CN103891900A - Processing method of bovine colostrum - Google Patents
Processing method of bovine colostrum Download PDFInfo
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- CN103891900A CN103891900A CN201410150131.8A CN201410150131A CN103891900A CN 103891900 A CN103891900 A CN 103891900A CN 201410150131 A CN201410150131 A CN 201410150131A CN 103891900 A CN103891900 A CN 103891900A
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- colostrum
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- ultrafiltration
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Abstract
The invention discloses a processing method of bovine colostrum. The processing method comprises the following specific steps: firstly collecting colostrum secreted in 72 hours after delivery of dairy cattle, standing, scratching floating foam, and then putting the colostrum in a freezer at the temperature of 4 DEG C; then under the condition that the temperature is 0-10 DEG C, performing ultrafiltration by adopting a molecular membrane, removing water in the bovine colostrum, and concentrating to the volume 15% of the original volume, wherein the ultrafiltration pressure is from 2*105Pa to 3 *105Pa; centrifuging the bovine colostrum treated by ultrafiltration and concentration and then taking out upper-layer centrifugate after centrifugation; and finally, freezing and drying lower-layer liquid after centrifugation to obtain freeze-dried powder of the bovine colostrum. Shown by test for feeding to animals and trial feeding to a human body, the product obtained by the processing method disclosed by the invention has the advantages that the immunity of the animals can be obviously improved, the growth and the development of the human body can be enhanced and the memory can be improved.
Description
Technical field
The invention belongs to health food preparing technical field, be specifically related to a kind of processing method of colostrum.
Background technology
Colostrum refers to secreted milk in 3 days postpartum of cow, contains panimmunity material, growth factor and all kinds of nutritional labeling, and that its immune factor has is antibacterial, antiviral, regulate immune effect.The growth factor being rich in colostrum and multiple enzyme, choline, phosphatide, brain peptide etc., can promote brain cell DNA, RNA and protein synthetic, to intelligence development, nerve conduction and visual function play an important role, IQ can effectively be improved, memory, enhancing development.
In colostrum, the secret panimmunity globulin containing is that human body is necessary, can effectively resist various bacteriums, virus, in and body in toxicant, regulate allergic reaction.Wherein Immunoglobulin IgG is the immunoglobulin (Ig) that content is maximum, can neutralize all kinds of pathogen of invasion, toxicant.Lactotransferrin is natural Anti-bacterium, the antiviral substance that effect is the strongest, can be directly with virus in conjunction with or mark on its surface, be convenient to macrophage phagocytic and remove.PRP(immunoloregulation polypeptide) can stimulate human immunity organ thymus gland T cell ability, strengthen the immunologic function falling into a decline, regulate again too drastic immune response simultaneously.So colostrum is many-sided, omnibearing to the function of Organism immunoregulation, is rare innate immune function enhancing substance.
In colostrum, also contain all kinds of growth factors, can promote growth and the regeneration of the organ-tissues such as the muscle, bone, nerve of human body, can improve fat metabolism ability, the chemical level of balance blood sugar and brain, the RNA that helps DNA plerosis, provides to the growth mechanism of human body the effect that comprehensively puts in, comprising NFG, epithelial cell growth factor, short living cells growth factor etc.
The taurine being rich in colostrum has another name called taurine, Taurine, by called after tarine, is a kind of P-amino acid in body, belongs to nonprotein amino acid; have promotion intelligence development, the effect of protection retina, protects liver; protect kidney, protect heart effect, blood pressure effect is adjusted in reducing blood lipid.
In colostrum, also have the necessary each dvielements of people's bulk-growth such as calcium, zinc, phosphorus.
The product of all kinds of nominals in the market " colostrum " is a lot, but main technique is, colostrum is collected, to spray, be dried, be prepared into tablet, capsule, granule etc. multi-form.In order to strengthen the mobility of powder, add starch, dextrin constituents to increase the uniformity of powder toward contact meeting.The product of preparation like this, active constituent content is low, and active material can run off in a large number in process, causes the content of active ingredient to decline, and effective rate of utilization reduces.
