CN211318188U - Optical detection system and sample analyzer - Google Patents
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- CN211318188U CN211318188U CN201922141252.7U CN201922141252U CN211318188U CN 211318188 U CN211318188 U CN 211318188U CN 201922141252 U CN201922141252 U CN 201922141252U CN 211318188 U CN211318188 U CN 211318188U
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Abstract
The utility model provides an optical detection system and a sample analyzer comprising the same, wherein the optical detection system comprises a plurality of light path components, a gating structure, an optical transmitter, a light splitting component and an optical receiver; each light path component comprises a compound color light source and a fixed seat for arranging the reaction cup, and the compound color light source emits light after passing through the reaction cup; emergent light of each light path component sequentially passes through the gating structure and the light transmitter and then is incident to the light splitting element, and the emergent light is split into multiple monochromatic lights by the light splitting element and then is incident to the light receiver; the gating structure moves relative to each light path component and allows at most emergent light of one light path component to be incident to the light transmitter at the same time. The utility model provides an optical detection system and sample analyzer under the condition that only adopts a beam split spare, can gather many light path assembly's multiple wavelength signal fast, not only simplified the structure, the cost is reduced, has still effectively promoted detection efficiency.
Description
Technical Field
The utility model belongs to the technical field of medical instrument, more specifically say, relate to an optical detection system and sample analysis appearance.
Background
Optical methods and magnetic bead methods are two methods currently on the market for analyzing blood coagulation samples, and among them, optical methods are favored by various manufacturers in recent years due to their excellent cost advantage and wide application range; in principle, the optical method is a method of irradiating a reaction solution with a light source, and calculating and analyzing specific properties of a substance to be analyzed in the reaction solution by detecting and recording changes in scattered light or transmitted light caused during the precipitation of fibrin in the reaction solution.
At present, in an instrument for performing blood coagulation item inspection by an optical method, in order to improve inspection efficiency, a plurality of detection channels are generally arranged, that is, a plurality of light sources are arranged, emergent light of each light source is subjected to filtering treatment and then is irradiated to each reaction liquid, so that each light source needs to be provided with a corresponding filtering piece, if light with a plurality of wavelengths needs to be collected, emergent light of each light source needs to be subjected to light splitting treatment by switching the filtering piece or switching the light source, and therefore the whole optical detection system is quite tedious and not beneficial to cost optimization and structural layout.
SUMMERY OF THE UTILITY MODEL
An object of the utility model is to provide an optical detection system to solve the tedious technical problem of optical detection system structure in the present sample analysis appearance.
In order to achieve the above object, the utility model adopts the following technical scheme: there is provided an optical inspection system comprising: a plurality of optical path components, a gating structure, an optical transmitter, a light splitting component and an optical receiver;
each light path component comprises a compound color light source and a fixed seat for arranging a reaction cup, and the compound color light source emits light after passing through the reaction cup;
emergent light of each light path component sequentially passes through the gating structure and the light transmitter and then enters the light splitting piece, and the emergent light is split into a plurality of monochromatic lights by the light splitting piece and then enters the light receiver;
the gating structure moves relative to each light path component and allows at most emergent light of one light path component to be incident to the light transmitter at the same time.
Furthermore, the gating structure comprises a driving component and a moving component, wherein the moving component is provided with a light through hole, and the driving component drives the moving component to move relative to each light path component, so that emergent light of at most one light path component enters the light transmitter through the light through hole at the same moment.
Furthermore, the light through holes are arranged in a plurality, and the light through holes are distributed on the moving member at intervals along the moving direction of the moving member.
Furthermore, the distance between any two adjacent light through holes is equal, and the distance between two adjacent light through holes is D; the light path components are distributed at equal intervals along the movement direction of the moving part, and the distance between any two adjacent light path components is L; the length of the light through hole along the self movement direction is d; the number of the light path components is n; the following conditional expressions are satisfied:
D＝d*(n+1)；
d＝L/n。
furthermore, the gating structure further comprises a light shielding box, the moving member movably penetrates through the light shielding box, the light shielding box is provided with a light passing groove, and the light passing groove is opposite to each light through hole.
