CN103977105A - A ledebouriella root/smoked plum composition for treating asthma and applications of the composition - Google Patents
A ledebouriella root/smoked plum composition for treating asthma and applications of the composition Download PDFInfo
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- CN103977105A CN103977105A CN201410200197.3A CN201410200197A CN103977105A CN 103977105 A CN103977105 A CN 103977105A CN 201410200197 A CN201410200197 A CN 201410200197A CN 103977105 A CN103977105 A CN 103977105A
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- radix saposhnikoviae
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- fructus mume
- asthma
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Abstract
The invention discloses a ledebouriella root/smoked plum composition for treating asthma and applications of the composition. The medicine provided by the invention can effectively improve the curative effects of asthma treatment.
Description
Technical field
The invention belongs to biological and materia medica technical field, in particular to a kind of Radix Saposhnikoviae Fructus Mume compositions and application thereof for the treatment of asthma.
Background technology
It is that distinguished veteran doctors of TCM is wished the proved recipe that Zan gives that allergy is decocted, and is mainly used in the treatment of the anaphylactic diseases such as bronchial asthma, allergic rhinitis, urticaria, has obtained satisfied curative effect; Allergy is decocted by Radix Stellariae, Fructus Mume, Radix Saposhnikoviae, Fructus Schisandrae Chinensis, Radix Glycyrrhizae and is formed, and allergy is decocted and be take Radix Saposhnikoviae as monarch, this medicine Xin Run and warm-dryness syndrome not, benefaction fur with through feeling pulse gas, Li Keda 12 warps that dispel the wind, the kind external ailment said due to cold or exposure of dispelling, and can spasmolytic antipruritic; Minister is sour and astringent with Fructus Mume, and one can astringing lung QI for relieving asthma, for lung qi, loses in respectful and falls, and the property that it is sour and astringent can restrain lung qi, helps improving inspiration by invigorating kidney-QI Dingchuan, and two can promoting the production of body fluid for nourishing the lung, also can prevent pungent loose impairment of body fluid.Radix Stellariae is pungent cool, and one can help Radix Saposhnikoviae dispelling wind loose evil, and two can fall apart evilly stops up fur and causes hot and suffocating; Fructus Schisandrae Chinensis sour in the mouth is sweet and warm, sour sweet nourishing YIN, and both theobromine convergence lung, prevented pungent loose impairing the lung, and theobromine is sweet again promotes the production of body fluid, and helps lung spreading functional activities of the body fluid, and above is adjuvant drug altogether.The sweet temperature of Radix Glycyrrhizae, one can invigorating the spleen and replenishing QI, and just, two can coordinating the actions of various ingredients in a prescription for anti-evil wound, with being to help to make.All medicines are harmonious, loose holding back and use, reinforcing and reducing concurrently, phase factor falls in a surname, medicine is flat, conceive odd, gather altogether expelling wind to relieve convulsion, astringe the lung and promote the production of body fluid, regulate the merit of negative and positive.Modern pharmacology research all confirms that irritated decocting has good anti-allergic effects, but research concentrates on full presciption medicine effect, learns and Mechanism Study, has no the research of the relevant compatibility of medicines in a prescription.
Monarch-minister drug Radix Saposhnikoviae, Fructus Mume, adopting falls apart receives and uses, Radix Saposhnikoviae enters bladder, liver, spleen channel, is the panacea dispeling the wind, and is again the profit agent in wind medicine, its acrid-sweet flavor and tepor, pungent loose and warm-dryness syndrome not, Gan Run and do not grow greasy, for asthma, can take into account the characteristic of exogenous wind and lung being a delicate viscus, in stage of attack treating asthma performance expelling wind and relieving convulsion, antipruritic effect; Fructus Mume sour in the mouth, puckery, property is flat.Enter liver, spleen, lung, large intestine channel.This product sour in the mouth and puckery, is the product of refrigerant astringent therapy, on the one hand can astringing lung QI for relieving asthma for asthma, for lung qi, lose in respectful and fall, the property that it is sour and astringent can restrain lung qi, helps improving inspiration by invigorating kidney-QI Dingchuan, its two energy promoting the production of body fluid for nourishing the lung, in Chinese medicine stage of attack asthma, normal and hormone share, the most traditional Chinese medical science thinks that the GC of exogenous super physiological dose is analogous to " excessive fire " easily impairment of YIN, therefore consumption impairing the lung Tianjin causes lung to lose clear and rich, Fructus Mume promotes the production of body fluid and contributes to tonifying the lung Tianjin, also can prevent that pungent loose medicine injures functional activities of the body fluid.Two medicines match, pungent loose eliminating evil and do not consume impairment of QI Tianjin; Acid is held back and is not stayed heresy, and system is coordinated mutually, bring out the best in each other, and performance expelling wind to relieve convulsion, the effect of astringing the lung and promoting the production of body fluid.Zhang Xichun says " lungs are entire machines of warding off, and the medicine of controlling lung is too loose to be an impediment to entirely, too holds back and is an impediment to and wards off ".Modern pharmacology shows that Radix Saposhnikoviae, Fructus Mume have good anti-allergic effects, and anti-wind energy is alleviated bronchospasm and effect that tool is relievingd asthma.Yet independent Radix Saposhnikoviae, Fructus Mume curative effect when treatment asthma is limited, how to improve its therapeutic effect, is those skilled in the art's technical problems urgently to be resolved hurrily.
