Abstract
The invention relates to a percutaneous biological optical detecting device which comprises an LED light source, a light-emitting lens, a light guide lens, a spectroscope, a first optical filter, a first photoelectric sensor, a second optical filter and a second photoelectric sensor. The emitting light of the LED light source is emitted to the skin to be detected through the light-emitting lens, reflected light of the skin to be detected is transmitted to the spectroscope through the light guide lens and is divided into two beams by the spectroscope, wherein one beam transmits through the first optical filter to be received by the first photoelectric sensor, and the other beam transmits through the second optical filter to be received by the second photoelectric sensor. Compared with a stroboscopic xenon lamp, the LED light source used by the percutaneous biological optical detecting device has high stability, does not need to be driven by a high voltage device, avoids influence of low frequency electromagnetic radiation, and can improve the detection precision. Meanwhile, because the complex driving device is not needed, the whole device is small in size, low in energy consumption and high in safety factor. Besides, the invention further relates to a percutaneous jaundice detector provided with the percutaneous biological optical detecting device.
Description
Technical field
The present invention relates to medical Instrument field, the Percutaneous Jaundice Instrumentation that especially relates to a kind of percutaneous Photobiology checkout gear and contain this checkout gear.
Background technology
Traditional percutaneous optical detecting instrument, as Percutaneous Jaundice Instrumentation, light source mainly uses xenon flashtube.Fig. 4 is a kind of curve of spectrum analysis of xenon source, and as can be seen from Figure 4 the spectrum of this xenon lamp has wider spectral region, covers the scope of light wave from 100 to more than 1900nm.The wide spectral range of xenon source makes it have good development properties, but determine that also it has the deficiency of high power consumption, therefore in mobile instrument, application has a lot of problems, no matter all can have inconvenience in design neutralization is used, for example, in interference design high voltage appearance and low-frequency electromagnetic wave immediate current generation, in the time of Design enlargement circuit, be difficult to filtering, because electromagnetic radiation intensity causes that the precision of instrument cannot ensure too by force.In addition,, because xenon flashtube needs high voltage drive, in operation and maintenance process, the larger use inconvenience of volume and potential safety hazard are high.
Summary of the invention
Based on this, be necessary to provide that a kind of certainty of measurement is higher, instrument small volume and safer percutaneous Photobiology checkout gear and the Percutaneous Jaundice Instrumentation that contains this checkout gear.
A kind of percutaneous Photobiology checkout gear, comprises LED light source, goes out light microscopic, leaded light mirror, spectroscope, the first optical filter, the first photoelectric sensor, the second optical filter and the second photoelectric sensor; The colour temperature of described LED light source is 3700K～5000K; Described spectroscope coordinates with described the first optical filter for seeing through the blue light that wavelength is 460nm; Described the first photoelectric sensor is for gathering the transillumination of described the first optical filter and converting corresponding first signal of telecommunication to; Described spectroscope coordinates with described the second optical filter for seeing through the green glow that wavelength is 550nm; Described the second photoelectric sensor is for gathering the transillumination of described the second optical filter and converting corresponding second signal of telecommunication to;
The utilizing emitted light of described LED light source via described go out light microscopic be irradiated on skin to be measured, reflected light by described skin reflex to be measured conducts to described spectroscope via described leaded light mirror, and be divided into two bundles by described spectroscope, wherein a branch ofly see through and received by described the first photoelectric sensor afterwards via described the first optical filter, another bundle sees through and is received by described the second photoelectric sensor afterwards via described the second optical filter.
In an embodiment, the colour temperature of described LED light source is 4300K～4800K therein.
Therein in an embodiment, described in go out light microscopic and described leaded light mirror adopts full gloss spectrum light transmissive material to make, light transmittance is not less than 90%.
In an embodiment, described spectroscope is dichroic mirror therein, the light that can to see through wavelength be 460nm light reflection wavelength is 550nm or can see through light that wavelength be 550nm and light that reflection wavelength is 460nm; And the angle of described spectroscopical minute surface and described leaded light mirror emergent light is 45 °.
In an embodiment, described the first optical filter is 460nm narrow band pass filter therein.
In an embodiment, described the first photoelectric sensor is light cell or gathers the color sensitive sensor that wave band is 350～550nm therein.
In an embodiment, described the second optical filter is 550nm narrow band pass filter therein.
