CN103994974B - Dry type biochemical analyzer - Google Patents
Dry type biochemical analyzer Download PDFInfo
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- CN103994974B CN103994974B CN201410256051.0A CN201410256051A CN103994974B CN 103994974 B CN103994974 B CN 103994974B CN 201410256051 A CN201410256051 A CN 201410256051A CN 103994974 B CN103994974 B CN 103994974B
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- dry
- push rod
- dry plate
- biochemical analyzer
- integrating sphere
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Abstract
The invention discloses a dry type biochemical analyzer belonging to the technical field of biochemical detection equipment. The dry type biochemical analyzer is characterized in that in a mechanical system, a dry sheet sampling position is arranged on an X and Y two-dimensional linear movement platform, two pushing rods are respectively arranged in an X direction of the X and Y two-dimensional linear movement platform, an incubation groove is fixed in front of the pushing rods, a baffle block is arranged in the front end of the incubation groove, and a pushing rod is arranged in a Y direction of the X and Y two-dimensional linear movement platform. In an optical system, (a), an LED (Light Emitting Diode) light source is arranged in an integrating sphere, a lens groove is arranged on an optical axis line of the integrating sphere and a dry sheet; and (b), a rear beam-splitting optical system is located at the underface position vertical to the dry sheet, and a lens group and a grating are arranged on a lower vertical line of the dry sheet. The dry type biochemical analyzer has the beneficial effects that 1, by applying an integrating sphere technology, the problem of difficulty in acquiring a signal due to diffuse reflection is solved, and the precision of an instrument is greatly improved; 2, the instrument is more flexible and is convenient to use; 3, by adopting a rear beam-splitting design, the detection accuracy is improved, and the stability of unit is higher; and 4, the dry type biochemical analyzer is low in cost, small and portable, and high in detection speed and performs detection for 120 tests per hour by applying a multi-channel means; and multiple reagent dry sheets are matched with the instrument, thus the demand of clinical testing is met.
Description
Technical field
The invention belongs to biochemistry detection equipment technical field, it is related to a kind of improvement of clinical treatment verifying attachment.
Background technology
Dry chemical inspection technology includes Dry-type biochemical analyzer and reagent dry plate (abbreviation dry plate), and dry plate is to secure reagent
Carrier, after sample (serum, blood plasma, whole blood, urine, cerebrospinal fluid etc.) is added on dry plate, in the reagent in dry plate and sample
Determinand produce chromogenic reaction, put into the incident illumination in Dry-type biochemical analyzer, light source being sent be mapped to dry after colour developing
On piece, calculate the concentration of analyte in sample according to measuring the respective change that on dry plate, light reflectivity occurs.
At present, it is luminous strong after commercially available Dry-type biochemical analyzer is mainly come in contact with chemical reagent by detection blood
Spend and to be detected.Wherein optical detection component is made up of light emitting diode and photocell.Detection process is flat by straight line lifting
Platform lifts reagent strip, makes reagent strip and optics be in close contact to complete.And the tight ness rating of optics and reagent strip is
The key factor of impact test result the mechanism of precise control pressure therebetween can carry out precise control straight line liter it is therefore desirable to have
Fall platform.Current moving component controls generally employing, photoelectrical coupler, grating scale, relay, the single skill such as on-off circuit
Art.There are many weak points, such as, control condition is single, detection key element is few, complex structure, volume is big, the shortcomings of short life.
Content of the invention
The purpose of the present invention is：There is provided a kind of Dry-type biochemical analyzer, it can be carried out accurately to dry chemistry reagent piece
Quantitative analysis, realizes the quick biochemistry detection such as emergency treatment, health check-up, disorder in screening, health care detection.
The technical scheme is that：By optical system, electric-control system and mechanical system and motion control portion three
It is grouped into.
1st, mechanical system：
Dry plate sample-adding position is located on X, Y two dimension linear motion platform, in two-dimentional linear motion platform X to being respectively equipped with push rod
301 and push rod 302, push rod 301 above fixing incubation slot, it is provided with block in incubation front of the slot, in two-dimentional linear motion platform Y-direction
It is provided with push rod 303, the optics blackboard being fixed on push rod 303, blank pass sequentially through detecting position.
2nd, optical system：
(1) light source assembly：It is made up of LED/light source 101-1, integrating sphere 101-2 and lens group 101-3.
LED/light source is located in integrating sphere, is provided with lens group on the optical axis with dry plate for the integrating sphere.
Using integrating sphere 101-2, the light that LED101-1 sends is concentrated, sent by the aperture on integrating sphere 101-2, through thoroughly
Microscope group 101-3 " collection " " convergence " is in dry plate.Luminous power utilization ratio is greatly improved.