Summary of the invention
The object of this invention is to provide a kind of Radix Saposhnikoviae Fructus Mume compositions and application thereof for the treatment of asthma, in order to realize object of the present invention, intend adopting following technical scheme:
One aspect of the present invention relates to the Radix Saposhnikoviae Fructus Mume compositions for the treatment of asthma, it is characterized in that containing Radix Saposhnikoviae-Fructus Mume extractum, and preferred, the weight proportion of crude drug Radix Saposhnikoviae and Fructus Mume is 1-2:1-2.
In a preferred embodiment of the present invention, contain the budesonide spray of independent packaging in described medicine, preferred, the concentration of described budesonide spray is 0.01-0.03%.
In another preferred embodiment of the present invention, described pharmaceutical composition contains or does not contain other active component.
The present invention also relates to the application of above-mentioned composition in treatment asthma on the other hand.
Accompanying drawing explanation
Fig. 1: the impact that Radix Saposhnikoviae-Fructus Mume compatibility is expressed the PAR-2mRNA of hyper responsiveness of allergic asthmatic mice lung tissue;
Fig. 2: the impact (SABC) of Radix Saposhnikoviae-Fructus Mume compatibility on the PAR-2 protein expression of hyper responsiveness of allergic asthmatic mice lung tissue;
Fig. 3: medicine affects (HE dyeing) on Radix Saposhnikoviae-Fructus Mume to hyper responsiveness of allergic asthmatic mice lung tissue disease Neo-Confucianism.
The specific embodiment
Embodiment 1
(1) prepare Radix Saposhnikoviae-Fructus Mume extractum (prescription is than being 1:1), the used time configures with distilled water.Clinical adult's consumption is 30g crude drug every day, by laboratory animal, gives mice with body surface area than conversion dose,equivalent.Select female BALB/C mice (SPF level), six week age, body weight: 18-22g, 60.Grouping: after the weight of animals numbering, divide animal is divided into 5 groups with table of random number, 12 every group.Modeling is with reference to researchs such as Temelkovski, test the 0th, 7,14 days lumbar injection antigen liquid 0.2ml (containing egg protein OVA100 μ g aluminium hydroxide 400 μ g), within the 21st day, mice is placed in a lucite container (30 * 15 * 20cm), with ultrasound atomizer, give 5%OVA solution atomization (mist particle diameter 3～5 μ m) 30min, excite mouse asthmatic.
(2) medication: the 21st day, continuous use was intervened 7 days, excites asthma with OVA solution after each pharmaceutical intervention 15min.Concrete interference method is as follows:
(3) experimental result:
1. the impact of Radix Saposhnikoviae-Fructus Mume compatibility on hyper responsiveness of allergic asthmatic mice SERUM IgE
Note: with Normal group comparison,
*p ﹤ 0.05,
*p ﹤ 0.01; With model group comparison
△p ﹤ 0.05,
△ △p ﹤ 0.01;
2. the regulating and controlling effect of Radix Saposhnikoviae-Fructus Mume compatibility to hyper responsiveness of allergic asthmatic mice serum il-4
Note: with Normal group comparison,
*p ﹤ 0.05,
*p ﹤ 0.01; With model group comparison
△p ﹤ 0.05,
△ △p ﹤ 0.01,
3. the impact (referring to Fig. 1) that Radix Saposhnikoviae-Fructus Mume compatibility is expressed the PAR-2mRNA of hyper responsiveness of allergic asthmatic mice lung tissue
The impact (RT-PCR) that Radix Saposhnikoviae-Fructus Mume compatibility is expressed the PAR-2mRNA of hyper responsiveness of allergic asthmatic mice lung tissue
Note: compare * P<0.05 with model group; * P<0.01
4. the impact (SABC) (referring to Fig. 2) of Radix Saposhnikoviae-Fructus Mume compatibility on the PAR-2 protein expression of hyper responsiveness of allergic asthmatic mice lung tissue
5. medicine affects (HE dyeing) (referring to Fig. 3) on Radix Saposhnikoviae-Fructus Mume to hyper responsiveness of allergic asthmatic mice lung tissue disease Neo-Confucianism
