CN103917658B - 用于监测血块形成的nmr方法 - Google Patents

用于监测血块形成的nmr方法 Download PDF

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Publication number
CN103917658B
CN103917658B CN201280044411.XA CN201280044411A CN103917658B CN 103917658 B CN103917658 B CN 103917658B CN 201280044411 A CN201280044411 A CN 201280044411A CN 103917658 B CN103917658 B CN 103917658B
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blood sample
sample
platelet
water
blood
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CN103917658A (zh
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T.J.洛厄里
V.帕普科夫
W.W.梅斯夫斯基
R.丹达
E.C.萨耶
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T2 Biosystems Inc
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • A—HUMAN NECESSITIES
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    • A61B5/02007—Evaluating blood vessel condition, e.g. elasticity, compliance
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    • A61B5/026—Measuring blood flow
    • A61B5/0263—Measuring blood flow using NMR
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    • A61M60/148—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable via, into, inside, in line, branching on, or around a blood vessel in line with a blood vessel using resection or like techniques, e.g. permanent endovascular heart assist devices
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    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N24/00—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects
    • G01N24/08—Investigating or analyzing materials by the use of nuclear magnetic resonance, electron paramagnetic resonance or other spin effects by using nuclear magnetic resonance
    • G01N24/088—Assessment or manipulation of a chemical or biochemical reaction, e.g. verification whether a chemical reaction occurred or whether a ligand binds to a receptor in drug screening or assessing reaction kinetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/448—Relaxometry, i.e. quantification of relaxation times or spin density
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/10—Location thereof with respect to the patient's body
    • A61M60/122—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body
    • A61M60/165—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart
    • A61M60/178—Implantable pumps or pumping devices, i.e. the blood being pumped inside the patient's body implantable in, on, or around the heart drawing blood from a ventricle and returning the blood to the arterial system via a cannula external to the ventricle, e.g. left or right ventricular assist devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/20—Type thereof
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    • A—HUMAN NECESSITIES
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    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
    • A61M60/50—Details relating to control
    • A61M60/508—Electronic control means, e.g. for feedback regulation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/226—Thrombotic disorders, i.e. thrombo-embolism irrespective of location/organ involved, e.g. renal vein thrombosis, venous thrombosis
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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  • Physics & Mathematics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Vascular Medicine (AREA)
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  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201280044411.XA 2011-07-13 2012-07-13 用于监测血块形成的nmr方法 Expired - Fee Related CN103917658B (zh)

Applications Claiming Priority (19)

Application Number Priority Date Filing Date Title
US201161507307P 2011-07-13 2011-07-13
US61/507,307 2011-07-13
US61/507307 2011-07-13
US201161537396P 2011-09-21 2011-09-21
US61/537,396 2011-09-21
US61/537396 2011-09-21
US201161538257P 2011-09-23 2011-09-23
US61/538257 2011-09-23
US61/538,257 2011-09-23
US201161560920P 2011-11-17 2011-11-17
US61/560,920 2011-11-17
US61/560920 2011-11-17
US201261596445P 2012-02-08 2012-02-08
US61/596445 2012-02-08
US61/596,445 2012-02-08
US201261625945P 2012-04-18 2012-04-18
US61/625945 2012-04-18
US61/625,945 2012-04-18
PCT/US2012/046669 WO2013010080A1 (en) 2011-07-13 2012-07-13 Nmr methods for monitoring blood clot formation

Publications (2)

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CN103917658A CN103917658A (zh) 2014-07-09
CN103917658B true CN103917658B (zh) 2016-09-21

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US (3) US9599627B2 (enExample)
EP (2) EP2732046B1 (enExample)
JP (3) JP6122848B2 (enExample)
CN (1) CN103917658B (enExample)
AU (1) AU2012281017B2 (enExample)
CA (1) CA2841484A1 (enExample)
WO (1) WO2013010080A1 (enExample)

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CN109740819A (zh) * 2019-01-11 2019-05-10 中国环境监测总站 一种水环境监测算法
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CN115081207B (zh) * 2022-06-17 2023-03-10 上海玫克生储能科技有限公司 锂电池的静置弛豫仿真方法、系统、终端设备及存储介质
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CN117233364B (zh) * 2023-11-16 2024-02-02 苏州思迈德生物科技有限公司 一种血栓弹力图的参数提取方法
CN119470535B (zh) * 2024-11-01 2025-07-22 中安绿能(成都)集团有限公司 一种鱼肉新鲜度评价方法及系统
CN119223825B (zh) * 2024-11-21 2026-02-17 武汉纺织大学 一种基于核磁共振波谱化学位移的磁纳米粒子质量浓度测量方法
CN120948776B (zh) * 2025-10-15 2026-03-20 上海基灵生物科技有限公司 一种用于动物凝血功能评估的多参数血栓弹力图仪

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