MX2007015933A - Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales. - Google Patents
Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales.Info
- Publication number
- MX2007015933A MX2007015933A MX2007015933A MX2007015933A MX2007015933A MX 2007015933 A MX2007015933 A MX 2007015933A MX 2007015933 A MX2007015933 A MX 2007015933A MX 2007015933 A MX2007015933 A MX 2007015933A MX 2007015933 A MX2007015933 A MX 2007015933A
- Authority
- MX
- Mexico
- Prior art keywords
- compositions
- expressed
- methods
- cancer cells
- immune responses
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 230000028993 immune response Effects 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 2
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/53—DNA (RNA) vaccination
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Toxicology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
La presente invencion proporciona un metodo para tratar cancer suministrado al sujeto que lo necesita una composicion inmunogenica que comprende una construccion de acido nucleico que codifica a un polipeptido que comprende epitopes CTL PSMA288-297 y PRAME425-4433, o un analogo reactivo transversal. En las modalidades de la presente invencion se proporcionan metodos y composiciones para inducir, entrenar y/o amplificar la respuesta inmune a los epitopes restringidos de la clase I de MHC de antigenos de carcinoma, para genera una respuesta inmune anticancerigeno efectiva.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US69157905P | 2005-06-17 | 2005-06-17 | |
PCT/US2006/023498 WO2006138567A2 (en) | 2005-06-17 | 2006-06-16 | Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007015933A true MX2007015933A (es) | 2008-04-21 |
Family
ID=37325697
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007015933A MX2007015933A (es) | 2005-06-17 | 2006-06-16 | Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales. |
Country Status (14)
Country | Link |
---|---|
US (2) | US7999088B2 (es) |
EP (3) | EP2385060A3 (es) |
JP (1) | JP5416968B2 (es) |
KR (1) | KR20080026181A (es) |
CN (1) | CN101198620A (es) |
AU (1) | AU2006259220C1 (es) |
BR (1) | BRPI0611794A2 (es) |
CA (1) | CA2612516C (es) |
ES (1) | ES2413079T3 (es) |
IL (1) | IL188113A (es) |
MX (1) | MX2007015933A (es) |
NZ (1) | NZ591908A (es) |
SG (1) | SG162817A1 (es) |
WO (1) | WO2006138567A2 (es) |
Families Citing this family (21)
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US6977074B2 (en) | 1997-07-10 | 2005-12-20 | Mannkind Corporation | Method of inducing a CTL response |
US20030215425A1 (en) * | 2001-12-07 | 2003-11-20 | Simard John J. L. | Epitope synchronization in antigen presenting cells |
US7178491B2 (en) * | 2003-06-05 | 2007-02-20 | Caterpillar Inc | Control system and method for engine valve actuator |
JP2008526764A (ja) * | 2004-12-29 | 2008-07-24 | マンカインド コーポレイション | 免疫応答の誘導におけるcd4+細胞の回避方法 |
AU2005321940B2 (en) * | 2004-12-29 | 2012-04-19 | Mannkind Corporation | Methods to trigger, maintain and manipulate immune responses by targeted administration of biological response modifiers into lymphoid organs |
AU2005321898B2 (en) * | 2004-12-29 | 2012-07-19 | Mannkind Corporation | Use of compositions comprising various tumor-associated antigens as anti-cancer vaccines |
US8084592B2 (en) * | 2005-06-17 | 2011-12-27 | Mannkind Corporation | Multivalent entrain-and-amplify immunotherapeutics for carcinoma |
EP2371850A3 (en) * | 2005-06-17 | 2012-08-01 | Mannkind Corporation | Epitope analogues |
EP2385060A3 (en) | 2005-06-17 | 2012-02-15 | Mannkind Corporation | Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma |
JP2009544610A (ja) * | 2006-07-14 | 2009-12-17 | マンカインド コーポレイション | 予防又は治療目的のためにmhcクラスi拘束エピトープに対する免疫応答を引き出し、増強し、保持する方法 |
CA2996732C (en) | 2007-03-26 | 2020-10-27 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Prame derived peptides and immunogenic compositions comprising these |
