CN107961445B - Percutaneous jaundice instrument - Google Patents
Percutaneous jaundice instrument Download PDFInfo
- Publication number
- CN107961445B CN107961445B CN201711380807.2A CN201711380807A CN107961445B CN 107961445 B CN107961445 B CN 107961445B CN 201711380807 A CN201711380807 A CN 201711380807A CN 107961445 B CN107961445 B CN 107961445B
- Authority
- CN
- China
- Prior art keywords
- light source
- light
- led light
- optical fiber
- receiving optical
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 206010023126 Jaundice Diseases 0.000 title claims abstract description 31
- 239000013307 optical fiber Substances 0.000 claims abstract description 42
- 230000000149 penetrating effect Effects 0.000 claims abstract description 4
- 238000013461 design Methods 0.000 abstract description 6
- 208000020564 Eye injury Diseases 0.000 abstract 1
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 description 24
- 230000005540 biological transmission Effects 0.000 description 13
- 210000003491 skin Anatomy 0.000 description 10
- 238000006243 chemical reaction Methods 0.000 description 8
- 239000000835 fiber Substances 0.000 description 6
- 206010033675 panniculitis Diseases 0.000 description 6
- 210000002966 serum Anatomy 0.000 description 6
- 210000004304 subcutaneous tissue Anatomy 0.000 description 6
- 238000005259 measurement Methods 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 210000002615 epidermis Anatomy 0.000 description 3
- 231100000040 eye damage Toxicity 0.000 description 3
- 206010023138 Jaundice neonatal Diseases 0.000 description 2
- 201000006346 Neonatal Jaundice Diseases 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 230000010287 polarization Effects 0.000 description 2
- 230000008092 positive effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 208000014644 Brain disease Diseases 0.000 description 1
- 238000008789 Direct Bilirubin Methods 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 208000027119 bilirubin metabolic disease Diseases 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 208000036796 hyperbilirubinemia Diseases 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 208000006663 kernicterus Diseases 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 210000003786 sclera Anatomy 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N5/0613—Apparatus adapted for a specific treatment
- A61N5/0621—Hyperbilirubinemia, jaundice treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N5/00—Radiation therapy
- A61N5/06—Radiation therapy using light
- A61N2005/0658—Radiation therapy using light characterised by the wavelength of light used
- A61N2005/0662—Visible light
- A61N2005/0663—Coloured light
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
Abstract
The invention provides a percutaneous jaundice instrument, which comprises: a light source device and a light source driving circuit. The light source device comprises a device body, a light source plate arranged in the device body, a blue light LED light source and a green light LED light source arranged on the light source plate, and a receiving optical fiber penetrating through the light source plate; one end of the device body is a perspective window for emitting light outwards and receiving external reflected light; the luminous surfaces of the blue light LED light source and the green light LED light source face the perspective window, and the incident end of the receiving optical fiber abuts against the perspective window. The light source driving circuit is a constant current driving circuit and drives the blue light LED light source and the green light LED light source on the light source plate to emit light. According to the invention, the blue light LED light source, the green light LED light source and the receiving optical fiber are integrated in the light source device, and the light emitting surfaces of the blue light LED light source and the green light LED light source directly face the perspective window to emit light outwards, so that the incident optical fiber is omitted, the design difficulty and the percutaneous jaundice instrument cost are reduced, and the eye injury caused by direct irradiation can be effectively avoided.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a percutaneous jaundice instrument.
Background
Bilirubin accumulates in blood tissues and interstitial fluid, causing yellow staining of the skin, mucous membranes, sclera and certain body fluids, clinically known as jaundice. Hyperbilirubinemia of neonates is a common disease in neonates, and severe nuclear jaundice can be caused, which can cause bilirubin brain disorder, so that dynamic observation is clinically needed for neonatal jaundice so as to discover and treat the neonatal jaundice in time. The traditional serum detection can accurately detect the total bilirubin and the direct bilirubin level in serum, but needs to collect blood, brings a certain pain to the infant, is inconvenient to repeatedly detect, has the advantages of rapidness and noninvasive property, is convenient for dynamic observation, and has wide application.
