CN104257995A - External application patch for treating traumatic injuries and preparation method thereof - Google Patents

External application patch for treating traumatic injuries and preparation method thereof Download PDF

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Publication number
CN104257995A
CN104257995A CN201410567986.0A CN201410567986A CN104257995A CN 104257995 A CN104257995 A CN 104257995A CN 201410567986 A CN201410567986 A CN 201410567986A CN 104257995 A CN104257995 A CN 104257995A
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parts
radix
preparation
application agent
external plaster
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张相才
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32—Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/32—Burseraceae (Frankincense family)
    • A61K36/324—Boswellia, e.g. frankincense
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/51—Gentianaceae (Gentian family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization

Abstract

The invention discloses an external application patch for treating traumatic injuries. The preparation method of the external application patch is prepared from the following main raw materials in parts by weight: 8-18 parts of dinodon rufozonatum, 6-12 parts of radix et rhizoma veratri, 6-12 parts of frankincense, 9-15 parts of radix angelicae pubescentis, 3-6 parts of pyritum, 5-10 parts of radix chloranthi serrate, 6-10 parts of marasmius androsaceus, 5-12 parts of dog's bone, 9-15 parts of radix gentianae macrophyllae and 6-9 parts of beaumontia grandiflora. The external application patch is based on the principle that the traumatic injuries are treated with traditional chinese medicines, an external application preparation is adopted, and drugs are enabled to directly act on parts with traumatic injuries through local permeation of the drugs, so that active ingredients of the drugs are directly sent to focus parts to have a good treatment effect on the traumatic injuries.

Description

A kind of external plaster application agent and preparation method for the treatment of traumatic injury
Technical field
The present invention relates to traditional Chinese medicine field, especially relate to a kind of external plaster application agent and preparation method for the treatment of traumatic injury.
Background technology
Traumatic injury refers to and stands direct wound, or the tissue of wound and long-term strain indirectly, has occurred microcirculation disturbance.Due to capillary wall sepage or hemorrhage, cause the formation of the hypostasis thing of tissue, and there occurs aseptic inflammation, cause swollen tissue pain.If the absorption of hypostasis thing can not be impelled, adhesion will be produced.Can there is ischemic contracture in the adhesion of muscle, tendon, the adhesion outside intraarticular just causes the tetanic of joint.Therefore strengthening the gastric qi of patient, improve gasification function, is the key point for the treatment of traumatic injury.Traumatic injury comprises weapons, tumbling down, hits, sprain and contusion, stab, abrade, athletic injury etc., there are pain, swelling, hemorrhage or fracture, dislocation etc. in injury more, also comprises some visceral injuries.Traumatic injury is divided into again closure traumatic injury and open traumatic injury.So-called closure traumatic injury briefly, in other words after wound, local skin or mucosa complete, communicate with the external world without breach, hemorrhage during damage accumulates in tissue.Closure traumatic injury is a type of soft tissue injury, mainly based on soft tissue injury.
Sprain and refer to that indirect violence makes limbs and periarticular fascia, muscle, ligament excessive distortion, tractive, cause damage or tear.Mostly occur at joint and periarticular tissue.Contusion refers to that direct violence hits or collide limbs local, causes this place's subcutaneous tissue, muscle, tendon equivalent damage.Neck, shoulder, elbow, wrist, refer between, wrist, knee joint, stamp, the position such as waist all can cause bruise.Traumatic injury the lighter injures skin, more than fully recovering in a short time; Severe one is injured in the sinews or bones, and wound surface pollutes, or Massive Bleeding, and causes deficiency of blood and decline of QI, even injures internal organs, critically ill.
If traumatic injury just occurs, just wash with medicine at once and control, affected part blood vessel will aggravate expansion, and oozing of blood, edema also can increase the weight of thereupon, not only can cause soft tissue adhesion and local miopragia, but also very easily strengthen pain.Therefore, after damaging, cold compress should be adopted immediately, affected part vasoconstriction can be made like this and reduce hemorrhage, edema and pain.After the three or four day of damage, adopt the external application of pseudo-ginseng blood-circulation-invigovating cream to wash again, be used in conjunction several days, just can reach the effect of blood circulation promoting and blood stasis dispelling, alleviating pain and detumescence.People when spraining extremity, the rotation usually can can't help or massage, but many times at random twisting will make the position exacerbation of symptoms of damage, especially before not carrying out definite diagnosis, more should the careless activity position of having sprained.If extremity, wrist be improved, raise, allow his blood flow can be unimpeded.Correct method is such: if fracture of upper arm is preferably placed on arm on the position with heart level, if lower limb then will lift to lower limb the position of more than knee level.