Further, the moving member is the hold-in range, drive assembly includes motor and band pulley group, the motor with the transmission of band pulley group is connected, the hold-in range is around locating on the band pulley group.
Further, the light splitting component is a grating.
Furthermore, the optical detection system further comprises a dark box, the grating and the optical receiver are both arranged in the dark box, a light through groove is arranged on the dark box, and emergent light of the optical transmitter enters the light splitting piece through the light through groove.
Furthermore, the optical transmitter is an optical fiber, the optical fiber includes an exit end and a plurality of incident ends, the exit light of each light path component is incident to the corresponding incident end after passing through the gating structure, and the exit light of the exit end is incident to the light splitting component.
The utility model also provides a sample analyzer, sample analyzer includes analyzer, controller and as above optical detection system, the controller with the polychromatic light source reaches gating structure electric connection, the analyzer with light receiver electric connection.
The utility model provides an optical detection system's beneficial effect lies in:
the utility model provides an optical monitoring system is equipped with a plurality of light path subassemblies, through setting up the gating structure that can move for each light path subassembly, makes the emergent light of at most one light path subassembly can get into optical transmission ware and finally incides to the beam split spare through the gating structure at one time, and the beam split spare can divide into the monochromatic light of a plurality of different wavelengths with the polychromatic light of inciding and transmit to the photoreceiver; it can be understood that, as time goes on, in the movement process of the gating structure, the emergent light of each light path component is divided into monochromatic light with multiple wavelengths after passing through the gating structure, the light transmitter and the light splitter at different time points, and then is collected by the light receiver. Therefore, the optical detection system can rapidly collect various wavelength signals of a plurality of light path components under the condition of only adopting one light splitting piece, thereby not only simplifying the structure and reducing the cost, but also effectively improving the detection efficiency;
in addition, the light splitting piece is positioned at the last stage before the light enters the light receiver, so that the optical detection system can filter the stray light outside the test wavelength at the last stage, and the capacity of the optical detection system for resisting the interference of the stray light is favorably improved.
The utility model provides a sample analyzer includes above-mentioned optical detection system, therefore has possessed this optical detection system's whole beneficial effect, does not do only limit here.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the embodiments or the prior art descriptions will be briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without inventive labor.
Fig. 1 is a schematic structural diagram of an optical detection system according to an embodiment of the present invention;
fig. 2 is a schematic diagram of a principle of an optical path of an optical detection system according to an embodiment of the present invention;
FIG. 3 is a schematic structural diagram of a moving member according to an embodiment of the present invention;
FIG. 4 is a schematic view of a matching structure of a moving member and a light shielding box according to an embodiment of the present invention;
fig. 5 is a schematic structural diagram of a sample analyzer according to an embodiment of the present invention.
Wherein, in the figures, the respective reference numerals:
10. an optical detection system; 20. a reaction cup; 30. an analyzer; 40. a controller;
100. an optical path component; 110. a polychromatic light source; 120. a light guide;
200. a gating structure; 210. a drive assembly; 2111. a driving pulley; 2112. a driven pulley; 212. a gear case;
300. an optical transmitter; 310. an incident end; 320. an exit end;
400. a light splitting member; 220. a moving member; 221. a light through hole; 230. a shading box;
500. an optical receiver; 510. a silicon photodiode;
600. a cassette.
Detailed Description
In order to make the technical problem, technical solution and advantageous effects to be solved by the present invention more clearly understood, the following description is given in conjunction with the accompanying drawings and embodiments to illustrate the present invention in further detail. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or be indirectly connected to the other element.
It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in an orientation or positional relationship indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.