In an embodiment, described the second photoelectric sensor is light cell or gathers the color sensitive sensor that wave band is 450～650nm therein.
Above-mentioned percutaneous Photobiology checkout gear can be widely used in handheld medical detecting instrument, for biological percutaneous is detected to pathology, as be applied in Percutaneous Jaundice Instrumentation, the LED light source of its use is than xenon flashtube, and stability is strong, and do not need to use high pressure equipment to drive, avoid the impact of low frequency electromagnetic wave radiation, can improve accuracy of detection, simultaneously, owing to not needing complicated driving arrangement, whole device volume is little, energy consumption is low, cost is low, safety coefficient is also promoted.
A kind of Percutaneous Jaundice Instrumentation, comprise processor and display, in addition, described Percutaneous Jaundice Instrumentation also comprises the percutaneous Photobiology checkout gear described in above-mentioned arbitrary embodiment, wherein, described the first photoelectric sensor is connected with described processor and sends described first signal of telecommunication to described processor, described the second photoelectric sensor is connected with described processor and sends described second signal of telecommunication to described processor, described processor compares to obtain icteric index by described first signal of telecommunication and described second signal of telecommunication that receive, described display is connected the analysis processing result for showing described processor with described processor.
In an embodiment, described Percutaneous Jaundice Instrumentation also comprises signal amplifier therein, and described the first photoelectric sensor and described the second photoelectric sensor are connected with described processor via described signal amplifier.
There is substantial connection in absorption and the serum mesobilirubin concentration of biological skin undertissue to special wavelength light, can utilize intensity difference between blue light wave (wavelength is 460nm) and the green light wave (wavelength is 550nm) in rayed skin back reflection light to detect and be deposited on bilirubinic concentration in skin histology.The reflected light that the LED light source of above-mentioned Percutaneous Jaundice Instrumentation irradiates after skin is divided into twice light beam by spectroscope, and after the first and second optical filters, obtain respectively blue light and green glow, wherein, green light intensity can reflect that intensity of illumination, the blue light of backlight are mainly used in reflecting jaundice value in person's blood to be measured.After the light intensity that the first and second photoelectric sensors receive converts voltage signal to, exist certain voltage difference, this voltage difference can reflect person's to be measured icteric index, and processor is processed by analysis and obtained this voltage difference, can reflect person's to be measured icteric index.
Brief description of the drawings
Fig. 1 is the structural representation of the percutaneous Photobiology checkout gear of an embodiment;
Fig. 2 is the radiant power schematic diagram of each wave band color temperature characteristic;
Fig. 3 is the relativity schematic diagram of the light intensity magnitude of voltage of the twice light beam that is divided into through spectroscope;
The spectrogram of the xenon flashtube light source that Fig. 4 is traditional.
Detailed description of the invention
For the ease of understanding the present invention, below with reference to relevant drawings, the present invention is described more fully.In accompanying drawing, provide preferred embodiment of the present invention.But the present invention can realize in many different forms, be not limited to embodiment described herein.On the contrary, providing the object of these embodiment is to make to the understanding of disclosure of the present invention more thoroughly comprehensively.
It should be noted that, when element is called as " being fixed on " another element, it can be directly on another element or also can have an element placed in the middle.When an element is considered to " connection " another element, it can be directly connected to another element or may have centering elements simultaneously.
Unless otherwise defined, all technology that use are herein identical with the implication that belongs to the common understanding of those skilled in the art of the present invention with scientific terminology.The term using in description of the present invention herein, just in order to describe the object of specific embodiment, is not intended to be restriction the present invention.Term as used herein " and/or " comprise one or more relevant Listed Items arbitrarily with all combinations.
As shown in Figure 1, the percutaneous Photobiology checkout gear 100 of an embodiment comprise LED light source 110, go out light microscopic 120, leaded light mirror 130, spectroscope 140, the first optical filter 150, the first photoelectric sensor 160, the second optical filter 170 and the second photoelectric sensor 180.This percutaneous Photobiology checkout gear 100 can be applicable in handheld medical detecting instrument, for biological percutaneous is detected to pathology, as is applied in Percutaneous Jaundice Instrumentation.The utilizing emitted light of LED light source 110 is irradiated on skin 200 to be measured via going out light microscopic 120, reflected light by skin reflex to be measured conducts to spectroscope 140 via leaded light mirror 130, and be divided into two bundles by spectroscope 140, wherein a branch ofly see through and received by the first photoelectric sensor 160 afterwards via the first optical filter 150, another bundle sees through and is received by the second photoelectric sensor 180 afterwards via the second optical filter 170.
