CN103893436A - Externally applied medicine for treatment of rheumatism - Google Patents

Abstract

The invention relates to an externally applied medicine for treatment of rheumatism and rheumatoid diseases, and in particular relates to an externally applied powdery medicine has the effects of warming channel, expelling cold, dispersing blood stasis, dredging collaterals, relieving swelling and pain, dehumidifying and the like. The medicine is prepared from the following raw materials by weight: 7 parts of eucommia, 7 parts of achyranthes root, 4 parts of homalomena occulta, 4 parts of peach seed, 4 parts of safflower, 4 parts of drynaria baronii, 7 parts of hindu datura flower, 1 part of radix aconiti preparata, 4 parts of Chinese angelica and 2 parts of radix angelicae. A preparation method is as follows: picking and cleaning the ten medicinal materials of eucommia, achyranthes root, homalomena occulta, peach seed, safflower, drynaria baronii, hindu datura flower, radix aconiti preparata, Chinese angelica and radix angelicae, drying in the sun, separately grinding into fine powder, mixing evenly, quantitatively packaging with each bag filled with 50g for standby use; when in use, mixing honey and the medicine in a ratio of 1:1, mixing into paste, putting the paste on a 5cm *5cm gauze to be externally applied to pain points of patients, then using infrared ray for radiation for 30 minutes for one time in every day, wherein one period of treatment is 10 days. By clinical observation, the externally applied powdery medicine has the advantages of good treatment effects, high cure rate and less tendency to recurrence after treatment.

Description

One is treated rheumatismal medicine for external use

Technical field

The present invention relates to a kind of medicine for external use for the treatment of rheumatism, rheumatoid disease, specifically a kind of external pulvis medicine with effects such as dispelling cold by warming the meridian, disperse blood stasis and dredge collateral, reducing swelling and alleviating pain and dehumidifying.

Background technology

At present treatment rheumatism, rheumatoid medicine are a lot, mostly are oral medicine, and treatment has certain effect, but because the rheumatism human therapy cycle is long, easily forms drug-induced liver disease, nephropathy, gastropathy.External used medicine of the present invention reduces oral dose, has avoided the damage of function, and external application Chinese medicine is different from other rheumatism plaster, is deeply subject to the approval of extensive patients, simple, and determined curative effect is without any side effects.

Summary of the invention

The object of the present invention is to provide a kind of medicine for external use for the treatment of rheumatism, its feature: pain relieving fast, have no adverse reaction, its analgesic effect is equivalent to rheumatism non-steroid antiinflammatory drug, and there is no the oral lesions of liver and kidney bringing of non-steroid antiinflammatory drug and gastral side reaction.

The object of the present invention is achieved like this, and this medicine is to be made up of the raw material of following parts by weight proportioning: 7 parts of the Cortexs Eucommiae, 7 parts of Radix Achyranthis Bidentataes, 4 parts of Rhizoma Homalomenae, 4 parts, Semen Persicae, 4 parts, Flos Carthami, 4 parts of drynaria baroniis, 7 parts of Flos Daturaes, 1 part of Radix Aconiti Preparata, 4 parts of Radix Angelicae Sinensis, 2 parts of the Radixs Angelicae Dahuricae;

Preparation method is: the Cortex Eucommiae, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, Semen Persicae, Flos Carthami, drynaria baronii, Flos Daturae, Radix Aconiti Preparata, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae 10 taste medical materials picked only, dries and be ground into respectively fine powder, and the quantitative package that is mixed, every bag of 50g is for subsequent use; When use, Mel and dose are pressed to 1:1 proportioning, after mixing batter shape, be placed on 5cm × 5cm gauze, spread on patient's pain spot place outward, then use infrared ray radiation (baking), each 30 minutes, once a day, every 10 days was a course for the treatment of.

