CN108078544A - Jaundice measurement device of being grown up and its detection method - Google Patents
Jaundice measurement device of being grown up and its detection method Download PDFInfo
- Publication number
- CN108078544A CN108078544A CN201711456125.5A CN201711456125A CN108078544A CN 108078544 A CN108078544 A CN 108078544A CN 201711456125 A CN201711456125 A CN 201711456125A CN 108078544 A CN108078544 A CN 108078544A
- Authority
- CN
- China
- Prior art keywords
- light
- keratoscope
- control unit
- jaundice
- light source
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010023126 Jaundice Diseases 0.000 title claims abstract description 30
- 238000001514 detection method Methods 0.000 title claims abstract description 20
- 238000005259 measurement Methods 0.000 title claims abstract description 12
- 238000012360 testing method Methods 0.000 claims abstract description 22
- 239000000523 sample Substances 0.000 claims abstract description 21
- 210000004087 cornea Anatomy 0.000 claims abstract description 11
- BPYKTIZUTYGOLE-IFADSCNNSA-N Bilirubin Chemical compound N1C(=O)C(C)=C(C=C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C=C)C(=O)N\3)C)N2)CCC(O)=O)N1 BPYKTIZUTYGOLE-IFADSCNNSA-N 0.000 claims description 28
- 230000003287 optical effect Effects 0.000 claims description 6
- 238000012545 processing Methods 0.000 claims description 6
- 239000011347 resin Substances 0.000 claims description 4
- 229920005989 resin Polymers 0.000 claims description 4
- 210000003786 sclera Anatomy 0.000 abstract description 8
- 210000003491 skin Anatomy 0.000 description 13
- 210000002966 serum Anatomy 0.000 description 7
- 206010023138 Jaundice neonatal Diseases 0.000 description 3
- 239000003365 glass fiber Substances 0.000 description 3
- 210000004400 mucous membrane Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 208000021130 Bilirubin encephalopathy Diseases 0.000 description 2
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 241001025261 Neoraja caerulea Species 0.000 description 2
- 238000008050 Total Bilirubin Reagent Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 238000005286 illumination Methods 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 208000006663 kernicterus Diseases 0.000 description 2
- 238000009940 knitting Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
- 239000004926 polymethyl methacrylate Substances 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 238000001959 radiotherapy Methods 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
- 241001662043 Icterus Species 0.000 description 1
- 206010058117 Ocular icterus Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000008499 blood brain barrier function Effects 0.000 description 1
- 210000001218 blood-brain barrier Anatomy 0.000 description 1
- 210000004556 brain Anatomy 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 102000034240 fibrous proteins Human genes 0.000 description 1
- 108091005899 fibrous proteins Proteins 0.000 description 1
- 238000009093 first-line therapy Methods 0.000 description 1
- 239000004811 fluoropolymer Substances 0.000 description 1
- 229920002313 fluoropolymer Polymers 0.000 description 1
- 210000001061 forehead Anatomy 0.000 description 1
- 229910002804 graphite Inorganic materials 0.000 description 1
- 239000010439 graphite Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002427 irreversible effect Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- HVHKMUMXERBUAN-IFADSCNNSA-N mesobilirubin IXalpha Chemical compound N1C(=O)C(CC)=C(C)\C1=C\C1=C(C)C(CCC(O)=O)=C(CC2=C(C(C)=C(\C=C/3C(=C(C)C(=O)N\3)CC)N2)CCC(O)=O)N1 HVHKMUMXERBUAN-IFADSCNNSA-N 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000005622 photoelectricity Effects 0.000 description 1
- 229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000001562 sternum Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 229910052724 xenon Inorganic materials 0.000 description 1
- FHNFHKCVQCLJFQ-UHFFFAOYSA-N xenon atom Chemical compound [Xe] FHNFHKCVQCLJFQ-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
Abstract
The invention discloses a kind of adult's jaundice measurement device and its detection methods, including analyzer body, it is arranged on the intrinsic light source of analyzer, test probe, control unit, further include the display being arranged on analyzer body outer surface, light source, test probe, display parallel connection is on the control unit, the keratoscope of contact cornea is provided in one end of the test probe of analyzer body, keratoscope directly detects sclera, make testing result more accurate, make detection light can larger range of detection sclera after keratoscope reflects, make detection more accurate, keratoscope outer surface is provided with light shield layer, light shield layer prevents light leaks from being damaged to testing staff.
