CN103994974A - Dry type biochemical analyzer - Google Patents
Dry type biochemical analyzer Download PDFInfo
- Publication number
- CN103994974A CN103994974A CN201410256051.0A CN201410256051A CN103994974A CN 103994974 A CN103994974 A CN 103994974A CN 201410256051 A CN201410256051 A CN 201410256051A CN 103994974 A CN103994974 A CN 103994974A
- Authority
- CN
- China
- Prior art keywords
- dry
- biochemical analyzer
- dry plate
- push rod
- integrating sphere
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Investigating Or Analysing Materials By Optical Means (AREA)
Abstract
The invention discloses a dry type biochemical analyzer belonging to the technical field of biochemical detection equipment. The dry type biochemical analyzer is characterized in that in a mechanical system, a dry sheet sampling position is arranged on an X and Y two-dimensional linear movement platform, two pushing rods are respectively arranged in an X direction of the X and Y two-dimensional linear movement platform, an incubation groove is fixed in front of the pushing rods, a baffle block is arranged in the front end of the incubation groove, and a pushing rod is arranged in a Y direction of the X and Y two-dimensional linear movement platform. In an optical system, (a), an LED (Light Emitting Diode) light source is arranged in an integrating sphere, a lens groove is arranged on an optical axis line of the integrating sphere and a dry sheet; and (b), a rear beam-splitting optical system is located at the underface position vertical to the dry sheet, and a lens group and a grating are arranged on a lower vertical line of the dry sheet. The dry type biochemical analyzer has the beneficial effects that 1, by applying an integrating sphere technology, the problem of difficulty in acquiring a signal due to diffuse reflection is solved, and the precision of an instrument is greatly improved; 2, the instrument is more flexible and is convenient to use; 3, by adopting a rear beam-splitting design, the detection accuracy is improved, and the stability of unit is higher; and 4, the dry type biochemical analyzer is low in cost, small and portable, and high in detection speed and performs detection for 120 tests per hour by applying a multi-channel means; and multiple reagent dry sheets are matched with the instrument, thus the demand of clinical testing is met.
Description
Technical field
The invention belongs to biochemistry detection equipment technical field, relate to a kind of improvement of clinical treatment verifying attachment.
Background technology
Dry chemical inspection technology comprises dry type Biochemical Analyzer and reagent dry plate (abbreviation dry plate), dry plate is the carrier of having fixed reagent, after sample (serum, blood plasma, whole blood, urine, cerebrospinal fluid etc.) is added on dry plate, reagent in dry plate and the determinand in sample produce chromogenic reaction, put into dry type Biochemical Analyzer, the incident illumination that light source is sent is mapped on the dry plate after colour developing, calculates the concentration of analyte in sample according to the respective change of measuring light reflectivity generation on dry plate.
At present, commercially available dry type Biochemical Analyzer is mainly that luminous intensity by detecting after blood and chemical reagent come in contact detects.Wherein optical detection parts are comprised of light emitting diode and photoelectric cell.Testing process is to promote reagent strip by straight line hoistable platform, and reagent strip and optics close contact are completed.And the tight ness rating of optics and reagent strip is the key factor that affects test result, therefore need to there is the mechanism that can accurately control pressure between the two accurately to control straight line hoistable platform.Current moving component is controlled conventionally and is adopted, photoelectrical coupler, grating scale, relay, the monotechnicses such as on-off circuit.There are many weak points, such as, controlled condition is single, detects key element few, complex structure, the shortcoming such as volume is large, and the life-span is short.
Summary of the invention
The object of the invention is: a kind of dry type Biochemical Analyzer is provided, and it can carry out quantitative test accurately to dry chemistry reagent sheet, realize the biochemistry detection fast such as emergency treatment, health check-up, disorder in screening, health care detection.
Technical scheme of the present invention is: optical system, electric-control system and mechanical system and motion control part three parts, consist of.
