CN103920031A - Cutireaction intervention medicine after radiotherapy and preparation method thereof - Google Patents
Cutireaction intervention medicine after radiotherapy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a cutireaction intervention medicine after radiotherapy and a preparation method thereof, and aims to solve the problem of prevention of cutireaction after radiotherapy. The preparation method is characterized by comprising the following steps: (1) melting yellow gelatin with a fistular onion stalk decoction to prepare gelatin beads for later use; (2) extracting volatile oil from ivy glorybind herb root and herba siegesbeckiae, collecting, mixing for later use, and taking decoction dregs for later use; (3) carrying out water extraction and alcohol precipitation on Cynachum uilfordii Hemsl, chalcanthite, papaya, Bulbophyllum inconspicuum Maxim, Sargassumthunbergii, petrel, Reed Rhizome, Magnolia amoena and the decoction dregs obtained in the step 1, and taking the supernate; (4) adding the supernate obtained in the step 3 into the gelatin beads obtained in the step 1; addition the mixed volatile oil obtained in the step 2, and evenly mixing to obtain a primary material; and (5) drying the primary material obtained in the step 4, pulverizing, and passing through a 100-mesh screen to obtain the medicinal powder. The clinical experiment proves that the medicine has the characteristics of favorable curative effect and higher safety when being used for preventing cutireaction after radiotherapy, and is worthy of clinical application and popularization.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of skin reactions and intervene medicine and preparation method thereof.
Background technology
Tumour radiotherapy (radiotherapy) is to utilize lonizing radiation as a kind of method of the treatment malignant tumor such as x ray, electric wire, proton beam and other particle beam of α, β, gamma-rays and all kinds of x roentgenotherapia machine of radiosiotope generation or accelerator generation.Radiation skin injury (radiation injuries of skin) is large area while irradiating or irradiate the modal radiotherapy side effect of gauffer and moist place of skin, relevant with radioactive source used, irradiated area and position to the dosis tolerata of ray with skin.Dermoreaction is divided into three degree: (1) I degree reaction: erythema, burn and prodding and itching feeling, while continuing to irradiate, skin, by the scarlet kermesinus that fades to, has desquamation later, claims dry reaction.(2) II degree reaction: highly congested, edema, blister form, and have transudate, erosion, claim wet reaction.(3) III degree reaction: ulcer or necrosis, invade to corium, cause radiation injury, be difficult to healing.
After current clinical prevention radiotherapy, skin injury does not have specificity method, mostly is and notices that local skin is clean dry, avoids with soap, can not be coated with ethanol, iodine tincture, mercurochrome, and avoid caloric stimulation, prevents day illumination solarization etc.Large multiplex the dispeling the wind of Chinese herb on the prevention radioactive skin reaction moisturized the product of removing heat from blood, and prescription is as loose in silver yellow, and medicine, as Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), can not carry out etiological treatment to " radiation injury " this basic cause of disease.
Summary of the invention
Technical assignment of the present invention is for above the deficiencies in the prior art, provides the skin reactions that a kind of curative effect is affirmed and side effect is little to intervene medicine and preparation method thereof.
The technical scheme that the present invention solves its technical problem is: a kind of pharmaceutical composition that prevents dermoreaction after radiotherapy, is characterized in that being prepared from by the crude drug of following weight proportion: 10 ~ 30 parts of Radix cynanchi wilfordii, 6 ~ 12 parts of Herba Bulbophylli inconspicui, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 3 ~ 10 6 ~ 12 parts of Fen, Herba Siegesbeckiaes, alizarin 3 ~ 10 parts of sea, 6 ~ 12 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 6 ~ 12 parts of Fructus Chaenomeliss, 6 ~ 12 parts of Flos Magnoliae Amoenae, 6 ~ 12 parts of Rhizoma Phragmitiss, 1 ~ 5 part of Bulbus Allii Fistulosi, 3 ~ 10 parts, stone gallbladder, 10 ~ 25 parts of gelatinum oxhide.