Referring to fig. 1 and 2, the present invention provides an optical detection system 10 and a sample analyzer, the sample analyzer includes an analyzer 30, a controller 40 and the optical detection system 10, the optical detection system 10 is used for collecting optical parameters required by analysis items, and converting the optical parameters into electrical signals to be transmitted to the analyzer 30, and the analyzer 30 obtains a detection result under the control and adjustment of the controller 40.
Referring to fig. 1, an optical inspection system 10 according to the present invention will now be described in detail. The optical detection system 10 includes a gating structure 200, an optical transmitter 300, a light splitter 400, an optical receiver 500, and a plurality of optical path components 100, wherein each optical path component 100 includes a polychromatic light source 110 and a fixing seat (not shown) for placing a reaction cup 20, the polychromatic light source 110 is electrically connected to the controller 40, light emitted from the polychromatic light source passes through the reaction cup 20 and then sequentially passes through the gating structure 200, the optical transmitter 300, the light splitter 400, and the optical receiver 500 is electrically connected to the analyzer 30 for converting a received optical signal into an electrical signal and transmitting the electrical signal to the analyzer.
The gate structure 200 is movable relative to the optical path members 100 and allows outgoing light of at most one optical path member 100 to be incident to the optical transmitter 300 at the same time. Specifically, the gating structure 200 is disposed between the fixing base and the optical transmitter 300 and electrically connected to the controller 40, and under the control of the controller 40, the gating structure 200 moves at a specific speed relative to the optical path component 100, so that at most only one light emitted from the optical path component 100 can pass through the gating structure 200 at each time, and all the others are blocked; thus, the light transmitter 300 will receive the emergent light from the specific light path component 100 at a certain time interval, the light transmitter 300 will transmit the emergent light to the light splitting component 400, and after the light splitting processing of the light splitting component 400, the light receiver 500 will also receive the monochromatic light with multiple wavelengths from the light splitting component 400 at a certain time interval, and after the processing of a certain algorithm, the change curve of the light with multiple wavelengths in each light path component 100 along with time can be obtained quickly, thereby effectively improving the detection efficiency.
In addition, the light splitting component 400 is used for splitting the polychromatic light into light with multiple wavelengths, the light receiver 500 collects the light with one wavelength or multiple light with different wavelengths to be detected, and the light is split by the light splitting component 400 and then directly enters the light receiver 500. Particularly, when multiple coagulation item analyses are performed, light with multiple wavelengths, such as five, seven, ten or even more, needs to be collected, and the more the types of the wavelengths need to be collected, the heavier the workload of collecting signals by adopting a traditional front light splitting mode of switching optical filters is, and the analysis efficiency is seriously affected; and adopt the utility model provides a sample analyzer can realize the collection of above-mentioned multiple wavelength signal fast, has very outstanding advantage on the analytical efficiency.
To sum up, the utility model provides an optical monitoring system under the condition that only adopts a beam split 400, can gather a plurality of light path component 100's multiple wavelength signal fast, not only simplified the structure, the cost is reduced, still effectively promoted detection efficiency and detection precision. Referring to fig. 1 and 2, the gating structure 200 includes a driving component 210 and a moving component 220, the moving component 220 is provided with a light-transmitting hole 221, the driving component 210 provides power for the moving component 220 to drive the moving component 220 to move at a specific speed relative to each light path component 100, so that at most one light path component 100 emits light to the light transmitter 300 through the light-transmitting hole 221 at the same time. Specifically, the driving assembly 210 is electrically connected to a controller, so as to control and adjust the speed and direction of the moving member 220.
In order to improve the detection efficiency, the moving member 220 is provided with a plurality of light-transmitting holes 221, and the light-transmitting holes 221 are distributed on the moving member 220 at intervals along the moving direction of the moving member 220. Thus, under the condition that the emergent light of at most one light path component 100 passes through the light-passing hole 221 at the same moment, the waiting time of the optical splitter is reduced as much as possible, and the signal sampling frequency and the detection efficiency are further improved.
In the present embodiment, the light passing hole 221 has a rectangular shape. The rectangular through hole is simple in processing technology, small in processing error and convenient in size measurement, and the calibration difficulty of the relative position of each light path component 100 and the light through hole 221 can be effectively reduced.
