CN103948036A - 一种抗神经衰弱的保健品及其应用 - Google Patents
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Abstract
本发明公开了一种抗神经衰弱的保健品及其应用，该组合物由活性成分和辅料制备而成，所述的活性成分包括氧化前胡素。本发明涉及的含有氧化前胡素的保健品组合物经多次服用后，能很好的提高脑内5-HT，DA，NA和5-HIAA等单胺类递质的含量，从而从根本上可改善神经衰弱症状，同时增强人民的学习和记忆能力。
Description
技术领域
本发明属于医药技术领域，具体而言，涉及一种抗神经衰弱的保健品及其应用。
背景技术
神经衰弱是一种常见的神经病症，由于内抑制过程减弱，当受到内外刺激时，神经衰弱病人的神经细胞易兴奋，能量消耗过多，长期如此，病人就表现为一系列衰弱症状：患者经常感到精力不足、蒌靡不振、不能用脑，或脑力迟钝、不能集中注意力、记忆力减退、工作效率减退。精力不好，白天时常打瞌睡，影响学习和工作。
当我国市场经济迅猛发展，人们的工作和生活节奏加快，使越来越多的人感到紧张和疲劳，造成工作和学习效率降低，甚至出现意外事故。人们疲倦无力，这一慢性，多发性疾病引起国内外专家的广泛关注。因此，开发无成瘾性，携带服用方便、效果明显的精神保健食品或药品尤为重要。
西医治疗神经衰弱主要依赖安定等安眠镇静剂对症治疗，但这些药物在安全性和依赖性方面存在缺陷，副作用比较大，容易形成成瘾性、耐药性，故不宜长时间服用。中医药治疗神经衰弱的药物较多，但良莠不齐，即使是较为畅销的安神补脑液，其抗神经衰弱的疗效也很一般。
氧化前胡素（Oxypeucedanin）是从中药材白芷中提取分离出的单体化合物，分子式为C16H14O5。邓士贤等人报道了氧化前胡素具有镇咳、镇痛及平滑肌解痉作用（氧化前胡素的药理研究；邓士贤、莫云强；中药通报；1985）。通过检索国内外文献，尚没有发现氧化前胡素具有抗神经衰弱的生物活性的文献报道。
发明内容
为了克服现有药物毒副作用大及保健效果不足的问题，本发明人的目的在于通过对天然药物进行研究，本发明提供了一种具有提神醒脑的抗神经衰弱保健品，以解决人们在工作和学习时出现反应迟钝的问题，满足人们的需要。该组合物以植物源性的氧化前胡素为活性成分，因此毒副作用小。
本发明的目的是这样实现的：
一种抗神经衰弱的保健品，由活性成分和辅料制备而成，所述的活性成分包括氧化前胡素。
优选地，如上所述抗神经衰弱的保健品，其中所述的活性成分由氧化前胡素组成。
学习记忆是脑的高级功能之一，是衡量动物智力发育的重要指标，学习记忆是通过神经系统一系列生理生化过程实现的。单胺类神经递质对注意力，记忆力和反应能力有着重要的调节作用，它包括NA，DA，5-HT，5-HIAA等，突触中NA，DA，5-HT含量丰富，其不仅与突触传递有关，而且与突触成熟有关。NA，DA，5-HT，5-HIAA的减少，必然影响脑内神经递质的平衡，导致智力损伤而减退。本发明人通过给小鼠多次灌胃氧化前胡素后发现，氧化前胡素能很好的提高小鼠脑内5-HT，DA，NA和5-HIAA等单胺类递质的含量，从而从根本上可改善神经衰弱症状。另外，本发明人还通过对NaNO2致记忆巩固障碍小鼠跳台试验研究证明，氧化前胡素对记忆巩固障碍小鼠的学习记忆有明显的改善作用。基于此项研究成果，本发明还提供一种制药用途，即：氧化前胡素在制备抗神经衰弱的保健品或药品中的应用。优选的方案为：氧化前胡素作为唯一活性成分在制备抗神经衰弱的保健品或药品中的应用。
与现有技术相比，本发明涉及的含有氧化前胡素的保健品组合物经多次服用后，能很好的提高脑内5-HT，DA，NA和5-HIAA等单胺类递质的含量，从而从根本上可改善神经衰弱症状，同时增强人民的学习和记忆能力。
具体实施方式
本发明人通过给小鼠多次灌胃氧化前胡素后发现，氧化前胡素能很好的提高小鼠脑内5-HT，DA，NA和5-HIAA等单胺类递质的含量，从而从根本上可改善神经衰弱症状。另外，本发明人还通过对NaNO2致记忆巩固障碍小鼠跳台试验研究证明，氧化前胡素对记忆巩固障碍小鼠的学习记忆有明显的改善作用。以下通过试验过程详细说明氧化前胡素的抗神经衰弱活性。
实施例1 氧化前胡素对小鼠脑内单胺类递质含量的影响试验研究
昆明种小鼠，SPF级，雌雄各半，体质量18～22g。取小鼠30只，适应性饲养3d后，随机分为空白对照组、阳性对照组（安神补脑液800mL/kg/d)、氧化前胡素组（150 mg/kg/d)。安神补脑液为吉林敖东延边药业股份有限公司生产，国药准字Z22022453。小鼠每天灌胃给药1次，连续15d，空白对照组给予等容积生理盐水。末次给药后1h将动物处死，迅速取脑组织，立即放入液氮灌内冷冻，分批取出匀浆，按荧光分光光度法测定小鼠脑组织中5-羟色胺(5-HT)，多巴胺(DA)，去甲肾上腺素(NA)和5-羟吲哚乙酸(5-HIAA)的含量（匡培根，周新富，徐波；脑组织中单胺类神经递质的提取和荧光光度测定法[J]；中国人民解放军军医进修学院学报，1982，3(2)：181）。
根据表1的试验结果可以看出，氧化前胡素组小鼠脑内单胺类递质含量显著高于空白对照组(P＜0.05或P＜0.01)，在5-HT、DA这两个指标上显著高于阳性对照组(P＜0.05)。这预示着氧化前胡素能很好的提高小鼠脑内5-HT，DA，NA和5-HIAA等单胺类递质的含量，从而从根本上可改善神经衰弱症状。