1, mechanical system:
Dry plate application of sample position is located on X, Y two dimension linear motion platform, in two-dimentional linear motion platform X-direction, be respectively equipped with push rod 301 and push rod 302, push rod 301 is fixing incubation slot above, at incubation slot front end, be provided with block, in two-dimentional linear motion platform Y-direction, be provided with push rod 303, the optics blackboard, the blank that are fixed on push rod 303 pass through detecting position successively.
2, optical system:
(1) light source assembly: formed by LED light source 101-1, integrating sphere 101-2 and lens combination 101-3.
LED light source is located in integrating sphere, on the optical axis of integrating sphere and dry plate, is provided with lens combination.
Utilize the light that integrating sphere 101-2 sends LED101-1 to concentrate, by the aperture on integrating sphere 101-2, sent, through lens combination 101-3 " collection ", also " converge " in dry plate.Significantly improve luminous power utilization ratio.
(2) beam-splitting optical system after:
Rear beam-splitting optical system be positioned at vertical with dry plate under position, on the drop wire of dry plate, be provided with lens combination and grating.
Incident light and reflected light two parts optical axis are at 45 °.
Diffusing of dry plate place sees through lens combination 102-2 by the grating beam splitting in rear beam-splitting optical system 102-1, and corresponding shaping, converge after, by line array CCD, received.The intensity of the middle multi-wavelength signals that diffuses detecting by CCD, the interference that can be good at removing other materials in test process, improves accuracy in detection.Simultaneously, beam-splitting optical system 102-1 does not have motor element in optical texture, and the stability of unit is higher.
The invention has the beneficial effects as follows:
1, the application of integrating sphere technology has solved the signal that diffuse reflection causes and has been difficult to the problem gathering, and greatly puies forward the precision of instrument.
2, the application of ARM embedded system on dry analysis instrument, has removed from and has made instrument more flexible to the demand of computer, easy to use.
3, adopt rear light splitting design, when can carry out multi-wavelength signals, detect simultaneously, the interference that can be good at removing other materials in test process, improves accuracy in detection.Simultaneously, beam splitting system does not have motor element in optical texture, and the stability of unit is higher.
4, cost is low; Miniature portable; Detection speed is fast, utilization hyperchannel means detection 120 tests/hour; The supporting plurality of reagents dry plate of instrument, meets the demand of clinical examination.
Accompanying drawing explanation
Fig. 1 is system chart of the present invention;
Fig. 2 is physical construction of the present invention and dry plate motion principle front view;
Fig. 3 is physical construction of the present invention and dry plate motion principle vertical view;
Fig. 4 is Systems for optical inspection schematic diagram of the present invention.
Embodiment
Embodiment 1
Below in conjunction with accompanying drawing, the present invention is described further:
As shown in Figure 1, the 100th, optical system, the 200th, electric-control system, the 300th, mechanical system and motion control part, the 400th, dry plate.
The basis that the Kubelka-Munk theory of take is Methodological Analysis, according to the multilayer diffuse reflection development dry plate detecting instrument of reflection photometry, i.e. dry type Biochemical Analyzer.Instrument adopts a kind of linear platform kinetic control system, and photoelectrical coupler and pressure loading meter are combined with, and has guaranteed the pressure stability between reagent dry plate and optics, has improved accuracy and the repeatability of apparatus measures result.
This instrument is mainly comprised of optical system 100, electric-control system 200 and mechanical system and motion control part 300 3 parts.Mechanical system and motion control partly adopt two-dimentional straight line project of motion control, and dry plate is realized the step motion in X, Y-direction under the drive of two-dimension moving platform, complete single dry plate loading, application of sample, hatch, detect and abandon.The high flux characteristic that can simultaneously hatch 6 dry plates by means of incubation slot 308 significantly shortens monomer detection time, has improved testing efficiency.
Mechanical system and motion control:
As shown in Figure 2,3, the 301st, track A, the 302nd, track B, the 303rd, push rod C, 304 push rod A, the 305th, push rod B, the 306th, block, the 307th, useless film magazine, the 308th, incubation slot, the 500th, loads position, the 501st, and position, the 503rd is hatched, detecting position, the 600th, optics blackboard, the 700th, optical whiteboard in application of sample position, the 502nd.