EP2148697B1 (en) * | 2007-05-24 | 2012-10-03 | GlaxoSmithKline Biologicals S.A. | Lyophilised cpg containing wt-1 composition |
EP2490713A2 (en) * | 2009-10-23 | 2012-08-29 | MannKind Corporation | Cancer immunotherapy and method of treatment |
EP4285922A1 (en) * | 2011-05-26 | 2023-12-06 | Geneius Biotechnology Investments, LLC | Modulated immunodominance therapy |
RU2554821C1 (ru) * | 2014-02-18 | 2015-06-27 | Государственное Бюджетное Образовательное Учреждение Высшего Профессионального Образования "Красноярский Государственный Медицинский Университет Имени Профессора В.Ф. Войно-Ясенецкого Министерства Здравоохранения Российской Федерации" | Способ оценки степени локальной холодовой травмы в раннем реактивном периоде |
EP3400004A1 (en) * | 2016-01-08 | 2018-11-14 | Vaccibody AS | Therapeutic anticancer neoepitope vaccine |
WO2017118702A1 (en) * | 2016-01-08 | 2017-07-13 | Vaccibody As | Neoepitope rna cancer vaccine |
CN106367406A (zh) * | 2016-08-28 | 2017-02-01 | 苏州普罗达生物科技有限公司 | Udp糖基转移酶免疫原多肽及其用途 |
CN106581668B (zh) * | 2016-12-31 | 2020-03-24 | 广州姿生生物科技有限公司 | 一种抗原表位肽组合物及其应用 |
CN112686128B (zh) * | 2020-12-28 | 2022-10-14 | 南京览众智能科技有限公司 | 基于机器学习的教室课桌检测方法 |
TW202309071A (zh) | 2021-05-05 | 2023-03-01 | 德商英麥提克生物技術股份有限公司 | 特異性結合prame之抗原結合蛋白 |
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2006
- 2006-06-16 EP EP11162844A patent/EP2385060A3/en not_active Withdrawn
- 2006-06-16 SG SG201004451-9A patent/SG162817A1/en unknown
- 2006-06-16 KR KR1020087001199A patent/KR20080026181A/ko not_active Application Discontinuation
- 2006-06-16 AU AU2006259220A patent/AU2006259220C1/en not_active Ceased
- 2006-06-16 EP EP06773349A patent/EP1896494B1/en not_active Not-in-force
- 2006-06-16 US US11/454,616 patent/US7999088B2/en not_active Expired - Fee Related
- 2006-06-16 JP JP2008517146A patent/JP5416968B2/ja not_active Expired - Fee Related
- 2006-06-16 NZ NZ591908A patent/NZ591908A/xx not_active IP Right Cessation
- 2006-06-16 CN CNA2006800216014A patent/CN101198620A/zh active Pending
- 2006-06-16 MX MX2007015933A patent/MX2007015933A/es active IP Right Grant
- 2006-06-16 EP EP11162841A patent/EP2385059A3/en not_active Withdrawn
- 2006-06-16 BR BRPI0611794-5A patent/BRPI0611794A2/pt not_active IP Right Cessation
- 2006-06-16 CA CA2612516A patent/CA2612516C/en not_active Expired - Fee Related
- 2006-06-16 WO PCT/US2006/023498 patent/WO2006138567A2/en active Application Filing
- 2006-06-16 ES ES06773349T patent/ES2413079T3/es active Active
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2007
- 2007-12-13 IL IL188113A patent/IL188113A/en not_active IP Right Cessation
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2011
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Also Published As
Publication number | Publication date |
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SG162817A1 (en) | 2010-07-29 |
NZ591908A (en) | 2012-09-28 |
CA2612516A1 (en) | 2006-12-28 |
EP2385059A3 (en) | 2012-02-15 |
EP1896494B1 (en) | 2013-04-03 |
WO2006138567A3 (en) | 2007-02-15 |
AU2006259220A1 (en) | 2006-12-28 |
EP2385060A2 (en) | 2011-11-09 |
CA2612516C (en) | 2015-03-24 |
WO2006138567A2 (en) | 2006-12-28 |
AU2006259220C1 (en) | 2013-05-16 |
US7999088B2 (en) | 2011-08-16 |
IL188113A0 (en) | 2008-03-20 |
KR20080026181A (ko) | 2008-03-24 |
JP2008543315A (ja) | 2008-12-04 |
EP2385060A3 (en) | 2012-02-15 |
CN101198620A (zh) | 2008-06-11 |
IL188113A (en) | 2015-03-31 |
EP2385059A2 (en) | 2011-11-09 |
US8674081B2 (en) | 2014-03-18 |
US20110269949A1 (en) | 2011-11-03 |
BRPI0611794A2 (pt) | 2010-09-28 |
US20070004662A1 (en) | 2007-01-04 |
EP1896494A2 (en) | 2008-03-12 |
ES2413079T3 (es) | 2013-07-15 |
AU2006259220B2 (en) | 2012-10-11 |
JP5416968B2 (ja) | 2014-02-12 |
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