Description
Technical field
The present invention relates to jaundice detection technique field, especially a kind of adult's jaundice measurement device and its detection method.
Background technology
Jaundice is common sympton and sign, is to cause bilirubin concentration in serum due to bilirubin metabolism obstacle
Caused by rise.Clinical signs are dyed to yellow for sclera, mucous membrane, skin and its hetero-organization.Because sclera contains more elasticity
Scleroprotein has stronger affinity with bilirubin, thus Patients with Jaundice icteric sclera often prior to mucous membrane, skin and be noticeable first.
When serum total bilirubin is in 17.1~34.2 μm of ol/L, and naked eyes do not see jaundice, claim jaundice occult or subclinical jaundice；When
When serum total bilirubin concentration is more than 34.2 μm of ol/L, jaundice can be clinically found, also referred to as clinical jaundice.
Icterus neonatorum is neonatal period common disease, is especially more common in premature, refers to that newborn mucous membrane occurs, consolidates
The clinical symptoms of film, xanthochromia, pathogenic factor be mainly neonatal blood-brain barrier develop at birth it is incomplete, such as
Fruit icterus index it is excessively high and treatment it is not prompt enough if can very big influence is brought to neonatal intellectual development, serious infant can
Cause bilirubin encephalopathy, so as to cause irreversible damage to infant brain, consequence is serious.Therefore, to the pre- of icterus neonatorum
Anti- and treatment should give enough attention.Blue-ray radiation therapy is that the treatment Jaundice in Premature Infants clinically approved most has all the time
One of cure method of effect.
The blue-light treatment light of 420~470nm of wavelength (irradiation), is the primary therapy of clinically icterus neonatorum, energy
The in vivo indirect bilirubin of infant is made to be changed into nontoxic soluble derivative, is contained so as to reduce the in vivo serum bilirubin of infant
Amount, prevents the generation of bilirubin encephalopathy.Blue-ray radiation therapy method is clinically frequently with two kinds at present：Interval blue light illumination is with holding
Continuous blue light illumination mode.Existing meter for newborns,jaundice be using blue light wave (450mm) and green light wave (550nm) it
Between light wave it is poor, to measure the concentration for being deposited in bilirubin in newborn baby's skin histology.There are two light for jaundice analyzer probe
Ripple, make can to determine in this way melanin and under the influence of the skin maturation phase in newborn skin tissue bilirubin concentration
Minimum value.This point is that traditional approach is not attainable.After probe is placed in before baby forehead or breastbone position and startup power supply,
The light that xenon light pipe is sent directs into skin surface through glass fibre, and direct projection is subcutaneous.Light wave on the skin repeatedly disperse with
It absorbs, is eventually returned to glass fibre.It is dispersed in back to the light part of glass fibre through fiber inner core (short in superficial skin tissue
Light wave), the outer core (long light wave) of another part light is deep into skin histology, and is reached in skin histology, and reaches corresponding photoelectricity
Diode.By calculating the difference of optical density, common light wave will be deducted between epidermis and corium.What is obtained is only skin group
The poor optical density of two range of wavelengths in knitting.The differential disply of light wave density goes out the serum bilirubin being connected, the reading on display
For serum bilirubin level value.
And for Patients with Jaundice of being grown up, since the skin of adult is thicker, the long glistening light of waves can not all be deep into skin histology
It is interior, it is incomplete to the absorption of light, so as to influence the accuracy of measurement result.Therefore, the detection for jaundice of being grown up, hospital generally pass through
Inspection to serum, urine, liver function detects the content of its mesobilirubin.But this detection method is taken a blood sample due to needing,
Human body is damaged larger.
The content of the invention
The technical problems to be solved by the invention are to provide a kind of adult with noninvasive jaundice analyzer.
The technical solution adopted in the present invention is：Adult's jaundice measurement device, including analyzer body, is arranged on analyzer
Intrinsic light source, test probe, control unit further include the display being arranged on analyzer body outer surface, light source, survey
Probe header, display parallel connection on the control unit, contact cornea are provided in one end of the test probe of analyzer body
Keratoscope, keratoscope directly detect sclera, make testing result more accurate, make detection light can be with bigger model after keratoscope reflects
The detection sclera enclosed, makes detection more accurate, and keratoscope outer surface is provided with light shield layer, and light shield layer prevents light from leaking to detecting people
Member damages.