As shown in Figure 2, the spectral characteristic collection of illustrative plates of LED is divided into two crests, is called large crest and little crest, and the ratio of crest directly has influence on environment and the color rendering properties of application, analyzes as follows:
A) Fig. 2 center line I, colour temperature 5000K～10000K, the little crest of its light wave is the most active between 440nm～475nm, reaches 100% in 460nm radiant power; Large crest is active between 520nm～600nm, but maximum 550nm place radiant power only has 50% peak value.Can analyze thus large crest and little crest and differ 50% left and right time, add the loss of light emission and reflection, the light intensity that photoelectric sensor receives is very weak, may cause photoelectric sensor to work, because two crest radiation differ too much, the calibration of photoelectric sensor is also had to direct impact, the LED of this section of colour temperature is not suitable for use in LED light source 110 as seen.
B) Fig. 2 center line II, colour temperature 3700K～5000K, the little crest of its light wave is the most active between 430nm～465nm, reaches 100% in 440nm radiant power; Active between large crest 510nm～660nm, maximum 580nm, radiant power peak value 89%.From then on the light wave radiant power that curve can be found out small echo 460nm is in 80% left and right, the light wave radiant power at large crest 550nm place is also in 80% left and right, both radiant powers are all on same line, also just show that the radiant power of two wavelength without interference in the situation that is substantially equal, the light wave radiant power of this wave band is on the same line, even if add interference effect, its dimension is also ideal.
C) Fig. 2 center line III, colour temperature 2600K～3700K, the little crest of its light wave is the most active between 440nm～465nm, reaches 62% left and right in 460nm radiant power; Active between large crest 520nm～675nm, maximum 600nm radiant power peak value 100%, the light wave radiant power at large crest 550nm place is 70%.The radiant power that is less than large crest by the radiant power of the little crest of Fig. 3 data show, both differ 8%, show that the light wave linearity of this wave band is slightly poor.
Therefore, the colour temperature of the LED light source 110 of present embodiment is selected 3700K～5000K, and preferably, between 4300K-4800K, if colour temperature deviation is too large, the linearity of photoelectric sensor will be affected.
Incorporated by reference to Fig. 2 and Fig. 4, the spectral region of the LED light source 110 of present embodiment is between 400nm～760nm, and the spectral region of traditional xenon source is from 100 to more than 1900nm.Xenon source is compared with LED light source 110 in present embodiment, and xenon source is much larger than the spectral radiant power of LED light source 110.Spectrum is to wait lattice with one of 100 rising as can be seen from Figure 4, thereby xenon lamp spectrum occupies the lattice such as 19-1=18, and LED light source 110 occupies 8-4=4 lattice such as grade from 400nm～800nm, by 18/4=4.5, calculate thus 4.5 times of radiant powers that traditional xenon source is equivalent to LED light source 110, and the light wave of other spectral bands of xenon source is all considered as useless wave band in illumination or in the time that percutaneous detects application, also traditional xenon source of comparing, it is little that the LED light source 110 of present embodiment has radiation, volume is little, and precision is high, good stability, low power consumption and other advantages.
Go out light microscopic 120 and leaded light mirror 130 and adopt full gloss spectrum light transmissive material to make, light transmittance is not less than 90%, as adopted full gloss spectrum quartz glass or the making of full gloss spectrum printing opacity lucite etc.Go out light microscopic 120 LED light source 110 is encapsulated in wherein, with the stability that ensures that LED light source 110 is luminous.Leaded light mirror 130 is cylindricality mirror, and as square-column-shaped, cylindrical etc., its homogeneity is good, does not contain the impurity such as bubble.The LED light source 110 of present embodiment arranges around leaded light mirror 130, and leaded light mirror 130 passes from the middle part of LED light source 110, for the reflected light of skin 200 to be measured is conducted to spectroscope 140.