In the method for existing Chinese traditional treatment traumatic injury, publication number CN102258689 A(application number 201010186472.2) patent discloses a kind of traumatic injury showy reiolaena root-bark, face is prepared by weight by Chinese herbal medicine, concrete scheme is: Herba Chloranthi Henryi (Herba Choranthi seu Lysimachiae) 5-40 part, Radix Aconiti Brachypodi (Radix Aconiti Szechenyiani) 2.5-20 part, Cortex Ampelopsis Aconitifoliae Radicis 5-40 part, HEIQIANNIU 4-30 part, Rhizoma Chuanxiong 5-40 part, Radix seu Caulis Schisandrae Sinensis 5-40 part, Caulis Sargentodoxae 5-40 part, Helwingia himalaica 5-40 part, Herba Ainsliaea Albotomentosae 5-30 part, RADIX PSAMMOSILENE 5-40 part, Os Draconis 5-40 part, Pyritum 5-40 part.Publication number CN 102302752 A(application number 201110241852.6) patent discloses a kind of plaster for treating traumatic injuries, it is made up of following Chinese herbal medicine component: Radix Notoginseng 6-9 gram, Rhizoma Zingiberis 6-9 gram, Rhizoma Et Radix Notopterygii 6-9 gram, Bombyx Batryticatus 6-9 gram, Radix Saposhnikoviae 6-9 gram, Radix Aconiti 10-14 gram, Radix Aconiti Kusnezoffii 10-14 gram, Scolopendra 2-4 gram, Rhizoma Sparganii 6-9 gram, Rhizoma Curcumae 6-9 gram, Flos Carthami 6-9 gram, Semen Persicae 6-9 gram, Rhizoma Alpiniae Officinarum 6-9 gram, Rhizoma Drynariae 6-9 gram, Radix Paeoniae Rubra 6-9 gram, Semen Ricini 6-9 gram, Rhizoma Curcumae Longae 6-8 gram; Semen Strychni liquid medicine 10-14 gram; Squama Manis 6-9 gram, Fructus Caryophylli 6-9 gram, Cortex Cinnamomi 6-9 gram, Borneolum Syntheticum 6-9 gram, Olibanum 6-9 gram, Moschus 1-3 gram.Publication number CN 102949648 A(application number 201110246697.7) patent discloses a kind of Chinese medicine for the treatment of traumatic injury, be made up of the Chinese medicine of following weight portion: Flos Campsis 50 parts, Herba Artemisiae Anomalae 50 parts, Myrrha 30 parts, Radix Sanguisorbae 40 parts, Soviet Union's art 50 parts, Flos Caryophylli 60 parts, Rhizoma Alpiniae Officinarum 60 parts, Cortex Acanthopancis 30 parts, Radix Notoginseng 100 parts, Radix Achyranthis Bidentatae 40 parts, Fructus Chebulae 60 parts, Sanguis Draxonis 20 parts, Rhizoma Polygoni Paleachi 30 parts, Eupolyphaga Seu Steleophaga 30 parts, Rhizoma Chuanxiong 30 parts, Herba Erodii 40 parts, Rhizoma Drynariae 60 parts, the Radix Aucklandiae 60 parts, Radix Ilicis Pubescentis 30 parts, Fructus Foeniculi 20 parts, the Cortex Eucommiae 30 parts, Herba Lycopi 20 parts, Radix Dipsaci 30 parts, Radix Angelicae Sinensis 30 parts, Pericarpium Granati 60 parts, 100 parts, Flos Carthami, Stigma Croci 10 parts, Fructus Piperis Longi 60 parts, Fructus Psoraleae 30 parts, 30 parts, Semen Persicae, Olibanum 30 parts, Fructus Liquidambaris 40 parts, Pyritum 20 parts, Borneolum Syntheticum 20 parts, 100 parts, Radix Glycyrrhizae, 30 parts, catechu, 20 parts, Cinnabaris, Caulis Piperis Kadsurae 40 parts, the Rhizoma Atractylodis Macrocephalae 30 parts, Herba Taxilli 30 parts, Radix Et Rhizoma Rhei 20 parts, Herba Gendarussae (Caulis et Folium Gendarussae vulgaris) 70 parts, Rubus Parvifolius L. 60 parts, Folium Et Cacumen Murrayae 70 parts, Cortex Magnoliae Officinalis 60 parts, kadsura root 70 parts.
Summary of the invention
An object of the present invention is to provide a kind of external plaster application agent for the treatment of traumatic injury, and it adopts Chinese crude drug comparatively common in the localities as raw material, with low cost.Another object is just to provide the preparation method of above-mentioned external plaster application agent.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
Treat an external plaster application agent for traumatic injury, take off the primary raw material stating weight proportion and be prepared from: Dinodon rufozonatum (Cantor) 8-18 part; Seven lis of red 6-12 parts; Olibanum 6-12 part; Radix Angelicae Pubescentis 9-15 part; Pyritum 3-6 part; Radix Chloranthi Serrati 5-10 part; Marasmius equicrinis Muell. 6-10 part; Os Canitis 5-12 part; Radix Gentianae Macrophyllae 9-15 part; Radix Beaumontiae Grandiflorae 6-9 part.
Treat an external plaster application agent for traumatic injury, preferred scheme is, takes off the primary raw material stating weight proportion and is prepared from: Dinodon rufozonatum (Cantor) 11-15 part; Seven lis of red 8-10 parts; Olibanum 8-10 part; Radix Angelicae Pubescentis 11-13 part; Pyritum 4-5 part; Radix Chloranthi Serrati 6-9 part; Marasmius equicrinis Muell. 7-9 part; Os Canitis 7-10 part; Radix Gentianae Macrophyllae 11-13 part; Radix Beaumontiae Grandiflorae 7-8 part.