Growing of people refers to the maturation from embryonated egg to adult, growing is a continual process, each age bracket has its different body feature, vigorous in the basic metabolism of growth and development stage body, basal metabolic rate is grown up high, and particularly intelligence development is more urgent to the demand of some nutritional labeling.Therefore, school-ager is as unbalanced in taken in nutritional labeling, there will be fatiguability, becomes thin, resistance declines, feeblemindedness, and the development indexs such as height are lower than situations such as normal values.
On present society, have all kinds of phenomenons, it is disadvantageous that children's normal growth is grown, and 1. foreign fast food spreads unchecked, serious harm children and health intelligence development.2. acidic food is too much, causes acidic constitution, unfavorable to children ' s intelligence development.3. staple food is too refining, the systematic growth thereby the absorption that has reduced B family vitamin affects the nerves.4. sugar in delicatessen food, salt content is too high, additive is excessive, affects child nutrition equilibrium.
The functional food of popular enhancing development is mainly some high protein, high heat based food or replenishes the calcium, zinc supplementation, benefit iron, mends the dietary supplements of each biostearin in the market.Can, for the situation of some nutritional labeling insufficiency of intake, play the effect that improves upgrowth and development of children, but colostrum preparation can be by improving immunization programs for children power, build up one's resistance to disease, improve intelligence, muscle power, the balanced absorption to all kinds of nutritional labelings, until the effect of enhancing development.
Summary of the invention
the technical problem that the present invention solves:the object of the invention is to provide for above the deficiencies in the prior art a kind of processing method of colostrum.
technical scheme
A processing method for colostrum, is characterized in that, is prepared according to following steps:
Step 1, the cow endocrine colostrum in 72 hours postpartum of gathering, leaves standstill, and scrapes off offscum, puts into Cool Room 4℃;
Step 2, adopts molecular film ultrafiltration, removes moisture in colostrum, and is concentrated into 15% of original volume, and ultrafiltration pressure is 2 × 10
5pa-3 × 10
5pa;
Step 3, by centrifugal the colostrum liquid after ultrafiltration concentration, takes out centrifugate upper strata after centrifugal;
Step 4, carries out freeze drying by centrifugal rear lower floor liquid, obtains colostrum freeze-dried powder.
The processing method of described colostrum, in step 2, to adopt specified pore diameter range be the miillpore filter of 0.001-0.01 micron in molecular film ultrafiltration.
The processing method of described colostrum, in step 2, ultrafiltration is carried out under the condition of 0 ~ 10 ℃.
The processing method of described colostrum, in step 3, centrifugal condition is 4000 revs/min, centrifugal 12 minutes.
The processing method of described colostrum, step 4 freeze drying vacuum is less than 10 handkerchiefs, 25 ~ 30 ℃ of freeze temperatures, time 2 h.
In above-described colostrum preparation method, in step 2, to adopt specified pore diameter range be the miillpore filter of 0.001-0.01 micron in molecular film ultrafiltration, is greater than 100 dalton with isolated molecule amount, and particle diameter is greater than the particle of 2 nanometers; The molecular film ultrafiltration adopting in step 2 is mainly to remove moisture in colostrum, play enrichment, inspissation, ultrafiltration environment under lower than 10 ℃ of conditions, carried out farthest avoiding high temperature to colostrum in the sex change of protein molecular.
beneficial effect
The processing method of colostrum provided by the invention after measured content wherein content of immunoglobulin IgG be greater than 30%; content of taurine is greater than 1%; lead content is less than 0.5PPm; arsenic content is less than 0.3PPm; mercury content is less than 0.1PPm; show that by animal clinical testing product that the processing method of colostrum provided by the invention obtains can obviously strengthen the immunologic function of body fluid and cell, have significantly enhancing development and improve memory effect through human body being carried out to product that test-meal test shows that the processing method of colostrum provided by the invention obtains.
This method does not adopt high temperature in overall process, has farthest retained the various functional components in colostrum, and removes fat by ultrafiltration, has reduced the energy resource consumption in freeze-drying process.Wherein ultrafiltration, centrifugal, freeze-drying are all carried out at clean area, to guarantee that finished product microbiological indicator meets the requirements.
The specific embodiment
Embodiment 1
A processing method for colostrum, carry out according to following steps:
(1) the cow endocrine colostrum 3kg in 72 hours postpartum that gathers, leaves standstill 5 minutes, and the offscum scraping off is put into Cool Room 4℃ preservation.