At present, percutaneous jaundice instrument utilizes the linear relation between percutaneous bilirubin and total serum bilirubin, and estimates the concentration of total serum bilirubin by measuring the concentration of percutaneous bilirubin. The light source irradiates the skin through the outer core of the optical fiber in the probe, one part of the light is reflected by the skin, the other part of the light enters subcutaneous tissue and is reflected, the light reflected by the two parts of the light is transmitted to the spectroscope at the inner side of the equipment through the inner wall of the optical fiber, the spectroscope divides the light into two light beams according to a proportion into 90-degree angles, and each light beam irradiates the light receiving end of the silicon diode after passing through filters (460 nm blue light and 550nm green light) with different wavelengths, and the light receiving end is subjected to photoelectric conversion, signal amplification, A/D conversion, data processing and analysis to obtain the serum bilirubin concentration value.
The existing percutaneous jaundice instrument mostly adopts an optical fiber structure and comprises an incident optical fiber and a receiving optical fiber, wherein the incident optical fiber and the receiving optical fiber comprise one path, two paths or more paths, so that the difficulty is increased for the optical fiber design, and the cost is also increased.
Disclosure of Invention
The invention provides a percutaneous jaundice instrument which aims to solve the problems in the prior art.
In order to solve the technical problems, the invention adopts the following technical scheme:
the invention provides a percutaneous jaundice instrument, comprising: a light source device and a light source driving circuit; the light source device comprises a device body, a light source plate arranged in the device body, a blue light LED light source and a green light LED light source arranged on the light source plate, and a receiving optical fiber penetrating through the light source plate; one end of the device body is a perspective window for emitting light outwards and receiving external reflected light; the luminous surfaces of the blue light LED light source and the green light LED light source face the perspective window, and the incident end of the receiving optical fiber abuts against the perspective window; the light source driving circuit is a constant current driving circuit and drives the blue light LED light source and the green light LED light source on the light source plate to emit light.
Preferably, the blue LED light sources and the green LED light sources are alternately distributed in a ring shape around the receiving optical fiber.
Preferably, the light source plate is a circular plate, and the receiving optical fibers are arranged concentrically with the light source plate.
Preferably, the blue LED light source is a light source with a half-width of 10nm centered at a wavelength of 460nm, and the green LED light source is a light source with a half-width of 10nm centered at a wavelength of 550 nm.
Preferably, the receiving optical fiber includes a sealed housing and an optical fiber provided inside the sealed housing.
Preferably, the inner wall of the sealed housing is coated with a black layer.
Preferably, the percutaneous jaundice instrument further comprises a lens; the lens comprises a cylindrical main body with two open ends, and a polarizer and an analyzer which are arranged at one end of the cylindrical main body; the cylindrical main body is connected with the device body of the light source device, the polarizer covers and is attached to the perspective window, the analyzer is opposite to the receiving optical fiber, and the analyzer covers and is attached to the incident end face of the receiving optical fiber.
Preferably, an included angle between the vibration transmission direction of the polarizer and the vibration transmission direction of the analyzer is 90 degrees.
Preferably, the aperture of the lens is gradually reduced in a direction away from the light source device; the inner wall of the lens is coated with a black layer.
Preferably, the lens is detachably connected to the light source device.
According to the technical scheme, the invention has the advantages and positive effects that: according to the invention, the blue light LED light source, the green light LED light source and the receiving optical fiber are integrated in the light source device, and the light emitting surfaces of the blue light LED light source and the green light LED light source directly face the perspective window to emit light outwards, so that the incident optical fiber is omitted, the design difficulty and the percutaneous jaundice instrument cost are reduced, discomfort of eyes caused by intense light in flash moment can be effectively avoided, and eye damage caused by direct irradiation is avoided. And constant current driving is adopted, so that the stability and consistency of the brightness of the light source are ensured, and the measurement error caused by the fluctuation of the light source is avoided.
Drawings
FIG. 1 is a schematic diagram of a preferred embodiment of a percutaneous jaundice apparatus of the present invention;
FIG. 2 is a schematic view of a light source device of a percutaneous jaundice apparatus according to a preferred embodiment of the present invention;
FIG. 3 is a schematic diagram of a preferred embodiment of a polarizer and analyzer of the percutaneous jaundice instrument of the present invention;
fig. 4 is a schematic diagram of the operation of a preferred embodiment of the percutaneous jaundice apparatus of the present invention.