The present invention has the following advantages and good effect:

1, the present invention, according to the theory of the traditional Chinese medical science " general rule not bitterly, stagnation of QI and blood may bring about pain ", sets up promoting the flow of QI in the collateral by warming the meridian, the dehumidifying of Eradicates wind, dissipating cold, stopping numbness pain.Wherein taking Flos Daturae, Radix Aconiti Preparata as monarch drug, both share can quickly alleviating pain, Flos Daturae can also suppress the toxicity of Radix Aconiti, the Cortex Eucommiae, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, drynaria baronii, there is invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, stopping numbness pain, for ministerial drug, Semen Persicae, Flos Carthami, Radix Angelicae Sinensis have the QI and blood of logical whole body, blood stasis dispelling and not hindering just for making medicine; The pungent temperature of the assistant Radix Angelicae Dahuricae, in awakening consciousness priming enters.All medicines match and play altogether invigorating the liver and kidney, bone and muscle strengthening, wind-damp dispelling, stopping numbness pain, effect of blood circulation promoting and blood stasis dispelling.

2, medicine of the present invention is medicine for external use, is different from traditional in the market rheumatic plaster, and rheumatism plaster of modern medicine, spray, liniment etc.It is that the prepared slices of Chinese crude drugs form powder through processes, packs quantitative every bag of 50g.Each arthroncus that it causes for rheumatism, rheumatoid wind-cold damp pathogen, ache, stiff, bend and stretch difficulty, fear of cold, be afraid of cold, aversion to wind has certain curative effect.

3, medicine of the present invention is observed through the clinical trail of 2 years 90 routine rheumatoid patient, and theoretical validation, has quick reducing swelling and alleviating pain, relief of symptoms.Can change patient's quality of life, delay or stop ankylosis distortion, instant effect, has no side effect.Be suitable for treatment and the popularization of rheumatism, rheumatoid arthritis.

the clinical observation material of medicine of the present invention

1, rheumatoid clinical case is selected

Totally 90 examples, treatment group 50 examples, matched group 40 examples.Treatment group man 10 examples, female's 40 examples; 18-66 years old age, average 43.2 years old.The course of disease 6 months 1 years, average 6.1 years.Matched group man 10 examples, female's 30 examples; 18 1 64 years old age, average 42.8 years old.The course of disease 6 months 1 years, average 5.9 years.Two groups of there was no significant differences, P<0.05.

" the practical internal medicine " that rheumatoid arthrosis diagnostic criteria is edited with reference to Shanghai Medical Univ: 1. stiff 1 hour >6 week in morning; 2. 3 above arthroncuss) 6 weeks; 3. type joint swelling or the swelling of near-end articulations digitorum manus) 6 weeks; 4. symmetry arthroncus) 6 weeks; 5. subcutaneous nodule; ) X sheet demonstration bone erosion; 7. the rheumatoid factor positive.In above 7, possess 4 diagnosable.Symptom: pain of joint muscle is fixed, sore spot tenderness, local swelling, scleroma or purpura, limitation of activity, thin white fur of tongue or BOHUANG, stringy pulse.

Exclusion standard: gestation or women breast-feeding their children, joint skin has damaged person, to medicine for external use powder or capsaicin ointment allergy sufferers, infective arthritis, serious liver, renal function pathological changes person.

2, verification method

Treatment group 50 exception the present invention, usage and dosage, external, each one to two bag, every bag with 50g-100g Mel, after mixing batter shape, be placed on 5cm × 5cm gauze, spread on affected part, thickness 2-3 millimeter, with plastic sheeting covering, then roasting with TDP infrared ray, after each 30 minutes, take off warm water washing affected part.Once a day, be weekly a course for the treatment of.Take each 2 of leflunomide, day is once oral simultaneously, and pain severe patient takes 2 of meloxicams, and day once.

Matched group 40 is routine with capsaicin ointment (being produced by Changchun 999 Bio-Pharmaceutical Co., Ltd), according to its joint size of getting involved get appropriate book layer evenly outer being applied to outside arthralgia surface, be coated with RA joint part, after preheating, TDP irradiates affected part, keeps 40 DEG C of skin surface temperatures to be advisable, and irradiation time is 30 min/ time, once a day, every 10 is a course for the treatment of, takes each 2 of leflunomide simultaneously, and day is once oral, pain severe patient takes 2 of meloxicams, and day once.