(2) under 0 ℃ of condition, adopt molecular film ultrafiltration, selecting specified pore diameter range is the miillpore filter of 0.001 micron, colostrum is concentrated into 15% left and right of original volume, ultrafiltration pressure is 2 × 10
5pa.
(3) the colostrum liquid of ultrafiltration concentration being crossed is centrifugal, 4000 revs/min approximately 12 minutes, centrifugate upper strata is taken out.
(4) lower floor's liquid is put into freeze dryer pallet, freeze drying, vacuum 8 handkerchiefs, 25 ℃ of freeze temperatures, time 2 h, can obtain colostrum freeze-dried powder, is the faint yellow crystallization of flakey.
Embodiment 2
A processing method for colostrum, carry out according to following steps:
(1) the cow endocrine colostrum 2kg in 72 hours postpartum that gathers, leaves standstill 5 minutes, and the offscum scraping off is put into Cool Room 4℃ preservation.
(2) under 6 ℃ of conditions, adopt molecular film ultrafiltration, selecting specified pore diameter range is the miillpore filter of 0.008 micron, colostrum is concentrated into 15% left and right of original volume, ultrafiltration pressure is 2.4 × 10
5pa.
(3) the colostrum liquid of ultrafiltration concentration being crossed is centrifugal, 4000 revs/min approximately 12 minutes, centrifugate upper strata is taken out.
(4) lower floor's liquid is put into freeze dryer pallet, freeze drying, vacuum 6 handkerchiefs, 28 ℃ of freeze temperatures, time 2 h, can obtain colostrum freeze-dried powder, is the faint yellow crystallization of flakey.
Embodiment 3
A processing method for colostrum, carry out according to following steps:
(1) the cow endocrine colostrum 2kg in 72 hours postpartum that gathers, leaves standstill 5 minutes, and the offscum scraping off is put into Cool Room 4℃ preservation.
(2) under 10 ℃ of conditions, adopt molecular film ultrafiltration, selecting specified pore diameter range is the miillpore filter of 0.01 micron, colostrum is concentrated into 15% left and right of original volume, ultrafiltration pressure is 3 × 10
5pa.
(3) the colostrum liquid of ultrafiltration concentration being crossed is centrifugal, 4000 revs/min approximately 12 minutes, centrifugate upper strata is taken out.
(4) lower floor's liquid is put into freeze dryer pallet, freeze drying, vacuum 3 handkerchiefs, 30 ℃ of freeze temperatures, time 2 h, can obtain colostrum freeze-dried powder, is the faint yellow crystallization of flakey.
In above embodiment preparation process, ultrafiltration environment, not higher than 10 ℃, can farthest be avoided the sex change of high temperature to protein molecular in colostrum; Ultrafiltration adopts the miillpore filter of 0.001-0.01 micron, is greater than 100 dalton with isolated molecule amount, and particle diameter is greater than the particle of 2 nanometers, is mainly to remove moisture in colostrum, plays enrichment, inspissation simultaneously.
The colostrum freeze-dried powder that above embodiment is prepared carries out content detection, obtains result as follows:
The colostrum freeze-dried powder that embodiment 1 is prepared carries out clinical testing, and detailed process is as follows:
1. cellular immune function experiment
Per os gives mouse 600,200 and 100mg/kgbw/d colostrum freeze-dried powder 30d every day, each dosage group mice auricle swelling degree is higher than control group, there is dose-response relationship, each group all has notable statistics difference (P < 0.01), illustrates that this product has the mouse cell of enhancing immunologic function.
2. humoral immune function experiment
Per os gives mouse 600,200 and 100mg/kgbw/d colostrum freeze-dried powder 30d every day, each dosage group mice serum HD50 value (HC50) is all higher than control group, there is dose-response relationship, have notable statistics difference, illustrate that this product has the mouse humoral immune of enhancing function.