Further, the smaller face connecting test probe of cornea curvature radius ensures that the dioptric of eyes can be adjusted
Degree.
Further, light shield layer is made of reflective resin.
Jaundice detection method, comprises the following steps：(a) by the eyes of keratoscope contact patient；(b) power supply, light source are opened
It is irradiated to through keratoscope on cornea, keratoscope is used to adjust the diopter of eyes；(c) the acquisition module acquisition of control unit
The light of light source transmitting simultaneously converts thereof into electric signal；(d) processing module of the electric signal through control unit handles to obtain bilirubin
Concentration information is shown by display.
Further, light source includes shortwave radiant and long wave radiant on the control unit in parallel, according to detecting
Short wavelength light, the poor optical density of the long glistening light of waves bilirubin concentration is calculated.The beneficial effects of the invention are as follows：
(1) keratoscope of contact cornea is provided in one end of the test probe of analyzer body, keratoscope is directly examined
Survey sclera, make testing result more accurate, make detection light after keratoscope reflects can larger range of detection sclera, make detection
It is more accurate and easy to operate, it is at low cost.
(2) keratoscope outer surface is provided with light shield layer, and light shield layer prevents light leaks from being damaged to testing staff.
Description of the drawings
Fig. 1 is the structure diagram of the present invention.
In figure mark for：1- analyzer bodies, 2- test probes, 3- displays, 4- keratoscopes, 5- light shield layers.
Specific embodiment
The present invention is further described below in conjunction with the accompanying drawings.
As shown in Figure 1, adult's jaundice measurement device of the present invention, including analyzer body 1, is arranged on analyzer body 1
Interior light source, test probe 2, control unit, light source include shortwave radiant in parallel and long wave radiant, further include and be arranged on
Display 3 on 1 outer surface of analyzer body, light source, test probe 2, display 3 are in parallel on the control unit, in analyzer
One end of the test probe 2 of body 1 is provided with the keratoscope 4 of contact cornea, connects on one side by 4 radius of curvature of keratoscope is smaller
Test probe 2 is connect, the cross-sectional area of keratoscope 4 should enable keratoscope 4 cover eyes, and 4 outer surface of keratoscope is provided with screening
Photosphere 5, light shield layer 5 is made of reflective resin, in order to further strengthen shaded effect, can again be applied in manufactured shading layer surface
Cover one layer of graphite, reflective resin can select PMMA, PHEMA, PMMA and NVP copolymer, HEMA and MAA copolymers, IPN, poly-
One kind in urethane hydrogel, silicone-hydrogel or fluoropolymer, specifically can be in the jaundice analyzer described in background technology
Keratoscope, light shield layer are added in test probe, shortwave radiant and long wave radiant are green light wave (550nm), blueness respectively
Light wave (450mm).
During specific measure, keratoscope 4 is contacted the eyes of patient by (a) first；(b) power supply, long wave radiant and short are opened
Light wave light source is irradiated to through keratoscope 4 on cornea, and short wavelength light is dispersed in superficial keratectomy tissue, and long light wave is deep into cornea group
In knitting, light source can more broadly be irradiated to cornea after keratoscope 4；(c) corresponding acquisition module receives optical signal
After feed back to control unit, the processing module of control unit converts thereof into electric signal；(d) processing module of control unit according to
Short wavelength light, the poor optical density calculating processing of the long glistening light of waves detected obtains bilirubin concentration information and passes through display 3 showing.
Claims (6)
1. jaundice measurement device of being grown up, including analyzer body (1), light source in analyzer body (1), test probe are arranged on
(2), control unit, power supply further include the display (3) being arranged on analyzer body (1) outer surface, light source, test probe
(2), display (3), power sources in parallel on the control unit, are provided in the port of the test probe (2) of analyzer body (1) and connect
The keratoscope (4) of eye-catching cornea, keratoscope (4) outer surface are provided with light shield layer (5).
2. adult's jaundice measurement device as described in claim 1, it is characterised in that：Keratoscope (4) radius of curvature smaller one
Face connecting test probe (2).
3. adult's jaundice measurement device as claimed in claim 2, it is characterised in that：Light shield layer (5) is made of reflective resin.
4. adult's jaundice measurement device as claimed in claim 3, it is characterised in that：Light source include it is in parallel on the control unit
Shortwave radiant and long wave radiant.
