CN104887775A - Traditional Chinese medicine preparation for treating neonatal scleredema and preparation method therefor - Google Patents
Traditional Chinese medicine preparation for treating neonatal scleredema and preparation method therefor Download PDFInfo
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- CN104887775A CN104887775A CN201510401308.1A CN201510401308A CN104887775A CN 104887775 A CN104887775 A CN 104887775A CN 201510401308 A CN201510401308 A CN 201510401308A CN 104887775 A CN104887775 A CN 104887775A
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Abstract
The invention belongs to the field of traditional Chinese medicines and particularly relates to a traditional Chinese medicine preparation for treating neonatal scleredema and a preparation method therefor. The traditional Chinese medicine preparation is prepared from the following raw pharmaceutical materials: angelica sinensis, Chinese date, safflowers, salvia miltiorrhiza, Corydalis yanhusuo, pubescent angelica root, prepared aconite root and illicium verum. The traditional Chinese medicine preparation disclosed by the invention has the main effects of promoting Qi circulation and tonifying blood, warming Yang and dispelling cold and promoting blood circulation to dispel blood stasis and has a very good treatment effect on the treatment of neonatal scleredema, particularly Qi-stasis-due-to-cold and internal-stagnation-of-blood type neonatal scleredema; and the side effect of drugs is low, so that the traditional Chinese medicine preparation is applicable to newborns and has a remarkable clinical popularization value.
Description
Technical field
The invention belongs to medical art, be specifically related to a kind of Chinese medicine preparation for the treatment of neonatal scleredema and preparation method thereof.
Background technology
Neonatal scleredema refer to neonate due to cold, premature labor, infect, skin that the many reasons such as to suffocate causes and subcutaneous fat is hardening and a kind of serious disease of edema, betide in neonate birth 7-10 days, be common in cold season.Serious symptom scleroderma neonatorum person can secondary pneumorrhagia, shock and MOFE and lethal.Neonatal scleredema treatment is except rewarming, heat supply, and infection control, corrects Organ Dysfunction, and in Drug therapy, vasospasm is removed in most important measure, improves microcirculation.
Motherland's medical science is thought, children's's internal organs are tender and lovely, and shape gas does not fill, and be the body of immature yin and yang, premature infant's natural endowment is more not enough, is subject to the outstanding attacked by the cold and evil of cold and heat, QI and blood is condensed, and runs not smooth and causes blood stasis, occurring that local is swollen and firmly send out cool.Also mention in errors in Medicine Corrected: blood catches cold, condense in bulk, therefore by this disease ownership Blood stasis.Chinese traditional treatment Blood stasis is with a long history, experienced, in conjunction with modern Chinese medicine theory of development, from improving curative effect of medication, reducing the angle of side effect, through carrying out to Chinese medicine the Chinese medicine preparation that screening is extracted and/or compatibility is obtained, side effect is little, and safety is high, have the advantage that chemical synthetic drug can not be compared, the Chinese medicine preparation therefore developing the more definite treatment neonatal scleredema of curative effect is necessary.
Summary of the invention
In order to solve the problem, the present invention aims to provide a kind of Chinese medicine preparation for the treatment of neonatal scleredema and preparation method thereof.
An object of the present invention is to provide a kind of Chinese medicine preparation for the treatment of neonatal scleredema.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine preparation of neonatal scleredema.
Chinese medicine preparation of the present invention is obtained by following crude drug: Radix Angelicae Sinensis, Fructus Jujubae, Flos Carthami, Radix Salviae Miltiorrhizae, Rhizoma Corydalis, Radix Angelicae Pubescentis, gun tab, Fructus Anisi Stellati.
Preferably, its active ingredient is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 12-16 part, Fructus Jujubae 8-13 part, Flos Carthami 3-7 part, Radix Salviae Miltiorrhizae 10-14 part, Rhizoma Corydalis 6-10 part, Radix Angelicae Pubescentis 10-14 part, gun tab 10-14 part, Fructus Anisi Stellati 8-12 part.
Preferred, its active ingredient is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 12-14 part, Fructus Jujubae 9-11 part, Flos Carthami 4-6 part, Radix Salviae Miltiorrhizae 11-13 part, Rhizoma Corydalis 7-9 part, Radix Angelicae Pubescentis 10-12 part, gun tab 11-13 part, Fructus Anisi Stellati 8-10 part.
