CN103906531A - 调节的免疫优势疗法 - Google Patents

调节的免疫优势疗法 Download PDF

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CN103906531A
CN103906531A CN201280037470.4A CN201280037470A CN103906531A CN 103906531 A CN103906531 A CN 103906531A CN 201280037470 A CN201280037470 A CN 201280037470A CN 103906531 A CN103906531 A CN 103906531A
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cells
antigen
cell
patient
subdominant
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A.E.斯拉内茨
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Geneius Biotechnology Ltd
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Geneius Biotechnology Ltd
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109475578A (zh) * 2016-05-25 2019-03-15 昆士兰医学研究所理事会 使用同种异体t细胞治疗自身免疫疾病的方法

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ749136A (en) 2016-05-25 2023-11-24 Council Queensland Inst Medical Res Methods of immunotherapy
JP7185530B2 (ja) 2016-06-13 2022-12-07 トルク セラピューティクス, インコーポレイテッド 免疫細胞機能を促進するための方法および組成物
KR20190037243A (ko) * 2016-06-28 2019-04-05 지니우스 바이오테크놀로지 인코포레이티드 면역치료를 위한 티 세포 조성물
JP7285828B2 (ja) 2017-09-05 2023-06-02 トルク セラピューティクス, インコーポレイテッド 治療用タンパク質組成物ならびにその作製および使用方法
AU2018355145A1 (en) 2017-10-23 2020-04-30 Atara Biotherapeutics, Inc. Methods of managing tumor flare in adoptive immunotherapy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001504799A (ja) 1996-03-11 2001-04-10 エピミューン インコーポレイテッド Hla分子への結合アフィニティーが増加したペプチド
WO1998033888A1 (en) * 1997-01-31 1998-08-06 Epimmune, Inc. Peptides and peptide-loaded antigen presenting cells for the activation of ctl
CA2330678C (en) 1998-05-11 2009-04-07 Miltenyi Biotec Gmbh Method of direct selection of antigen-specific t cells
IL141868A0 (en) * 1998-10-05 2002-03-10 M & E Biotech As Novel methods for therapeutic vaccination
DE60142615D1 (de) * 2000-04-28 2010-09-02 Mannkind Corp Epitop-synchronisierung in antigen präsentierenden zellen
FR2812087B1 (fr) * 2000-07-21 2007-05-11 Inst Nat Sante Rech Med Procede de criblage de peptides utilisables en immunotherapie
WO2004042041A1 (en) 2002-11-07 2004-05-21 Johnson & Johnson Research Pty Limited A means of producing and utilising a population of disease specific cytotoxic t-lymphoctyes
CN100591761C (zh) * 2004-08-19 2010-02-24 加的夫大学学院咨询有限公司 呈递抗原的人γδT细胞的制备和在免疫治疗中的用途
US20060165711A1 (en) * 2004-12-29 2006-07-27 Bot Adrian I Methods to elicit, enhance and sustain immune responses against MHC class I-restricted epitopes, for prophylactic or therapeutic purposes
MX2007015933A (es) * 2005-06-17 2008-04-21 Mannkind Corp Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales.
EP3101122B1 (en) 2009-08-24 2023-06-14 Baylor College of Medicine Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
AISHA N. HASAN ET AL.: "A Panel of Artificial APCs Expressing Prevalent HLA Alleles Permits Generation of Cytotoxic T Cells Specific for Both Dominant and Subdominant Viral Epitopes for Adoptive Therapy", 《J IMMUNOL》 *
CATHERINE M. BOLLARD ET AL.: "Complete responses of relapsed lymphoma following genetic modification of tumor-antigen presenting cells and T-lymphocyte transfer", 《BLOOD》 *
MARION SUBKLEWE ET AL.: "Dendritic Cells Expand Epstein Barr Virus Specific CD8+ T Cell Responses More Efficiently Than EBV Transformed B Cells", 《HUMAN IMMUNOLOGY》 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109475578A (zh) * 2016-05-25 2019-03-15 昆士兰医学研究所理事会 使用同种异体t细胞治疗自身免疫疾病的方法

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