Spectroscope 140 is dichroic mirror, the light that can to see through wavelength be 460nm light reflection wavelength is 550nm or can see through light that wavelength be 550nm and light that reflection wavelength is 460nm.The angle of the minute surface of spectroscope 140 and leaded light mirror 130 emergent lights is 45 °, thereby after spectroscope 140, can be divided into through the reflected light of skin to be measured the green glow that blue light that wavelength is 460nm and wavelength are 550nm.
The first optical filter 150 coordinates with spectroscope 140 for seeing through the blue light that wavelength is 460nm.In the present embodiment, the first optical filter 150 is 460nm narrow band pass filter, screens the blue light obtaining and further screens through the first optical filter 150, to improve the accuracy of testing result through spectroscope 140.
The first photoelectric sensor 160 is for gathering the transillumination of the first optical filter 150 and converting corresponding first signal of telecommunication to, as voltage signal etc.In the present embodiment, the first photoelectric sensor 170 is for gathering the color sensitive sensor (as light sensitive diode or photoconductive resistance etc.) of wave band between 350～550nm.
The second optical filter 170 coordinates with spectroscope 140 for seeing through the green glow that wavelength is 550nm.In the present embodiment, the second optical filter 170 is 550nm narrow band pass filter, screens the green glow obtaining and further screens through the second optical filter 170, to improve the accuracy of testing result through spectroscope 140.
The second photoelectric sensor 180 is for gathering the transillumination of the second optical filter 170 and converting corresponding second signal of telecommunication to, as voltage signal etc.In the present embodiment, the second photoelectric sensor 180 is for gathering the color sensitive sensor (as light sensitive diode or photoconductive resistance etc.) of wave band between 350～550nm.
The light that the spectroscope 140 of present embodiment can the see through wavelength light that be 460nm reflection wavelength is 550nm or can see through light that wavelength be 550nm and light that reflection wavelength is 460nm, and the green glow that the blue light that the first optical filter 150 and the second optical filter 170 are 460nm through wavelength respectively and wavelength are 550nm, but can understand, in other embodiments, be not limited to design above, as long as satisfied the first optical filter 150 coordinates with spectroscope 140 for seeing through blue light and the second optical filter 170 that wavelength is 460nm and coordinates with spectroscope 140 for seeing through the green glow that wavelength is 550nm.
The first photoelectric sensor 160 and the second photoelectric sensor 180 all adopt color sensitive sensor, and precision is high, operating circuit simplicity of design, volume are little, use the small-sized movable hand-held instrument of present embodiment.Can understand, in other embodiments, the first photoelectric sensor 160 and the second photoelectric sensor 180 can also adopt the elements such as light cell to make.Light cell spectral response range is between 300～1100nm, and peak wavelength is 800～900nm, and short circuit current is relevant with the volume area of sensor, and the larger short circuit current of area is also just larger, and response time is from 0.5 μ s～30 μ s.When making photoelectric sensor, application light cell should note the needed reaction response time of instrument, in detecting instrument, conventionally strengthen photronic area for adding fast attack time, be designed to current mode (I/V electric current turns potential circuit) amplifying circuit and meet the requirement of testing circuit.
This percutaneous Photobiology checkout gear 100 can be widely used in handheld medical detecting instrument, for biological percutaneous is detected to pathology, as be applied in Percutaneous Jaundice Instrumentation, the LED light source 110 of its use is than xenon flashtube, and stability is strong, and do not need to use high pressure equipment to drive, avoid the impact of low frequency electromagnetic wave radiation, can improve accuracy of detection, simultaneously, owing to not needing complicated driving arrangement, whole device volume is little, energy consumption is low, cost is low, safety coefficient is also promoted.
In addition, present embodiment also provides a kind of Percutaneous Jaundice Instrumentation, and it comprises processor, display, signal amplifier and above-mentioned percutaneous Photobiology checkout gear.Wherein, the first photoelectric sensor and the second photoelectric sensor are connected with processor via signal amplifier, the first photoelectric sensor is for sending first signal of telecommunication to processor, the second photoelectric sensor is for sending second signal of telecommunication to processor, processor compares to obtain icteric index by first signal of telecommunication and second signal of telecommunication that receive, and display is connected the analysis processing result for video-stream processor with processor.