Most preferred, its active ingredient is made up of the crude drug of following weight portion: Radix Angelicae Sinensis 13 parts, 10 parts, Fructus Jujubae, 5 parts, Flos Carthami, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Pubescentis 11 parts, gun tab 12 parts, Fructus Anisi Stellati 9 parts.
The Chinese medicine preparation that the present invention treats neonatal scleredema can also contain pharmaceutically acceptable carrier, is prepared into conventional formulation, as lotion, tincture or ointment, is preferably ointment.
The preparation method of Chinese medicine preparation of the present invention comprises the steps: the crude drug of above-mentioned weight portion to pulverize 120 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 4-6 times amount, each 2 hours, filter cleaner extracting juice merges, when filtrate after merging is concentrated into 75 DEG C, its relative density is the clear paste of 1.0-1.1, be directly used as medicine use or to add again on pharmaceutics acceptable adjuvant routinely technique make clinical acceptable dosage form.
Chinese medicine preparation of the present invention, has the following advantages and effect:
(1) Chinese medicine preparation of the present invention is from the cogitive theory reasonable formula of the traditional Chinese medical science to neonatal scleredema, has that circulation of qi promoting is enriched blood, effect of warming YANG to expel cold, blood circulation promoting and blood stasis dispelling, and particularly to QI stagnated by cold, type of blood-stasis obstructing in the interior neonatal scleredema is treated targetedly.
(2) Chinese medicine preparation of the present invention treat neonatal scleredema time for chemical drugs, untoward reaction and few side effects.
(3) through clinical practice checking, use invention formulation treatment QI stagnated by cold, type of blood-stasis obstructing in the interior neonatal scleredema, the routine infant for the treatment of group 45, effective 15 examples, effective 28 examples, invalid 2 examples, total effective rate 95.6%, clinical effectiveness is remarkable.And tracing observation therapeutic outcome is significantly better than matched group.
The functional effect of Chinese medicine preparation of the present invention each Chinese medicine component is as follows:
Radix Angelicae Sinensis, sweet, acrid, warm.Enter the heart, liver, spleen channel.Enrich blood and invigorate blood circulation, menstruction regulating and pain relieving, moisturize laxation.Control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia; Headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome; Dryness of the intestine dyschezia is heavy after bloody dysentery; Carbuncle skin ulcer is stolen, injury from falling down.
Fructus Jujubae, sweet, temperature.Return spleen, stomach warp.Invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.
Flos Carthami, pungent, temperature.GUIXIN, Liver Channel.Promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain.For amenorrhea, dysmenorrhea, lochia ， mass in the abdomen mass in the abdomen, injury from falling down, skin infection swells and ache.
Radix Salviae Miltiorrhizae, bitter, be slightly cold.GUIXIN, Liver Channel.Stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea ， lumps in the chest and abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris.
Rhizoma Corydalis, pungent, bitter, temperature.Return liver, spleen channel.Invigorate blood circulation, promoting the circulation of QI, pain relieving.For the breast side of body, epigastric pain, amenorrhea dysmenorrhea, postpartum stagnation, tumbling and swelling.
Radix Angelicae Pubescentis, pungent, bitter, temperature.Return liver, kidney, urinary bladder channel.Expelling wind and removing dampness, numbness relieving and pain relieving, induces sweat.Anemofrigid-damp arthralgia, lumbocrural pain, few sun volt wind headache.Damp person and SHAO YIN headache etc. is had concurrently for rheumatic arthralgia, exterior syndrome due to wind-cold.
Radix Aconiti Lateralis Preparata, pungent, sweet, hot greatly; Poisonous.GUIXIN, kidney, spleen channel.Recuperating depleted YANG and rescuing the patient from collapse, mends fire supporing yang, by wind-cold damp pathogen.For YANG-depletion collapse, cold extremities faint pulse, sexual impotence, cold womb, trusted subordinate's cold type of pain, deficiency and coldness is vomited and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, arthralgia due to cold-dampnes.Gun tab: get Radix Aconiti Lateralis Preparata, according to the method for scalding, scalds to heaving and micro-variable color with sand.
Fructus Anisi Stellati, pungent, temperature.Return liver,kidney,spleen, stomach warp.Warming YANG to expel cold, regulating QI to relieve pain.For colic of cold type stomachache, lumbago due to renal deficiency, gastrofrigid vomiting, coldness and pain in the epigastrium.