Further, in order to satisfy the condition that only at most one light-passing hole 221 is allowed to transmit light under the condition of a plurality of light-passing holes 221, the spacing between any two adjacent light-passing holes 221 is defined to be equal, and the spacing between two adjacent light-passing holes 221 is defined as D; each light path component 100 is equidistantly distributed along the moving direction of the moving member 220, and the distance between any two adjacent light path components 100 is L; the length of the light-passing hole 221 in the self-movement direction is d; the number of optical path components 100 is n; the following conditional expressions are satisfied:
D＝d*(n+1)；
d＝L/n。
under the condition of satisfying the above conditional expression, the optical detection system 10 can be applied to sample analyzers of various specifications and other medical analyzers that need to acquire optical signals in multiple paths, and has low error rate and small difficulty in setting the relative positions of the components.
In this embodiment, the moving member 220 is a synchronous belt, the driving assembly 210 includes a motor and a pulley set, the motor is electrically connected to the controller and is in transmission connection with the pulley set, and the synchronous belt is wound on the pulley set. The band pulley group plays the effect of transmission power, and hold-in range and band pulley complex structural stability are high, and the shake is little, can realize the motion control of higher accuracy, even also can keep higher cooperation precision under the higher condition of rate of motion, help promoting the accuracy of testing result.
In this embodiment, the driving assembly 210 further includes a gear box 212, the pulley set includes a driving pulley 2111 and a driven pulley 2112, an output end of the gear box 212 is coaxially connected with the driving pulley 2111, and the synchronous belt is wound around the peripheries of the driving pulley 2111 and the driven pulley 2112. The gear box 212 may also be referred to as a decelerator, and is used to output the kinetic energy output from the motor to the driving pulley 2111 after performing a certain speed change and a certain direction change. Specifically, in the present embodiment, the plurality of driven pulleys 2112 are provided, so that the stability of the movement can be further improved, the matching precision and the service life of the driving assembly 210 and the moving member 220 can be improved, and the arrangement of other components in the optical detection system 10, such as the optical transmitter 300, can be facilitated.
In another embodiment, the gear box 212 may be omitted, and the driving gear is directly driven by the motor, which is not limited herein.
In addition, referring to fig. 1, in the present embodiment, the gating structure 200 further includes a light shielding box 230, the moving member 220 movably penetrates through the light shielding box 230, and the light shielding box 230 is provided with a light passing groove 231, which is opposite to each light passing hole 221. Specifically, the light passing grooves 231 are strip-shaped through grooves extending along the moving direction of the moving member 220 and disposed opposite to the light passing holes 221 along the incident direction of light. Thus, under the condition that light rays do not interfere to enter the light through hole 221, stray light in the outer environment can be reduced as much as possible to enter the light through hole 221, the detection effect is affected, and the strip-shaped groove is convenient to process. Of course, in other embodiments of the present invention, the shape of the light passing groove 231 is not limited to a bar-shaped groove; for example, the light shielding box 230 is provided with the same number of light passing grooves 231 as the light path modules 100, and the size of each light passing groove 231 is the same as that of the light passing hole 221.
In the present embodiment, each light path assembly 100 further includes two light guiding members 120, for example, one light path assembly 100 is provided, and one light guiding member 120 is disposed between the reaction cup 20 and the polychromatic light source 110, and the other light guiding member 120 is disposed between the reaction cup 20 and the gating structure 200, so as to reduce light attenuation and scattering and ensure the light intensity and the incident angle of the light entering the gating structure 200. It is understood that the number of the light guides 120 in each light path assembly 100 can be increased or decreased according to specific needs, for example, in other embodiments of the present invention, the light guides 120 can be omitted, and is not limited herein.