There is substantial connection in absorption and the serum mesobilirubin concentration of biological skin undertissue to special wavelength light, can utilize intensity difference between blue light wave (wavelength is 460nm) and the green light wave (wavelength is 550nm) in rayed skin back reflection light to detect and be deposited on bilirubinic concentration in skin histology.The reflected light that the LED light source 110 of above-mentioned Percutaneous Jaundice Instrumentation irradiates after skin 200 to be measured is divided into twice light beam by spectroscope, and after the first and second optical filters, obtains blue light and green glow respectively.As shown in Figure 3, after converting voltage signal to, the light intensity that the first photoelectric sensor 160 and the second photoelectric sensor 180 receive exists certain voltage difference, this voltage difference can reflect person's to be measured icteric index, processor is processed by analysis and is obtained this voltage difference, can reflect person's to be measured icteric index.
The above embodiment has only expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but can not therefore be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. a percutaneous Photobiology checkout gear, is characterized in that, comprises LED light source, goes out light microscopic, leaded light mirror, spectroscope, the first optical filter, the first photoelectric sensor, the second optical filter and the second photoelectric sensor; The colour temperature of described LED light source is 3700K～5000K; Described spectroscope coordinates with described the first optical filter for seeing through the blue light that wavelength is 460nm; Described the first photoelectric sensor is for gathering the transillumination of described the first optical filter and converting corresponding first signal of telecommunication to; Described spectroscope coordinates with described the second optical filter for seeing through the green glow that wavelength is 550nm; Described the second photoelectric sensor is for gathering the transillumination of described the second optical filter and converting corresponding second signal of telecommunication to;
The utilizing emitted light of described LED light source via described go out light microscopic be irradiated on skin to be measured, reflected light by described skin reflex to be measured conducts to described spectroscope via described leaded light mirror, and be divided into two bundles by described spectroscope, wherein a branch ofly see through and received by described the first photoelectric sensor afterwards via described the first optical filter, another bundle sees through and is received by described the second photoelectric sensor afterwards via described the second optical filter.
2. percutaneous Photobiology checkout gear as claimed in claim 1, is characterized in that, the colour temperature of described LED light source is 4300K～4800K.
3. percutaneous Photobiology checkout gear as claimed in claim 1, is characterized in that, described in go out light microscopic and described leaded light mirror and adopt full gloss spectrum light transmissive material to make, light transmittance is not less than 90%.
4. percutaneous Photobiology checkout gear as claimed in claim 1, it is characterized in that, described spectroscope is dichroic mirror, the light that can to see through wavelength be 460nm light reflection wavelength is 550nm or can see through light that wavelength be 550nm and light that reflection wavelength is 460nm; And the angle of described spectroscopical minute surface and described leaded light mirror emergent light is 45 °.
5. the percutaneous Photobiology checkout gear as described in claim 1 or 4, is characterized in that, described the first optical filter is 460nm narrow band pass filter.
6. percutaneous Photobiology checkout gear as claimed in claim 5, is characterized in that, described the first photoelectric sensor is light cell or gathers the color sensitive sensor that wave band is 350～550nm.
7. the percutaneous Photobiology checkout gear as described in claim 1 or 4, is characterized in that, described the second optical filter is 550nm narrow band pass filter.
8. percutaneous Photobiology checkout gear as claimed in claim 7, is characterized in that, described the second photoelectric sensor is light cell or gathers the color sensitive sensor that wave band is 450～650nm.
9. a Percutaneous Jaundice Instrumentation, comprise processor and display, it is characterized in that, also comprise the percutaneous Photobiology checkout gear described in any one in claim 1～8, described the first photoelectric sensor is connected with described processor and sends described first signal of telecommunication to described processor, described the second photoelectric sensor is connected with described processor and sends described second signal of telecommunication to described processor, described processor compares to obtain icteric index by described first signal of telecommunication and described second signal of telecommunication that receive, described display is connected the analysis processing result for showing described processor with described processor.
10. Percutaneous Jaundice Instrumentation as claimed in claim 9, is characterized in that, also comprises signal amplifier, and described the first photoelectric sensor and described the second photoelectric sensor are connected with described processor via described signal amplifier.
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| CN114002193A (en) * | 2021-10-19 | 2022-02-01 | 杭州英诺维科技有限公司 | Percutaneous bilirubin detection method and device |
| CN114305336A (en) * | 2021-12-28 | 2022-04-12 | 深圳市比特原子科技有限公司 | Multi-spectral fusion percutaneous health index rapid detection device and method |
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