CN105250548A - Treatment medicine for severe fever with thrombocytopenia syndrome - Google Patents

Treatment medicine for severe fever with thrombocytopenia syndrome Download PDF

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Publication number
CN105250548A
CN105250548A CN201510775669.2A CN201510775669A CN105250548A CN 105250548 A CN105250548 A CN 105250548A CN 201510775669 A CN201510775669 A CN 201510775669A CN 105250548 A CN105250548 A CN 105250548A
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parts
blood
medicine
heat
thrombocytopenia syndrome
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蓝本祥
李先强
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蓝本祥
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Abstract

The invention relates to a treatment medicine for a severe fever with thrombocytopenia syndrome and belongs to the technical field of medicines. The medicine is used for solving the severe fever with thrombocytopenia syndrome caused by virus infections due to tick bites. The severe fever with thrombocytopenia syndrome is caused by dual depletion of qi and blood and exhaustion of yin and yang due to toxin entering construction-blood, pathogenic toxin thriving, viscera retrocession, and the traditional Chinese medicines including 15 parts of honeysuckle, 10 parts of mung beans, 12 parts of rehmannia roots, 10 parts of exocarpium benincasae, 10 parts of folium isatidis, 10 parts of jasmine, 10 parts of the seeds of Chinese dodder, 10 parts of fructus forsythia, 10 parts of talc, 10 parts of lithospermum, 12 parts of oldenlandia diffusa, 12 parts of cistanche, 10 parts of spina gleditsiae, 10 parts of colocasia antiquorum and 7 parts of liquorice are combined for clearing Ying heat and cooling blood, relieving heat and achieving detoxification, invigorating qi and blood and expelling toxin and eliminating evil. All the medicines are combined to form the mixed treatment medicine which is used for being decocted and taken orally, and the treatment effect is obvious.

