CN103918916A - Feed additive for dairy cows at earlier perinatal stage - Google Patents
Feed additive for dairy cows at earlier perinatal stage Download PDFInfo
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- CN103918916A CN103918916A CN201410159006.3A CN201410159006A CN103918916A CN 103918916 A CN103918916 A CN 103918916A CN 201410159006 A CN201410159006 A CN 201410159006A CN 103918916 A CN103918916 A CN 103918916A
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Abstract
The invention discloses a feed additive for dairy cows at the earlier perinatal stage, and belongs to the field of feed additives. The feed additive for dairy cows at the earlier perinatal stage is formed by combining anion salt and/or traditional Chinese medicine additives in the mass ratio of (90-100):(5-10). The anion salt is added into daily ration of dairy cows at the earlier perinatal stage so as to reduce the dry matter intake; the traditional Chinese medicines are added so as to increase the appetite of dairy cows at the perinatal stage, thereby improving the dry matter intake. By the mixing and adding of the anion salt and the traditional Chinese medicine additives, the dry matter intake of dairy cows is nearly not different from that of a control group, and thus the palatability problem of the anion salt is relieved to a certain extent.
Description
Technical field
The invention belongs to feed additive field, is a kind of for the pre-perinatal compound health additive of milk cow.
Background technology
Cow in perinatal period generally refers to that the antenatal 15d of milk cow is to 15d in postpartum, is a special and important stage in raising dairy cattle.In this period, milk cow will experience the variation in physiology, nutrition, metabolism, and the low blood calcium that childbirth and lactation bring can cause a series of disease.Pregnant dairy cows also must be transferred to just Ruzhong the immunoglobulin (Ig) in blood, causes the reduction of immunologic function.The minimizing of feed intake, causes negative energy balance simultaneously, has strengthened immunosupress, causes milk cow to reduce various diseases resistance.In addition studies confirm that in a large number in addition that many Diseases of Cow common diseases are all mutually related, and all with perinatal period diet closely related.By add suitable feed addictive in daily ration, allow milk cow successfully tide over perinatal period, ensure cow health, voluminous milk and being normally multiplied into for one of the research focus in nutrition and focus.
Anion salt refers to that chlorion, sulphion content are relatively high, the mineral matter salt that sodium ion and potassium content are relatively low.Dietary cation-anion balance (dietary cation-anion balance DCAB) refers to the poor of contained zwitterion in every kilogram (mEq/kg DM) in daily ration or 100 grams of (mEq/l00g DM) diet dry substances (DM) mM, also be called Different Dietary Cation-anion Balance difference (dietary cation-anion difference, DCAD).In the antenatal daily ration of milk cow, add anion salt, daily ration DCAB value is regulated to negative value, make can effectively to absorb in daily ration anion concentration higher than cationic concentration, can cause like this metabolic acidosis of animal, and long-term metabolic acidosis meeting increases the excretion of urine calcium, result shortens calcium RT in vivo, cause 1 by feedback mechanism, the increase of the synthetic and secretion of 25-(OH) 2D3 and PTH, thereby reduce the discharge of kidney to calcium, promote the absorption of enteron aisle to calcium, increase mobilization and the release of bone to calcium, make blood calcium recover normal.
Chinese medicine has medicine and nutrition double action as feed addictive, except can disease preventing and treating, can also improve production performance and promote the recovery of milk cow Reproductive Performance in postpartum.From the theory analysis of modern pharmacology and nutrition, think that its growth promoting function and Chinese herbal medicine improve immunity of organisms closely related, the effect of its disease preventing and treating is to be mainly in harmonious proportion and strengthening vital QI to eliminate pathogenic factors by negative and positive, transfer and the interior Disease-resistant factor of excitating organism, improve organ-tissue function, strengthen the ability of resisting germ infringement, Chinese herbal medicine itself also contains amino acid, mineral matter, vitamin, unknown growth regulator and the pigment of some simultaneously, thereby can, by the effect of antibacterial material and immunologic active material, improve the premunition of body.