Treat an external plaster application agent for traumatic injury, the scheme be more preferably is, takes off the primary raw material stating weight proportion and is prepared from: Dinodon rufozonatum (Cantor) 13 parts; Seven lis of pellets 9 parts; Olibanum 9 parts; Radix Angelicae Pubescentis 12 parts; Pyritum 4.5 parts; Radix Chloranthi Serrati 8 parts; Marasmius equicrinis Muell. 8 parts; Os Canitis 9 parts; Radix Gentianae Macrophyllae 12 parts; Radix Beaumontiae Grandiflorae 7.5 parts.
The preparation method of above-mentioned external plaster application agent, step is as follows:
(1) Dinodon rufozonatum (Cantor) is killed, remove head, tail, skin and internal organs, trunk part clear water is cleaned, is placed in meat grinder and rubs, by the Carnis Serpentis defibrination after rubbing, adopt centrifugal spray dryer to carry out drying, grind as smalls, cross 140-180 mesh sieve;
(2) seven lis of pellets, Radix Angelicae Pubescentis, Radix Chloranthi Serrati, Radix Gentianae Macrophyllae and Radix Beaumontiae Grandiflorae are cut into the lamellar of thick 2-4mm, are placed in glass container, soak 1-2 days;
(3) smashed by Pyritum, be placed in marmite, add water, after intense fire is fried open, fire of larding speech with literary allusions boils 40-60 minute, and Marasmius equicrinis Muell. is placed in gauze bag, puts into marmite, adds step (2) gains simultaneously, decocts 20-40 minute, filters;
(4) added by ethanol in step (3) gained filtrate, leave standstill 3-5 hour, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.2-1.4 at 45 DEG C;
(5) Os Canitis and Olibanum are ground into smalls, cross 120-160 mesh sieve, powder and step (1) gains are joined in the thick paste of step (4) gained, mix homogeneously, makes external plaster application agent.
The preparation method of above-mentioned external plaster application agent, preferred scheme is: the preferred 20-40 μm of step (1) defibrination fineness, is more preferably 30 μm.
The preparation method of above-mentioned external plaster application agent, preferred scheme is: inlet temperature preferred 190-220 DEG C when step (1) is dry, is more preferably 210 DEG C; The preferred 80-90 DEG C of leaving air temp, is more preferably 85 DEG C.
The preparation method of above-mentioned external plaster application agent, preferred scheme is: step (1) is preferred crosses 150-170 mesh sieve, is more preferably 160 mesh sieves.
The preparation method of above-mentioned external plaster application agent, preferred scheme is: step (2) is preferably cut into the lamellar of thick 2.5-3.5mm, is more preferably 3mm.
The preparation method of above-mentioned external plaster application agent, preferred scheme is: step (4) is preferably condensed into the thick paste that relative density is 1.25-1.35, is more preferably and is condensed into the thick paste that relative density is 1.3.
The preparation method of above-mentioned external plaster application agent, preferred scheme is: step (5) is preferred crosses 130-150 mesh sieve, is more preferably 140 mesh sieves.
using method: for making the present invention reach optimum therapeuticing effect, being cleaned by sore place and drying, directly this product being affixed on affected part, often paste and use 8-15 hour, every other day using one to paste, 4 days is a course for the treatment of.
The pharmacological effect of each crude drug is respectively:
Dinodon rufozonatum (Cantor): sweet in the mouth, warm in nature.GUIXIN, spleen channel.For the reptile that Colubridae chain Serpentis belongs to, there is wind-damp dispelling, pain relieving, effect of removing toxic substances sore.For rheumatic arthritis, overall pain, tuberculous lymphadenitis, chronic fistula, ulcer, scabies.
Seven lis of pellets: acrid in the mouth, hardship, cold in nature.For rhizome and the root of the black purple Rhizoma et radix veratri (Radix Rhizoma Veratri) of liliaceous plant.There is effect of inducing vomiting, dissipating blood stasis, pain relieving, parasite killing.Sheng, traumatic injury congestive edema, scabies is gushed for apoplexy, demented sputum.
Olibanum: acrid in the mouth, hardship, warm in nature.Enter the heart, liver, spleen channel.For the gum resin of olive subject plant Boswellia carterii Birdw.Resinous 60-70%, gummy 27%-35%, volatile oil 3%-8%.The main component of resin is free α, β-boswellic acid 33%, in conjunction with boswellic acid 1.5%, and olibanoresene 33%.Natural gum is calcium salt and the magnesium salt 20% of arabitic acid, bassorin 6%; In addition, still containing amaroid 0.5%.Have and invigorate blood circulation, circulation of qi promoting, effect of pain relieving.For the epigastric pain of the stasis blocking stagnation of QI, rheumatic arthralgia, traumatic injury, dysmenorrhea, puerperal abdonimal pain.
Radix Angelicae Pubescentis: acrid in the mouth, hardship, slightly warm in nature.Return kidney, urinary bladder channel.For the dry root of samphire Angelica pubescens.There is expelling wind and removing dampness, effect of numbness relieving and pain relieving.For anemofrigid-damp arthralgia, lumbocrural pain, few cloudy volt wind headache.
