CN103961567A - Medicine for treating gall-stone and muddy gall-stone - Google Patents
Medicine for treating gall-stone and muddy gall-stone Download PDFInfo
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- CN103961567A CN103961567A CN201310036446.5A CN201310036446A CN103961567A CN 103961567 A CN103961567 A CN 103961567A CN 201310036446 A CN201310036446 A CN 201310036446A CN 103961567 A CN103961567 A CN 103961567A
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Abstract
The invention relates to a medicine for treating gall-stone and muddy gall-stone. The medicine is prepared from 15-20g of herba glechomae longitubae, 10-15g of carapax trionycis, 15-20g of endothelium corneum gigeriae galli, 15-20g of radix seu cortex acanthopanacis trifoliati, 30-50g of corn stigma, 30-50g of herba lysimachiae and 20-30g of radix clematidis by crushing and mixing. The medicine is obtained by matching of the pure natural medicinal materials and has functions of removing toxins and relieving swelling, clearing heat and draining dampness, thawing stone, benefiting gallbladder and expelling stone. The medicine can promote full dredging of bile stasis, eliminate bacterial infection and change bile components. Through use of the medicine, whatever a disease cycle is long or short, the gall-stone and muddy gall-stone can be eliminated and a recurrence rate is zero. The medicine has a short treatment course and produces effects fast. The medicine does not produce adverse action on stomach and kidney functions and avoids operation pain.
Description
Technical field
The present invention relates to a kind of medicine for the treatment of cholelithiasis gallbladder silt calculus, be specifically related to one taking Chinese medicine as raw material, be widely used in common bile duct silt calculus, the medicine of choledocholithiasis.
Technical background
The current raising numerous disease along with medical level and technology and health care consciousness is as parasitic disease, and the development rate of infectious disease is all controlled to some extent and declined.But due to many reasons such as society & cultures.Choledocholithiasis, silt calculus, the disease progression rate of gallbladder polyp system is all still high, even present the trend that rises and become younger in some cities, only taking common bile duct disease as example, add up according to World Health Organization (WHO), various countries' 100,000 people's sickness rate are: Britain 78.9%, the U.S. 45.8%, China 40.1% is average ill up to 40-8/10 ten thousand, and now to treatment, choledocholithiasis, silt calculus, cholecystitis, gallbladder polyp systemic disease, doctor trained in Western medicine there is no good method.The general Western medicine anti-inflammatory analgetic method that adopts.Great majority can only respite patient misery, and Most patients selects Minimally Invasive Surgery that gallbladder is extractd.In the U.S., annual new diagnosis Patients with Cholelithiasis approximately 1,000,000 people, accepts patient's approximately 700,000 examples of Cholecystectomy every year.Silt sample cholelithiasis is a type in gall stone, and its composition is mainly bilirubin, and the silt disease that size is generally, is extensively distributed in whole gallbladder and biliary system.Gallbladder is full of type calculus and is conventionally accompanied by atrophy of gallbladder or expansion, and atrophy of gallbladder is more serious.And calculus of bile duct very easily occurs block, so generally on therapeutic treatment, very trouble.The expectant treatment of the traditional Chinese medical science at present, its therapeutic effect is little.And the possibility of utilizing expectant treatment to also have certain acute pancreatitis to occur.Operation utilizes laparoscopic cholecystectomy excision gallbladder, and the gallbladder of pathological changes and silt sample cholelithiasis are together excised, and side effect is large, causes many untoward reaction, as poor in functions of expelling toxin, and the digestion sense of stomach is moved back, and produces abdominal part gas and rises etc.Utilize some endoscopic drainages to treat silt sample cholelithiasis, except side effect, the chance that need to perform the operation is again more, what have postoperatively produces silt calculus equally less than 2 years total roots of gallbladder, ask originally as principle to control in view of above situation the present inventor medicine practice experience, theory and combining is for many years clinical, by Exploration and conclusion constantly, improve, development is without hormone, without Western medicine, without any side effects, safety, medicine that effectively again can treating both the principal and secondary aspects of a disease, to meet vast clinical demand.
Summary of the invention
The object of the present invention is to provide one to be made up of pure Chinese medicine, treating both the principal and secondary aspects of a disease, has no side effect, safe and effective, and prevents a kind of medicine for the treatment of common bile duct silt calculus of recurrence.