Description

The medicine of heating companion thrombocytopenic syndromes
Technical field
The present invention relates to the medicine of heating companion thrombocytopenic syndromes, particularly with the medicine that Chinese medicine combines, belong to medical art.
Background technology
Heating companion thrombocytopenic syndromes is by a kind of viral infection acute infectious disease because causing caused by Ticks insect stings, clinical manifestation accompanies thrombocytopenia for principal character to generate heat, the small number of patients state of an illness is heavier and development is rapid, can be dead because of MOFE; Isolated virus in poisoner's body, is identified as a kind of new virus, is called novel Bunyavirus.Investigation finds that this disease exists the aggregation epidemic situation of human-to-human transmission, illustrates that Patients with Acute blood has infectiousness.On hills, mountain region, the area such as forest produce, the population infection risk of life is higher.Bunyavirus natural infection sees many vertebratess and arthropod (mosquito, Ticks, sand fly etc.), can infecting mouse, and can grow in some mammalss, birds and mosquito cell culture; The disease of similar influenza or dengue fever, hemorrhagic fever (Li Fute paddy heat and Crimea-Crimean-Congo Hemorrhagic Fever etc.) and encephalitis (galifornia encephalitis) can be caused to people.There are mosquito matchmaker, Ticks matchmaker, sand fly matchmaker 3 kinds of Spread type.Newfound virus belongs to bunyaviridae (Bunyaviridae)phlebovirus ( phlebovirus), virion is spherical in shape, and diameter 80-100nm, has lipid envelope outward, and there is spinous process on surface.Genome comprises three sub-thread strand RNA fragments (L, M and S), and L fragment total length is 6368 nucleotide, comprises the RNA polymerase that single reading frame codes RNA relies on; M fragment total length is 3378 nucleotide, containing single single open reading frame, and 1073 amino acid whose glycoprotein precursors of encoding; S fragment is an ambisense RNA, and genome is encode viral nucleoprotein and non-structural protein in a bi-directional way.Viral genome end sequence high conservative, other virus panel are identical with Phlebovirus, can form panhandle shape structure.
causebunyaviridae viral resistance weak, not acidproof, Yi Beire, ether, the sodium deoxycholate of heating companion thrombocytopenic syndromes and the rapid inactivation such as common disinfectants and ultraviolet radiation.Infection symptoms is mainly body local hyperemia, edema, concurrent inflammatory reaction, causes secondary infection, continues fever, blood test is thrombocytopenia and causes Multiple organ dysfunction.The minority case state of an illness is critical, occurs disturbance of consciousness, the dermal ecchymosis, digestive tract hemorrhage, pneumorrhagia etc., can be dead because of MOFE such as shock, respiratory failure, disseminated inravascular coagulations (DIC).
Heating companion thrombocytopenic syndromes there is no specific treatment means, is mainly Supporting Therapy to the ill.Vitro Experimental Results prompting ribavirin has inhibitory action to this virus, can try out clinically.Secondary bacterial, fungal infections, should select sensitive antibiotic to treat.Note the treatment of underlying diseases simultaneously.Still there be no evidence to suggest the therapeutic effect of glucocorticoid at present, should use cautiously.
Summary of the invention
Heating companion thrombocytopenic syndromes is not only the result of human body by outer poisonous insect challenge infection, and the power of resisting of concurrency bacteriological infection, people itself, immunity are also the reasons of morbidity.With the viewpoint analysis of Chinese medicine heating companion thrombocytopenic syndromes, belong to that poison enters nutrient blood, evil poison is flourishing, inside fire attack internal organs cause deficiency of both QI and blood, negative and positive two exhaust and form primary disease.Treatment heating companion thrombocytopenic syndromes, should treat with the Chinese Medicine and Clavicular that clearing away heat from YING and blood systems, the removing toxic substances that expels the heat-evil, benefiting vital QI and blood, toxin expelling are eliminating evil.
The medicine of heating companion thrombocytopenic syndromes combines by each Chinese medicine quality part ratio below: Flos Lonicerae 15 parts, 10 parts, Semen phaseoli radiati, 12 parts, the Radix Rehmanniae, Exocarpium Benincasae 10 parts, Folium Isatidis 10 parts, Fructus Gardeniae 10 parts, Semen Cuscutae 10 parts, Fructus Forsythiae 10 parts, 10 parts, Talcum, Radix Arnebiae (Radix Lithospermi) 10 parts, Herba Hedyotidis Diffusae 12 parts, Herba Cistanches 12 parts, Spina Gleditsiae 10 parts, Rhizoma Colocasiae antiquori 10 parts, 7 parts, Radix Glycyrrhizae.
The property of medicine of each Chinese medicine ingredients in the medicine of lower surface analysis heating companion thrombocytopenic syndromes.Flos Lonicerae is cold in nature, sweet in the mouth; Attach to the lung and stomach meridians; Heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly carbuncle furunculosis from the beginning of, red and swollen heat pain, affection due to external wind and heat, epidemic febrile disease from the beginning of, toxic-heat and blood stasis, summer-heat excessive thirst, laryngopharynx swelling and pain.Semen phaseoli radiati sweet in the mouth cool in nature, have heat-clearing and toxic substances removing, quench the thirst relieve summer heat, effect of diuresis skin moistening.Radix Rehmanniae cooling blood for hemostasis, promoting the production of body fluid to quench thirst, radioprotective, reduction blood glucose, heart tonifying, diuresis.Exocarpium Benincasae heat clearing away, removing heat from blood, nourishing the stomach to promote the production of body fluid, wash dirty control tired, detumescence.Folium Isatidis heat-clearing and toxic substances removing, induce sweat loose wind; Above-mentioned patient is seen for anemopyretic cold and influenza, parotitis.The fruit of Fructus Gardeniae is Chinese medicine, has the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, is usually used in treating icterohepatitis, bruise, hypertension at tcm clinical practice.Semen Cuscutae invigorating the liver and kidney, beneficial marrow, improving eyesight; Control soreness of waist and knee joint, seminal emission, quench one's thirst, dripping urination, order is dark.The heat clearing away of Fructus Forsythiae energy, removing toxic substances, eliminating stagnation, detumescence, controls warm, erysipelas, macule, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.Effect of Talcum and effect: promoting diuresis to eliminate damp pathogen, clearing away summer-heat is antipyretic.Radix Arnebiae (Radix Lithospermi) removing heat from blood, invigorates blood circulation, heat clearing away, and removing toxic substances, controls warm macule, jaundice due to damp-heat, purpura, tell, is defeated in battle, hematuria, stranguria with turbid discharge, constipation with heat retention, burn, eczema, erysipelas, carbuncle and ulcer.Effect of Agkistrodon house grass: heat-clearing and toxic substances removing, diuresis of blood circulation promoting; For tonsillitis, pharyngolaryngitis, urinary tract infection, pelvic inflammatory disease, appendicitis, hepatitis, bacillary dysentery, venom, tumor.Herba Cistanches sweet in the mouth, salty, warm in nature; Energy kidney-replenishing, benefiting essence-blood, loosening bowel to relieve constipation; Lose for insufficiency of kidney-YANG, essence and blood void, sexual impotence or infertile, soreness of the waist and knees, muscles and bones is unable; Dryness of the intestine constipation, can also enhancing immunity, and adjustment endocrine promotes metabolism, enhancing development.Radix Angelicae Sinensis effect: benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, moisturizes laxation, for blood deficiency, shallow complexion, dizzy cardiopalmus, rheumatic arthralgia, traumatic injury etc.Unfolded tender leaf of Sinocalamus affinis (Rendle) Mcclure clearing heat and relieving fidgetness, diuresis of promoting the production of body fluid, control calentura excessive thirst, pediatric epilepsy scared, cough with dyspnea tells nosebleed, flushed complexion, oliguria also, erosion of the oral mucosa tongue boil.Spina Gleditsiae has another name called SPINA GLEDITSIAE, property and flavor of peppery and warm, and function has detumescence and apocenosis, wind dispelling insecticide, for skin sore from the beginning of or the disease of difficulty in discharging of pus and tinea, leprosy etc.Rhizoma Colocasiae antiquori is the rhizome of aroid Rhizoma colocasiae giganteae; Effect: removing toxic substances and promoting subsidence of swelling, spasmolytic of eliminating the phlegm, dispel the wind counteracting toxic substances.Radix Glycyrrhizae tabellae is relieving cough and expelling phlegm medicine, and effect is rather extensive, in Chinese medicine decoction and Chinese patent medicine compatibility, and effect of its QI invigorating strengthening the spleen conventional and middle emergency, coordinating the actions of various ingredients in a prescription.
The beneficial effect of the medicine of heating companion thrombocytopenic syndromes is: the medicine analysis heating companion thrombocytopenic syndromes of heating companion thrombocytopenic syndromes, belong to that poison enters nutrient blood, evil poison is flourishing, inside fire attack internal organs cause deficiency of both QI and blood, negative and positive two exhaust and form primary disease, take with the eliminating evil Chinese Medicine and Clavicular treatment of clearing away heat from YING and blood systems, the removing toxic substances that expels the heat-evil, benefiting vital QI and blood, toxin expelling, start with the correct theoretical scheme for the treatment of by Chinese herbs heating companion thrombocytopenic syndromes, and received safety, obvious curative effect.
Detailed description of the invention
Further implementation is made below with the medicine of preferred embodiment to heating companion thrombocytopenic syndromes.
It is combine by each Chinese medicine quality below that the medicine of heating companion thrombocytopenic syndromes is applicable to a dose drug that a heating companion thrombocytopenic syndromes patient takes: Flos Lonicerae 15 grams, 10 grams, Semen phaseoli radiati, 12 grams, the Radix Rehmanniae, Exocarpium Benincasae 10 grams, Folium Isatidis 10 grams, Fructus Gardeniae 10 grams, Semen Cuscutae 10 grams, Fructus Forsythiae 10 grams, 10 grams, Talcum, Radix Arnebiae (Radix Lithospermi) 10 grams, Herba Hedyotidis Diffusae 12 grams, Herba Cistanches 12 grams, Spina Gleditsiae 10 grams, Rhizoma Colocasiae antiquori 10 grams, 7 grams, Radix Glycyrrhizae.
The medicine using method of heating companion thrombocytopenic syndromes: decoct soup and take orally, take a dosage for one day, can suitably decrement use after being used in conjunction three dosage.The result of use of the medicine of heating companion thrombocytopenic syndromes: taken by Ticks insect stings the infected through 12, the lighter's recovery from illness in three days, one week of severe one fully recovers.Heating companion thrombocytopenic syndromes medicine be not only applicable to Ticks insect stings viral infection, for venom, scorpion, Scolopendra, Aranea etc. bite poisoning cause heating companion thrombocytopenia all have obvious curative effect.