Pathological examination: Normal group lung tissue alveolar structure is clear, in the same size, and alveolar wall is thin, and bronchiolar epithelium is complete, in tube chamber, without secretions, periphery has no inflammatory cell infiltration.Centered by bronchioles, there is as seen massive inflammatory cells infiltrated in model group, and interstitial lung telangiectasis or hyperemia, alveolar wall thickens, and sees exudate in alveolar space, part alveolar is fused into pulmonary belb, has massive inflammatory cells infiltrated, airway smooth muscle to thicken in bronchus.Budesonide group and model group comparison, inflammatory lesion obviously alleviates, but smooth muscle cell does not thicken improvement; Radix Saposhnikoviae-Fructus Mume group, pathological changes obviously alleviates, but still visible a small amount of inflammatory cell infiltration, smooth muscle cell thickens obvious improvement; Budesonide+Radix Saposhnikoviae-Fructus Mume group has no inflammatory disorders substantially, thickens and improves significantly with model group, budesonide group comparison airway smooth muscle cells.Prompting Radix Saposhnikoviae-Fructus Mume improve respiratory inflammation effect that asthma causes and budesonide group more relatively a little less than, but Radix Saposhnikoviae-Fructus Mume has the effect that stronger inhibition smooth muscle cell thickens.
The above, be only the specific embodiment of the present invention, but protection scope of the present invention is not limited to this, and any variation of expecting without creative work or replacement, within all should being encompassed in protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain that claims were limited.
Claims (4)
1. the Radix Saposhnikoviae Fructus Mume compositions for the treatment of asthma, is characterized in that containing Radix Saposhnikoviae-Fructus Mume extractum, and preferred, the weight proportion of crude drug Radix Saposhnikoviae and Fructus Mume is 1-2:1-2.
2. pharmaceutical composition according to claim 1, contains the budesonide spray of independent packaging in described medicine, preferred, the concentration of described budesonide spray is 0.01-0.03%.
3. pharmaceutical composition according to claim 2, described pharmaceutical composition contains or does not contain other active component.
4. according to the pharmaceutical composition described in claim 1-3, the application in treatment asthma.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692517A (en) * | 2017-02-15 | 2017-05-24 | 沂南县迎辉农业开发有限公司 | Anti-candida-infection aerosol for treating bronchial asthma |
| CN107334953A (en) * | 2017-07-18 | 2017-11-10 | 北京国医九和医药科技有限公司 | A kind of Chinese herbal granules and preparation method for adjusting allergic constitution |
| CN107349345A (en) * | 2017-07-18 | 2017-11-17 | 北京国医九和医药科技有限公司 | A kind of Chinese medicine and extraction process for adjusting allergic constitution |
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| WO2006007538A2 (en) * | 2004-07-01 | 2006-01-19 | Baek Sung H | Composition and method for the treatment of asthma symptoms |
| CN101543543A (en) * | 2009-04-30 | 2009-09-30 | 上海市中医医院 | Herbal medicine compound preparation capable of treating children recurrent respiratory tract infection and preparation and application thereof |
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2014
- 2014-05-13 CN CN201410200197.3A patent/CN103977105A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006007538A2 (en) * | 2004-07-01 | 2006-01-19 | Baek Sung H | Composition and method for the treatment of asthma symptoms |
| CN101543543A (en) * | 2009-04-30 | 2009-09-30 | 上海市中医医院 | Herbal medicine compound preparation capable of treating children recurrent respiratory tract infection and preparation and application thereof |
Non-Patent Citations (2)
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| 周德生: "《常用中药配伍与名方精要》", 31 January 2006, 山西科学技术出版社 * |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106692517A (en) * | 2017-02-15 | 2017-05-24 | 沂南县迎辉农业开发有限公司 | Anti-candida-infection aerosol for treating bronchial asthma |
| CN107334953A (en) * | 2017-07-18 | 2017-11-10 | 北京国医九和医药科技有限公司 | A kind of Chinese herbal granules and preparation method for adjusting allergic constitution |
| CN107349345A (en) * | 2017-07-18 | 2017-11-17 | 北京国医九和医药科技有限公司 | A kind of Chinese medicine and extraction process for adjusting allergic constitution |
| CN107334953B (en) * | 2017-07-18 | 2018-09-04 | 北京国医九和医药科技有限公司 | A kind of Chinese herbal granules and preparation method adjusting allergic constitution |
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Application publication date: 20140813 |