Mainly comprise and add anion salt, Chinese herbal medicine, vitamin, mineral matter, probiotics etc. for the additive research of Diseases of Cow at present.Application number is the patent " a kind of milk cow Chinese herbal medicine cow galactic ", application number of " 200410011239.5 " the many sections of patented feed additives such as patent " composite microorganism additive agent for milk cattle feed stuff and preparation method thereof " that are " 200810103485.1 " for the patent of " 201110276378.0 " " a kind of manufacture method of the cow feed additive containing active Chinese drug component probio ", application number, but these feed addictive existence or complex process or act on single shortcoming.
Summary of the invention
The object of this invention is to provide a kind of fully natural green feed addictive, make pre-perinatal milk cow can alleviate negative energy balance, improve immunologic function, cow producing milk performance, improves milk cow health situation, makes Diseases of Cow in a healthy state.
A kind of milk cow is pre-perinatal to be composited by anion salt and/or Chinese medicine additive with feed addictive, and wherein the mass ratio of anion salt and Chinese medicine additive is 90～100: 5～10.Preferably wherein the mass ratio of anion salt and Chinese medicine additive is 100: 8.5
Wherein said anion salt is a kind of of magnesium sulfate, magnesium chloride, ammonium sulfate and calcium chloride or mixes; The mixing quality ratio of magnesium sulfate, magnesium chloride, ammonium sulfate and calcium chloride is 35～45: 15～25: 15～25: 15～25.The mixing quality ratio of preferably sulfuric acid magnesium, magnesium chloride, ammonium sulfate and calcium chloride is 40: 20: 20: 20.
Wherein said Chinese medicine additive is a kind of or mixing of Astragalus Root P.E, siberian Ginseng P.E and angelica extract, and wherein the mixing quality of Astragalus Root P.E, siberian Ginseng P.E and angelica extract ratio is 40～50: 5～10: 40～50.Preferably the mixing quality ratio of Astragalus Root P.E, siberian Ginseng P.E and angelica extract is 40: 5: 40.
The wherein preparation method of Astragalus Root P.E, carry out according to following step: will be dried Radix Astragali Astragalus membranaceus (Fisch.) Bunge. root raw material, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merges No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, and staticly settles, centrifugal sediment, sediment continue to add ethanol stir, leave standstill centrifugal after, remove protein, mucilaginous substance constituents, is dried as brown color or pale powder.Active constituent content: Astragaloside IV 0.3%-98%, astragalus polyose 10-70%.
The wherein preparation method of siberian Ginseng P.E, carry out according to following step: by the dry root and rhizome of Araliaceae wilsonii Acanthopanax senticosus, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merges No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, and staticly settles, centrifugal sediment, sediment continue to add ethanol stir, leave standstill centrifugal after, remove protein, mucilaginous substance constituents, is dried as brown color powder.Active ingredient: Eleutheroside B, eleutheroside E, content 0.8%.
The wherein preparation method of angelica extract, carry out according to following step: by the dry root of umbelliferae angelica Angelica sinensis, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merges No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, and staticly settles, centrifugal sediment, sediment continue to add ethanol stir, leave standstill centrifugal after, remove protein, mucilaginous substance constituents, is dried as brown color powder.Active ingredient: Ligustilide, normal-butyl.
Advantage of the present invention:
1. in pre-perinatal dairy cow diet, add anion salt and can reduce dry matter intake, add Chinese herbal medicine and can make the appetite of Diseases of Cow increase, thereby improved the feed intake of dry.Mixing by both is added, and feed intake and the control group of dry do not have significant difference, have alleviated to a certain extent the palatability problem of anion salt.
2. perinatal milk cow, in immunosuppressive condition, easily produces disease.The generation of these diseases all can reduce the output of milk and affect milk quality.Interpolation Chinese herbal medicine extract can improve the oxidation resistance of Diseases of Cow, improves immunity of organisms
3. herb extracts is improved the content of IgG, IgM, IgA in Diseases of Cow serum
4. add anion salt and Chinese herbal medicine and can not significantly improve the output of milk, but be all improved the trend of the output of milk of Postpartum Cows.