In this embodiment, the light splitting element 400 is a grating, the grating can split the polychromatic light into spectral bands, and the split lights with different wavelengths are irradiated onto the light receiver 500, so that the time loss caused by switching the optical filter or the switch light source during the conventional multi-wavelength collection is eliminated, and the detection efficiency and the detection accuracy are further improved. Moreover, the grating has a simple structure, is convenient to install, purchase and design, can be well suitable for the optical detection system 10 of the sample analyzer, and is beneficial to obtaining high detection precision.
Preferably, in the present embodiment, the light splitting member 400 is a holographic grating. The holographic grating has no ghost line and small stray light, can eliminate the inherent defects of the mechanically-etched grating, and the actual resolution capability of the holographic grating can reach 80-100% of the theoretical resolution capability.
In the present embodiment, the optical detection system 10 further includes a cassette 600, and the optical grating and the optical receiver 500 are disposed in the cassette 600. The cassette 600 is provided with a light-transmitting slot (not shown), and the emergent light of the light transmitter 300 is incident on a grating via the light-transmitting slot, and the grating is obliquely arranged on the cassette 600. Understandably, the arrangement of the cassette 600 can greatly reduce the interference of the ambient light, and provide guarantee for obtaining accurate detection results; specifically, the light through groove is a strip-shaped through groove, so that incident light is in a strip light spot shape, the grating light splitting effect is improved, and the light splitting effectiveness is improved.
In the present embodiment, the optical receiver 500 includes a plurality of silicon photodiodes 510, and the plurality of silicon photodiodes 510 correspondingly receive light with different wavelengths from the optical splitter 400. Specifically, the plurality of silicon photodiodes 510 are arranged in an array, and different silicon photodiodes 510 correspondingly receive optical signals with specific wavelengths.
In this embodiment, the optical transmitter 300 is an optical fiber, the optical fiber includes an exit end 320 and a plurality of entrance ends 310, the exit light of each optical path assembly 100 passes through the gating structure 200 and then enters the corresponding entrance end 310, and the exit end 320 faces the grating. The optical fiber is adopted as the optical transmission structure, so that the optical transmission efficiency can be effectively improved, the optical attenuation is reduced, the occupied area is small, and the position setting is very flexible.
In another embodiment, the optical transmitter 300 may also be replaced by a lens assembly, specifically, the lens assembly includes a plurality of refractive lenses and a plurality of reflective lenses, and the lenses are combined with each other to implement the above-mentioned optical transmission function with multiple inputs and single output. Of course, in other embodiments of the present invention, the optical transmitter 300 may have other structures, so as to achieve the optical transmission effect of multiple inputs and single output, which is not limited herein.
In the present embodiment, the multi-color light source 110 is a white LED. The life of the white light LED light source is significantly better than that of the conventional tungsten halogen bulb and the cost is low, which is helpful for cost optimization of the optical detection system 10 and even the sample analyzer, and improves the service life of the optical detection system 10.
Based on the above structural features, it is now right that the utility model provides a detailed explanation is made to the working process of sample analyzer 10:
the emission of the polychromatic light by each polychromatic light source 110 is first controlled by the controller 40 and the movement of the timing belt with respect to the light-shielding box is controlled while the analyzer 30 is turned on for collecting the optical signal data from the optical receiver 500 in real time.
And a certain time point is set as t1, at t1, the polychromatic light emitted by one polychromatic light source 110 penetrates through the light-transmitting hole 221 and is incident on the optical fiber, the optical fiber continuously transmits the polychromatic light to the grating, the grating automatically divides the polychromatic light into a plurality of monochromatic lights with different wavelengths, the monochromatic lights with different wavelengths respectively irradiate different silicon photodiodes, the analyzer acquires data of wavelength signals to be analyzed from the silicon photodiodes, and the data is analyzed and converted to obtain detection data of a sample to be detected corresponding to the polychromatic light source at t 1. Here, one or more wavelength signals to be analyzed may be used.
Let the next time point be t2, at t2, the light emitted by another polychromatic light source 110 passes through the light-transmitting hole 221 and is incident on the optical fiber, and the analyzer 30 obtains the detection data of the sample to be detected corresponding to the polychromatic light source at t2 through the same acquisition process as at t 1.