Wherein reference numerals are as follows: 1. percutaneous jaundice instrument; 11. a light source device; 111. a device body; 112. a light source board; 113. a blue LED light source; 114. a green light LED light source; 115. receiving an optical fiber; 12. a light source driving circuit; 13. a lens; 131. a cylindrical main body; 132. a polarizer; 133. an analyzer; 14. a beam splitter; 15. a filter lens; 16. a photoelectric conversion circuit; 171. a/D conversion; 172. an MCU; 18. and a display screen.
Detailed Description
Exemplary embodiments that embody features and advantages of the present invention will be described in detail in the following description. It will be understood that the invention is capable of various modifications in various embodiments, all without departing from the scope of the invention, and that the description and illustrations herein are intended to be by way of illustration only and not to be construed as limiting the invention.
For the purpose of further illustrating the principles and structure of the present invention, preferred embodiments of the invention will now be described in detail with reference to the accompanying drawings.
Referring to fig. 1 to 3, the present invention provides a percutaneous jaundice apparatus 1, comprising: a light source device 11, a lens 13, and a light source driving circuit 12. The light source device 11 includes a device body 111, a light source board 112 provided in the device body 111, a blue LED light source 113 and a green LED light source 114 provided on the light source board 112, and a receiving fiber 115 penetrating the light source board 112. One end of the device body 111 is a perspective window for transmitting the light emitted by the blue LED light source 113 and the green LED light source 114 and the reflected light of the skin. The light source driving circuit 12 is a constant current driving circuit, and drives the blue LED light source 113 and the green LED light source 114 on the light source board 112 to emit light. According to the invention, the blue light LED light source 113, the green light LED light source 114 and the receiving optical fiber 115 are integrated in the light source device 11, so that the incident optical fiber is omitted, the design difficulty and the cost of the percutaneous jaundice instrument 1 are reduced, discomfort of eyes caused by strong light in the flash moment can be effectively avoided, and eye damage caused by direct irradiation is avoided. And constant current driving is adopted, so that the stability and consistency of the brightness of the light source are ensured, and the measurement error caused by the fluctuation of the light source is avoided.
Preferably, the blue LED light sources 113 and the green LED light sources 114 are alternately distributed in a ring shape around the receiving optical fiber 115. Specifically, in the present embodiment, the light source plate 112 is a circular plate, and the blue LED light sources 113 and the green LED light sources 114 are four pairs, alternately distributed in a ring shape. In other embodiments, the light source board 112 may be square, hexagonal or irregular, and may be set according to practical needs. The number of the blue LED light sources 113 and the green LED light sources 114 may be two pairs, three pairs or other numbers, and may be set according to actual needs.
The blue LED light source 113 is a light source having a half-width of 10nm centered at a wavelength of 460nm, and the green LED light source 114 is a light source having a half-width of 10nm centered at a wavelength of 550 nm. By adopting the design, the interference of other wavelength light sources can be avoided, the accuracy of the instrument is improved, and the damage of ultraviolet rays to the skin can be avoided. And the blue light LED light source 113 and the green light LED light source 114 have low working voltage, low power consumption, stable performance, long service life and small volume.
The receiving optical fiber 115 includes a hermetic case and an optical fiber provided inside the hermetic case. To eliminate interference of external light with the receiving fiber 115, the inner wall of the hermetic case is coated with a black layer, which absorbs the external light reaching the inner wall of the hermetic case.
The percutaneous jaundice instrument 1 further comprises a lens 13. The lens 13 is detachably connected to the light source device 11. In this embodiment, the percutaneous jaundice instrument 1 is used with the lens 13, and in other embodiments, the lens 13 may not be required to be used alone.
The lens 13 includes a cylindrical body 131 having both ends open, and a polarizer 132 and an analyzer 133 provided at one end of the cylindrical body 131, the polarizer 132 covering and attaching to the see-through window, the analyzer 133 opposing the receiving optical fiber 115 and the analyzer 133 covering and attaching to the end face of the receiving optical fiber 115.