The object of the present invention is achieved like this: it is by HUOXUEDAN 15-20 gram, Carapax Trionycis 10-15 gram, Endothelium Corneum Gigeriae Galli 15-20 gram, white Jin root 15-20 gram, Stigma Maydis 30-50 gram, Herba Lysimachiae 30-50 gram, and Radix Clematidis 20-30 gram proportioning, through being pulverized and mixed a kind of medicine for the treatment of common bile duct silt calculus being prepared from.
Wherein, HUOXUEDAN (Herba Glechomae Longitubae), another name: gold thread Chinese mugwort, Glechota longituba (Nakai) Kupr, lung-wind syndrome grass, make GUCAO.For the herb of labiate HUOXUEDAN Glechoma longituba (Nakai) Kupr.Containing executing pinocamphone, left-handed menthone, pulegone etc. in a left side.Bitter in the mouth, pungent, cool in nature.Clearing away heat and promoting diuresis, the secondary removing toxic substances that disappears, controls renal calculus, wing light calculus, cholelithiasis, eczema, impetigo, paddy field dermatitis, scabies, burn etc.
Carapax Trionycis (Carapax Trionycis) is the carapace of Trionychidae animal Trionyx sinensis Wiegmann Trionyx sinensis Wiegmann.Containing ossein, calcium carbonate, calcium phosphate, iodine etc.Salty in the mouth, cold nature, return liver,spleen,kidney warp.Nourishing YIN for suppressing the hyperactive YANG, eliminating stagnation eliminating mass, seemingly have the calculus of dissolving effect, again can hard masses softening and resolving, and treating the liver splenomegaly, mass in abdomen, amenorrhea.
Endothelium Corneum Gigeriae Galli (Endothelium Corneum Gigeriae Galli) is the dry inner wall of sandbag of the chicken Gallusgallus domesticus Brisson of Phasianidae animal man.Containing gastric hormone, keratin, micro-pepsin, amylase, multivitamin etc.Sweet in the mouth, slightly warm in nature, returns spleen, stomach, bladder.Function, promoting digestion and invigorating the stomach, arresting enursis, the inducing decomposition of calculi.Control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.
White Jin root (Radix seu Cortex Acanthopanacis Trifoliati), another name: front three skin, Radix Acanthopanacis Trifoliati, thorn Acanthopanan trifoliatus (L.) Merr., bitter tartar, Radix Acanthopanacis Trifoliati.For Araliaceae Bai le (is root or the root bark of Araliaceae Bai le Acanthopanax trifoliatus (L.) Merr..Fatty acids, Pentadecane acid, Palmic acid, heptadecanoic acid, stearic acid, arachidic acid, sitosterol etc.Bitter in the mouth, pungent, cool in nature.Clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, control cholelithiasis, urinary system calculus, mastitis, venom, ulcer of the lower limb etc.
Stigma Maydis (Corn Stigma), has another name called maize palpus, is style and the stigma of grass Semen Maydis ZeamaysL..Fatty oil, volatile oil, tree gelatinoid, resin, bitterness glucoside etc.Sweet in the mouth, light, property is flat, people's kidney, stomach, liver, gallbladder meridian.Relieving stranguria by diuresis, jaundice eliminating detumescence.Cure mainly usage: oedema due to nephritis, urinary tract infection, lithangiuria, cirrhotic ascites, Biliary Calculi, silt calculus, cholecystitis, icterohepatitis, diabetes, hypertension.
Herba Lysimachiae (Herba Lysimachiae), has another name called Lysimachia christinae Hance.For the dry herb of Ofthe Primulaceae Lysimachia christinae Hance Lysimachia christinae Hance.Herb is containing flavones ingredient, p-hydroxy benzoic acid (p-hydroxy benzoic acid), uracil (uridine) etc.Sweet in the mouth, micro-hardship, cool in nature.Return liver, gallbladder, kidney, urinary bladder channel.Relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling.For expelling wind and cold, the cough that cures cold, headache body pain, diarrhoea.
Radix Clematidis (Radix Clematidis) is the dry root and rhizome of ranunculaceae plant Radix Clematidis Clematis chinensisOsbeck, Clematis hexapetala Clematis hexapetala Pall. or northeast clematis Clematismanshurica Rupr..Root is containing Anemonin, anemonol, sterol, saccharide, Saponin etc.Acrid in the mouth is salty, warm in nature, poisonous.Enter lung, kidney two warps.Expelling wind and removing dampness, removing obstruction in the collateral to relieve pain, expectorant water, the loose hypochondriac lump.Cure mainly gout insensitive impediment, rheumatic arthralgia, numb limbs and tense tendons, chills and pain of the waist and kness, the contracture of muscle arteries and veins, joint stuffiness, beriberi, malaria, lump in the abdomen, tetanus, tonsillitis, all a fishbone or other bone caught in the throat pharynxs.