3. in Xianju County in Zhejiang Province White Tower central primary school senior class student, choose voluntarily 110 experimenters, age 9-11 year, after test for the first time, be divided at random control group and test-meal group, control group and test-meal group health check-up indices no difference of science of statistics, every group of 55 children, test-meal group everyone every day of oral 1.20g bovine colostrum, control group is taken the blank sample that packing is identical with test-meal group, test-meal test discovery afterwards in 30 days, test-meal group exceedes 0.6 centimetre than control group height, body weight exceedes 0.2 kilogram, chest measurement exceedes 0.4 centimetre, upper-arm circumference exceedes 0.3 centimetre, body fat content is low by 0.3%, all produce significant difference, in contrasting before and after memory, pointing to memory, associative learning and image are freed recall in the test of three subscales, test-meal group is all obviously better than control group, illustrate that bovine colostrum prepared by the present invention has enhancing development and improvement memory effect significantly.
Claims (5)
1. a processing method for colostrum, is characterized in that, is prepared according to following steps:
Step 1, the cow endocrine colostrum in 72 hours postpartum of gathering, leaves standstill, and scrapes off offscum, puts into Cool Room 4℃;
Step 2, adopts molecular film ultrafiltration, removes moisture in colostrum, and is concentrated into 15% of original volume, and ultrafiltration pressure is 2 × 10
5pa-3 × 10
5pa;
Step 3, by centrifugal the colostrum liquid after ultrafiltration concentration, takes out centrifugate upper strata after centrifugal;
Step 4, carries out freeze drying by centrifugal rear lower floor liquid, obtains colostrum freeze-dried powder.
2. the processing method of colostrum according to claim 1, is characterized in that, in step 2, to adopt specified pore diameter range be the miillpore filter of 0.001-0.01 micron in molecular film ultrafiltration.
3. the processing method of colostrum according to claim 1, is characterized in that, in step 2, ultrafiltration is carried out under the condition of 0 ~ 10 ℃.
4. the processing method of colostrum according to claim 1, is characterized in that, in step 3, centrifugal condition is 4000 revs/min, centrifugal 12 minutes.
5. the processing method of colostrum according to claim 1, is characterized in that, step 4 freeze drying vacuum is less than 10 handkerchiefs, 25 ~ 30 ℃ of freeze temperatures, time 2 h.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410150131.8A CN103891900A (en) | 2014-04-15 | 2014-04-15 | Processing method of bovine colostrum |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410150131.8A CN103891900A (en) | 2014-04-15 | 2014-04-15 | Processing method of bovine colostrum |
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| CN103891900A true CN103891900A (en) | 2014-07-02 |
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| CN201410150131.8A Pending CN103891900A (en) | 2014-04-15 | 2014-04-15 | Processing method of bovine colostrum |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330890A (en) * | 2018-09-27 | 2019-02-15 | 康道生物（南通）有限公司 | A kind of preparation process improving Lyophilized Bovine Colostrums capsule content uniformity |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1043861A (en) * | 1988-12-30 | 1990-07-18 | 中国科学院上海生理研究所 | The refinement method of colostrum and edible colostrum powder thereof |
| CN1267549A (en) * | 2000-02-21 | 2000-09-27 | 湖北楚冠实业股份有限公司 | Oral immune globulin preparation and its preparing process |
| CN103053687A (en) * | 2013-01-11 | 2013-04-24 | 山东银香大地乳业有限公司 | Organic bovine colostrum powder and preparation method thereof |
-
2014
- 2014-04-15 CN CN201410150131.8A patent/CN103891900A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1043861A (en) * | 1988-12-30 | 1990-07-18 | 中国科学院上海生理研究所 | The refinement method of colostrum and edible colostrum powder thereof |
| CN1267549A (en) * | 2000-02-21 | 2000-09-27 | 湖北楚冠实业股份有限公司 | Oral immune globulin preparation and its preparing process |
| CN103053687A (en) * | 2013-01-11 | 2013-04-24 | 山东银香大地乳业有限公司 | Organic bovine colostrum powder and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| 胡立新等: "利用膜分离技术对牛初乳进行除菌浓缩的研究", 《食品科技》 * |
| 薛海燕等: "牛初乳加工工艺及开发研究进展", 《中国乳品工业》 * |
| 袁霖等: "牛初乳食品加工工艺的研究", 《肉类工业》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330890A (en) * | 2018-09-27 | 2019-02-15 | 康道生物（南通）有限公司 | A kind of preparation process improving Lyophilized Bovine Colostrums capsule content uniformity |
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Application publication date: 20140702 |