CN103889437A - 硫醚、醚和烷基胺连接的氢键替代物肽模拟物 - Google Patents

硫醚、醚和烷基胺连接的氢键替代物肽模拟物 Download PDF

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Publication number
CN103889437A
CN103889437A CN201280051966.7A CN201280051966A CN103889437A CN 103889437 A CN103889437 A CN 103889437A CN 201280051966 A CN201280051966 A CN 201280051966A CN 103889437 A CN103889437 A CN 103889437A
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China
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formula
alkyl
aryl
heterocyclyl
heteroaryl
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CN201280051966.7A
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English (en)
Chinese (zh)
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P·阿罗拉
A·马洪
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New York University
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New York University
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Publication of CN103889437A publication Critical patent/CN103889437A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
CN201280051966.7A 2011-08-31 2012-08-31 硫醚、醚和烷基胺连接的氢键替代物肽模拟物 Pending CN103889437A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161529414P 2011-08-31 2011-08-31
US61/529,414 2011-08-31
PCT/US2012/053538 WO2013033645A1 (en) 2011-08-31 2012-08-31 Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics

Publications (1)

Publication Number Publication Date
CN103889437A true CN103889437A (zh) 2014-06-25

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CN201280051966.7A Pending CN103889437A (zh) 2011-08-31 2012-08-31 硫醚、醚和烷基胺连接的氢键替代物肽模拟物

Country Status (6)

Country Link
US (1) US20130123196A1 (cg-RX-API-DMAC7.html)
EP (1) EP3041491A1 (cg-RX-API-DMAC7.html)
CN (1) CN103889437A (cg-RX-API-DMAC7.html)
AU (1) AU2012301605A1 (cg-RX-API-DMAC7.html)
IN (1) IN2014CN02398A (cg-RX-API-DMAC7.html)
WO (1) WO2013033645A1 (cg-RX-API-DMAC7.html)

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CA2686827C (en) 2006-12-14 2014-09-16 Aileron Therapeutics, Inc. Bis-sulfhydryl macrocyclization systems
US8889632B2 (en) 2007-01-31 2014-11-18 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
CN109627287A (zh) 2007-02-23 2019-04-16 爱勒让治疗公司 三唑大环系统
EP2508531B1 (en) 2007-03-28 2016-10-19 President and Fellows of Harvard College Stitched polypeptides
US8524653B2 (en) 2008-09-22 2013-09-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010060112A1 (en) 2008-11-24 2010-05-27 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
EP2376100B1 (en) 2009-01-14 2017-10-25 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
CA2774973A1 (en) 2009-09-22 2011-03-31 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
SI2603600T1 (sl) 2010-08-13 2019-04-30 Aileron Therapeutics, Inc. Peptidomimetični makrocikli
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
JP2015504048A (ja) 2011-12-21 2015-02-05 ニューヨーク・ユニバーシティ タンパク質分解抵抗性水素結合サロゲートヘリックス
HK1205454A1 (en) 2012-02-15 2015-12-18 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
WO2014071241A1 (en) 2012-11-01 2014-05-08 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
WO2014113792A1 (en) * 2013-01-19 2014-07-24 New York University Hydrogen-bond surrogate peptides and peptidomimetics for p53 reactivation
EP3041492A4 (en) * 2013-09-03 2017-08-02 New York University INHIBITING INTERACTION BETWEEN HIF-1alfa AND P300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES
JP2018503595A (ja) 2014-09-24 2018-02-08 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． ペプチド模倣大環状分子およびその製剤
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
WO2016154058A1 (en) 2015-03-20 2016-09-29 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
US10023613B2 (en) 2015-09-10 2018-07-17 Aileron Therapeutics, Inc. Peptidomimetic macrocycles as modulators of MCL-1
AU2016347456B2 (en) 2015-10-27 2018-12-13 F. Hoffmann-La Roche Ag Peptide macrocycles against acinetobacter baumannii
EP3388444A1 (en) 2017-04-10 2018-10-17 F. Hoffmann-La Roche AG Anti-bacterial peptide macrocycles and use thereof
US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
US11819532B2 (en) 2018-04-23 2023-11-21 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1642978A (zh) * 2002-01-17 2005-07-20 坎巴斯有限公司 具有抗增殖活性和/或可增强核酸损伤剂或治疗的效果的肽和肽模拟物
US20100056432A1 (en) * 2002-08-20 2010-03-04 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
US20100234563A1 (en) * 2004-05-27 2010-09-16 Paramjit Arora Methods for Preparing Internally Constrained Peptides and Peptidomimetics

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8524653B2 (en) * 2008-09-22 2013-09-03 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
WO2010060112A1 (en) * 2008-11-24 2010-05-27 Aileron Therapeutics, Inc. Peptidomimetic macrocycles with improved properties
JP2015504048A (ja) * 2011-12-21 2015-02-05 ニューヨーク・ユニバーシティ タンパク質分解抵抗性水素結合サロゲートヘリックス
EP2817023A4 (en) * 2012-02-22 2015-11-25 Univ New York REVERSIBLE NETWORKED SCREW-MOUNTED HYDROGEN BONDING SUPPLY MACROCYCLES
EP3041492A4 (en) * 2013-09-03 2017-08-02 New York University INHIBITING INTERACTION BETWEEN HIF-1alfa AND P300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1642978A (zh) * 2002-01-17 2005-07-20 坎巴斯有限公司 具有抗增殖活性和/或可增强核酸损伤剂或治疗的效果的肽和肽模拟物
US20100056432A1 (en) * 2002-08-20 2010-03-04 Polyphor Ltd. Template-fixed peptidomimetics with antibacterial activity
US20100234563A1 (en) * 2004-05-27 2010-09-16 Paramjit Arora Methods for Preparing Internally Constrained Peptides and Peptidomimetics

Also Published As

Publication number Publication date
US20130123196A1 (en) 2013-05-16
WO2013033645A1 (en) 2013-03-07
IN2014CN02398A (cg-RX-API-DMAC7.html) 2015-06-19
EP3041491A1 (en) 2016-07-13
AU2012301605A1 (en) 2014-04-17

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Application publication date: 20140625