Pyritum: acrid in the mouth, property is put down.Return Liver Channel.For sulfide-based mineral yellow iron mine race pyrite.Main containing ferrous disulfide (FeS 2).There is dissipating blood stasis, synthetism, effect of pain relieving.Flutter for jumping and swell and ache, traumatic injury, tendon breaking is fractured, and blood stasis pain, gathers, goiter, skin infection, scalds.
Radix Chloranthi Serrati: bitter in the mouth, property is put down.For the root of golden Li Lanke gold chestnut epidendrum Radix Chloranthi Serrati.Root contains dihydro burnt Rhizoma Curcumae furan ketenes, cowherb Rhizoma Atractylodis Macrocephalae furan ketenes, chloranthalactone E, F, new acorone, the new acorone of 7-a-hydroxyl, acorone, Rhizoma Curcumae furan ether ketone, different Rhizoma Curcumae furanodiene etc.There is promoting blood circulation to remove blood stasis, wind-expelling pain-stopping, effect of removing toxic substances parasite killing.For traumatic injury, fracture, amenorrhea, rheumatic arthralgia, furuncle furuncle and phyma, scabies, skin pruritus, venom.
Marasmius equicrinis Muell.: mildly bitter flavor, warm in nature.For the shoestring of Bai Mo section Marasmius fungus Marasmius androsaceus (L.ex Fr.) Fr..There is effect of promoting blood circulation and stopping pain, can promote that the inflammation of nervous tissue and fibrous connective tissue disappears, improve local blood circulation and histotrophic nutrition situation, recover function of nervous system.For traumatic injury, fracture pain.
Os Canitis: sweet in the mouth, salty, warm in nature.For the skeleton of Canidae Canis animal kennel.Fresh bone about contains: moisture 50%, fat 16%, ossein 12%, inorganic matter 22%, mainly calcium phosphate and calcium carbonate in inorganic matter.There is invigorating the kidney and strengthening the bones, wind-expelling pain-stopping, hemostasis and dysentery-stopping, effect of expelling pus and promoting granulation.For Fengshi Guanjie pain, waist skelasthenia, numb limbs and tense tendons, bleeding not during menses, chronic dysentery is more than, traumatic hemorrhage, children's's infantile metopism, carbuncle skin ulcer fistula, chilblain.
Radix Gentianae Macrophyllae: acrid in the mouth, hardship, property is put down.Return stomach, liver, gallbladder meridian.For the dry root of gentianaceae plant Radix Gentianae Macrophyllae, gentiana straminea maxim, gentiana crassicaulis Duthie or Gentiana dahurica.There is wind-damp dispelling, clearing away damp-heat, effect of stopping numbness pain.For rheumatic arthralgia, the contracture of muscle arteries and veins, joint is ached, and day feeds hectic fever, and infantile malnutrition generates heat.
Radix Beaumontiae Grandiflorae: taste is micro-pungent, numb, warm in nature.For root, the leaf of Apocynaceae clear and bright flower plant flower in Clear and Bright.Book on Chinese herbal medicine contains Digitoxin, scopolin, benzyl-8-β-D-pyranglucoside, kaempferol-3-O-β-D-pyranglucoside etc.There is expelling wind and removing dampness, removing blood stasis and activating blood flow, effect of synthetism.For fracture, traumatic injury, lumbago, skelalgia of rheumatism, lumbar muscle strain, rheumatic arthritis.
External plaster application agent of the present invention is based on the principle of Chinese traditional treatment traumatic injury, and the medical material selected is more common, cheap and easy to operate.Fabulous therapeutical effect is had to traumatic injury, adopt externally applied formulation, by the local penetration of medicine, medicine is made to be applied directly to the position of traumatic injury, thus the effective ingredient of medicine is directly sent to lesions position, avoid the drug effect of oral medicine faint and larger side effect is caused to health, eliminate damage quickly, be applied on human body and reach optimum therapeuticing effect.Treatment cycle is short, misery less, expense is low, can recover substantially completely after therapy rehabilitation ill before life.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
embodiment 1treat an external plaster application agent for traumatic injury, take off and state primary raw material and be prepared from (getting 30g for every part): Dinodon rufozonatum (Cantor) 8 parts; Seven lis of pellets 6 parts; Olibanum 6 parts; Radix Angelicae Pubescentis 9 parts; Pyritum 3 parts; Radix Chloranthi Serrati 5 parts; Marasmius equicrinis Muell. 6 parts; Os Canitis 5 parts; Radix Gentianae Macrophyllae 9 parts; Radix Beaumontiae Grandiflorae 6 parts.