Compared with prior art, it is pure natural medical material compatibility in the present invention, has removing toxic substances and promoting subsidence of swelling, clearing away heat-damp and promoting diuresis, dissolves calculus, function of gallbladder promoting, calculus effect.Promote cholestasis, can be fully unimpeded, eliminate that antibacterial infects and bile component changes.To choledocholithiasis, no matter disease cycle length all can be cured, and do not recur.This medicine short treating period, instant effect, by patient's inspection being found to this pharmaceutically active ingredient can make irritability dredging, promote gallbladder antiperspirant to be retarded by silt, and controls and intend dredging, the liver and gall efficient medicine of calculus removing that purges heat.In side, Radix Clematidis, HUOXUEDAN have certain antibacterial action to pathogenic bacterium such as staphylococcus aureus, streptococcus, meningococcus, Diplococcus pneumoniae, dysentery bacterium, Bacillus typhi, Salmonella paratyphi, diphtheria corynebacterium, bacillus pyocyaneus.At ligation Fel Canitis pipe, in the experiment by common bile duct intubate collection bile, prove, biliary tract can obviously increase Fel Canitis juice discharge, and the choleretic effect of Canis familiaris L. is strengthened, and can make choleresis increase, and the intrinsic pressure rising of biliary tract, increases calculus removing power.Inject after this medicament to rabbit vein, find that sphincter myoelectricity activity starts to disappear, sphincter dilatation, thereafter start to occur high amplitude, the spastic compressor electrical activity of the fast rhythm and pace of moving things, continue to enter again relaxed state after approximately 20 minutes, sphincter is the motion of " lax-to shrink-lax " type, is conducive to calculus.Dynamic change taking lithogenic index (LI) and unconjugated bilirubin percentage ratio (UCB%) as index observing gallstone trend.Patient takes relatively LI and all obviously reductions of UCB% of the present invention and matched group and sodium cholate group, and gallstone trend is reversed.In zoopery, becoming stone group gallstone formation rate is 91%, and anti-stone group day feed adds the present invention, and gallstone formation rate is 10%, and LI and UCB% reduce also highly significant simultaneously, show that this medicament has obvious reverse gallstone, has anti-masonry and uses.Though the vigor of the β-G enzyme in liver and bile and bile UCB% be positive correlation obviously, after taking, can obviously suppress the activity of β-G enzyme, thereby in inhibition bile, bilirubin direct is hydrolyzed to unconjugated bilirubin, the process (UCB% reduction) that forms calcium bilirubinate precipitation, this is one of mechanism of anti-stone.Take effect a general course for the treatment of (10 doses), and can effect a radical cure 2-4 the course for the treatment of.Can make Patients with Cholelithiasis discharge calculus, discharge maximum calculus 3 × 1.8cm3, the maximum persons of calculus reach 153, and lithagogue rate is up to 96% left and right.Due to short treating period, greatly reduced the danger of part patient's canceration, institute of the present invention compatibility be all nontoxic crude drug, genuineness, takes safety.Stomach, renal function are had no adverse reaction, and avoid operation painful.
Detailed description of the invention
Further illustrate the present invention below in conjunction with embodiment
Embodiment 1
Choose respectively and meet the HUOXUEDAN that the Pharmacopoeia of the People's Republic of China specifies, Carapax Trionycis, Endothelium Corneum Gigeriae Galli, white Jin root, Stigma Maydis, Herba Lysimachiae and Radix Clematidis are raw material, through screening, clean respectively, dry, pulverize, weigh 20 grams of HUOXUEDAN, 15 grams of Carapax Trionycis, 20 grams of Endothelium Corneum Gigeriae Galli, 20 grams of white Jin roots, 50 grams of Stigma Maydis, 30 grams of Herba Lysimachiaes, and 20 grams of Radix Clematidis, pulverize after mixing, pack powder into high temperature resistant wide-mouth vial sterilization, aseptic packaging, obtains a kind of medicine for the treatment of cholelithiasis gallbladder silt calculus.Be 10 days a course for the treatment of, 1 dose of every day, be decocted in water for oral dose, and point early, middle and late decocting three times, each 300ml (milliliter) left and right.During taking, after patient is taken medicine, one does blood test one time in thoughtful two weeks, without abnormal conditions; Urine, feces are carried out once checking for every two days, without abnormal conditions; To liver, kidney inspection also without abnormal conditions.Carry out the various data such as side effect, toxic reaction, anaphylaxis, secondary response, all without abnormal.Taking medicine after 5 days, patient's calculus situation is checked, check result is: after patient's feces is eluriated, find to contain buff or brown silt stone composition in feces, again by CT examination, find that calculus is loose to tail off, and existed to can not find calculus after 15 days.