Detailed description of the invention
Further describe the present invention below by way of specific embodiment, the present invention is not limited only to following examples.Within the scope of the invention or not departing from content of the present invention, spirit and scope, the change carried out the present invention, combination or replacement, be apparent for a person skilled in the art, and be included within the scope of the present invention.
Embodiment 1 ointment
Each raw material is taken: Radix Angelicae Sinensis 13 parts, 10 parts, Fructus Jujubae, 5 parts, Flos Carthami, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Pubescentis 11 parts, gun tab 12 parts, Fructus Anisi Stellati 9 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 120 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 5 times amount, each 2 hours, filter cleaner extracting juice merges, when filtrate after merging is concentrated into 75 DEG C, its relative density is the clear paste of 1.0-1.1, then to add on pharmaceutics acceptable adjuvant routinely technique be prepared into ointment.
When using Chinese medicine preparation of the present invention to treat neonatal scleredema, use prepared ointment, smear affected part thickness is 0.1-0.2mm at every turn, and massage absorbs, every day 3-5 time.Every 10g ointment is containing crude drug amount 5g.
Embodiment 2 lotion
Each raw material is taken: Radix Angelicae Sinensis 13 parts, 10 parts, Fructus Jujubae, 5 parts, Flos Carthami, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Pubescentis 11 parts, gun tab 12 parts, Fructus Anisi Stellati 9 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 120 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 5 times amount, each 2 hours, filter cleaner extracting juice merges, when filtrate after merging is concentrated into 75 DEG C, its relative density is the clear paste of 1.0-1.1, gets 10g clear paste during treatment at every turn, adds appropriate warm water and stirs, clean affected part, every day twice.
Embodiment 3 tincture
Each raw material is taken: Radix Angelicae Sinensis 13 parts, 10 parts, Fructus Jujubae, 5 parts, Flos Carthami, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Pubescentis 11 parts, gun tab 12 parts, Fructus Anisi Stellati 9 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 120 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 5 times amount, each 2 hours, filter cleaner extracting juice merges, when filtrate after merging is concentrated into 75 DEG C, its relative density is the clear paste of 1.0-1.1, then to add on pharmaceutics acceptable adjuvant routinely technique be prepared into tincture.
When using Chinese medicine preparation of the present invention to treat neonatal scleredema, use prepared tincture, every bottle of 35ml is containing crude drug amount 17.5g, and every day 3 times, in affected part, spraying is appropriate, and massage absorbs.
Embodiment 4 ointment
Each raw material is taken: Radix Angelicae Sinensis 12 parts, 8 parts, Fructus Jujubae, 3 parts, Flos Carthami, Radix Salviae Miltiorrhizae 10 parts, Rhizoma Corydalis 6 parts, Radix Angelicae Pubescentis 10 parts, gun tab 10 parts, Fructus Anisi Stellati 8 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 120 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 4 times amount, each 2 hours, filter cleaner extracting juice merges, when filtrate after merging is concentrated into 75 DEG C, its relative density is the clear paste of 1.0-1.1, then to add on pharmaceutics acceptable adjuvant routinely technique be prepared into ointment.
When using Chinese medicine preparation of the present invention to treat neonatal scleredema, use prepared ointment, smear affected part thickness is 0.1-0.2mm at every turn, and massage absorbs, every day 3-5 time.
Embodiment 5 ointment
Each raw material is taken: Radix Angelicae Sinensis 16 parts, 13 parts, Fructus Jujubae, 7 parts, Flos Carthami, Radix Salviae Miltiorrhizae 14 parts, Rhizoma Corydalis 10 parts, Radix Angelicae Pubescentis 14 parts, gun tab 14 parts, Fructus Anisi Stellati 12 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 120 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 6 times amount, each 2 hours, filter cleaner extracting juice merges, when filtrate after merging is concentrated into 75 DEG C, its relative density is the clear paste of 1.0-1.1, then to add on pharmaceutics acceptable adjuvant routinely technique be prepared into ointment.
When using Chinese medicine preparation of the present invention to treat neonatal scleredema, use prepared ointment, smear affected part thickness is 0.1-0.2mm at every turn, and massage absorbs, every day 3-5 time.
Embodiment 6 ointment
Each raw material is taken: Radix Angelicae Sinensis 12 parts, 9 parts, Fructus Jujubae, 4 parts, Flos Carthami, Radix Salviae Miltiorrhizae 11 parts, Rhizoma Corydalis 7 parts, Radix Angelicae Pubescentis 10 parts, gun tab 11 parts, Fructus Anisi Stellati 8 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 7 ointment
Each raw material is taken: Radix Angelicae Sinensis 14 parts, 11 parts, Fructus Jujubae, 6 parts, Flos Carthami, Radix Salviae Miltiorrhizae 13 parts, Rhizoma Corydalis 9 parts, Radix Angelicae Pubescentis 12 parts, gun tab 13 parts, Fructus Anisi Stellati 10 parts by following weight portion.