The motion principle of physical construction of the present invention and dry plate.Two dimension linear motion platform 300 carries dry plate and moves on X, Y both direction.Dry plate first on directions X respectively along two orbital motions, dry plate is after being manually placed in the loading position of track A (301), stepping under the drive of push rod A (304), stop in application of sample to be moved to position (501), splash into the follow-up continuous incubation slot (502) that moves to of 10 μ l samples, then the block of incubation slot front end (306) rises, stop retreating of dry plate, push rod A (304) returns, sample falls into incubation slot, continuous circulation like this, incubation slot can be hatched 6 dry plates simultaneously, hatch after 2-7 minute, push rod B (305) is pushed into detecting position (503) by the dry plate that is positioned at incubation slot bottom in the same direction along track B (302), after optical detection, push rod B (302) returns, by the push rod C (303) moving along Y-direction, promoting dry plate drops in useless film magazine 307, be fixed on the optics blackboard 600 on push rod C (303) simultaneously, blank 700 passes through detecting position successively, pass through respectively optical detection, finally utilize Williams-Clapper model to calculate these two values, in conjunction with calibration parameter, finally obtain the concentration of sample.
Optical system:
As shown in Figure 4, optical system be positioned at vertical with dry plate under position.Light source assembly 101 and receiver assembly 102 two parts, consist of, two parts optical axis is at 45 °.
(1) light source assembly: formed by LED light source 101-1, integrating sphere 101-2 and lens combination 101-3.Utilize the light that integrating sphere 101-2 sends LED101-1 to concentrate, by the aperture on integrating sphere 101-2, sent, through lens combination 101-3 " collection ", also " converge " in dry plate.Significantly improve luminous power utilization ratio.
(2) beam-splitting optical system after: diffusing of dry plate place sees through lens combination 102-2 by the grating beam splitting in rear beam-splitting optical system 102-1, and corresponding shaping, converge after, by line array CCD, received.The intensity of the middle multi-wavelength signals that diffuses detecting by CCD, the interference that can be good at removing other materials in test process, improves accuracy in detection.Simultaneously, beam-splitting optical system 102-1 does not have the stability of motor element unit higher in optical texture.
Claims (1)
1. a dry type Biochemical Analyzer, is characterized in that:
In mechanical system, dry plate application of sample position is located on X, Y two dimension linear motion platform, in two-dimentional linear motion platform X-direction, be respectively equipped with push rod 301 and push rod 302, push rod 301 is fixing incubation slot above, at incubation slot front end, be provided with block, in two-dimentional linear motion platform Y-direction, be provided with push rod 303, the optics blackboard, the blank that are fixed on push rod 303 pass through detecting position successively;
In optical system, (a) LED light source is located in integrating sphere, on the optical axis of integrating sphere and dry plate, is provided with lens combination; (b) after beam-splitting optical system be positioned at vertical with dry plate under position, on the drop wire of dry plate, be provided with lens combination and grating; Incident light and reflected light two parts optical axis are at 45 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410256051.0A CN103994974B (en) | 2014-06-11 | 2014-06-11 | Dry type biochemical analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410256051.0A CN103994974B (en) | 2014-06-11 | 2014-06-11 | Dry type biochemical analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103994974A true CN103994974A (en) | 2014-08-20 |
| CN103994974B CN103994974B (en) | 2017-02-22 |
Family
ID=51309198