Embodiment 2
Choose respectively and meet the HUOXUEDAN that the Pharmacopoeia of the People's Republic of China specifies, Carapax Trionycis, Endothelium Corneum Gigeriae Galli, white Jin root, Stigma Maydis, Herba Lysimachiae and Radix Clematidis are raw material, through screening, clean respectively, dry, pulverize, weigh 15 grams of HUOXUEDAN, 10 grams of Carapax Trionycis, 15 grams of Endothelium Corneum Gigeriae Galli, 15 grams of white Jin roots, 50 grams of Stigma Maydis, 50 grams of Herba Lysimachiaes, and 30 grams of Radix Clematidis, after mixing, pulverize, pack powder into high temperature resistant wide-mouth vial sterilization, mix film-making, aseptic packaging, obtains a kind of medicine for the treatment of cholelithiasis gallbladder silt calculus.Be 10 days a course for the treatment of, 1 dose of every day, be decocted in water for oral dose, and point early, middle and late decocting three times, each 300ml (milliliter) left and right.During taking, after patient is taken medicine, one does blood test one time in thoughtful two weeks, without abnormal conditions; Urine, feces are carried out once checking for every two days, without abnormal conditions; To liver, kidney inspection also without abnormal conditions.Carry out the various data such as side effect, toxic reaction, anaphylaxis, secondary response, all without abnormal.Taking medicine after 4 days, calculus situation to patient checks, check result is: after patient's feces is eluriated, find to contain buff or brown silt stone composition in feces, again by CT examination, find that calculus is loose tail off and exist to can not find calculus after 12 days.
Embodiment 3
Choose respectively and meet the HUOXUEDAN that the Pharmacopoeia of the People's Republic of China specifies, Carapax Trionycis, Endothelium Corneum Gigeriae Galli, white Jin root, Stigma Maydis, Herba Lysimachiae and Radix Clematidis are raw material, through screening, clean respectively, dry, pulverize, weigh 18 grams of HUOXUEDAN, 12 grams of Carapax Trionycis, 18 grams of Endothelium Corneum Gigeriae Galli, 17 grams of white Jin roots, 40 grams of Stigma Maydis, 40 grams of Herba Lysimachiaes, and 25 grams of Radix Clematidis, after mixing, pulverize, pack powder into high temperature resistant wide-mouth vial sterilization, mix film-making, aseptic packaging, obtains a kind of medicine for the treatment of cholelithiasis gallbladder silt calculus.Be 10 days a course for the treatment of, 1 dose of every day, be decocted in water for oral dose, and point early, middle and late decocting three times, each 300ml (milliliter) left and right.During taking, after patient is taken medicine, one does blood test one time in thoughtful two weeks, without abnormal conditions; Urine, feces are carried out once checking for every two days, without abnormal conditions; To liver, kidney inspection also without abnormal conditions.Carry out the various data such as side effect, toxic reaction, anaphylaxis, secondary response, all without abnormal.Taking medicine after 3 days, calculus situation to patient checks, check result is: after patient's feces is eluriated, find to contain buff or brown silt stone composition in feces, again by CT examination, find that calculus is loose tail off and exist to can not find calculus after 10 days.