Preparation technology is with embodiment 1.
Embodiment 8 ointment
Each raw material is taken: Radix Angelicae Sinensis 13 parts, 10 parts, Fructus Jujubae, 5 parts, Flos Carthami, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Pubescentis 11 parts, gun tab 12 parts, Fructus Anisi Stellati 9 parts by following weight portion.
Preparation method: the crude drug of above-mentioned weight portion pulverized 120 mesh sieves respectively, mix homogeneously, add the soak by water 2 times of medical material gross mass 5 times amount, each 2 hours, filter cleaner extracting juice merges, and when the filtrate after merging is concentrated into 75 DEG C, its relative density is the clear paste of 1.0-1.1, directly to be used as medicine use, and technique is prepared into ointment routinely.
When using Chinese medicine preparation of the present invention to treat neonatal scleredema, use prepared ointment, smear affected part thickness is 0.1-0.2mm at every turn, and massage absorbs, every day 3-5 time.
The clinical observation of embodiment 9 Chinese medicine preparation treatment of the present invention neonatal scleredema
1, case-data:
Select obstetrics of institute of traditional Chinese medicine to meet neonate infant 90 example of neonatal scleredema, all case all meets the diagnostic criteria of " the neonatal scleredema conventional treatment " that nineteen ninety formulates, and by this scale and calibration.Neonatal scleredema diagnostic criteria: 1. subcutaneous fat gathers cold, hard, the swollen performance of position generation; 2. body temperature is down to 3l-35 DEG C; 3. the skin hardened is aubergine or pale yellow, and severe one is touched like hard rubber sample.And be QI stagnated by cold through tcm diagnosis, type of blood-stasis obstructing in the interior.Treatment group and each 45 examples of matched group, wherein treatment group man 24 example is divided into, female 21 example, premature infant 41 example, small for date infant 4 example according to the principle of parallel control.Slight 27 examples, moderate 13 example, severe 5 example.Merge pneumonia 11 example, omphalitis 4 example, thrush 2 example, septicemia 1 example, 2 examples of suffocating, intracranial hemorrhage 1 example, congenital malformation 1 example, respiratory failure 2 example.Matched group, man 23 example, female 22 example, premature infant 42 example, small for date infant 3 example.Slight 26 examples, moderate 14 example, severe 5 example.Merge pneumonia 12 example, omphalitis 6 example, thrush 4 example, congenital heart disease 1 example, 3 examples of suffocating, pneumorrhagia 1 example, respiratory failure 2 example.Two groups of sexes, gestational age, age in days, state of an illness there was no significant differences (P > 0.05), have comparability.
2, Therapeutic Method:
Two groups all give comprehensive therapy, comprise warming rewarming, supply sufficient heat and liquid, correct Organ Dysfunction in time, regulate soda acid and electrolyte imbalance, infection control etc., oxygen uptake if desired, plasma transfusion Supporting Therapy.
Treatment group: use the ointment prepared by embodiment 1 on the basis of comprehensive therapy, smear affected part thickness is 0.1-0.2mm at every turn, and massage absorbs, every day 3-5 time.General medication 3-5d, discontinued medication after 10 days.
3, curative effect determinate standard:
Effective: in 12h, temperature recovery is normal, in 5d, hard swelling is disappeared;
Effective: in 24h, temperature recovery is normal, in 7d, hard swelling is disappeared;
Invalid: after 24h, temperature recovery is normal, in 7d, hard swelling is not disappeared completely or firmly swells unchanged.
Total effective rate=obvious effective rate+effective percentage.
4, therapeutic outcome:
In clinical observation process, 90 routine infants all complete clinical observation, and nothing exits, come off infant.
Clinical observation result is: the routine infant for the treatment of group 45, effective 15 examples (33.3%), effective 28 examples, invalid 2 examples, total effective rate 95.6%, and clinical effectiveness is remarkable; The routine infant of matched group 45, effective 8 examples (17.8%), effective 19 examples, invalid 18 examples, total effective rate 60%, two groups of obvious effective rates, total effective rates compare, have significant difference (P < 0.05), treatment group group is significantly better than matched group.