A kind of external plaster application agent preparation process for the treatment of traumatic injury is as follows:
(1) Dinodon rufozonatum (Cantor) is killed, remove head, tail, skin and internal organs, trunk part clear water is cleaned, is placed in meat grinder and rubs, by the Carnis Serpentis defibrination after rubbing, adopt centrifugal spray dryer to carry out drying, grind as smalls, cross 140 mesh sieves;
(2) seven lis of pellets, Radix Angelicae Pubescentis, Radix Chloranthi Serrati, Radix Gentianae Macrophyllae and Radix Beaumontiae Grandiflorae are cut into the lamellar of thick 2mm, are placed in glass container, soak 1 day;
(3) smashed by Pyritum, be placed in marmite, add water, after intense fire is fried open, fire of larding speech with literary allusions boils 40 minutes, and Marasmius equicrinis Muell. is placed in gauze bag, puts into marmite, adds step (2) gains simultaneously, decocts 20 minutes, filters;
(4) added by ethanol in step (3) gained filtrate, leave standstill 3 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.2 at 45 DEG C;
(5) Os Canitis and Olibanum are ground into smalls, cross 120 mesh sieves, powder and step (1) gains are joined in the thick paste of step (4) gained, mix homogeneously, makes external plaster application agent.
Using method: cleaned by sore place and dry, directly this product is affixed on affected part, often paste use 8 hours, every other day using one to paste, 4 days is a course for the treatment of.
model case onekorea Spro XX, female, 43 years old, people from Shuangpai County of Hunan Province.Because carrying a bundle bavin under the Gao Po of more than 7 meters slips and falls, lose consciousness 2 hours, whole body can not move, Ji Song county people's hospital treats, right rib seven to eight comminuted fracture, lower left quarter pelvis and ischium upper and lower comminuted fracture 2 place is diagnosed through X sheet, whole body can not move, and private prosecution hurt like hell, sound is without cease.Diagnosis: blue, the right rib of entire patient's number place blood stasis swelling seven to eight side rednesses are blue, qi depression to blood stasis.Left pelvis and ischium place redness blue, blood stasis does not fall apart.
After being affectedly bashful reset, use the external plaster application agent of embodiment 1 gained treatment traumatic injury to apply affected part treatment, about 1 course for the treatment of of medication, see that patient feels at ease to sleep soundly, do not hear ow, all take a turn for the better.Sit up voluntarily as seen after 3 courses for the treatment of, red and swollen blood stasis disperses a greater part of on inspection, painless.Can stand voluntarily during 4 courses for the treatment of, but can't walking, tenderness kowtows pain, and red and swollen blood stasis disperses, and singly can turn and progressively practise walking voluntarily time about 5 courses for the treatment of.Without all untoward reaction during medication.
embodiment 2treat an external plaster application agent for traumatic injury, take off and state primary raw material and be prepared from (getting 20g for every part): Dinodon rufozonatum (Cantor) 18 parts; Seven lis of pellets 12 parts; Olibanum 12 parts; Radix Angelicae Pubescentis 15 parts; Pyritum 6 parts; Radix Chloranthi Serrati 10 parts; Marasmius equicrinis Muell. 10 parts; Os Canitis 12 parts; Radix Gentianae Macrophyllae 15 parts; Radix Beaumontiae Grandiflorae 9 parts.
A kind of external plaster application agent preparation process for the treatment of traumatic injury is as follows:
(1) Dinodon rufozonatum (Cantor) is killed, remove head, tail, skin and internal organs, trunk part clear water is cleaned, is placed in meat grinder and rubs, by the Carnis Serpentis defibrination after rubbing, adopt centrifugal spray dryer to carry out drying, grind as smalls, cross 180 mesh sieves;
(2) seven lis of pellets, Radix Angelicae Pubescentis, Radix Chloranthi Serrati, Radix Gentianae Macrophyllae and Radix Beaumontiae Grandiflorae are cut into the lamellar of thick 4mm, are placed in glass container, soak 2 days;
(3) smashed by Pyritum, be placed in marmite, add water, after intense fire is fried open, fire of larding speech with literary allusions boils 60 minutes, and Marasmius equicrinis Muell. is placed in gauze bag, puts into marmite, adds step (2) gains simultaneously, decocts 40 minutes, filters;
(4) added by ethanol in step (3) gained filtrate, leave standstill 5 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.4 at 45 DEG C;
(5) Os Canitis and Olibanum are ground into smalls, cross 160 mesh sieves, powder and step (1) gains are joined in the thick paste of step (4) gained, mix homogeneously, makes external plaster application agent.
Using method: cleaned by sore place and dry, directly this product is affixed on affected part, often paste use 15 hours, every other day using one to paste, 4 days is a course for the treatment of.
model case twoland XX, female, 45 years old, peasant's (rural area is without phone), because traffic accident causes left foot condyle injured, hurt like hell, namely moving difficulty sends into the treatment of this county people's hospital, through the diagnosis of X sheet, without fracture, hospitalize one week, but misery alleviates to some extent, blood stasis swelling is not obviously disappeared, and action also has obstacle, hospital side to prove that healing can be left hospital, leave hospital more than 20 day rear or handicapped.