By analogy, after the data of the sample to be detected corresponding to each polychromatic light source 110 is collected for one round, the synchronous belt continues to move, the next round of cyclic collection is performed, and finally the data of each obtained polychromatic light source at each time point are arranged together according to the time sequence, so that the change curve of one or more wavelength signals caused by the time lapse of the sample to be detected corresponding to a certain polychromatic light source can be obtained, and the analysis result can be obtained.
The above description is only exemplary of the present invention and should not be taken as limiting the scope of the present invention, as any modifications, equivalents, improvements and the like made within the spirit and principles of the present invention are intended to be included within the scope of the present invention.
Claims (10)
1. An optical inspection system, characterized by: the optical path component comprises a plurality of optical path components, a gating structure, an optical transmitter, an optical splitter and an optical receiver;
each light path component comprises a compound color light source and a fixed seat for arranging a reaction cup, and the compound color light source emits light after passing through the reaction cup;
emergent light of each light path component sequentially passes through the gating structure and the light transmitter and then enters the light splitting piece, and the emergent light is split into a plurality of monochromatic lights by the light splitting piece and then enters the light receiver;
the gating structure moves relative to each light path component and allows at most emergent light of one light path component to be incident to the light transmitter at the same time.
2. The optical inspection system of claim 1 wherein: the gating structure comprises a driving component and moving components, wherein the moving components are provided with light through holes, the driving component drives the moving components to move relative to the light path components, so that emergent light of at most one light path component enters the light transmitter through the light through holes at the same moment.
3. The optical inspection system of claim 2, wherein: the light through holes are arranged in a plurality, and the light through holes are distributed on the moving member at intervals along the moving direction of the moving member.
4. The optical inspection system of claim 3, wherein: the distance between any two adjacent light through holes is equal, and the distance between every two adjacent light through holes is D; the light path components are distributed at equal intervals along the movement direction of the moving part, and the distance between any two adjacent light path components is L; the length of the light through hole along the self movement direction is d; the number of the light path components is n; the following conditional expressions are satisfied:
D＝d*(n+1)；
d＝L/n。
5. the optical inspection system of claim 3, wherein: the gating structure further comprises a light shielding box, the moving member movably penetrates through the light shielding box, the light shielding box is provided with a light passing groove, and the light passing groove is opposite to each light passing hole.
6. The optical inspection system of claim 2, wherein: the moving member is the hold-in range, drive assembly includes motor and band pulley group, the motor with the transmission of band pulley group is connected, the hold-in range is around locating on the band pulley group.
7. The optical detection system of any one of claims 1 to 6, wherein: the light splitting component is a grating.
8. The optical detection system of any one of claims 1 to 6, wherein: the optical detection system further comprises a dark box, the light splitting piece and the optical receiver are arranged in the dark box, a light through groove is formed in the dark box, and emergent light of the optical transmitter enters the light splitting piece through the light through groove.
9. The optical detection system of any one of claims 1 to 6, wherein: the optical transmitter is an optical fiber which comprises an emergent end and a plurality of incident ends, the emergent light of each light path component is incident to the corresponding incident end after passing through the gating structure, and the emergent light of the emergent end is incident to the light splitting piece.
10. Sample analyzer, its characterized in that: the sample analyzer includes an analyzer, a controller and the optical detection system of any one of claims 1 to 9, the controller is electrically connected to the polychromatic light source and the gating structure, and the analyzer is electrically connected to the light receiver.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112378887A (en) * | 2020-11-16 | 2021-02-19 | 深圳传世生物医疗有限公司 | Analysis method of blood coagulation analyzer and blood coagulation analyzer |
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| CN112378887A (en) * | 2020-11-16 | 2021-02-19 | 深圳传世生物医疗有限公司 | Analysis method of blood coagulation analyzer and blood coagulation analyzer |
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