Chinese medicine of the present invention can be prepared from by following method:
(1) Bulbus Allii Fistulosi decocts 0.5 ~ 1 hour, boils liquid and filters, and boils in liquid and adds the gelatinum oxhide coarse powder after pulverizing, heat 80 ~ 100 ℃ and melts completely to gelatinum oxhide, is concentrated into relative density 1.2 ~ 1.3, takes advantage of heat dropwise to splash in cold water cooling, and taking-up is dried in the shade, and to become glue pearl standby;
(2) Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Siegesbeckiae coarse powder is extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are standby;
(3) in Radix cynanchi wilfordii, stone gallbladder, Fructus Chaenomelis, Herba Bulbophylli inconspicui, Hai Qian, Potiria pectinifera (Mukller et Tro Sehel), Rhizoma Phragmitis, Flos Magnoliae Amoenae and step 2, gained medicinal residues mix and add 5 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get supernatant;
(4) by gained supernatant concentration in step 3 to relative density 1.05 ~ 1.2, heat and under 80 ℃ of stirrings, add step 1 gained glue pearl to grind to make it to dissolve; Under stirring while being cooled to 40 ℃, add step 2 gained mixed volatilization oil, be mixed into just material;
(5) step 4 gained is just expected to drying and crushing, cross 100 mesh sieves, obtain medicated powder.
Wherein said: Radix cynanchi wilfordii is the tuber of asclepiadaceae plant cynanchum auriculatum Royle Cynanchum wilfordii (Maxim.) Hemsl..Nature and flavor are sweet; Micro-hardship; Slightly warm in nature; Return spleen; Stomach; Kidney channel.Merit can invigorating the liver and kidney; Bone and muscle strengthening; Strengthening the spleen and stomach; Removing toxic substances.
Herba Bulbophylli inconspicui, for the orchid family Bulbophyllum platymiscium Herba Bulbophylli inconspicui Bulbophyllum inconspicuum Maxim., with all herbal medicine.Nature and flavor are sweet, light, cool.Merit can nourishing YIN and clearing away heat, preventing phlegm from forming and stopping coughing.
Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) is herb or the root of the plant DAWANHUA Calystegia hederacea Wall. of dicotyledon scammonia section.Property sweet and slightly bitter taste; Flat.Return liver; Kidney channel.Merit can spleen invigorating; Dampness removing; Regulating menstruation.
Herba Siegesbeckiae is the aerial parts of composite family Zhi Wu Herba Siegesbeckiae Siegesbeckia orientalis L., Herba Siegesbeckiae Siegesbeckia pubescens Makino or siegesbeckia glabrescens Makino Siegesbeckia glabrescens Makino.Nature and flavor are bitter; Pungent; Cold in nature; Mild toxicity.Return liver; Kidney channel.Merit can wind-damp dispelling; The meridian dredging; Heat-clearing and toxic substances removing.
Hai Qian is Sargassaceae plant Alga Sgrgassi Enerves Sargassum enerve C.Ag., Heng Shi Alga Sgrgassi Enerves Sargassum henslowianum C.Ag., sargassum thunbergii Sargassum thunbergii(Mert.) O.Kuntze or Sargassum phyllocystum Tseng et Lu,Sargassum horneri (Turn.) C. Ag. (Fucus horneri (Turn.)C.Ag.,Spongocarpus horneri Kutz.) argassum horneri(Turn.) frond of C. Ag.Nature and flavor are salty; Cold.Return liver; Stomach; Kidney channel.Merit can hard masses softening and resolving; Removing heat-phlegm.
Potiria pectinifera (Mukller et Tro Sehel), is Echinodermata Asterinidae Potiria pectinifera (Mukller et Tro Sehel) Asterina pectinifera Miller et Troschel, with all (removing internal organs), is used as medicine.Nature and flavor are salty, and temperature is nontoxic.Merit can YIN nourishing, tonifying YANG, wind-damp dispelling.
Fructus Chaenomelis is the dry almost ripe fruit of rosaceous plant chaenomeles lagenaria Chaenomeles speciosa.Nature and flavor acid, temperature.Return liver, spleen channel.Merit can suppressing the hyperactive liver relaxing muscles and tendons, stomach function regulating removing dampness.
Flos Magnoliae Amoenae, for Magnoliaceae head Drymotaenium miyoshianum (Mak.) Mak. Magnolia amoena Cheng, is used as medicine with alabastrum.Nature and flavor are bitter, cold.Merit can diuresis, detumescence, nourishing the lung to arrest cough.