Specifically, in the present embodiment, the polarizer 132 and the analyzer 133 are located on the same plane and concentric. The polarizer 132 allows light having a vibration direction on the same plane as the vibration direction of the polarizer 132 in the incident light to pass therethrough, and the passed light is called polarized light. The analyzer 133 allows polarized light in accordance with the direction of the transmitted vibration of the polarizer 132 to pass therethrough. The light rays pass through the polarizer 132 to form polarized light with a specific angle, after the polarized light irradiates the skin of a human body, part of the polarized light enters the analyzer 133 after being reflected by the epidermis, and part of the polarized light enters the subcutaneous tissue to enter the analyzer 133 after being reflected and refracted. In this embodiment, the vibration transmission direction of the analyzer 133 is designed to be perpendicular to the vibration transmission direction of the polarizer 132, that is, the angle between the vibration transmission direction of the polarizer 132 and the vibration transmission direction of the analyzer 133 is 90 degrees. Therefore, the light reflected by the epidermis cannot pass through the analyzer 133 because the vibration direction is 90 degrees to the polarization transmission direction of the analyzer, and thus cannot enter the receiving fiber 115 to be detected, but the light reflected by the subcutaneous tissue cannot enter the receiving fiber 115 to be detected because the vibration direction is not 90 degrees to the polarization transmission direction of the analyzer, and thus can enter the analyzer 133 to be detected. In other embodiments, the included angle between the vibration transmission direction of the polarizer 132 and the vibration transmission direction of the analyzer 133 may be other angles, which may be set according to practical needs. The polarizer 132 and the analyzer 133 are provided by adopting a polarized light technique, so that reflected light from the surface of the skin is eliminated, the difference between blue light and green light for calculating bilirubin in blood is increased, and the accuracy and precision of a calculation result are improved.
In order to adjust the included angle between the vibration transmission direction of the polarizer 132 and the vibration transmission direction of the analyzer 133 to 90 degrees, one of the polarizer 132 and the analyzer 133 is fixed, and the other is rotatably adjustable about an axis. In this embodiment, the analyzer 133 is fastened to the receiving fiber 115, and the polarizer 132 is rotatably adjusted about the axis. In other embodiments, the polarizer 132 may be fastened to the apparatus body 111, and the analyzer 133 may be rotatably adjusted about an axis and set as needed.
Preferably, the inner wall of the cylindrical body 131 is coated with a black layer in order to prevent light not reflected through the skin from entering the analyzer 133. When the light is reflected to the inner wall of the cylindrical body 131, the black layer absorbs the light, and does not continue to reflect as much as other colors (not black) so that the light passes through the analyzer 133 and enters the receiving fiber 115, resulting in inaccurate detected reflected light and measurement errors.
In order to reduce the interference of external light and thus the inaccuracy of the detection data, the lens 13 tapers away from the light source device 11.
Referring to fig. 4, the percutaneous jaundice apparatus 1 of the present invention operates as follows: the percutaneous jaundice instrument 1 contacts the skin and presses to start the test, the blue LED light source 113 and the green LED light source 114 on the light source device 11 emit light, the light reaches the polarizer 132, and polarized light transmitted through the polarizer 132 reaches the skin. Some polarized light enters the analyzer 133 after being reflected by the epidermis, some polarized light enters the subcutaneous tissue and enters the analyzer 133 after being reflected and refracted, and the analyzer 133 only allows the light reflected by the subcutaneous tissue to enter the receiving optical fiber 115, because the vibration direction of the light reflected by the subcutaneous tissue and the vibration transmission direction of the analyzer do not form 90 degrees, the light can pass through. The light reaching the receiving optical fiber 115 enters the optical filter 15 (460 nm optical filter and 550nm optical filter) according to the ratio of 50:50 through the spectroscope 14, is irradiated to enter the photoelectric conversion circuit 16 to be converted into an electric signal, and then is converted, acquired, processed and analyzed through the A/D conversion 171 and the MCU172 of the data processing system to calculate the percutaneous bilirubin concentration (TCB), the total serum bilirubin concentration (TSB) is estimated based on the percutaneous bilirubin concentration (TCB), and the measured result is displayed on the display screen 18. The percutaneous jaundice instrument 1 can rapidly and accurately detect the bilirubin concentration of the neonate, and reduce the risk of the neonate suffering from the illness.
The specific structure and arrangement of the beam splitter 14, the optical filter 15, the photoelectric conversion circuit 16, the a/D conversion 171, the mcu172, the display 18, and the like are described in the prior art, and will not be described in detail herein.