Observe in treatment at clinical trail, the firmly swollen regression time for the treatment of group is 4.62 ± 1.38d, and matched group is 7.34 scholar 4.25d, and two groups are compared and have significant difference (P < 0.05); Treatment group temperature recovery normal time is 8.68 native 6.64h, and matched group is 16.7 ± 10.74h, and two groups are compared and have significant difference (P < 0.01).And there is not obvious untoward reaction over the course for the treatment of in treatment group, show thus, use Chinese medicine preparation of the present invention to treat neonatal scleredema determined curative effect, safe and reliable, the present invention can be used as the active drug for the treatment of neonatal scleredema, is worth studying and applying further.
Claims (9)
1. treat a Chinese medicine preparation for neonatal scleredema, it is characterized in that, it is obtained by the crude drug of following weight portion: Radix Angelicae Sinensis 12-16 part, Fructus Jujubae 8-13 part, Flos Carthami 3-7 part, Radix Salviae Miltiorrhizae 10-14 part, Rhizoma Corydalis 6-10 part, Radix Angelicae Pubescentis 10-14 part, gun tab 10-14 part, Fructus Anisi Stellati 8-12 part.
2. Chinese medicine preparation as claimed in claim 1, is characterized in that, it obtains primarily of the crude drug of following weight portion: Radix Angelicae Sinensis 12-14 part, Fructus Jujubae 9-11 part, Flos Carthami 4-6 part, Radix Salviae Miltiorrhizae 11-13 part, Rhizoma Corydalis 7-9 part, Radix Angelicae Pubescentis 10-12 part, gun tab 11-13 part, Fructus Anisi Stellati 8-10 part.
3. Chinese medicine preparation as claimed in claim 2, is characterized in that, it obtains primarily of the crude drug of following weight portion: Radix Angelicae Sinensis 13 parts, 10 parts, Fructus Jujubae, 5 parts, Flos Carthami, Radix Salviae Miltiorrhizae 12 parts, Rhizoma Corydalis 8 parts, Radix Angelicae Pubescentis 11 parts, gun tab 12 parts, Fructus Anisi Stellati 9 parts.
4. the Chinese medicine preparation as described in any one of claim 1-3, it is also containing pharmaceutically acceptable carrier.
5. Chinese medicine preparation as claimed in claim 4, it is characterized in that, described Chinese medicine preparation is lotion, tincture or ointment.
6. Chinese medicine preparation as claimed in claim 5, it is characterized in that, described Chinese medicine preparation is preferably ointment.
7. one kind prepare as arbitrary in claim 1-6 as described in the method for Chinese medicine preparation, it is characterized in that, it comprises the following steps: the crude drug of above-mentioned weight portion was pulverized 120 mesh sieves respectively, mix homogeneously, adds the soak by water 2 times of medical material gross mass 4-6 times amount, each 2 hours, filter cleaner extracting juice merges, when filtrate after merging is concentrated into 75 DEG C, its relative density is the clear paste of 1.0-1.1, then to add on pharmaceutics acceptable adjuvant routinely technique make clinical acceptable dosage form.
8. the purposes of the Chinese medicine preparation as described in as arbitrary in claim 1-3 in the medicine of preparation treatment neonatal scleredema.
9. the Chinese medicine preparation as described in as arbitrary in claim 1-3 in preparation treatment QI stagnated by cold, the purposes in the medicine of type of blood-stasis obstructing in the interior neonatal scleredema.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075022A (en) * | 2016-07-29 | 2016-11-09 | 盛鹰 | A kind of enema treating neonatal scleredema |
| CN106177544A (en) * | 2016-07-29 | 2016-12-07 | 孙大宏 | A kind of enema treating cold blood stagnation neonatal scleredema |
-
2015
- 2015-07-10 CN CN201510401308.1A patent/CN104887775A/en active Pending
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| Title |
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| 刘弼臣等，: "《中医儿科治疗大成》", 30 April 1998, 河北科学技术出版社 * |
| 陈胜兰: "中西医结合治疗新生儿硬肿症42例", 《黑龙江中医药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106075022A (en) * | 2016-07-29 | 2016-11-09 | 盛鹰 | A kind of enema treating neonatal scleredema |
| CN106177544A (en) * | 2016-07-29 | 2016-12-07 | 孙大宏 | A kind of enema treating cold blood stagnation neonatal scleredema |
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Application publication date: 20150909 |