Heard that the present invention treated the curative effect of external plaster application agent to traumatic injury of traumatic injury afterwards fine, so determine the external plaster application agent using embodiment 2 gained treatment traumatic injury, the drug of topical application is after 24 hours, all take a turn for the better, when changing dressings, blood stasis swelling is disappeared a greater part of, when using 1 course for the treatment of, action is basic recovers, without obviously keenly feeling.Substantially cure during 2 courses for the treatment of, can take part in the work.Without all untoward reaction during medication, not by any other medicine auxiliary treatment.
embodiment 3treat an external plaster application agent for traumatic injury, take off and state primary raw material and be prepared from (getting 50g for every part): Dinodon rufozonatum (Cantor) 11 parts; Seven lis of pellets 8 parts; Olibanum 8 parts; Radix Angelicae Pubescentis 11 parts; Pyritum 4 parts; Radix Chloranthi Serrati 6 parts; Marasmius equicrinis Muell. 7 parts; Os Canitis 7 parts; Radix Gentianae Macrophyllae 11 parts; Radix Beaumontiae Grandiflorae 7 parts.
A kind of external plaster application agent preparation process for the treatment of traumatic injury is as follows:
(1) Dinodon rufozonatum (Cantor) is killed, remove head, tail, skin and internal organs, trunk part clear water is cleaned, is placed in meat grinder and rubs, by the Carnis Serpentis defibrination after rubbing, adopt centrifugal spray dryer to carry out drying, grind as smalls, cross 150 mesh sieves;
(2) seven lis of pellets, Radix Angelicae Pubescentis, Radix Chloranthi Serrati, Radix Gentianae Macrophyllae and Radix Beaumontiae Grandiflorae are cut into the lamellar of thick 2.5mm, are placed in glass container, soak 1 day;
(3) smashed by Pyritum, be placed in marmite, add water, after intense fire is fried open, fire of larding speech with literary allusions boils 45 minutes, and Marasmius equicrinis Muell. is placed in gauze bag, puts into marmite, adds step (2) gains simultaneously, decocts 25 minutes, filters;
(4) added by ethanol in step (3) gained filtrate, leave standstill 3.5 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.25 at 45 DEG C;
(5) Os Canitis and Olibanum are ground into smalls, cross 130 mesh sieves, powder and step (1) gains are joined in the thick paste of step (4) gained, mix homogeneously, makes external plaster application agent.
Using method: cleaned by sore place and dry, directly this product is affixed on affected part, often paste use 10 hours, every other day using one to paste, 4 days is a course for the treatment of.
embodiment 4treat an external plaster application agent for traumatic injury, take off and state primary raw material and be prepared from (getting 20g for every part): Dinodon rufozonatum (Cantor) 15 parts; Seven lis of pellets 10 parts; Olibanum 10 parts; Radix Angelicae Pubescentis 13 parts; Pyritum 5 parts; Radix Chloranthi Serrati 9 parts; Marasmius equicrinis Muell. 9 parts; Os Canitis 10 parts; Radix Gentianae Macrophyllae 13 parts; Radix Beaumontiae Grandiflorae 8 parts.
A kind of external plaster application agent preparation process for the treatment of traumatic injury is as follows:
(1) Dinodon rufozonatum (Cantor) is killed, remove head, tail, skin and internal organs, trunk part clear water is cleaned, is placed in meat grinder and rubs, by the Carnis Serpentis defibrination after rubbing, adopt centrifugal spray dryer to carry out drying, grind as smalls, cross 170 mesh sieves;
(2) seven lis of pellets, Radix Angelicae Pubescentis, Radix Chloranthi Serrati, Radix Gentianae Macrophyllae and Radix Beaumontiae Grandiflorae are cut into the lamellar of thick 3.5mm, are placed in glass container, soak 2 days;
(3) smashed by Pyritum, be placed in marmite, add water, after intense fire is fried open, fire of larding speech with literary allusions boils 55 minutes, and Marasmius equicrinis Muell. is placed in gauze bag, puts into marmite, adds step (2) gains simultaneously, decocts 35 minutes, filters;
(4) added by ethanol in step (3) gained filtrate, leave standstill 4.5 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.35 at 45 DEG C;
(5) Os Canitis and Olibanum are ground into smalls, cross 150 mesh sieves, powder and step (1) gains are joined in the thick paste of step (4) gained, mix homogeneously, makes external plaster application agent.
Using method: cleaned by sore place and dry, directly this product is affixed on affected part, often paste use 10 hours, every other day using one to paste, 4 days is a course for the treatment of.
model case threesoviet Union XX, man, 41 years old, Rizhao City, Shandong Province from Donggang District.Because external force is caused injury left lower limb condyle bony site, red and swollen blue, left lower limb can not move, hurt like hell, and head two place is by wound, and bleed too much, amount of bleeding reaches about 1 kilogram, and dizziness can not be walked.Ji Song county people's hospital treats, and patients head meets line two place, and on left eye angle, line one place is met at eyebrow place, and it is blue that eyes were puffy and red, eyeball is covered with red blood streak, and whole body number place is red and swollen, and left foot condyle bone place redness is blue, process in hospital, still without positive effect after 6 days, have number place blood stasis.