(2) light splitting afterwards optical system：
Light splitting afterwards optical system is located at the position directly below vertical with dry plate, the drop wire of dry plate is provided with lens group and
Grating.
Incident light and reflected light two parts optical axis are at 45 °.
At dry plate diffuse through after lens group 102-2 through the grating beam splitting in light splitting afterwards optical system 102-1, with
And corresponding shaping, converge after, received by line array CCD.The intensity of the middle multi-wavelength signals that diffuse being detected by CCD,
Can be good at removing the interference of other materials in test process, improve accuracy in detection.Light splitting afterwards optical system 102-1 simultaneously
There is no motor element in optical texture, the stability of unit is higher.
The invention has the beneficial effects as follows：
1st, the application of integrating sphere technology solves the problems, such as that the signal that diffusing reflection causes is difficult to gather, and significantly carries instrument
Precision.
2nd, application on Urine dipsticks analyzer for the ARM embedded system, the demand to computer that eliminates makes instrument more
Flexibly, easy to use.
3rd, adopt light splitting afterwards to design, detection while multi-wavelength signals can be carried out simultaneously, can be good at removing test
During other materials interference, improve accuracy in detection.Light splitting afterwards system does not have motor element in optical texture simultaneously, single
The stability of unit is higher.
4th, low cost；Miniature portable；Detection speed is fast, detects 120 tests/hour with multichannel means；Instrument is supporting
Plurality of reagents dry plate, meets the demand of clinical examination.
Brief description
Fig. 1 is present system block diagram；
Fig. 2 is frame for movement of the present invention and dry plate motion principle front view；
Fig. 3 is frame for movement of the present invention and dry plate motion principle top view；
Fig. 4 is Systems for optical inspection schematic diagram of the present invention.
Specific embodiment
Embodiment 1
Below in conjunction with the accompanying drawings the present invention is described further：
As shown in figure 1,100 be optical system, 200 be electric-control system, 300 be mechanical system and motion control portion, 400
It is dry plate.
With the theoretical basis as Methodological Analysis of Kubelka-Munk, the multilayer diffusing reflection according to reflectance photometry method is developed dry
Piece detecting instrument, i.e. Dry-type biochemical analyzer.Instrument adopts a kind of linear platform kinetic control system, by photoelectrical coupler and pressure
Power loading meter is used in combination the pressure stability it is ensured that between reagent dry plate and optics, improves apparatus measures knot
The accuracy of fruit and repeatability.
This instrument is mainly by optical system 100, electric-control system 200 and mechanical system and motion control portion 300 3
It is grouped into., using two dimension linear motion control program, dry plate 400 is in two-dimension moving platform for mechanical system and motion control portion
The step motion realizing in the x, y direction with respect to optical system 100 under drive, completes the loading of single dry plate, is loaded, incubates
Educate, detect and abandon.The high pass flow characteristic that 6 dry plates can be simultaneously incubated by means of incubation slot 308 is greatly shortened monomer inspection
The survey time, improve detection operating efficiency.
Mechanical system and motion control：
As shown in Figure 2,3,301 be track A, 302 be track B, 303 be push rod C, 304 push rod A, 305 be push rod B, 306
Be block, 307 be waste paper box, 308 be incubation slot, 500 be load position, 501 be sample-adding position, 502 be incubation position, 503 be detection
Position, 600 be optics blackboard, 700 be optical whiteboard.The frame for movement of the present invention and the motion principle of dry plate.Two-dimentional straight line fortune
Moving platform 300 carries dry plate and moves in X, Y both direction.Dry plate, first in the X direction respectively along two track motions, is done
Piece through being manually located behind the loading position in track A (301), stepping under the drive of push rod A (304), wait to move to sample-adding position
(501) stop, instill follow-up continuous block (306) rise moving to incubation slot (502), being then incubated front of the slot of 10 μ l samples,
Stop the retrogressing of dry plate, push rod A (304) returns, and sample falls into incubation slot, so continuously circulates, incubation slot can be to 6 dry plates
Be incubated simultaneously, incubation 2-7 minute after, push rod B (305) by positioned at incubation trench bottom dry plate along track B (302) in phase Tongfang
It is pushed into detecting position (503) upwards, after being finished by optical system 100 detection fixed with base, push rod B (302) returns, by along Y
The push rod C (303) of direction motion promotes dry plate to drop in waste paper box 307, and the optics being simultaneously fixed on push rod C (303) is black
Plate 600, blank 700 pass sequentially through detecting position, respectively through optical detection, finally utilize Williams-Clapper model to this
Two values are calculated, and in conjunction with calibration parameter, finally obtain the concentration of sample.
Optical system：
As shown in Figure 4, positioned at the position directly below that dry plate detecting position is vertical.By light source assembly 101 and receiver assembly
102 two parts compositions, two parts optical axis is at 45 °.
