MX2007015933A - Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales. - Google Patents

Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales.

Info

Publication number
MX2007015933A
MX2007015933A MX2007015933A MX2007015933A MX2007015933A MX 2007015933 A MX2007015933 A MX 2007015933A MX 2007015933 A MX2007015933 A MX 2007015933A MX 2007015933 A MX2007015933 A MX 2007015933A MX 2007015933 A MX2007015933 A MX 2007015933A
Authority
MX
Mexico
Prior art keywords
compositions
expressed
methods
cancer cells
immune responses
Prior art date
Application number
MX2007015933A
Other languages
English (en)
Inventor
Adrian Bot
Zhiyong Qiu
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of MX2007015933A publication Critical patent/MX2007015933A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A61K39/0011—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4748—Tumour specific antigens; Tumour rejection antigen precursors [TRAP], e.g. MAGE
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/53—DNA (RNA) vaccination
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Oncology (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invencion proporciona un metodo para tratar cancer suministrado al sujeto que lo necesita una composicion inmunogenica que comprende una construccion de acido nucleico que codifica a un polipeptido que comprende epitopes CTL PSMA288-297 y PRAME425-4433, o un analogo reactivo transversal. En las modalidades de la presente invencion se proporcionan metodos y composiciones para inducir, entrenar y/o amplificar la respuesta inmune a los epitopes restringidos de la clase I de MHC de antigenos de carcinoma, para genera una respuesta inmune anticancerigeno efectiva.
MX2007015933A 2005-06-17 2006-06-16 Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales. MX2007015933A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US69157905P 2005-06-17 2005-06-17
PCT/US2006/023498 WO2006138567A2 (en) 2005-06-17 2006-06-16 Methods and compositions to elicit multivalent immune responses against dominant and subdominant epitopes, expressed on cancer cells and tumor stroma

Publications (1)

Publication Number Publication Date
MX2007015933A true MX2007015933A (es) 2008-04-21

Family

ID=37325697

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2007015933A MX2007015933A (es) 2005-06-17 2006-06-16 Metodos y composiciones para generar respuestas inmunes multivalentes contra espitopes dominantes y subdominantes, expresados en celulas cancerigenas y estromas tumorales.

Country Status (14)

Country Link
US (2) US7999088B2 (es)
EP (3) EP2385060A3 (es)
JP (1) JP5416968B2 (es)
KR (1) KR20080026181A (es)
CN (1) CN101198620A (es)
AU (1) AU2006259220C1 (es)
BR (1) BRPI0611794A2 (es)
CA (1) CA2612516C (es)
ES (1) ES2413079T3 (es)
IL (1) IL188113A (es)
MX (1) MX2007015933A (es)
NZ (1) NZ591908A (es)
SG (1) SG162817A1 (es)
WO (1) WO2006138567A2 (es)

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Also Published As

Publication number Publication date
SG162817A1 (en) 2010-07-29
NZ591908A (en) 2012-09-28
CA2612516A1 (en) 2006-12-28
EP2385059A3 (en) 2012-02-15
EP1896494B1 (en) 2013-04-03
WO2006138567A3 (en) 2007-02-15
AU2006259220A1 (en) 2006-12-28
EP2385060A2 (en) 2011-11-09
CA2612516C (en) 2015-03-24
WO2006138567A2 (en) 2006-12-28
AU2006259220C1 (en) 2013-05-16
US7999088B2 (en) 2011-08-16
IL188113A0 (en) 2008-03-20
KR20080026181A (ko) 2008-03-24
JP2008543315A (ja) 2008-12-04
EP2385060A3 (en) 2012-02-15
CN101198620A (zh) 2008-06-11
IL188113A (en) 2015-03-31
EP2385059A2 (en) 2011-11-09
US8674081B2 (en) 2014-03-18
US20110269949A1 (en) 2011-11-03
BRPI0611794A2 (pt) 2010-09-28
US20070004662A1 (en) 2007-01-04
EP1896494A2 (en) 2008-03-12
ES2413079T3 (es) 2013-07-15
AU2006259220B2 (en) 2012-10-11
JP5416968B2 (ja) 2014-02-12

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