5. anion salt and the Chinese herbal medicine mitigation certain to having of Postpartum Cows retention of afterbirth, milk fever.Anion salt can obviously strengthen the blood buffer ability, prevention hypocalcemia of milk cow, effectively alleviate milk cow stress.
Detailed description of the invention
1. anion salt adds principle
All basal feed raw materials are first analyzed the content of its Na, K, Cl, S before preparation, especially particularly importantly analyze the composition of hay and agricultural byproducts.The compound interpolation of multiple anion salt is best mode.First selects to should be Sulfates, and these salts can supplement total sulfur in diet dry and reach 0.4%, reach maximum tolerance level.If add Mg salt, should be noted that total Mg amount should not exceed dry 0.4%.The selection of next is villaumite; Relying on sulfate completely can not be enough to make diet DCAD to reach desirable acidizing effect, now supplements villaumite the most applicable.In addition, sodium chloride can not change DCAD value, therefore just in time electric charge offsets that to change the effect of DCAD be zero due to its supplementary Na+, Cl-.The best DCAD value that should use for dry milk phase diet at present is not also determined.By summing up multiple experimental studies, point out that best DCAD value should be between-10～-5mEq/100g DM.
2. Chinese herbal medicine adds principle
Milk cow is ruminant, there is the special physiological feature of 4 stomaches, ensure that Chinese herbal medicine is not decomposed by the Institute of Micro-biology of cud when through cud, ruminant is because of its special Rumen Internal Environment simultaneously, and some Chinese herb feed additive causes adverse effect to microorganism in cud.Meanwhile, the also performance of more unfavorable Chinese herbal medicine effects of Rumen Internal Environment and PH.Therefore suitable Chinese herb feed additive be should select, a large amount of practice and research needed.Wilsonii can improve lactational milk production of cow.The Radix Astragali not only can improve lactational milk production of cow, can also strengthen the non-specific immune function of milk cow.Radix Angelicae Sinensis is as galactopoietic, respond well.
Milk cow is fed respectively and is added with the diet of additive to giving a birth for 21 days from the expected date of childbirth for first 1 day, and the anion salt that will feed, Chinese herbal medicine mix with fine fodder, and by feeding of every ox 5kg every day, day feeds three times.
The preparation method of Astragalus Root P.E, carry out according to following step: will be dried Radix Astragali Astragalus membranaceus (Fisch.) Bunge. root raw material, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merges No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, and staticly settles, centrifugal sediment, sediment continue to add ethanol stir, leave standstill centrifugal after, remove protein, mucilaginous substance constituents, is dried as brown color or pale powder.Active constituent content: Astragaloside IV 0.3%-98%, astragalus polyose 10-70%.
The preparation method of siberian Ginseng P.E, carry out according to following step: by the dry root and rhizome of Araliaceae wilsonii Acanthopanax senticosus, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merges No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, and staticly settles, centrifugal sediment, sediment continue to add ethanol stir, leave standstill centrifugal after, remove protein, mucilaginous substance constituents, is dried as brown color powder.Active ingredient: Eleutheroside B, eleutheroside E, content 0.8%.
The preparation method of angelica extract, carry out according to following step: by the dry root of umbelliferae angelica Angelica sinensis, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merges No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, and staticly settles, centrifugal sediment, sediment continue to add ethanol stir, leave standstill centrifugal after, remove protein, mucilaginous substance constituents, is dried as brown color powder.Active ingredient: Ligustilide, normal-butyl.
Embodiment 1
Anion salt addition: 40gMgSO
4, 20gMgCl
2, 20g (NH
4)
2sO
4, 20gCaCl
2
Chinese herbal medicine addition: 4g Astragalus Root P.E, 0.5g siberian Ginseng P.E, 4g angelica extract are example diet recipe below
Premix is containing 8,000mg/kg Fe; 2,400mg/kg Cu; 8,000mg/kg Mn; 15,000mg/kg Zn; 200mg/kg I100mg/kg Se:100mg/kg Co:860,000IU/kg VA; 200,000IU/kg VD; 10,000mg/kg VE
Experiment
Test adopts random packet design, and selective body focuses on 550 ± 50Kg, 2-4 parity, and the expected date of childbirth is close, and the upper cycle output of milk of giving milk approaches, and Body Condition Score, 24 of the holstein cows of 3.25-3.5, is divided into 4 groups, 6 every group at random.Each group of basal diet composition of feeding is the same, the test I group basal diet of feeding, test II group basal diet+anion salt 100g/d head of feeding, test III group basal diet+Chinese herbal medicine extract 8.5g/d head of feeding, test IV group basal diet+anion salt 100g/d head+Chinese herbal medicine extract 8.5g/d head of feeding.From the expected date of childbirth 21 days to the interpolation in first 1 day of giving a birth.