(1) light source assembly：It is made up of LED/light source 101-1, integrating sphere 101-2 and lens group 101-3.Using integrating sphere
The light that LED101-1 is sent by 101-2 is concentrated, and is sent by the aperture on integrating sphere 101-2, through lens group 101-3 " collection " and
" convergence " is in dry plate.Luminous power utilization ratio is greatly improved.
(2) light splitting afterwards optical system：At dry plate diffuse through after lens group 102-2 through light splitting afterwards optical system
After grating beam splitting in 102-1, and corresponding shaping, convergence, received by line array CCD.By diffusing that CCD detects
The intensity of middle multi-wavelength signals, can be good at removing the interference of other materials in test process, improves accuracy in detection.Simultaneously
Light splitting afterwards optical system 102-1 does not have the stability of motor element unit higher in optical texture.
Claims (1)
1. a kind of Dry-type biochemical analyzer, is characterized in that：In mechanical system, dry plate sample-adding position is located at X, Y two dimension linear motion
On platform, in two-dimentional linear motion platform X to being respectively equipped with push rod A (304) and push rod B (305), push rod A (304) is above fixing
Incubation slot, the dry plate positioned at incubation trench bottom is pushed into detecting position along track B (302) by push rod B (305) in the same direction
(503), push rod B (305) returns, and promotes dry plate to drop in waste paper box (307) by the push rod C (303) moving along Y-direction,
Incubation front of the slot is provided with block, is provided with push rod C (303) in two-dimentional linear motion platform Y-direction, is fixed on the light on push rod C (303)
Learn blackboard, blank passes sequentially through detecting position；Respectively through optical detection, finally utilize Williams-Clapper model to this two
Individual value is calculated；In optical system, (a) LED/light source is located in integrating sphere, sets on integrating sphere with the optical axis of dry plate
There is lens group；B () light splitting afterwards optical system is located at the position directly below vertical with dry plate, be provided with lens on the drop wire of dry plate
Group and grating；Incident light and reflected light two parts optical axis are at 45 °.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410256051.0A CN103994974B (en) | 2014-06-11 | 2014-06-11 | Dry type biochemical analyzer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410256051.0A CN103994974B (en) | 2014-06-11 | 2014-06-11 | Dry type biochemical analyzer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103994974A CN103994974A (en) | 2014-08-20 |
| CN103994974B true CN103994974B (en) | 2017-02-22 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410256051.0A Expired - Fee Related CN103994974B (en) | 2014-06-11 | 2014-06-11 | Dry type biochemical analyzer |
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| Country | Link |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108918467B (en) * | 2018-05-14 | 2021-05-18 | 中国科学院苏州生物医学工程技术研究所 | High-flux dry-type chemical detection device |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6183694B1 (en) * | 1998-10-30 | 2001-02-06 | Bayer Corporation | Spectrophotometric apparatus for reducing fluid carryover |
| CN2716842Y (en) * | 2004-06-14 | 2005-08-10 | 桂林市医疗电子仪器厂 | Transversal and horizontal automatic sample introduction mechanism for dry chemical urinalysis instrument |
| CN1683918A (en) * | 1998-08-06 | 2005-10-19 | 爱科来株式会社 | Test piece transfer assembly |
| CN1727902A (en) * | 2003-09-04 | 2006-02-01 | 合肥新月电子技术有限责任公司 | Full-automatic urine analysis system |
| CN201637672U (en) * | 2009-11-11 | 2010-11-17 | 上海科华实验系统有限公司 | Biochemical analyzer |
-
2014
- 2014-06-11 CN CN201410256051.0A patent/CN103994974B/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1683918A (en) * | 1998-08-06 | 2005-10-19 | 爱科来株式会社 | Test piece transfer assembly |
| US6183694B1 (en) * | 1998-10-30 | 2001-02-06 | Bayer Corporation | Spectrophotometric apparatus for reducing fluid carryover |
| CN1727902A (en) * | 2003-09-04 | 2006-02-01 | 合肥新月电子技术有限责任公司 | Full-automatic urine analysis system |
| CN2716842Y (en) * | 2004-06-14 | 2005-08-10 | 桂林市医疗电子仪器厂 | Transversal and horizontal automatic sample introduction mechanism for dry chemical urinalysis instrument |
| CN201637672U (en) * | 2009-11-11 | 2010-11-17 | 上海科华实验系统有限公司 | Biochemical analyzer |
Non-Patent Citations (1)
| Title |
|---|
| SP-4430 干式生化分析仪日常维护与常见故障排除;李丽丽;《医疗设备信息》;20060531;第21卷(第5期);110 * |
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| CN103994974A (en) | 2014-08-20 |
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