When using 2 courses for the treatment of of external plaster application agent of embodiment 4 gained treatment traumatic injury, see patient eyes were puffy and red and eliminate a greater part of, eyeball red blood streak disperses substantially, and whole body is painless, and spirit takes a favorable turn.Use again 1 course for the treatment of of external plaster application agent of embodiment 4 gained treatment traumatic injury, eyes were puffy and red, and the blood streak disperses, and the basic red and swollen blood stasis of left foot condyle bony site disperses, and voluntarily on foot, but can also have distending pain sense during walking, and tenderness kowtows pain.After adhering to again 1 course for the treatment of of use, basic clinical cure, all recover as front, clinical recovery.Without all untoward reaction during medication, do not use other drug auxiliary treatment.
embodiment 5treat an external plaster application agent for traumatic injury, take off and state primary raw material and be prepared from (getting 10g for every part): Dinodon rufozonatum (Cantor) 13 parts; Seven lis of pellets 9 parts; Olibanum 9 parts; Radix Angelicae Pubescentis 12 parts; Pyritum 4.5 parts; Radix Chloranthi Serrati 8 parts; Marasmius equicrinis Muell. 8 parts; Os Canitis 9 parts; Radix Gentianae Macrophyllae 12 parts; Radix Beaumontiae Grandiflorae 7.5 parts.
A kind of external plaster application agent preparation process for the treatment of traumatic injury is as follows:
(1) Dinodon rufozonatum (Cantor) is killed, remove head, tail, skin and internal organs, trunk part clear water is cleaned, is placed in meat grinder and rubs, by the Carnis Serpentis defibrination after rubbing, adopt centrifugal spray dryer to carry out drying, grind as smalls, cross 160 mesh sieves;
(2) seven lis of pellets, Radix Angelicae Pubescentis, Radix Chloranthi Serrati, Radix Gentianae Macrophyllae and Radix Beaumontiae Grandiflorae are cut into the lamellar of thick 3mm, are placed in glass container, soak 2 days;
(3) smashed by Pyritum, be placed in marmite, add water, after intense fire is fried open, fire of larding speech with literary allusions boils 50 minutes, and Marasmius equicrinis Muell. is placed in gauze bag, puts into marmite, adds step (2) gains simultaneously, decocts 30 minutes, filters;
(4) added by ethanol in step (3) gained filtrate, leave standstill 4 hours, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.3 at 45 DEG C;
(5) Os Canitis and Olibanum are ground into smalls, cross 140 mesh sieves, powder and step (1) gains are joined in the thick paste of step (4) gained, mix homogeneously, makes external plaster application agent.
Using method: cleaned by sore place and dry, directly this product is affixed on affected part, often paste use 13 hours, every other day using one to paste, 4 days is a course for the treatment of.
test example: the clinical practice of the external plaster application agent of embodiment 5 gained treatment traumatic injury: in October ,-2012 in June, 2010, screen 250 routine patients in Duo Suo hospital, wherein women 97 example, male 153 example, max age 79 years old, minimal ages 9 years old.Be divided into experimental group and matched group two groups (wherein experimental group has 150 people, and matched group has 100 people) at random.Experimental group uses the external plaster application agent of embodiment 5 gained treatment traumatic injury, and using method is: cleaned by sore place and dry, directly this product is affixed on affected part, often paste use 12 hours, and every other day using one to paste, 4 days is a course for the treatment of.Matched group uses other medicine (as medicine powder for traumatic injury etc.), oral, one time 1 bag, 2 times on the one.Curative effect situation criterion: cure: the transference cures such as traumatic injury position congestion, malaise symptoms disappears completely.Effective: the symptoms such as traumatic injury position congestion alleviate or partial disappearance, and malaise symptoms is eased.Invalid: the various malaise symptoms such as traumatic injury is unchanged.Result is as shown in the table:
Table 1
therapeutic effect: healing 123 people using the external plaster application agent of embodiment 5 gained treatment traumatic injury, cure rate is up to 82%, and effective 25 people, effective percentage 16.67%, invalid 2 people, total effective rate reaches 98.67%.And using healing 38 people of other products, cure rate only reaches 38%, effective 47 people, and invalid number is but up to 15 people, and inefficiency reaches 15%, effective percentage only 85%.Can find out: use the successful of the external plaster application agent of embodiment 5 gained treatment traumatic injury to be better than using the effect of other products.
Table 2
As apparent from table 2 can: use ratio that each symptom of the experimental group of the external plaster application agent of embodiment 5 gained treatment traumatic injury is eased apparently higher than the matched group using other medicine, and after 3 courses for the treatment of, each remission rate of experimental group all reaches more than 94%, can conclude that this external plaster application agent has better curative effect to traumatic injury.
External plaster application agent traumatic injury of the present invention has significant curative effect, compared with the medicine for the treatment of traumatic injury with other, side effect is little, and batching is all choose more common medical material, cheap, ordinary people can life-time service, and the pain not only decreased on health also reduces pecuniary burden.Use 1 course for the treatment of, more than 49% feel takes a turn for the better to some extent; Use 2 courses for the treatment of, more than 78% feel takes a turn for the better to some extent, and malaise symptoms improves or disappears, and the symptoms such as congestion are largely improved; Use 3 courses for the treatment of, more than 94% feel takes a turn for the better to some extent, and malaise symptoms disappears substantially, and all malaise symptoms disappear, most of patient's self-induction recovery from illness, when 3 courses for the treatment of of use matched group only have the patient of 78% to feel each symptom is eased.