According to the technical scheme, the invention has the advantages and positive effects that: according to the invention, the blue light LED light source, the green light LED light source and the receiving optical fiber are integrated in the light source device, and the light emitting surfaces of the blue light LED light source and the green light LED light source directly face the perspective window to emit light outwards, so that the incident optical fiber is omitted, the design difficulty and the percutaneous jaundice instrument cost are reduced, discomfort of eyes caused by intense light in flash moment can be effectively avoided, and eye damage caused by direct irradiation is avoided. And constant current driving is adopted, so that the stability and consistency of the brightness of the light source are ensured, and the measurement error caused by the fluctuation of the light source is avoided.
The foregoing is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention, and all equivalent structural changes made by applying the descriptions and the drawings of the present invention are included in the scope of the present invention.
Claims (7)
1. A percutaneous transluminal Huang Dayi comprising:
the light source device comprises a device body, a light source plate arranged in the device body, a blue light LED light source and a green light LED light source arranged on the light source plate, and a receiving optical fiber penetrating through the light source plate; the light source plate is a circular plate, and the receiving optical fibers and the light source plate are concentrically arranged; the blue light LED light sources and the green light LED light sources are alternately distributed in a ring shape around the receiving optical fiber; one end of the device body is a perspective window for emitting light outwards and receiving external reflected light; the luminous surfaces of the blue light LED light source and the green light LED light source face the perspective window, and the incident end of the receiving optical fiber abuts against the perspective window;
the light source driving circuit is a constant current driving circuit and drives the blue light LED light source and the green light LED light source on the light source plate to emit light;
a lens; the lens comprises a cylindrical main body with two open ends, and a polarizer and an analyzer which are arranged at one end of the cylindrical main body; the cylindrical main body is connected with the device body of the light source device, the polarizer covers and is attached to the perspective window, the analyzer is opposite to the receiving optical fiber, and the analyzer covers and is attached to the incident end face of the receiving optical fiber; the polarizer and the analyzer are positioned on the same plane and concentric.
2. The percutaneous jaundice instrument of claim 1, wherein the blue LED light source is a light source having a 10nm peak width centered at a wavelength of 460nm, and the green LED light source is a light source having a 10nm peak width centered at a wavelength of 550 nm.
3. The percutaneous jaundice instrument of claim 1, wherein the receiving optical fiber comprises a sealed housing and an optical fiber disposed inside the sealed housing.
4. The percutaneous jaundice instrument of claim 3, wherein the inner wall of the sealed housing is coated with a black layer.
5. The percutaneous jaundice instrument of claim 1, wherein an included angle between a direction of the transmitted vibration of the polarizer and a direction of the transmitted vibration of the analyzer is 90 degrees.
6. The percutaneous jaundice instrument of claim 1, wherein the lens tapers in a direction away from the light source device; the inner wall of the lens is coated with a black layer.
7. The percutaneous jaundice instrument of claim 1, wherein the lens is removably coupled to the light source device.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711380807.2A CN107961445B (en) | 2017-12-20 | 2017-12-20 | Percutaneous jaundice instrument |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711380807.2A CN107961445B (en) | 2017-12-20 | 2017-12-20 | Percutaneous jaundice instrument |
Publications (2)
Publication Number | Publication Date |
---|---|
CN107961445A CN107961445A (en) | 2018-04-27 |
CN107961445B true CN107961445B (en) | 2024-01-26 |
Family
ID=61995743
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711380807.2A Active CN107961445B (en) | 2017-12-20 | 2017-12-20 | Percutaneous jaundice instrument |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107961445B (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108078544A (en) * | 2017-12-28 | 2018-05-29 | 中国人民解放军成都军区总医院 | Jaundice measurement device of being grown up and its detection method |