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410256051.0A Expired - Fee Related CN103994974B (en) | 2014-06-11 | 2014-06-11 | Dry type biochemical analyzer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN103994974B (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108918467A (en) * | 2018-05-14 | 2018-11-30 | 中国科学院苏州生物医学工程技术研究所 | A kind of high-flux dry chemical detection devices |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183694B1 (en) * | 1998-10-30 | 2001-02-06 | Bayer Corporation | Spectrophotometric apparatus for reducing fluid carryover |
| CN2716842Y (en) * | 2004-06-14 | 2005-08-10 | 桂林市医疗电子仪器厂 | Transversal and horizontal automatic sample introduction mechanism for dry chemical urinalysis instrument |
| CN1683918A (en) * | 1998-08-06 | 2005-10-19 | 爱科来株式会社 | Test piece transfer assembly |
| CN1727902A (en) * | 2003-09-04 | 2006-02-01 | 合肥新月电子技术有限责任公司 | Full-automatic urine analysis system |
| CN201637672U (en) * | 2009-11-11 | 2010-11-17 | 上海科华实验系统有限公司 | Biochemical analyzer |
-
2014
- 2014-06-11 CN CN201410256051.0A patent/CN103994974B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1683918A (en) * | 1998-08-06 | 2005-10-19 | 爱科来株式会社 | Test piece transfer assembly |
| US6183694B1 (en) * | 1998-10-30 | 2001-02-06 | Bayer Corporation | Spectrophotometric apparatus for reducing fluid carryover |
| CN1727902A (en) * | 2003-09-04 | 2006-02-01 | 合肥新月电子技术有限责任公司 | Full-automatic urine analysis system |
| CN2716842Y (en) * | 2004-06-14 | 2005-08-10 | 桂林市医疗电子仪器厂 | Transversal and horizontal automatic sample introduction mechanism for dry chemical urinalysis instrument |
| CN201637672U (en) * | 2009-11-11 | 2010-11-17 | 上海科华实验系统有限公司 | Biochemical analyzer |
Non-Patent Citations (1)
| Title |
|---|
| 李丽丽: "SP-4430 干式生化分析仪日常维护与常见故障排除", 《医疗设备信息》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108918467A (en) * | 2018-05-14 | 2018-11-30 | 中国科学院苏州生物医学工程技术研究所 | A kind of high-flux dry chemical detection devices |
| CN108918467B (en) * | 2018-05-14 | 2021-05-18 | 中国科学院苏州生物医学工程技术研究所 | High-flux dry-type chemical detection device |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103994974B (en) | 2017-02-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101982330B1 (en) | Apparatus and systems for collecting and analyzing vapor condensate, in particular condensate, and methods of using the apparatus and system | |
| CN103675053B (en) | A kind of local electrochemistry imaging test system based on surface plasma resonance | |
| CN107923839A (en) | For testing device, there is the station of integrated reaction and testing agency | |
| CN204462172U (en) | A kind of full-automatic high flux multicolor fluorescence immunochromatography chip analysis system | |
| CN1851458A (en) | Lateral flow assay systems and methods | |
| JP2007501415A (en) | Apparatus and method for process monitoring | |
| CN213301472U (en) | Automatic change spectrum collection system of demarcation | |
| JP2010197248A (en) | Apparatus for quantitatively detecting target substance used for lateral-flow type fluorescence immunochromatography | |
| CN205229055U (en) | Urine mummification analytical equipment based on many monochromatic light and optic fibre | |
| CN204789292U (en) | Micropore board formation of image mechanism | |
| CN103994974A (en) | Dry type biochemical analyzer | |
| CN105388131A (en) | Fluorescence detection instrument and system based on micro-fluidic chip | |
| CN101504418B (en) | Bioassay sensor | |
| CN103675306A (en) | Automatic analysis instrument and system for microfluidic immunodetection chip | |
| CN109709040A (en) | Miniature biochemical analysis instrument is used in a kind of detection of papery miniflow test card | |
| CN211292604U (en) | Portable gold mark detector based on silicon photocell | |
| CN103994978A (en) | Label-free light reflection interference optical fiber biosensor | |
| CN211318188U (en) | Optical detection system and sample analyzer | |
| CN203908938U (en) | Non-marked light reflection interference optical fiber biosensor | |
| CN203561580U (en) | Optical system for medical examination microplate reader | |
| CN210572325U (en) | POCT analysis device | |
| CN113295651A (en) | High-flux array scanning type LSPR sensing detection system based on MEMS galvanometer | |
| CN102854307B (en) | Optical splitting system and optical splitting method for enzyme-linked immunosorbent assay | |
| CN214539249U (en) | Optical detection mechanism and in-vitro diagnostic instrument | |
| CN213843032U (en) | Fluorescence analyzer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20170222 Termination date: 20200611 |