Rhizoma Phragmitis is the rhizome of grass phragmites communis.Nature and flavor are sweet, cold.Enter lung, stomach warp.Merit can lung heat clearing gastric heat, promoting the production of body fluid to quench thirst.
Bulbus Allii Fistulosi, is the cauloid of Liliaceae allium Herba Alii fistulosi, and merit can be delivered and activate yang, removing toxic substances parasite killing.
Stone gallbladder is natural or made aqueous sulfuric acid copper crystalline solid.Sour, pungent, cold.Removing the necrotic tissue; Removing toxic substances.
Gelatinum oxhide, the glue of making for the skin of bovid cattle Bos taurus domesticus Gmelin.Sweet in the mouth; Property is put down.Return lung; Large intestine channel.Merit can be nourshing Yin and drynsessmoistening prescription; Nourishing blood and hemoslasis; Promoting blood circulation and detumescence; Removing toxic substances.
Composition principle: after current clinical prevention radiotherapy, skin injury does not have specificity method, mostly is and notices that local skin is clean dry, avoids with soap, can not be coated with ethanol, iodine tincture, mercurochrome, and avoid caloric stimulation, prevents day illumination solarization etc.Chinese herb on the prevention radioactive skin reacts mostly according to symptom, thinks and belongs to " fire-toxin ", and heated blood is burnt, and moisturizes the product of removing heat from blood with dispeling the wind, and prescription is as loose in silver yellow, and medicine, as Radix seu caulis Berberidis Gagnepainii (Radix Berberidis Virgetori), can not carry out etiological treatment to " radiation injury " this basic cause of disease.But radiological dose is different, individual's skin reaction exists very big-difference, often with radiological dose, produces replacing of dry reaction and wet reaction.With symptom, raw prevention does not meet the principle of the traditional Chinese medical science " cure the disease ask because of " " preventive treatment of disease " to this kind.After radiotherapy, the cause of disease of dermoreaction is the destruction that the DNA of substrate stem cell is subject to ray in fact, and cell regeneration is obstructed.Inventor thinks, radiotherapy is not equal to " fire-toxin ", ray is damaged to protein denaturation side for " burn " to cell, but under general therapeutic dose, after I degree, the radiation of II degree, dermoreaction not yet arrives this kind of situation, is more to get involved in part, the moon can not drive sun and to cause skin venation obstructed, skin network is obstructed, and ying-qi body fluid can not reach in skin, and the cell regeneration described in this pathogenesis process and doctor trained in Western medicine is obstructed and is matched.Therefore its prevention, just should protect, eliminates the phlegm, eliminating stagnation, dredging collateral go forward side by side, can prevent the appearance of dermoreaction after radiotherapy.
Compared with prior art, the present invention has following characteristics.
1, prescription is unique: in side, get Radix cynanchi wilfordii, Herba Bulbophylli inconspicui is monarch, described Radix cynanchi wilfordii, Herba Bulbophylli inconspicui coordinate, and a temperature one is cool, for dermoreaction after radiotherapy, its role is to strengthening the body resistance, corrects cloudyly not to protect positive pathologic problems, and can too not grow again greasy; Radix cynanchi wilfordii, Herba Bulbophylli inconspicui are treated Cavia porcellus radiation skin injury with the water decoction of 2:1 mixing, and effective percentage is that 78.33%(Gentian Violet group is 50,22%).
2, in side, getting Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Siegesbeckiae, Hai Qian, Potiria pectinifera (Mukller et Tro Sehel) is minister, and Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Potiria pectinifera (Mukller et Tro Sehel) help Radix cynanchi wilfordii righting; The Herba Siegesbeckiae removing toxic substances of stimulating the menstrual flow; The alizarin hard masses softening and resolving in sea; Experimentation shows: 20-40mg/kg Herba Siegesbeckiae water extraction liquid can resist the experimental skin injury that lonizing radiation albumen Heat probe coagulation produces, and its effect may be relevant Yu darutin-bitter and alkaloid.And Potiria pectinifera (Mukller et Tro Sehel) is blood vessel two-ways regulation medicine, contribute to calm down the too drastic blood capillary reaction causing of local skin after radiotherapy.