Embodiment 4
Choose respectively and meet the HUOXUEDAN that the Pharmacopoeia of the People's Republic of China specifies, Carapax Trionycis, Endothelium Corneum Gigeriae Galli, white Jin root, Stigma Maydis, Herba Lysimachiae and Radix Clematidis are raw material, through screening, clean respectively, dry, pulverize, weigh 17 grams of HUOXUEDAN, 13 grams of Carapax Trionycis, 17 grams of Endothelium Corneum Gigeriae Galli, 18 grams of white Jin roots, 40 grams of Stigma Maydis, 40 grams of Herba Lysimachiaes, and 25 grams of Radix Clematidis, pulverize after mixing, pack powder into high temperature resistant wide-mouth vial sterilization, aseptic packaging, obtains a kind of medicine for the treatment of cholelithiasis gallbladder silt calculus.Be 10 days a course for the treatment of, 1 dose of every day, be decocted in water for oral dose, and point early, middle and late decocting three times, each 300ml (milliliter) left and right.During taking, after patient is taken medicine, one does blood test one time in thoughtful two weeks, without abnormal conditions; Urine, feces are carried out once checking for every two days, without abnormal conditions; To liver, kidney inspection also without abnormal conditions.Carry out the various data such as side effect, toxic reaction, anaphylaxis, secondary response, all without abnormal.Taking medicine after 3 days, calculus situation to patient checks, check result is: after patient's feces is eluriated, find to contain buff or brown silt stone composition in feces, again by CT examination, find that calculus is loose tail off and exist to can not find calculus after 11 days.
Embodiment 5
Clinical summary
Sum up object: 200 people, age 30-60 year, wherein women 48 people, male 52 people.
Clinical method: the medicine of the treatment common bile duct silt calculus of the oral embodiment of the present invention 3.Be decocted in water for oral dose 1 dose of every day, early, middle and late decocting three times, about each 300ml (milliliter), be 10 days a course for the treatment of.
Result: be listed below:
Conclusion and therapeutic evaluation:
Claims (1)
1. treat a medicine for cholelithiasis gallbladder silt calculus, it is by HUOXUEDAN 15-20 gram, Carapax Trionycis 10-15 gram, Endothelium Corneum Gigeriae Galli 15-20 gram, white Jin root 15-20 gram, Stigma Maydis 30-50 gram, Herba Lysimachiae 30-50 gram, and Radix Clematidis 20-30 gram proportioning, be prepared from through being pulverized and mixed.
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| CN201310036446.5A CN103961567A (en) | 2013-01-31 | 2013-01-31 | Medicine for treating gall-stone and muddy gall-stone |
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| CN201310036446.5A CN103961567A (en) | 2013-01-31 | 2013-01-31 | Medicine for treating gall-stone and muddy gall-stone |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925474A (en) * | 2019-04-26 | 2019-06-25 | 杭州健亨中医药研究所 | A kind of Chinese medicinal formulae and preparation method thereof for treating liver and bile stone |
| CN115671131A (en) * | 2022-12-01 | 2023-02-03 | 广东药科大学 | Application of trifoliate acanthopanax polysaccharide in preparation of medicine for treating hyperuricemia |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106276A (en) * | 1994-07-08 | 1995-08-09 | 淮南矿务局第一矿工医院 | Compound oral liquor for killing gallbladder pain |
| CN1204520A (en) * | 1997-07-08 | 1999-01-13 | 贾书红 | Medicine for treatment of lithiasis |
| CN101607067A (en) * | 2009-07-23 | 2009-12-23 | 袁玲玲 | A kind of Chinese medicine preparation and preparation method for the treatment of cholelithiasis |
-
2013
- 2013-01-31 CN CN201310036446.5A patent/CN103961567A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1106276A (en) * | 1994-07-08 | 1995-08-09 | 淮南矿务局第一矿工医院 | Compound oral liquor for killing gallbladder pain |
| CN1204520A (en) * | 1997-07-08 | 1999-01-13 | 贾书红 | Medicine for treatment of lithiasis |
| CN101607067A (en) * | 2009-07-23 | 2009-12-23 | 袁玲玲 | A kind of Chinese medicine preparation and preparation method for the treatment of cholelithiasis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109925474A (en) * | 2019-04-26 | 2019-06-25 | 杭州健亨中医药研究所 | A kind of Chinese medicinal formulae and preparation method thereof for treating liver and bile stone |
| CN115671131A (en) * | 2022-12-01 | 2023-02-03 | 广东药科大学 | Application of trifoliate acanthopanax polysaccharide in preparation of medicine for treating hyperuricemia |
| CN115671131B (en) * | 2022-12-01 | 2023-05-23 | 广东药科大学 | Application of acanthus trifoliatus polysaccharide in preparing medicine for treating hyperuricemia |
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Application publication date: 20140806 |