Claims (1)

1. the medicine of heating companion thrombocytopenic syndromes, is characterized in that combining by each Chinese medicine quality part ratio below: Flos Lonicerae 15 parts, 10 parts, Semen phaseoli radiati, 12 parts, the Radix Rehmanniae, Exocarpium Benincasae 10 parts, Folium Isatidis 10 parts, Fructus Gardeniae 10 parts, Semen Cuscutae 10 parts, Fructus Forsythiae 10 parts, 10 parts, Talcum, Radix Arnebiae (Radix Lithospermi) 10 parts, Herba Hedyotidis Diffusae 12 parts, Herba Cistanches 12 parts, Spina Gleditsiae 10 parts, Rhizoma Colocasiae antiquori 10 parts, 7 parts, Radix Glycyrrhizae.
CN201510775669.2A 2015-11-15 2015-11-15 Treatment medicine for severe fever with thrombocytopenia syndrome Withdrawn CN105250548A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210880A (en) * 2016-12-21 2018-06-29 天津大学 Compound PS-341 is in the application for preparing bunyaviridae Phlebovirus viral inhibitors

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104940691A (en) * 2015-06-28 2015-09-30 李先强 Treatment medicine for novel bunyaviridae infection
CN104997956A (en) * 2015-07-30 2015-10-28 庞群 Behcet's syndrome and treatment drug thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104940691A (en) * 2015-06-28 2015-09-30 李先强 Treatment medicine for novel bunyaviridae infection
CN104997956A (en) * 2015-07-30 2015-10-28 庞群 Behcet's syndrome and treatment drug thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108210880A (en) * 2016-12-21 2018-06-29 天津大学 Compound PS-341 is in the application for preparing bunyaviridae Phlebovirus viral inhibitors
CN108210880B (en) * 2016-12-21 2021-08-03 天津大学 Application of compound PS-341 in preparation of bunyaviridae phlebovirus inhibitor

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