The impact on Diseases of Cow feed intake of table 1 anion salt and Chinese herbal medicine
The impact on Diseases of Cow glutathione peroxidase, superoxide dismutase, MDA and TAC of table 2 anion salt and Chinese herbal medicine
The impact on IgG, IgM, IgA in Diseases of Cow serum of table 3 anion salt and Chinese herbal medicine
The impact on milk production of cow of table 4 anion salt and Chinese herbal medicine
The impact on IgG, IgM, IgA in Bovine Colostrum of table 5 anion salt and Chinese herbal medicine
| Group | IgG | IgM | IgA |
| Control group | 31.49±6.99 a | 3.53±0.77 | 4.17±0.27 |
| Chinese herbal medicine group | 39.35±7.98 ab | 3.04±0.83 | 4.79±1.16 |
| Anion salt group | 38.25±10.63 ab | 2.93±1.10 | 4.23±1.13 |
| Anion Chinese herbal medicine group | 46.19±7.01 b | 3.66±1.23 | 4.59±1.07 |
The impact on Diseases of Cow health status of table 6 anion salt and Chinese herbal medicine
| Project | Control group | Anion salt group | Chinese herbal medicine group | Anion salt Chinese herbal medicine group |
| Retention of afterbirth | 2/6 | 06 | 0/6 | 0/6 |
| Postpartum udder edema | 3/6 | 1/6 | 1/6 | 1/6 |
| Milk fever | 1/6 | 0/6 | 1/6 | 0/6 |
| Postpartum mammitis | 2/6 | 1/6 | 1/6 | 0/6 |
| Metria | 1/6 | 1/6 | 0/6 | 0/6 |
| Postpartum ketoacidosis | 0/6 | 0/6 | 0/6 | 0/6 |
The above results shows that anion salt and Chinese herb feed additive are to Diseases of Cow oxidation resistance, antibody content in serum and colostrum, and milk production of cow, Diseases of Cow health status increases or raising trend.
Claims (9)
1. milk cow is pre-perinatal is characterized in that being composited by anion salt and/or Chinese medicine additive with a feed addictive, and wherein the mass ratio of anion salt and Chinese medicine additive is 90～100: 5～10.
2. a kind of milk cow according to claim 1 is pre-perinatal with feed addictive, it is characterized in that wherein said anion salt is a kind of of magnesium sulfate, magnesium chloride, ammonium sulfate and calcium chloride or mixes; The mixing quality ratio of magnesium sulfate, magnesium chloride, ammonium sulfate and calcium chloride is 35～45: 15～25: 15～25: 15～25.
3. a kind of milk cow according to claim 1 is pre-perinatal with feed addictive, it is characterized in that wherein the mass ratio of anion salt and Chinese medicine additive is 100: 8.5.
4. a kind of milk cow according to claim 2 is pre-perinatal with feed addictive, it is characterized in that the mixing quality ratio of wherein said magnesium sulfate, magnesium chloride, ammonium sulfate and calcium chloride is 40: 20: 20: 20.
5. a kind of milk cow according to claim 1 is pre-perinatal with feed addictive, it is characterized in that wherein said Chinese medicine additive is a kind of of Astragalus Root P.E, siberian Ginseng P.E and angelica extract or mixes, wherein the mixing quality of Astragalus Root P.E, siberian Ginseng P.E and angelica extract ratio is 40～50: 5～10: 40～50.
6. a kind of milk cow according to claim 5 is pre-perinatal with feed addictive, it is characterized in that wherein said Chinese medicine additive is a kind of of Astragalus Root P.E, siberian Ginseng P.E and angelica extract or mixes, wherein the mixing quality of Astragalus Root P.E, siberian Ginseng P.E and angelica extract ratio is 40: 5: 40.