表1 各组小鼠脑内单胺类递质含量比较(ng/g)
| 组别 | 样本量 | 5-HT | DA | NA | 5-HIAA |
| 空白对照组 | 10 | 120.8±24.5 | 58.0±10.1 | 97.4±22.8 | 70.3±6.0 |
| 阳性对照组 | 10 | 125.3±31.7* | 66.4±9.3▼ | 121.3±15.6▼ | 76.4±11.9 |
| 氧化前胡素组 | 10 | 184.6±39.8▼▼★ | 78.3±14.7▼★ | 130.6±20.1▼ | 80.3±10.5▼ |
与空白对照组比较，▼ P＜0.05，▼▼ P＜0.01；与阳性对照组比较，★ P＜0.05，★★ P＜0.01。
实施例2 氧化前胡素对NaNO
2
致记忆巩固障碍小鼠跳台试验的影响研究
昆明种小鼠，SPF级，雌雄各半，体质量18～22g。取小鼠50，适应性饲养3d后，随机分为空白对照组、模型对照组、阳性对照组（安神补脑液800mL/kg/d)、氧化前胡素组（150 mg/kg/d)。安神补脑液为吉林敖东延边药业股份有限公司生产，国药准字Z22022453。小鼠每天灌胃给药1次，连续12d，空白对照组和模型对照组给予等容积生理盐水。第12天给药后采用跳台法对小鼠进行训练，训练时先将；XZC-5A型小鼠跳台仪与可调变压器相连，电压控制在36 V。小鼠训练前1 h给药，训练时将小鼠分别放人跳台仪的格子内，先适应5min，然后通电，小鼠受电击后，多数跳上跳台，逃避电击。跳下时以小鼠双足同时接触铜栅为触电，视为错误反应，训练5min(将反应迟钝的小鼠剔除，各组选10只)。训练完成后模型对照组和各给药组小鼠分别皮下注射亚硝酸纳(NaNO2)120mg/kg，空白对照组腹腔注射等体积的生理盐水，24h后重新测试。测试时先将小鼠放在跳台上，同时开动秒表，记录小鼠第1次跳下跳台的时间(即触电潜伏期)及小鼠10min内跳下的次数(即错误次数)作为记忆指标。
根据表2的试验结果可以看出，模型组小鼠触电潜伏期明显缩短，10min内错误次数明显增多，与空白组相比均有明显的统计学差异(P＜0.01)，说明小鼠记忆巩固障碍模型建立成功。在触电潜伏期和错误次数两方面来看，氧化前胡素组均可延长小鼠触电潜伏期，减少小鼠10min内的错误次数，与模型组相比有极为明显的统计学差异(P＜0.01)。这预示着氧化前胡素对NaNO2所致记忆巩固障碍小鼠的学习记忆有明显的改善作用。
表2 各组受试物对NaNO2致记忆巩固障碍小鼠跳台试验的影响比较
| 组别 | 样本量 | 触电潜伏期 | 10min内错误次数 （min） |
| 空白对照组 | 10 | 121.18±71.99 | 2.74 ±0.90 |
| 模型对照组 | 10 | 10.05 ±19.83▼▼ | 5.39 ±1.24▼▼ |
| 阳性对照组 | 10 | 97.30±38.04●● | 3.55 ±0.92● |
| 氧化前胡素组 | 10 | 89.07 ±26.68●● | 3.13 ±0.84●● |
与空白对照组比较，▼ P＜0.05，▼▼ P＜0.01；与模型对照组比较，● P＜0.05，●● P＜0.01。
Claims (4)
1.一种抗神经衰弱的保健品，其特征在于：由活性成分和辅料制备而成，所述的活性成分包括氧化前胡素。
2.根据权利要求1所述抗神经衰弱的保健品，其特征在于：所述的活性成分由氧化前胡素组成。
3.氧化前胡素在制备抗神经衰弱的保健品或药品中的应用。
4.氧化前胡素作为唯一活性成分在制备抗神经衰弱的保健品或药品中的应用。
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| WO2003059309A1 (fr) * | 2002-01-16 | 2003-07-24 | Chapelle Andre | Composition a base de 5,7 dmc et/ou de bergamonttine |
| CN101500611A (zh) * | 2006-06-23 | 2009-08-05 | 埃斯蒂维实验室股份有限公司 | 胆碱脂酶抑制剂与具有5-ht6受体亲和力的化合物的组合 |
| CN103083315A (zh) * | 2011-10-27 | 2013-05-08 | 中国中医科学院中药研究所 | 一种中药成分组合物及其用途 |
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| WO2003059309A1 (fr) * | 2002-01-16 | 2003-07-24 | Chapelle Andre | Composition a base de 5,7 dmc et/ou de bergamonttine |
| CN101500611A (zh) * | 2006-06-23 | 2009-08-05 | 埃斯蒂维实验室股份有限公司 | 胆碱脂酶抑制剂与具有5-ht6受体亲和力的化合物的组合 |
| CN103083315A (zh) * | 2011-10-27 | 2013-05-08 | 中国中医科学院中药研究所 | 一种中药成分组合物及其用途 |
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