3, supplementary drug thing is fewer but better, Fructus Chaenomelis relaxing muscles and tendons; Flos Magnoliae Amoenae detumescence; Rhizoma Phragmitis promotes the production of body fluid; Bulbus Allii Fistulosi is activated yang.
4, stone gallbladder is aqueous sulfuric acid copper crystalline solid, and laboratory result proves, for Cavia porcellus radiation skin injury, prescription of the present invention adds stone gallbladder and do not add the comparison of stone gallbladder, and skin injury incidence rate has reduced by 29.31%.
5, the effect of gelatinum oxhide is the cold of anti-Herba Siegesbeckiae fierce, surely alters using pungent drugs for dispersion and bitter drugs for purgation.
6, medicine material consumption of the present invention is groped in a large number to sum up through inventor and is drawn, each raw material consumption is for all to have good curative effect in following weight parts scope.
The specific embodiment
Below in conjunction with practical situation, the specific embodiment of the present invention is elaborated.
Embodiment 1, crude drug weight proportion: 20 parts of Radix cynanchi wilfordii, 10 parts of Herba Bulbophylli inconspicui, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 6 10 parts of Fen, Herba Siegesbeckiaes, alizarin 6 parts of sea, 10 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 10 parts of Fructus Chaenomeliss, 10 parts of Flos Magnoliae Amoenae, 10 parts of Rhizoma Phragmitiss, 2 parts of Bulbus Allii Fistulosi, 6 parts, stone gallbladder, 20 parts of gelatinum oxhide.
The preparation method of embodiment 1 is: Radix cynanchi wilfordii, Herba Bulbophylli inconspicui, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Siegesbeckiae, Hai Qian, Potiria pectinifera (Mukller et Tro Sehel), Fructus Chaenomelis, Flos Magnoliae Amoenae, Rhizoma Phragmitis, Bulbus Allii Fistulosi, stone gallbladder mixing and water adding are decocted, after 30 minutes, get filtrate, medicinal residues add water continuation decoction and get filtrate after 20 minutes, molten gelatinum oxhide after twice filtrate merges, local wet dressing, each half an hour, twice of every day.
Embodiment 2, crude drug weight proportion: 10 parts of Radix cynanchi wilfordii, 6 parts of Herba Bulbophylli inconspicui, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 36 parts of Fen, Herba Siegesbeckiaes, alizarin 3 parts of sea, 6 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 6 parts of Fructus Chaenomeliss, 6 parts of Flos Magnoliae Amoenae, 6 parts of Rhizoma Phragmitiss, 1 part of Bulbus Allii Fistulosi, 3 parts, stone gallbladder, 10 parts of gelatinum oxhide.
Embodiment 3, crude drug weight proportion: 20 parts of Radix cynanchi wilfordii, 10 parts of Herba Bulbophylli inconspicui, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 6 10 parts of Fen, Herba Siegesbeckiaes, alizarin 6 parts of sea, 10 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 10 parts of Fructus Chaenomeliss, 10 parts of Flos Magnoliae Amoenae, 10 parts of Rhizoma Phragmitiss, 2 parts of Bulbus Allii Fistulosi, 6 parts, stone gallbladder, 20 parts of gelatinum oxhide.
Embodiment 4, crude drug weight proportion: 30 parts of Radix cynanchi wilfordii, 12 parts of Herba Bulbophylli inconspicui, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 10 12 parts of Fen, Herba Siegesbeckiaes, alizarin 10 parts of sea, 12 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 12 parts of Fructus Chaenomeliss, 12 parts of Flos Magnoliae Amoenae, 12 parts of Rhizoma Phragmitiss, 5 parts of Bulbus Allii Fistulosi, 10 parts, stone gallbladder, 25 parts of gelatinum oxhide.