Finally it should be noted that, embodiment is the detailed description of the invention of optimum of the present invention, be not limited to the present invention, although with reference to previous embodiment to invention has been detailed description, for a person skilled in the art, it still can be modified to the technical scheme described in foregoing embodiments, or carries out equivalent replacement to wherein portion of techniques feature.Within the spirit and principles in the present invention all, any amendment done, equivalent replacement, improvement etc., all should be included within protection scope of the present invention.

Claims (10)

1. treat an external plaster application agent for traumatic injury, it is characterized in that, take off the primary raw material stating weight proportion and be prepared from: Dinodon rufozonatum (Cantor) 8-18 part; Seven lis of red 6-12 parts; Olibanum 6-12 part; Radix Angelicae Pubescentis 9-15 part; Pyritum 3-6 part; Radix Chloranthi Serrati 5-10 part; Marasmius equicrinis Muell. 6-10 part; Os Canitis 5-12 part; Radix Gentianae Macrophyllae 9-15 part; Radix Beaumontiae Grandiflorae 6-9 part.
2. external plaster application agent according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Dinodon rufozonatum (Cantor) 11-15 part; Seven lis of red 8-10 parts; Olibanum 8-10 part; Radix Angelicae Pubescentis 11-13 part; Pyritum 4-5 part; Radix Chloranthi Serrati 6-9 part; Marasmius equicrinis Muell. 7-9 part; Os Canitis 7-10 part; Radix Gentianae Macrophyllae 11-13 part; Radix Beaumontiae Grandiflorae 7-8 part.
3. external plaster application agent according to claim 1, is characterized in that, takes off the primary raw material stating weight proportion and is prepared from: Dinodon rufozonatum (Cantor) 13 parts; Seven lis of pellets 9 parts; Olibanum 9 parts; Radix Angelicae Pubescentis 12 parts; Pyritum 4.5 parts; Radix Chloranthi Serrati 8 parts; Marasmius equicrinis Muell. 8 parts; Os Canitis 9 parts; Radix Gentianae Macrophyllae 12 parts; Radix Beaumontiae Grandiflorae 7.5 parts.
4., according to the preparation method of the arbitrary described external plaster application agent of claim 1-3, it is characterized in that, step is as follows:
(1) Dinodon rufozonatum (Cantor) is killed, remove head, tail, skin and internal organs, trunk part clear water is cleaned, is placed in meat grinder and rubs, by the Carnis Serpentis defibrination after rubbing, adopt centrifugal spray dryer to carry out drying, grind as smalls, cross 140-180 mesh sieve;
(2) seven lis of pellets, Radix Angelicae Pubescentis, Radix Chloranthi Serrati, Radix Gentianae Macrophyllae and Radix Beaumontiae Grandiflorae are cut into the lamellar of thick 2-4mm, are placed in glass container, soak 1-2 days;
(3) smashed by Pyritum, be placed in marmite, add water, after intense fire is fried open, fire of larding speech with literary allusions boils 40-60 minute, and Marasmius equicrinis Muell. is placed in gauze bag, puts into marmite, adds step (2) gains simultaneously, decocts 20-40 minute, filters;
(4) added by ethanol in step (3) gained filtrate, leave standstill 3-5 hour, filter, filtrate recycling ethanol is also condensed into the thick paste that relative density is 1.2-1.4 at 45 DEG C;
(5) Os Canitis and Olibanum are ground into smalls, cross 120-160 mesh sieve, powder and step (1) gains are joined in the thick paste of step (4) gained, mix homogeneously, makes external plaster application agent.
5. preparation method according to claim 4, is characterized in that: the preferred 20-40 μm of step (1) defibrination fineness, is more preferably 30 μm.
6. preparation method according to claim 4, is characterized in that: inlet temperature preferred 190-220 DEG C when step (1) is dry, is more preferably 210 DEG C; The preferred 80-90 DEG C of leaving air temp, is more preferably 85 DEG C.
7. preparation method according to claim 4, is characterized in that: step (1) is preferred crosses 150-170 mesh sieve, is more preferably 160 mesh sieves.
8. preparation method according to claim 4, is characterized in that: step (2) is preferably cut into the lamellar of thick 2.5-3.5mm, is more preferably 3mm.
9. preparation method according to claim 4, is characterized in that: step (4) is preferably condensed into the thick paste that relative density is 1.25-1.35, is more preferably and is condensed into the thick paste that relative density is 1.3.
10. preparation method according to claim 4, is characterized in that: step (5) is preferred crosses 130-150 mesh sieve, is more preferably 140 mesh sieves.
CN201410567986.0A 2014-10-23 2014-10-23 External application patch for treating traumatic injuries and preparation method thereof Pending CN104257995A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114748597A (en) * 2022-05-26 2022-07-15 大竹县中医院 Traumatic injury treating wine and preparation method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
杨晓国等: "伤宁膏治疗关节扭伤", 《中国乡村医药》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114748597A (en) * 2022-05-26 2022-07-15 大竹县中医院 Traumatic injury treating wine and preparation method thereof

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