5. jaundice detection method, it is characterised in that：It is carried out using claim 1-5 any one of them adult's jaundice measurement device
Detection, comprises the following steps：(a) by the eyes of keratoscope (4) contact patient；(b) power supply is opened, light source penetrates keratoscope (4)
It is irradiated on cornea；(c) acquisition module of control unit gathers the light of light source transmitting and converts thereof into electric signal；(d)
Processing module of the electric signal through control unit, which handles to obtain bilirubin concentration information and pass through display (3), to be shown.
6. jaundice detection method as claimed in claim 5, it is characterised in that：Light source includes shortwave radiant and long glistening light of waves light
Bilirubin concentration is calculated according to the short wavelength light, the poor optical density of the long glistening light of waves that detect in source, the processing module of control unit.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711456125.5A CN108078544A (en) | 2017-12-28 | 2017-12-28 | Jaundice measurement device of being grown up and its detection method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711456125.5A CN108078544A (en) | 2017-12-28 | 2017-12-28 | Jaundice measurement device of being grown up and its detection method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108078544A true CN108078544A (en) | 2018-05-29 |
Family
ID=62180194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711456125.5A Pending CN108078544A (en) | 2017-12-28 | 2017-12-28 | Jaundice measurement device of being grown up and its detection method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108078544A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113040712A (en) * | 2021-03-08 | 2021-06-29 | 歌尔科技有限公司 | Jaundice detection device, equipment and storage medium |
Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04127035A (en) * | 1990-09-19 | 1992-04-28 | Minolta Camera Co Ltd | Jaundice meter with multiple display mode |
| US6305804B1 (en) * | 1999-03-25 | 2001-10-23 | Fovioptics, Inc. | Non-invasive measurement of blood component using retinal imaging |
| CN201036551Y (en) * | 2007-04-14 | 2008-03-19 | 马健 | Percutaneous icterus detecting instrument |
| CN201602953U (en) * | 2010-01-15 | 2010-10-13 | 王美 | Eyeshades for therapy of new arrivals |
| CN102861379A (en) * | 2012-09-04 | 2013-01-09 | 北京天助基业科技发展有限公司 | Icterus neonatorum therapeutic system |
| CN204931687U (en) * | 2015-09-19 | 2016-01-06 | 王金辉 | A kind of percutaneous jaundice for obstetrical nursing and body temperature one detector |
| CN205286326U (en) * | 2015-12-31 | 2016-06-08 | 徐州市科健高新技术有限公司 | Novel percutaneous jaundice appearance |
| CN107961445A (en) * | 2017-12-20 | 2018-04-27 | 深圳乐普智能医疗器械有限公司 | Skin icterus tester |
| CN208492063U (en) * | 2017-12-28 | 2019-02-15 | 中国人民解放军成都军区总医院 | Adult jaundice measurement device |
-
2017
- 2017-12-28 CN CN201711456125.5A patent/CN108078544A/en active Pending
Patent Citations (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04127035A (en) * | 1990-09-19 | 1992-04-28 | Minolta Camera Co Ltd | Jaundice meter with multiple display mode |
| US6305804B1 (en) * | 1999-03-25 | 2001-10-23 | Fovioptics, Inc. | Non-invasive measurement of blood component using retinal imaging |
| CN201036551Y (en) * | 2007-04-14 | 2008-03-19 | 马健 | Percutaneous icterus detecting instrument |
| CN201602953U (en) * | 2010-01-15 | 2010-10-13 | 王美 | Eyeshades for therapy of new arrivals |
| CN102861379A (en) * | 2012-09-04 | 2013-01-09 | 北京天助基业科技发展有限公司 | Icterus neonatorum therapeutic system |
| CN204931687U (en) * | 2015-09-19 | 2016-01-06 | 王金辉 | A kind of percutaneous jaundice for obstetrical nursing and body temperature one detector |
| CN205286326U (en) * | 2015-12-31 | 2016-06-08 | 徐州市科健高新技术有限公司 | Novel percutaneous jaundice appearance |
| CN107961445A (en) * | 2017-12-20 | 2018-04-27 | 深圳乐普智能医疗器械有限公司 | Skin icterus tester |
| CN208492063U (en) * | 2017-12-28 | 2019-02-15 | 中国人民解放军成都军区总医院 | Adult jaundice measurement device |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113040712A (en) * | 2021-03-08 | 2021-06-29 | 歌尔科技有限公司 | Jaundice detection device, equipment and storage medium |
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