The Chinese medicine of embodiment 2 ~ 4 can be prepared from by following method:
(1) Bulbus Allii Fistulosi decocts 0.5 ~ 1 hour, boils liquid and filters, and boils in liquid and adds the gelatinum oxhide coarse powder after pulverizing, heat 80 ~ 100 ℃ and melts completely to gelatinum oxhide, is concentrated into relative density 1.2 ~ 1.3, takes advantage of heat dropwise to splash in cold water cooling, and taking-up is dried in the shade, and to become glue pearl standby;
(2) Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Siegesbeckiae coarse powder is extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are standby;
(3) in Radix cynanchi wilfordii, stone gallbladder, Fructus Chaenomelis, Herba Bulbophylli inconspicui, Hai Qian, Potiria pectinifera (Mukller et Tro Sehel), Rhizoma Phragmitis, Flos Magnoliae Amoenae and step 2, gained medicinal residues mix and add 5 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get supernatant;
(4) by gained supernatant concentration in step 3 to relative density 1.05 ~ 1.2, heat and under 80 ℃ of stirrings, add step 1 gained glue pearl to grind to make it to dissolve; Under stirring while being cooled to 40 ℃, add step 2 gained mixed volatilization oil, be mixed into just material;
(5) step 4 gained is just expected to drying and crushing, cross 100 mesh sieves, obtain medicated powder.
After dissolving with water purification during use, dress part.
Effective combination of said medicine, coordinates mutually, righting, eliminate the phlegm, eliminating stagnation, dredging collateral, effectively reach the object of dermoreaction after prevention radiotherapy, and side effect is less.The above results is that clinical data fully proves, interrelated data is as follows.
1 object and method.
1.1 object.
1.1.1 case selection: head-neck malignant tumor 79 examples of the initial journey radiotherapy that make a definite diagnosis through pathologic finding year October in March, 2010 ~ 2013, male's 44 examples wherein, women's 35 examples, 24～77 years old age.Nasopharyngeal carcinoma 39 examples, laryngeal carcinoma 16 examples, hypopharyngeal cancer 11 examples, each 7 examples of carcinoma of tongue and oropharynx cancer, waldeyer ring lymphoma 6 examples.All cases are just controls initial journey radiotherapy, and radiation adopts 6MVX line, 200cGy/f, 5f/w, accumulated dose D50～70Gy.All patients are divided into matched group 26 examples at random, and soak group 25 examples dress group 28 examples.Three groups of Genders, age, sickly plant, by stages, on Radiotherapy dosimetry relatively, difference not statistically significant (P>0.05), has comparability.
1.2 method.
1.2.1 interference method: matched group is taked conventional radiotheraphy skin nursing.On this basis, soak group, with gained decoction soak in the embodiment of the present invention 1, dresses group and dresses with gained powder in the embodiment of the present invention 3,2 times/d, finishes to radiotherapy.Soak group is organized the inactive medicine of intervening of radiation period 3h before radiotherapy every day with dressing, and water purification cleans (avoiding using the zest abluents such as soap), wipes away dry in time with soft cloth or cotton swab.
1.2.2 dermoreaction evaluation criterion: according to RTOG acute radiation skin injury grade scale, 0 grade: unchanged; I level: show as the dark red mottle of skin folliculus sample or alopecia or dryness decortication or perspire and reduce; II level: show as skin tenderness or fresh color erythema or the moist decortication of lamellar or intermediate edema; III level: show as the skinfold moist decortication of amalgamation or the pitting edema at position in addition; IV level: show as ulcer or hemorrhage, downright bad.
1.2.3 statistical analysis: SPSS15.0 carries out statistical analysis.Measurement data is checked with t, enumeration data χ
2check.
2 results.
2.1 acute radiation skin injury incidence rates: see the following form,
| Group | Number of cases | I level | II level | III level | IV level |
| Matched group | 26 | 4（15.4%） | 11（42.3%） | 8（30.8%） | 3（11.5%） |
| Soak group | 25 | 10（40.0%） | 12（48.0%） | 3（12.0%） | 0（0%） |
| Dress group | 28 | 10（35.7%） | 15（53.6%） | 3（10.7%） | 0（0%） |
Result shows: three groups of skin reactions occurrence rates are 100%.But slight radiation reaction (I+II level), matched group 57.7%, soak group 88.0%, dresses group 89.3%; Severe radioreaction is respectively 42.3%, 12.0%, 10.7%.Soak group and the order of severity that dresses group are significantly lower than matched group (P value <0.05).