Therapentic part: unified select to refer to, wrist, knee joint, ankle joint treatment, once a day.After 10 days, clinical efficacy is judged.

3, observation index

(1), general health check-up project

(2), hematuria routine test

4, health giving quality observation

(1) local symptom such as joint, skin, muscles and bones, as pain, numbness, cool, stiff, miserable, swollen

The symptom variation situation such as swollen.

(2) erythrocyte sedimentation rate, c reactive protein.

5, criterion of therapeutical effect

Effective: cardinal symptom, sign entirety improvement rate 75%, erythrocyte sedimentation rate and CRP often or obviously improve or approach normal; Progressive: cardinal symptom, sign entirety improvement rate 50%, erythrocyte sedimentation rate and CRP are improved; Effective: cardinal symptom, sign entirety improvement rate 30%, erythrocyte sedimentation rate and CRP are improved or without improvement; Invalid: cardinal symptom, sign entirety improvement rate 30%, erythrocyte sedimentation rate and CRP are without improvement.

6, therapeutic outcome

Effective 10 examples for the treatment of group, progressive 30 examples, effective 7 examples, invalid 3 examples, total effective rate 94 .%; Matched group is effective 7, progressive 12 examples, effective 11 examples, invalid 10 examples, total effective rate 75%.

Two groups relatively there were significant differences.Treatment group takes effect 3 one 4 days, average 6.2 days; The matched group 5-9 days that takes effect.Treatment group is not found toxic and side effects; There is Glutamate pyruvate transaminase rises in matched group 1 example, after drug withdrawal, disappears.

Obviously treatment group is better than matched group, illustrates that this patent medicine for external use has certain effect to treatment rheumatism.

Detailed description of the invention

By proportioning weighting raw materials Cortex Eucommiae 7kg, Radix Achyranthis Bidentatae 7 kg, Rhizoma Homalomenae 4 kg, Herba Chelidonii 4 kg, Herba Epimedii 4 kg, drynaria baronii 4 kg, Flos Daturae 7 kg, Radix Aconiti Preparata 1 kg, Radix Angelicae Sinensis 4 kg, the Radix Angelicae Dahuricae 2 kg, above-mentioned all crude drug are dried, after pulverizing, cross 40 mesh sieves, the quantitative package that is mixed, every bag of 50g.

Using method: the invention belongs to external application Chinese medicine, Mel and dose are pressed 1:1 proportioning, adjusts and evenly becomes pasty state, and the used time is placed on 5cm × 5cm gauze, is placed on patient's pain spot place.Then use infrared ray radiation (baking), each 30 minutes, every 10 days was a course for the treatment of.Skin allergy person answers drug withdrawal.Or add desensitizer.

Claims (1)

1. the rheumatismal medicine for external use for the treatment of, is characterized in that: this medicine is to be made up of the raw material of following parts by weight proportioning: 7 parts of the Cortexs Eucommiae, 7 parts of Radix Achyranthis Bidentataes, 4 parts of Rhizoma Homalomenae, 4 parts, Semen Persicae, 4 parts, Flos Carthami, 4 parts of drynaria baroniis, 7 parts of Flos Daturaes, 1 part of Radix Aconiti Preparata, 4 parts of Radix Angelicae Sinensis, 2 parts of the Radixs Angelicae Dahuricae;

Preparation method is: the Cortex Eucommiae, Radix Achyranthis Bidentatae, Rhizoma Homalomenae, Semen Persicae, Flos Carthami, drynaria baronii, Flos Daturae, Radix Aconiti Preparata, Radix Angelicae Sinensis, the Radix Angelicae Dahuricae 10 taste medical materials picked only, dries and be ground into respectively fine powder, and the quantitative package that is mixed, every bag of 50g is for subsequent use; When use, Mel and dose are pressed to 1:1 proportioning, after mixing batter shape, be placed on 5cm × 5cm gauze, spread on patient's pain spot place outward, then use infrared ray radiation, each 30 minutes, once a day, every 10 days was a course for the treatment of.