7. pre-perinatal with feed addictive according to a kind of milk cow described in claim 5 or 6, it is characterized in that the wherein preparation method of Astragalus Root P.E, carry out according to following step: will be dried astragalus root raw material, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merge No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, staticly settle, centrifugal sediment, sediment continues to add ethanol to stir, after standing centrifugal, remove protein, mucilaginous substance constituents, be dried as brown color or pale powder.
8. pre-perinatal with feed addictive according to a kind of milk cow described in claim 5 or 6, it is characterized in that the wherein preparation method of siberian Ginseng P.E, carry out according to following step: by the dry root and rhizome of Araliaceae wilsonii, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merge No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, staticly settle, centrifugal sediment, sediment continues to add ethanol to stir, after standing centrifugal, remove protein, mucilaginous substance constituents, be dried as brown color powder.
9. pre-perinatal with feed addictive according to a kind of milk cow described in claim 5 or 6, it is characterized in that the wherein preparation method of angelica extract, carry out according to following step: by the dry root of umbelliferae angelica, clean, dry, pulverize, the water of 10 times of quality, ebuillition of heated extracts three times, each 2 hours, merge No. three times extract, concentration and evaporation water is to the medicinal extract of proportion d=1.20, leave standstill and cool, medicinal extract adds ethanol to stir, staticly settle, centrifugal sediment, sediment continues to add ethanol to stir, after standing centrifugal, remove protein, mucilaginous substance constituents, be dried as brown color powder.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104642799A (en) * | 2015-01-30 | 2015-05-27 | 西藏自治区农牧科学院 | Special premix suitable for early perinatal stage of diary cow in agricultural areas of Tibet and preparation method of special premix |
| CN104920884A (en) * | 2015-06-25 | 2015-09-23 | 中国农业科学院兰州畜牧与兽药研究所 | Anion feed additive for cows as well as preparation method and application of anion feed additive |
| CN105981922A (en) * | 2015-02-14 | 2016-10-05 | 哈尔滨博善联合生物饲料有限公司 | Preparation method of anion salt with high palatability for cows |
| CN106260784A (en) * | 2016-08-24 | 2017-01-04 | 明光市永言水产食品有限公司 | A kind of Chinese medicine aquatic feeds and preparation method thereof |
| CN107683961A (en) * | 2017-08-18 | 2018-02-13 | 吉林农业大学 | One kind utilizes yeast waste liquor production feedstuff mildew water-preserving promoting agent |
| CN115486492A (en) * | 2021-06-17 | 2022-12-20 | 华实畜牧科技(山东)集团有限公司 | Production method of pure natural compound traditional Chinese medicine plant extract feed |
-
2014
- 2014-04-21 CN CN201410159006.3A patent/CN103918916A/en active Pending
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104642799A (en) * | 2015-01-30 | 2015-05-27 | 西藏自治区农牧科学院 | Special premix suitable for early perinatal stage of diary cow in agricultural areas of Tibet and preparation method of special premix |
| CN105981922A (en) * | 2015-02-14 | 2016-10-05 | 哈尔滨博善联合生物饲料有限公司 | Preparation method of anion salt with high palatability for cows |
| CN104920884A (en) * | 2015-06-25 | 2015-09-23 | 中国农业科学院兰州畜牧与兽药研究所 | Anion feed additive for cows as well as preparation method and application of anion feed additive |
| CN106260784A (en) * | 2016-08-24 | 2017-01-04 | 明光市永言水产食品有限公司 | A kind of Chinese medicine aquatic feeds and preparation method thereof |
| CN107683961A (en) * | 2017-08-18 | 2018-02-13 | 吉林农业大学 | One kind utilizes yeast waste liquor production feedstuff mildew water-preserving promoting agent |
| CN115486492A (en) * | 2021-06-17 | 2022-12-20 | 华实畜牧科技(山东)集团有限公司 | Production method of pure natural compound traditional Chinese medicine plant extract feed |
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Application publication date: 20140716 |