2.2 3 groups of adverse reactions of patients incidence rates comparison: three groups all do not occur obvious adverse reaction.
3. conclusion.
This result of study shows, take soak group of the present invention and be starkly lower than matched group with the skin reactions order of severity that dresses group, illustrate that pharmaceutical composition prepared by the inventive method has good effect, the higher advantage of safety aspect dermoreaction after prevention radiotherapy.
Claims (1)
1. a skin reactions is intervened medicine and preparation method thereof, it is characterized in that, crude drug comprises: 10 ~ 30 parts of Radix cynanchi wilfordii, 6 ~ 12 parts of Herba Bulbophylli inconspicui, Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae) 3 ~ 10 6 ~ 12 parts of Fen, Herba Siegesbeckiaes, alizarin 3 ~ 10 parts of sea, 6 ~ 12 parts of Potiria pectinifera (Mukller et Tro Sehel)s, 6 ~ 12 parts of Fructus Chaenomeliss, 6 ~ 12 parts of Flos Magnoliae Amoenae, 6 ~ 12 parts of Rhizoma Phragmitiss, 1 ~ 5 part of Bulbus Allii Fistulosi, 3 ~ 10 parts, stone gallbladder, 10 ~ 25 parts of gelatinum oxhide; By following steps, formed:
(1) Bulbus Allii Fistulosi decocts 0.5 ~ 1 hour, boils liquid and filters, and boils in liquid and adds the gelatinum oxhide coarse powder after pulverizing, heat 80 ~ 100 ℃ and melts completely to gelatinum oxhide, is concentrated into relative density 1.2 ~ 1.3, takes advantage of heat dropwise to splash in cold water cooling, and taking-up is dried in the shade, and to become glue pearl standby;
(2) Rhizoma Calystegiae Hederaceae (Herba Calystegiae Hederaceae), Herba Siegesbeckiae coarse powder is extracted to volatile oil with vapor distillation respectively, and mixing for standby use after collecting, medicinal residues are standby;
(3) in Radix cynanchi wilfordii, stone gallbladder, Fructus Chaenomelis, Herba Bulbophylli inconspicui, Hai Qian, Potiria pectinifera (Mukller et Tro Sehel), Rhizoma Phragmitis, Flos Magnoliae Amoenae and step 2, gained medicinal residues mix and add 5 times of water yields, decoct with water 2 times, and each 1 hour, collecting decoction, standing; Then toward 95% the ethanol that adds 3 ~ 4 times of medicinal liquids in decocting liquid, standing 15 minutes, then with 3000rpm/min centrifugal 20 minutes, get supernatant;
(4) by gained supernatant concentration in step 3 to relative density 1.05 ~ 1.2, heat and under 80 ℃ of stirrings, add step 1 gained glue pearl to grind to make it to dissolve; Under stirring while being cooled to 40 ℃, add step 2 gained mixed volatilization oil, be mixed into just material;
(5) step 4 gained is just expected to drying and crushing, cross 100 mesh sieves, obtain medicated powder.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1174041A (en) * | 1996-08-21 | 1998-02-25 | 甘肃昌盛贸易有限责任公司 | Scald ointment made of Chinese herbal medicine extracts |
| CN103040956A (en) * | 2013-01-18 | 2013-04-17 | 江其生 | Traditional Chinese medicine composition capable of preventing and treating skin radiation injuries |
| CN103127436A (en) * | 2013-01-17 | 2013-06-05 | 武传华 | Traditional Chinese medicine composition for treating acute radioactive skin injury |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1174041A (en) * | 1996-08-21 | 1998-02-25 | 甘肃昌盛贸易有限责任公司 | Scald ointment made of Chinese herbal medicine extracts |
| CN103127436A (en) * | 2013-01-17 | 2013-06-05 | 武传华 | Traditional Chinese medicine composition for treating acute radioactive skin injury |
| CN103040956A (en) * | 2013-01-18 | 2013-04-17 | 江其生 | Traditional Chinese medicine composition capable of preventing and treating skin radiation injuries |
Non-Patent Citations (1)
| Title |
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| 李凤玉等: ""放射性皮炎的防治"", 《山西医药杂志》 * |
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