CN116671869A (en) * | 2023-06-21 | 2023-09-01 | 四川指南熊医疗科技有限公司 | Jaundice measuring probe and jaundice detection device |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102933137A (en) * | 2010-06-03 | 2013-02-13 | 皇家飞利浦电子股份有限公司 | Apparatus and method for measuring a tissue analyte such as bilirubin using the brewster's angle |
CN103445764A (en) * | 2013-09-04 | 2013-12-18 | 广州医软智能科技有限公司 | Device and method for monitoring microcirculation imaging |
CN104000600A (en) * | 2014-06-16 | 2014-08-27 | 广州白云蓝天电子科技有限公司 | Percutaneous biological optical detecting device and percutaneous jaundice detector |
CN104224125A (en) * | 2014-09-17 | 2014-12-24 | 中国人民解放军空军总医院 | Demoscopy image acquisition device and method |
CN105664372A (en) * | 2016-02-24 | 2016-06-15 | 广州美琳美健医疗科技有限公司 | Blue-light therapeutic instrument for jaundice detection |
CN105943056A (en) * | 2016-05-19 | 2016-09-21 | 苏州阿尔星科电子科技有限公司 | Neonate pertacuneous jaundice tester and client |
CN208464988U (en) * | 2017-12-20 | 2019-02-05 | 深圳乐普智能医疗器械有限公司 | Skin icterus tester |
-
2017
- 2017-12-20 CN CN201711380807.2A patent/CN107961445B/en active Active
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102933137A (en) * | 2010-06-03 | 2013-02-13 | 皇家飞利浦电子股份有限公司 | Apparatus and method for measuring a tissue analyte such as bilirubin using the brewster's angle |
CN103445764A (en) * | 2013-09-04 | 2013-12-18 | 广州医软智能科技有限公司 | Device and method for monitoring microcirculation imaging |
WO2015032251A1 (en) * | 2013-09-04 | 2015-03-12 | 广州医软智能科技有限公司 | Microcirculation imaging monitoring apparatus and method therefor |
CN104000600A (en) * | 2014-06-16 | 2014-08-27 | 广州白云蓝天电子科技有限公司 | Percutaneous biological optical detecting device and percutaneous jaundice detector |
CN104224125A (en) * | 2014-09-17 | 2014-12-24 | 中国人民解放军空军总医院 | Demoscopy image acquisition device and method |
CN105664372A (en) * | 2016-02-24 | 2016-06-15 | 广州美琳美健医疗科技有限公司 | Blue-light therapeutic instrument for jaundice detection |
CN105943056A (en) * | 2016-05-19 | 2016-09-21 | 苏州阿尔星科电子科技有限公司 | Neonate pertacuneous jaundice tester and client |
CN208464988U (en) * | 2017-12-20 | 2019-02-05 | 深圳乐普智能医疗器械有限公司 | Skin icterus tester |
Also Published As
Publication number | Publication date |
---|---|
CN107961445A (en) | 2018-04-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7430445B2 (en) | Noninvasive blood analysis by optical probing of the veins under the tongue | |
AU749033B2 (en) | Apparatus and method for noninvasive glucose measurement | |
US6014204A (en) | Multiple diameter fiber optic device and process of using the same | |
US9265457B2 (en) | Apparatus and method for measuring a tissue analyte such as bilirubin using the Brewster's angle | |
US20120277556A1 (en) | Apparatus for non-invasive blood glucose monitoring | |
CN110476051B (en) | Non-invasive monitoring method for fluorescent tracers with background separation correction | |
US9279763B2 (en) | Apparatus and method for measuring an analyte such as bilirubin, using light | |
CN103747732A (en) | A non-invasive device and method for measuring bilirubin levels | |
CN107961445B (en) | Percutaneous jaundice instrument | |
CN103536275A (en) | Reflection detection measurement device for skin autofluorescence | |
JP2004248820A (en) | Blood analyzer | |
CN207623224U (en) | Bilirubin measuring device | |
CN208464988U (en) | Skin icterus tester | |
US20230148312A1 (en) | Device for non-invasive blood glucose concentration measurement | |
KR102348195B1 (en) | Optical Analyte Monitering System and Method | |
CN216622169U (en) | Skin tissue spectrum detection device based on fluorescence and Raman fusion technology | |
CN105232055A (en) | Noninvasive glucometer | |
CN209899401U (en) | Four-wavelength combined noninvasive glucometer | |
JP2009232876A (en) | Biopsy probe, and biopsy apparatus | |
CN208492063U (en) | Adult jaundice measurement device | |
CN108007910B (en) | Depth-sensitive optical fiber probe for in-situ measurement of fluorescence spectrum and back-scattered light spectrum of skin tissue | |
JP6885231B2 (en) | Detection device and biological information measuring device | |
CN220385041U (en) | Jaundice measuring probe and jaundice detection device | |
Chiarelli et al. | Flexible CW-fNIRS system based on Silicon Photomultipliers: In-Vivo characterization of sensorimotor response | |
CN107966410A (en) | Bilirubin measuring device |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
GR01 | Patent grant | ||
GR01 | Patent grant |